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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
TKL BRAF 456
TK FGFR1 478
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
TK MET 1078
TK NTRK1 510
AGC PDPK1 82
TK PTK2 422
TK RET 724
STE SLK 34
TK SRC 270
TK SYK 371
TK TEK 824
TK TNK2 150
TK TXK 271
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKA-NKE-IL-DEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR--EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKE--YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGER----LPQPPICT--IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV---EE-FL-KEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR--EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM----T--GDTY--TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYR----MERPEGCP--EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQD-ELD-FL-MEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR--ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY--RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFV-TSGGR----MDPPKNCP--GPVYRIMTQCWQHQPEDRPNFAIILER--I-----------
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV---EH-QLRREVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ-KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV------HAPSSRR--TT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETY-KRISR----VEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
---ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-V-TA-PT-PQQ-LQA-FK-NEVGVLRKT-RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH--II-----------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK--S-R--WSGS--HQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMV-GRGYLSPDLSKVRSNCP--KAMKRLMAECLKKKRDERPLFPQILA---SI----------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKD-LSD-LI-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ--ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI--H-H--IDYY--KKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLL-KEGHR----MDKPSNCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV---EA-FL-AEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK--SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAIN-----FGS---FTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRAL-ERGYR----MPRPENCP--EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
---ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRE-RIE-FL-NEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR--SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFV-MEGGL----LDKPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I-----------
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRE-RIE-FL-NEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR--SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFV-MDGGY----LDQPDNCP--ERVTDLMRMCWQFNPKMRPTFLEIVNLL-------------
---LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E--G-AM-SE---ED-FI-EEAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR--TQ-----------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTRFV----L--DDQY--TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDI-STGFR----LYKPRLAS--THVYQIMNHCWKERPEDRPAFSRLLRQL-------------
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H--S-TE--EH-LRD-FE-REIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ--KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL-PQ-D--KEYY--KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGR----LPRPDGCP--DEIYMIMTECWNNNVNQRPSFRDLA----LRV---------
--L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-H--S-GP-DQ--QRD-FQ-REIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ--RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLL-PL-D--KDYY--VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQR----LPAPPACP--AEVHELMKLCWAPSPQDRPSFSALGP---QL----------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP---DA-FL-AEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK--TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEY--TAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYR----MVRPDNCP--EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
---VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGE-VSQ-FL-TEGIIMKDF-SHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIR--NE-----------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQ-----TQK---FTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYL-LQGRR----LLQPEYCP--DPLYEVMLKCWHPKAEMRPSFSELVSR--I-----------
-IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-E--A-SE-SA--RQD-FQ-REAELLTML-QHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLR--SHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI--Y-S--TDYY--RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-SNTEAIDCI-TQGRE----LERPRACP--PEVYAIMRGCWQREPQQRHSIKDVHARL-------------
--F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN---KVPYVTRERDVMSRL-DHPFFVKLYFTFQ--DDEKLYFGLSYAKNGELLKYIR-KIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLS--PESKQARA--NS---FVGTAQYVSPELLT-----EKS---ACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIF-QKIIK----LEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
---IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS-DSV-REK-FL-QEALTMRQF-DHPHIVKLIGVIT---ENPVWIIMELCTLGELRSFLQ--VR-----------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM----E--DSTY--YKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGVKP---------------FQGV-KNNDVIGRI-ENGER----LPMPPNCP--PTLYSLMTKCWAYDPSRRPRFTELKAQL-------------
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSE-LRD-LL-SEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR--ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY--VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLL-KTGHR----MERPDNCS--EEMYRLMLQCWKQEPDKRPVFADISKDL-------------
---WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVIDTK--S-EEELE---DY-M--VEIDILASC-DHPNIVKLLDAFY--YENNLWILIEFCAGGAVDAVMLELER-------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTL---DGDIKLADFGVSAKN----TRTIQRR--DS---FIGTPYWMAPEVVMCETSKDRP---YDYKADVWSLGITLIEMAE-IEPP---------------HHEL-NPMRVLLKI-AKSEP----PTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-----------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP---EA-FL-QEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK--GE----------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQV-ERGYR----MPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N--E-AN-DPALKDE-LL-AEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ--QN------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKAL--R-A--DENY-YKAQTHGKWPVKWYAPECIN-----YYK---FSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAML-EKGER----MGCPAGCP--REMYDLMNLCWTYDVENRPGFAAVE----LRL---------
---IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-E--Y-AS-KDD-HRD-FA-GELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLR--KSRVLETDP--------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ--------EVY--VKKTMGRLPVRWMAIESLN-----YSV---YTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKL-PQGYR----LEKPLNCD--DEVYDLMRQCWREKPYERPSFAQILV---SL----------
--L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEA-MDD-FI-REVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR--KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL-PQ-N--DDHY--VMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGER----LPRPEDCP--QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
--L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAIKAIN-E--G-SM-SE---ED-FI-EEAKVMMKL-SHSKLVQLYGVCI--QRKPLYIVTEFMENGCLLNYLR--EN-----------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS---TCIVKISDFGMTRYV----L--DDEY--VSSFGAKFPIKWSPPEVFL-----FNK---YSSKSDVWSFGVLMWEVFTEGKMP---------------FENK-SNLQVVEAI-SEGFR----LYRPHLAP--MSIYEVMYSCWHEKPEGRPTFAELLR---AV----------
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