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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK CSF1R 203
TK ABL1 261
TK ALK 1116
TKL BRAF 456
TK EGFR 712
TK ERBB2 720
TK ERBB4 718
TK FGFR1 478
TK FGFR3 472
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LYN 247
TK MET 1078
TK NTRK1 510
TK PDGFRB 600
TK PTK6 191
TK SRC 270
TK TEK 824
--LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLKS-TAHADEKEALMSELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN---GHVAKIGDFGLARDI-MNDSNY--IVKGNARLPVKWMAPESIFDCV---YTVQSDVWSYGILLWEIFSLGLNP---------------YPGILVNSKFYKLVKDGYQ----MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL---
--ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM--TGDTY--TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F--
-I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLPE-VCSEQDELDFLMEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLRETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YRASYY--RKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGR----MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I--
--ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK-SRWSGS--HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI-
-F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELRE-ATSPKANKEILDEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVREH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL-GAEEKE--YHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGER----LPQPPICTIDVYMIMVKCWMIDADSRPKFRELI---IEF
-L-RKVKVLGSGAFGTVYKGIWIP---DGENVKIPVAIKVLRE-NTSPKANKEILDEAYVMAGV-GSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHVREN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKS---PNHVKITDFGLARLL-DIDETE--YHADGGKVPIKWMALESILRRR---FTHQSDVWSYGVTVWELMTFGAKP---------------YDGI-PAREIPDLLEKGER----LPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSE-F--
-L-KRVKVLGSGAFGTVYKGIWVP---EGETVKIPVAIKILNE-TTGPKANVEFMDEALIMASM-DHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYVHEH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKS---PNHVKITDFGLARLL-EGDEKE--YNADGGKMPIKWMALECIHYRK---FTHQSDVWSYGVTIWELMTFGGKP---------------YDGI-PTREIPDLLEKGER----LPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAE-F--
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS-DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI-HHIDYY--KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHR----MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL---
--LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD-DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLRARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE---DNVMKIADFGLARDV-HNLDYY--KKTTNGRLPVKWMAPEALFDRV---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHR----MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL---
--LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMKP-GSMSV--EAFLAEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI--EDNEY--TAREGAKFPIKWTAPEAINFGS---FTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRALERGYR----MPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSV-L--
--ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVNE-AASMRERIEFLNEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLRSLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI-YETDYY--RKGGKGLLPVRWMSPESLKDGV---FTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGL----LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS-I--
--ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVNE-SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI-YETDYY--RKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQH-STE-EHLRDFEREIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVLPQDKEYY--KVKEPGESPIFWYAPESLTESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
-L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQH-SGPDQ-QRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLLPLDKDYY--VVREPGQSPIFWYAPESLSDNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQR----LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGP--QL-
--LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI-KNDSNY--VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMIKEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I--
--LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI--EDNEY--TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
--IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLKP-GTMSV--QAFLEEANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE---SLMCKIADFGLARVI--EDNEY--TAREGAKFPIKWTAPEAINFGC---FTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-TNADVMTALSQGYR----MPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSV-L--
--VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIRNE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM-YDKEYYSVHNKTGAKLPVKWMALESLQTQK---FTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYLLQGRR----LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I--
IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALKE-ASESA-RQDFQREAELLTML-QHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLRSHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI-YSTDYY--RVGGRTMLPIRWMPPESILYRK---FTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-SNTEAIDCITQGRE----LERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL---
-L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLKS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE---GKLVKICDFGLARDI-MRDSNY--ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAIKRGYR----MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL-
-F-TLCRKLGSGYFGEVFEGLWK--------DRVQVAIKVISR-DNLLH-QQMLQSEIQAMKKL-RHKHILALYAVVS--VGDPVYIITELMAKGSLLELLRDS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGE---NTLCKVGDFGLARLI---KEDV--YLSHDHNIPYKWTAPEALSRGH---YSTKSDVWSFGILLHEMFSRGQVP---------------YPGM-SNHEAFLRVDAGYR----MPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL---
-L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLKP-GTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI--EDNEY--TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYR----MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
--IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ----EVY--VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKLPQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL-
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