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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK CSF1R 203
TK ABL1 261
TK ABL2 288
TK FLT3 610
TK FLT4 845
TK KDR 834
TK KIT 589
TK LCK 245
TK PDGFRA 593
TK PDGFRB 600
TKL RIPK1 17
---LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT-HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-------MNDSNY------IVKGNARLPVKWMAPESIFDCV--YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMA---QPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL--
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTL-KEDTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--------TGDTY------TAHAGAKFPIKWTAPESLAYNK--FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRME---RPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
---ITMKHKLGGGQYGEVYVGVWK-----KYSLTVAVKTL-KEDTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--------TGDTY------TAHAGAKFPIKWTAPESLAYNT--FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYDLLEKGYRME---QPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F-
---LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREALMSELKMMTQLGSHENIVNLLGACT-LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSRE-------------------------VQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI-------MSDSNY------VVRGNARLPVKWMAPESLFEGI--YTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMD---QPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL--
---LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKML-KEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-------YKDPDY------VRKGSARLPLKWMAPESIFDKV--YTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMR---APELATPAIRRIMLNCWSGDPKARPAFSELVEIL--
---LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKML-KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------YKDPDY------VRKGDARLPLKWMAPETIFDRV--YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR---APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
---LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-------KNDSNY------VVKGNARLPVKWMAPESIFNCV--YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRML---SPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
---LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSL-KQGSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--------EDNEY------TAREGAKFPIKWTAPEAINYGT--FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMV---RPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
--L-VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-------MHDSNY------VSKGSTFLPVKWMAPESIFDNL--YTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMA---KPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
--L-VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKML-KSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-------MRDSNY------ISKGSTFLPLKWMAPESIFNSL--YTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMA---QPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
LES----AELDSGGFGKVSLCFHR------TQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRL-RHSRVVKLLGVII-EEGKYSLVMEYMEKGNLMHVLKAE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNE--EHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEK-F-
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