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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK CSF1R 203
TK ALK 1116
TK BTK 402
TK EGFR 712
TK ERBB2 720
TK FGFR1 478
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LYN 247
TK MET 1078
TK NTRK1 510
TK PDGFRA 593
TK SRC 270
TK TNK2 150
--LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLKS--TAHADEKEALMSELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR-----------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN---GHVAKIGDFGLARDI-MNDSNY--IVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP---------------YPGILVNSKFYKLV-KDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL---
-I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLPE--VCSEQDELDFLMEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLRETRP-------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YRASYY--RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFV-TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I--
--LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIKE--GSMSE--DEFIEEAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLREM-------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVVKVSDFGLSRYV--LDDEY--TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-TNSETAEHI-AQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSN-I--
-F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELRE--ATSPKANKEILDEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVREH-------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL-GAEEKE--YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELI---IEF
-L-RKVKVLGSGAFGTVYKGIWIP---DGENVKIPVAIKVLRE--NTSPKANKEILDEAYVMAGV-GSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHVREN-------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKS---PNHVKITDFGLARLL-DIDETE--YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKP---------------YDGI-PAREIPDLL-EKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSE-F--
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS--DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQARRPPGLEY----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI-HHIDYY--KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLL-KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL---
--LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMKP--GSMSV--EAFLAEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLKSD------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI--EDNEY--TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRAL-ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSV-L--
--ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVNE--AASMRERIEFLNEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLRSLRPEM----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI-YETDYY--RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS-I--
--ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVNE--SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLRSLRPEA----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI-YETDYY--RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFV-MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQH--STE-EHLRDFEREIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH-------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVLPQDKEYY--KVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
-L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQH--SGPDQ-QRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRH-------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLLPLDKDYY--VVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGP--QL-
--LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLKP--SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI-KNDSNY--VVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMI-KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I--
--LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLKQ--GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLKTP------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI--EDNEY--TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
--IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLKP--GTMSV--QAFLEEANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLKSD------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE---SLMCKIADFGLARVI--EDNEY--TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-TNADVMTAL-SQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSV-L--
--VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIRNE-------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM-YDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYL-LQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I--
IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALKE--ASESA-RQDFQREAELLTML-QHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLRSHGPDAKL-----------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI-YSTDYY--RVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-SNTEAIDCI-TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL---
-L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKMLKP--TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ---GKIVKICDFGLARDI-MHDSNY--VSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTP---------------YPGMMVDSTFYNKI-KSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV-
-L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLKP--GTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGE------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI--EDNEY--TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
-L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLRKH-------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRALPQNDDHY--VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDF-L--
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