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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
TK EPHA3 621
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK LCK 245
TK MET 1078
Other NEK7 34
STE OXSR1 17
AGC PDPK1 82
TK PTK2 422
TK RET 724
TK SRC 270
STE STK24 24
TK TNK2 150
F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANKE-IL-D-EAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVR---------EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G---A--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSIL-EKGERLPQPPICT----------IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--EE-FL-K-EAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLR---------EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-------T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL-EKDYRMERPEGCP----------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDELD-FL-M-EALIISKF-NHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLR---------ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y---R--ASYY--RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV-TSGGRMDPPKNCP----------GPVYRIMTQCWQHQPEDRPNFAIILER--I-----------
-FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--EH-QLRR-EVEIQSHL-RHPNILRLYGYFH-DATRVYLILEYAPLGTVYRELQ--------KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV---------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETY-KRISRVEFTFPDFVT--------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V--G-YT-EKQRRD-FL-G-EASIMGQF-DHPNIIRLEGVVT-KSKPVMIVTEYMENGSLDSFLR---------KH-----------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL---E---D--DPEA-AYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAV-DEGYRLPPPMDCP----------AALYQLMLDCWQKDRNNRPKFEQIVSIL-------------
L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-D--K-SG-RQSFQA-VT-D-HMLAIGSL-DHAHIVRLLGLCP--GSSLQLVTQYLPLGSLLDHVR---------QH-----------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL---P---P--DDKQ--LLYSEAKTPIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLL-EKGERLAQPQICT----------IDVYMVMVKCWMIDENIRPTFKELANE--F-----------
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLSD-LI-S-EMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H---H--IDYY--KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL-KEGHRMDKPSNCT----------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLSD-LV-S-EMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLR---------ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI---N---N--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL-KEGHRMDKPANCT----------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
-LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--EA-FL-A-EANVMKTL-QHDKLVKLHAVVT--KEPIYIITEFMAKGSLLDFLK---------SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI-------E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCP----------EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
-ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERIE-FL-N-EASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLR---------SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y---E--TDYY--RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEGGLLDKPDNCP----------DMLFELMRMCWQYNPKMRPSFLEIISS--I-----------
-ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERIE-FL-N-EASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLR---------SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y---E--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDGGYLDQPDNCP----------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-------------
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--DA-FL-A-EANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLK---------TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI-------E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCP----------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
-VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVSQ-FL-T-EGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR---------NE-----------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM---Y---D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYL-LQGRRLLQPEYCP----------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-----------
-FRIEKKIGRGQFSEVYRAACL-------LDGVPVALKKVQIF--D-LMDAK--AR-ADCIKEIDLLKQL-NHPNVIKYYASFI-EDNELNIVLELADAGDLSRMIKHF----KKQKR-------------------------LIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITA---TGVVKLGDLGLGRFF-------SSKTTAA--HS---LVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEMAA-LQSPFYGD-KMNLYSLC-KKIEQCDYPPLPSDHYS------EELRQLVNMCINPDPEKRPDVTYV------YDVA-------
-YELQEVIGSGATAVVQAAYCA-------PKKEKVAIKRINLE--K-CQTSM--DE--LLK-EIQAMSQC-HHPNIVSYYTSFV-VKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG-------------------------VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGE---DGSVQIADFGVSAFLAT--GGDITRNKVR--KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKYPPMKVLMLT-LQNDPPSLETGVQDKE-MLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF-----------
F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN--KVPYVTR-ERDVMSRL-DHPFFVKLYFTFQ-DDEKLYFGLSYAKNGELLKYIR--------KIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLS-----PESKQARA--NS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIF-QKIIKLEYDFPEKFF--------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
-IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS-DSVREK-FL-Q-EALTMRQF-DHPHIVKLIGVIT--ENPVWIIMELCTLGELRSFLQ---------VR-----------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM-------E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI-ENGERLPMPPNCP----------PTLYSLMTKCWAYDPSRRPRFTELKAQL-------------
L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELRD-LL-S-EFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y---E--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL-KTGHRMERPDNCS----------EEMYRLMLQCWKQEPDKRPVFADISKDL-------------
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--EA-FL-Q-EAQVMKKL-RHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLK---------GE----------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-------E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECP----------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
-FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--ED-IQ-Q-EITVLSQC-DSPYVTKYYGSYL-KDTKLWIIMEYLGGGSALDLLE---------PG-------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL-------TDTQIKR--NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLI-PKNNPPTLEGNYS----------KPLKEFVEACLNKEPSFRPTAKELLKHKFI-----------
L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMDD-FI-R-EVNAMHSL-DHRNLIRLYGVVL--TPPMKMVTELAPLGSLLDRLR---------KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL--PQ---N--DDHY--VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP----------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
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