|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK5 4
CAMK CHEK2 220
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK14 24
AGC PDPK1 82
CAMK PIM1 38
AGC ROCK2 92
AGC SGK1 98
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPEN-I-KK------EICIN-KMLNHEN--VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSA--RIT----IPDIKKDRW-Y----------
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQ-SHLRHPN--ILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQ--RPM----LREVLEHPWI-----------
--FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVE-HQLR-----REIEIQ-AHLHHPN--ILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLP----LAQVSAHPWV-----------
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPS-TAIR------EISLL-KELRHPN--IVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS----GKMALNHPYF-----------
--YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPS-SALR------EICLL-KELKHKN--IVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLF---GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS----AEEALQHPYF-----------
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEIL-KKLNHPC--IIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVS-VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKA--RFT----TEEALRHPWL-----------
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIM-RKLDHCN--IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT----PLEACAHSFF-----------
--YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAK-RAYR------ELVLM-KCVNHKN--IISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS----VDDALQHPYI-----------
--YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAK-RTYR------ELRLL-KHMKHEN--VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTGYVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT----AAQALAHAYF-----------
-F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVM-SRLDHPF--FVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT----EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATK--RLG----CEEM------EGYGPLKAHPF
--YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGEL-PNGTRV--PMEVVLL-KKVSSGFSGVIRLLDWFER------PDSFV--LILERPEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD---------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSD--RPT----FEEIQNHPWM-----------
--YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFE-MIKRSDS-AFFW-----EERDIM-AFANSPW--VVQLFYAFQD------DRYLY--MVMEYMPGG--DLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHL---KLADFGTCMKM-DETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTPFYAD---SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNG----VEEIRQHPFF-----------
--FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA-ILKKKEE-KHIM-----SERNVLLKNVKHPF--LVGLHFSFQT------ADKLY--FVLDYINGG--ELFYHLQ----RERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD-SQGHI---VLTDFGLCKEN--IEHNSTTSTFCGTPEYLAPEVLH----KQPYDRTVDWWCLGAVLYEMLY-GLPPFYSR---NTAEMYDNILNKPLQLKPNIT---------------------------------------NSARHLLEGLLQKDRTK--RLGAKDDFMEIKSHV--FF---------
|