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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
TK BLK 241
TK BMX 422
TKL BRAF 456
TK BTK 402
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EPHA1 624
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
TK LYN 247
STE MAP2K5 166
TK MUSK 575
Other NEK5 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
STE OXSR1 17
STE PAK1 270
STE PAK2 249
STE PAK3 268
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
TK PTK2B 425
TK PTK6 191
TK RET 724
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA3 68
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK3 27
TK SYK 371
TK TEC 370
TK TNK1 116
TK TNK2 150
TK TXK 271
TK YES1 277
TK ZAP70 338
------F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAI-KEL---R-E--A-TS-PKA-NKE-IL-DEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT-----PQHV-KITDFGLAKLL-------------G---A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEISSIL----EK----GER----LPQPPICT-----------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF---------
-------ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---EE-FL-KEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE-----NHLV-KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EK----DYR----MERPEGCP-----------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F-----------
-------ITMKHKLGGGQYGEV---YVGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---EE-FL-KEAAVMKEI-KHPNLVQLLGVCT--LEPPFYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE-----NHVV-KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYDLL----EK----GYR----MEQPEGCP-----------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F-----------
------I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAV-KTL---P-E--V-CS-EQD-ELD-FL-MEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP--GPGRVA-KIGDFGMARDI-------------Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-SNQEVLEFV----TS----GGR----MDPPKNCP-----------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I-----------
-------FEIGRPLGKGKFGNV---YLAREK----------------QSKF---ILAL-KVL---FKA--QLEKAGV---EH-QLRREVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ--------KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS-----AGEL-KIADFGWSV-------------------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN----TYQETY----KR----ISR----VEFTFPDFVT---------EGARD-LISRLLKHNPSQRPM-----LREVLEHPWI-----------
------L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAI-KTL---K-E--G-TM-SP---EA-FL-GEANVMKAL-QHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE-----ALCC-KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-SNPEVIRNL----ER----GYR----MPRPDTCP-----------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L-----------
-------ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAV-KMI---K-E--G-SM-SE---DE-FF-QEAQTMMKL-SHPKLVKFYGVCS--KEYPIYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDR-----DLCV-KVSDFGMTRYV-----------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK---YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-DNSQVVLKV----SQ----GHR----LYRPHLAS-----------DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I-----------
-------ITVGQRIGSGSFGTV---YKGKWH-------------------G---DVAV-KML---N-V-TA-PT-PQQ-LQA-FK-NEVGVLRKT-RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH---------II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE-----DLTV-KIGDFGLATVK-------------S---R--WSGS--------------HQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNINNRDQIIFMV----GR----GYLSPDLSKVRSNCP-----------KAMKR-LMAECLKKKRDERPL-----FPQILA---SI----------
-------LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAI-KMI---K-E--G-SM-SE---DE-FI-EEAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND-----QGVV-KVSDFGLSRYV-----------------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK---FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-TNSETAEHI----AQ----GLR----LYRPHLAS-----------EKVYT-IMYSCWHEKADERPT-----FKILLSN--I-----------
-------LQFGKTLGAGAFGKV---VEATAFG-----------LGKEDAVL---KVAV-KML---K-S--T-AH-ADE-KEA-LM-SELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-----GHVA-KIGDFGLARDI-------------M---N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGILVNSKFYKLV----KD----GYQ----MAQPAFAP-----------KNIYS-IMQACWALEPTHRPT-----FQQICSFL-------------
-------LKLLQTIGKGEFGDV---MLGDYR------------------GN---KVAV-KCI---K-N--D-AT-AQ----A-FL-AEASVMTQL-RHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE-----DNVA-KVSDFGLTKEA-----------------------S--------------STQDTGKLPVKWTAPEALR-----EKK---FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI-PLKDVVPRV----EK----GYK----MDAPDGCP-----------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL-------------
-------LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAV-KIL---R-P--D-AT-KNA-RND-FL-KEVKIMSRL-KDPNIIRLLGVCV--QDDPLCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE-----NFTI-KIADFGMSRNL-------------Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP-----------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL-------------
-------LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAV-KML---R-A--D-AN-KNA-RND-FL-KEIKIMSRL-KDPNIIHLLAVCI--TDDPLCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK-----NYTI-KIADFGMSRNL-------------Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK---FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL-SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP-----------DSVYK-LMLSCWRRDTKNRPS-----FQEIHL---LL----------
-----LM--VDTVIGEGEFGEV---YRGTLR-------------LPSQDCK---TVAI-KTL---K-D--T-SP-GGQ-WWN-FL-REATIMGQF-SHPHILHLEGVVT--KRKPIMIITEFMENGALDAFLR---------ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQ-----NLCC-KVSDFGLTRLL-------------D---D--FDGT--------------YETQGGKIPIRWTAPEAIA-----HRI---FTTASDVWSFGIVMWEVLSFGD-KP---------------YGEM-SNQEVMKSI----ED----GYR----LPPPVDCP-----------APLYE-LMKNCWAYDRARRPH-----FQKLQAHL-------------
------I-SIDKVVGAGEFGEV---CSGRLK-------------LPSKKEI---SVAI-KTL---K-V--G-YT-EKQ-RRD-FL-GEASIMGQF-DHPNIIRLEGVVT--KSKPVMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS-----NLVC-KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTSPEAIA-----YRK---FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM-SNQDVIKAV----DE----GYR----LPPPMDCP-----------AALYQ-LMLDCWQKDRNNRPK-----FEQIVSIL-------------
-------IKIEKVIGVGEFGEV---CSGRLK-------------VPGKREI---CVAI-KTL---K-A--G-YT-DKQ-RRD-FL-SEASIMGQF-DHPNIIHLEGVVT--KCKPVMIITEYMENGSLDAFLR---------KN--------------------------------------------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNS-----NLVC-KVSDFGMSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-SNQDVIKAI----EE----GYR----LPPPMDCP-----------IALHQ-LMLDCWQKERSDRPK-----FGQIVNML-------------
-------ITIERVIGAGEFGEV---CSGRLK-------------LPGKREL---PVAI-KTL---K-V--G-YT-EKQ-RRD-FL-GEASIMGQF-DHPNIIHLEGVVT--KSKPVMIVTEYMENGSLDTFLK---------KN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS-----NLVC-KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----FRK---FTSASDVWSYGIVMWEVVSYGE-RP---------------YWEM-TNQDVIKAV----EE----GYR----LPSPMDCP-----------AALYQ-LMLDCWQKERNSRPK-----FDEIVNML-------------
LPPRIPA---------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR---------KH--------------------------------------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNS-----NLVC-KVSDFGLSRVL-------------E---D--DPEA-------------AYTTTGGKIPIRWTAPEAIA-----YRK---FSSASDAWSYGIVMWEVMSYGE-RP---------------YWEM-SNQDVILSI----EE----GYR----LPAPMGCP-----------ASLHQ-LMLHCWQKERNHRPK-----FTDIVSFL-------------
-------IHIEKIIGSGDSGEV---CYGRLR-------------VPGQRDV---PVAI-KAL---K-A--G-YT-ERQ-RRD-FL-SEASIMGQF-DHPNIIRLEGVVT--RGRLAMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS-----NLVC-KVSDFGLSRVL-------------E---D--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT---FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-TNRDVISSV----EE----GYR----LPAPMGCP-----------HALHQ-LMLDCWHKDRAQRPR-----FSQIVSVL-------------
------V-KIEEVIGAGEFGEV---YKGRLK-------------LPGKREI---YVAI-KTL---K-A--G-YS-EKQ-RRD-FL-SEASIMGQF-DHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS-----NLVC-KVSDFGLSRYLQ----------DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQ----DYR----LPPPMDCP-----------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL-------------
------V-KIEQVIGAGEFGEV---CSGHLK-------------LPGKREI---FVAI-KTL---K-S--G-YT-EKQ-RRD-FL-SEASIMGQF-DHPNVIHLEGVVT--KSTPVMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS-----NLVC-KVSDFGLSRFLE----------DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-TNQDVINAI----EQ----DYR----LPPPMDCP-----------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL-------------
------V-KIEEVIGAGEFGEV---CRGRLK-------------APGKKES---CVAI-KTL---K-G--G-YT-ERQ-RRE-FL-SEASIMGQF-EHPNIIRLEGVVT--NSMPVMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-----NLVC-KVSDFGLSRFLE----------ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----FRK---FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQ----DYR----LPPPPDCP-----------TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL-------------
-------IKIEEVIGTGSFGEV---RQGRLQ-------------PRGRREQ---TVAI-QAL---W-A--G-GA-ESL-QMT-FL-GRAAVLGQF-QHPNILRLEGVVT--KSRPLMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNS-----HLVC-KVARLGHSPQG-------------------------------------------PSCLLRWAAPEVIA-----HGK---HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-SEQEVLNAI----EQ----EFR----LPPPPGCP-----------PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF----------
------L-KRVKVLGSGAFGTV---YKGIWVP------------EGETVKI---PVAI-KIL---N-E--T-TG-PKA-NVE-FM-DEALIMASM-DHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKS-----PNHV-KITDFGLARLL-------------E---G--DEKE--------------YNADGGKMPIKWMALECIH-----YRK---FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-PTREIPDLL----EK----GER----LPQPPICT-----------IDVYM-VMVKCWMIDADSRPK-----FKELAAE--F-----------
-----VI--LGELLGKGNFGEV---YKGTLK-----------------DKT---SVAV-KTC---K-E--D-LP-QEL-KIK-FL-QEAKILKQY-DHPNIVKLIGVCT--QRQPVYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGE-----NNVL-KISDFGMSRQE-----------------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGR---YSSESDVWSFGILLWETFSLGV-CP---------------YPGM-TNQQAREQV----ER----GYR----MSAPQHCP-----------EDISK-IMMKCWDYKPENRPK-----FSELQKEL-------------
------L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAV-KSC---R-E--T-LP-PDL-KAK-FL-QEARILKQY-SHPNIVRLIGVCT--QKQPIYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTE-----KNVL-KISDFGMSREE-------------A---D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR---YSSESDVWSFGILLWETFSLGA-SP---------------YPNL-SNQQTREFV----EK----GGR----LPCPELCP-----------DAVFR-LMEQCWAYEPGQRPS-----FSTIYQEL-------------
------L-VLGKPLGEGCFGQV---VLAEAIGL---------DKDKPNRVT---KVAV-KML---K-S--D-AT-EKD-LSD-LI-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE-----DNVM-KIADFGLARDI-------------H---H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KE----GHR----MDKPSNCT-----------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
-------LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAV-KML---K-D--D-AT-EKD-LSD-LV-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE-----NNVM-KIADFGLARDI-------------N---N--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-PVEELFKLL----KE----GHR----MDKPANCT-----------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
-------LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAV-KML---K-D--D-AT-DKD-LSD-LV-SEMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE-----DNVM-KIADFGLARDV-------------H---N--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI-PVEELFKLL----KE----GHR----MDKPANCT-----------HDLYM-IMRECWHAAPSQRPT-----FKQLVEDL-------------
------L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPDQAS---TVAV-KML---K-D--N-AS-DKD-LAD-LV-SEMEVMKLIGRHKNIINLLGVCT--QEGPLYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTE-----DNVM-KIADFGLARGV-------------H---H--IDYY--------------KKTSNGRLPVKWMAPEALF-----DRV---YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI-PVEELFSLL----RE----GHR----MDRPPHCP-----------PELYG-LMRECWHAAPSQRPT-----FKQLVEAL-------------
-------ITLERRLGTGCFGDV---WLGTWN-----------------GST---KVAV-KTL---K-P--G-TM-SP---KA-FL-EEAQVMKLL-RHDKLVQLYAVVS---EEPIYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGE-----RLAC-KIADFGLARLI-----------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM-NKREVLEQV----EQ----GYH----MPCPPGCP-----------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL-------------
-------IQLLKRLGSGQFGEV---WEGLWN-----------------NTT---PVAV-KTL---K-P--G-SM-DP---ND-FL-REAQIMKNL-RHPKLIQLYAVCT--LEDPIYIITELMRHGSLQEYLQ---------ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGE-----HNIY-KVADFGLARVFK-----------VD---N--EDIY--------------ESRHEIKLPVKWTAPEAIR-----SNK---FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-TGAQVIQML----AQ----NYR----LPQPSNCP-----------QQFYN-IMLECWNAEPKERPT-----FETLRWK--L-----------
-------LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAI-KTL---K-P--G-TM-SP---ES-FL-EEAQIMKKL-KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN-----GLIC-KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-NNREVLEQV----ER----GYR----MPCPQDCP-----------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL-------------
-------LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAV-KTM---K-P--G-SM-SV---EA-FL-AEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA-----SLVC-KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-SNPEVIRAL----ER----GYR----MPRPENCP-----------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L-----------
-------ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAI-KTV---N-E--A-AS-MRE-RIE-FL-NEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE-----DFTV-KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL-SNEQVLRFV----ME----GGL----LDKPDNCP-----------DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I-----------
-------ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAV-KTV---N-E--S-AS-LRE-RIE-FL-NEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH-----DFTV-KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-SNEQVLKFV----MD----GGY----LDQPDNCP-----------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL-------------
------I-SIIRELGQGSFGMV---YEGLARG-----------LEAGEEST---PVAL-KTV---N-E--L-AS-PRE-CIE-FL-KEASVMKAF-KCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ-----DFTV-KIGDFGMTRDV-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGI---FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL-SNEQVLKFV----MD----GGV----LEELEGCP-----------LQLQE-LMSRCWQPNPRLRPS-----FTHILD---SI----------
-------LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAI-KTI---R-E--G-AM-SE---ED-FI-EEAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE-----NQVI-KVSDFGMTRFV-----------------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-SNSEVVEDI----ST----GFR----LYKPRLAS-----------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL-------------
-------LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAV-KKL---Q-H--S-TE--EH-LRD-FE-REIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN-----ENRV-KIGDFGLTKVL------------PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KN----NGR----LPRPDGCP-----------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV---------
------L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAV-KQL---Q-H--S-GP-DQ--QRD-FQ-REIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES-----EAHV-KIADFGLAKLL------------PL---D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRLLELL----EE----GQR----LPAPPACP-----------AEVHE-LMKLCWAPSPQDRPS-----FSALGP---QL----------
-------LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAV-KML---K-P--S-AH-LTE-REA-LM-SELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH-----GRIT-KICDFGLARDI-------------K---N--DSNY--------------VVKGNARLPVKWMAPESIF-----NCV---YTFESDVWSYGIFLWELFSLGS-SP---------------YPGMPVDSKFYKMI----KE----GFR----MLSPEHAP-----------AEMYD-IMKTCWDADPLKRPT-----FKQIVQL--I-----------
-------LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAV-KSL---K-Q--G-SM-SP---DA-FL-AEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD-----TLSC-KIADFGLARLI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ER----GYR----MVRPDNCP-----------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L-----------
-----LI--HGEVLGKGCFGQA---IKVTHR----------------ETGE---VMVM-KEL---I----R-FD-EET-QRT-FL-KEVKVMRCL-EHPNVLKFIGVLY--KDKRLNFITEYIKGGTLRGIIK---------SM--------------------------------------------------------------------------------------------------DSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRE-----NKNV-VVADFGLARLM-------------V---D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEMIN-----GRS---YDEKVDVFSFGIVLCEIIGRVN-AD---------------PDYLPRTMDFGLNV----RG----FLD----RYCPPNCP-----------PSFFP-ITVRCCDLDPEKRPS-----FVKLEH---WL----------
-----LI--HGEVLGKGFFGQA---IKVTHK-----------------ATG---KVMVMKEL-----I--R-CD-EET-QKT-FL-TEVKVMRSL-DHPNVLKFIGVLY--KDKKLNLLTEYIEGGTLKDFLR---------SM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKL-----DKTV-VVADFGLSRLIVEERKRAPMEKATT---------KKRTL-----RKNDRKKRYTVVGNPYWMAPEMLN-----GKS---YDETVDIFSFGIVLCEIIGQVY-AD---------------PDCLPRTLDFGLNV----KL----FWE----KFVPTDCP-----------PAFFP-LAAICCRLEPESRPA-----FSKLED---SF----------
------V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAI-KTL---P-E--L-CS-PQD-ELD-FL-MEALIISKF-RHQNIVRCVGLSL--RATPRLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCA--GPSRVA-KIGDFGMARDI-------------Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI---FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-TNQEVLDFV----VG----GGR----MDPPRGCP-----------GPVYR-IMTQCWQHEPELRPS-----FASILERL-------------
-------IKLVKRLGAGQFGEV---WMGYYN-----------------NST---KVAV-KTL---K-P--G-TM-SV---QA-FL-EEANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE-----SLMC-KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGC---FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADVMTAL----SQ----GYR----MPRVENCP-----------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L-----------
----IRY---RDTLGHGNGGTV---YKAYHV----------------PSGK---ILAV-KVI---LLD--I-TLELQ---KQ-I-MSELEILYKC-DSSYIIGFYGAFF--VENRISICTEFMDGGSLD------------VYR----------------------------------------------------------------------------------------------------KMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNT-----RGQV-KLCDFGVST-------------------QLVNSIA--------------KT---YVGTNAYMAPERIS-----GEQ---YGIHSDVWSLGISFMELAL-GR-FP---------------YPQI-QKNQGSLMP----LQ----LLQ----CIVDEDSPVLPVGEF---SEPFVH-FITQCMRKQPKERPA-----PEELMGHPFI-----------
------I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYEPFT---MVAV-KML---K-E--E-AS-ADM-QAD-FQ-REAALMAEF-DNPNIVKLLGVCA--VGKPMCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE-----NMVV-KIADFGLSRNI-------------Y---S--ADYY--------------KANENDAIPIRWMPPESIF-----YNR---YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-AHEEVIYYV----RD----GNI----LSCPENCP-----------VELYN-LMRLCWSKLPADRPS-----FTSIHRIL-------------
-------YDVIKAIGQGAFGKA---YLAKGK----------------SDSK---HCVI-KEI---NFE--K-MPIQE---KE-ASKKEVILLEKM-KHPNIVAFFNSFQ--ENGRLFIVMEYCDGGDLMKRINR------QRGV----------------------------------------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSK-----NGMVAKLGDFGIARVL-----------------NNSMELA--------------RT---CIGTPYYLSPEICQ-----NKP---YNNKTDIWSLGCVLYELCT-LK-HP---------------FEGN----NLQQLV----LK----ICQ----AHFAPISPGF---S-----RELHS-LISQLFQVSPRDRPS-----INSILKRPFL-----------
-----IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAV-KAL---K-E--A-SE-SA--RQD-FQ-REAELLTML-QHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ-----GLVV-KIGDFGMSRDI-------------Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL-SNTEAIDCI----TQ----GRE----LERPRACP-----------PEVYA-IMRGCWQREPQQRHS-----IKDVHARL-------------
------I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAV-KTL---K-D--A-SD-NA--RKD-FH-REAELLTNL-QHEHIVKFYGVCV--EGDPLIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE-----NLLV-KIGDFGMSRDV-------------Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-SNNEVIECI----TQ----GRV----LQRPRTCP-----------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L-----------
------I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAV-KAL---K-D--P-TL-AA--RKD-FQ-REAELLTNL-QHEHIVKFYGVCG--DGDPLIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA-----NLLV-KIGDFGMSRDV-------------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI----TQ----GRV----LERPRVCP-----------KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL-------------
-------YELQEVIGSGATAVV---QAAYCA----------------PKKE---KVAI-KRI---NLE--K-CQTSM---DE--LLKEIQAMSQC-HHPNIVSYYTSFV--VKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG----------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGE-----DGSV-QIADFGVSAFLAT------------GGDITRNKVR--------------KT---FVGTPCWMAPEVME----QVRG---YDFKADIWSFGITAIELAT-GA-AP---------------YHKY-PPMKVLMLT----LQ----NDP----PSLETGVQDKE--MLKKYGKSFRK-MISLCLQKDPEKRPT-----AAELLRHKFF-----------
-------YTRFEKIGQGASGTV---YTAMDV----------------ATGQ---EVAI-KQM---NLQ--Q-QPKKE---LI-I--NEILVMREN-KNPNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVVT---------ET----------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGM-----DGSV-KLTDFGFCAQI-----------------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----RKA---YGPKVDIWSLGIMAIEMIE-GE-PP---------------YLNE-NPLRALYLI----AT----NGT----PELQNPEKLS---------AIFRD-FLNRCLEMDVEKRGS-----AKELLQHQFL-----------
-------YTRYEKIGQGASGTV---FTATDV----------------ALGQ---EVAI-KQI---NLQ--K-QPKKE---LI-I--NEILVMKEL-KNPNIVNFLDSYL--VGDELFVVMEYLAGGSLTDVVT---------ET----------------------------------------------------------------------------------------------------CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGM-----EGSV-KLTDFGFCAQI-----------------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----RKA---YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE-NPLRALYLI----AT----NGT----PELQNPEKLS---------PIFRD-FLNRCLEMDVEKRGS-----AKELLQHPFL-----------
-------YTRFEKIGQGASGTV---YTALDI----------------ATGQ---EVAI-KQM---NLQ--Q-QPKKE---LI-I--NEILVMREN-KNPNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVVT---------ET----------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM-----DGSV-KLTDFGFCAQI-----------------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----RKA---YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE-NPLRALYLI----AT----NGT----PELQNPERLS---------AVFRD-FLNRCLEMDVDRRGS-----AKELLQHPFL-----------
------L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAV-KML---K-P--T-AR-SSE-KQA-LM-SELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ-----GKIV-KICDFGLARDI-------------M---H--DSNY--------------VSKGSTFLPVKWMAPESIF-----DNL---YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGMMVDSTFYNKI----KS----GYR----MAKPDHAT-----------SEVYE-IMVKCWNSEPEKRPS-----FYHLSE---IV----------
------L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAV-KML---K-S--T-AR-SSE-KQA-LM-SELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE-----GKLV-KICDFGLARDI-------------M---R--DSNY--------------ISKGSTFLPLKWMAPESIF-----NSL---YTTLSDVWSFGILLWEIFTLGG-TP---------------YPELPMNEQFYNAI----KR----GYR----MAQPAHAS-----------DEIYE-IMQKCWEEKFEIRPP-----FSQLVL---LL----------
------F-KFGKILGEGSFSTV---VLAREL----------------ATSR---EYAI-KIL---EKR--H-IIKEN---KVPYVTRERDVMSRL-DHPFFVKLYFTFQ--DDEKLYFGLSYAKNGELLKYIR--------KIG----------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE-----DMHI-QITDFGTAKVLS---------------PESKQARA--------------NS---FVGTAQYVSPELLT-----EKS---ACKSSDLWALGCIIYQLVA-GL-PP---------------FRAG----NEYLIF----QK----IIK----LEYDFPEKFF---------PKARD-LVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
------V-VLNRILGEGFFGEV---YEGVYT-------------NHKGEKI---NVAV-KTC---K-K--D-CT-LDN-KEK-FM-SEAVIMKNL-DHPHIVKLIGIIE---EEPTWIIMELYPYGELGHYLE---------RN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS-----PECV-KLGDFGLSRYI-----------------E--DEDY--------------YKASVTRLPIKWMSPESIN-----FRR---FTTASDVWMFAVCMWEILSFGK-QP---------------FFWL-ENKDVIGVL----EK----GDR----LPKPDLCP-----------PVLYT-LMTRCWDYDPSDRPR-----FTELVCS--L-----------
------F-TLCRKLGSGYFGEV---FEGLWK-----------------DRV---QVAI-KVI---S-R--D-NL-LH--QQM-LQ-SEIQAMKKL-RHKHILALYAVVS--VGDPVYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGE-----NTLC-KVGDFGLARLI--------------------KEDV--------------YLSHDHNIPYKWTAPEALS-----RGH---YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-SNHEAFLRV----DA----GYR----MPCPLECP-----------PSVHK-LMLTCWCRDPEQRPC-----FKALRERL-------------
------L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAV-KML---K-E--N-AS-PSE-LRD-LL-SEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE-----GRKM-KISDFGLSRDV-------------Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERLFNLL----KT----GHR----MERPDNCS-----------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL-------------
-----LT--LRLLLGSGAFGEV---YEGTAVDI----------LGVGSGEI---KVAV-KTL---K-K--G-ST-DQE-KIE-FL-KEAHLMSKF-NHPNILKQLGVCL--LNEPQYIILELMEGGDLLTYLR---------KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIV-KIGDFGLARDI-------------Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM-----DGI---FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH-SNLDVLNYV----QT----GGR----LEPPRNCP-----------DDLWN-LMTQCWAQEPDQRPT-----FHRIQDQL-------------
-------FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAM-KVL---KKA--T-LKVRD---RV-RTKMERDILADV-NHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE-----EGHI-KLTDFGLSKEA-----------------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----RQG---HSHSADWWSYGVLMFEMLT-GS-LP---------------FQGK----DRKETM----TL----ILK----AKLGMPQFLS---------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
-------FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAM-KVL---KKA--T-LKVRD---RV-RTKMERDILVEV-NHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE-----EGHI-KLTDFGLSKES-----------------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----RRG---HTQSADWWSFGVLMFEMLT-GT-LP---------------FQGK----DRKETM----TM----ILK----AKLGMPQFLS---------PEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
-------WEIIGELGDGAFGKV---YKAQNK----------------ETSV---LAAA-KVI---DTK--S-EEELE---DY-M--VEIDILASC-DHPNIVKLLDAFY--YENNLWILIEFCAGGAVDAVML-------ELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTL-----DGDI-KLADFGVSAKN-----------------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP---YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL-NPMRVLLKI----AK----SEP----PTLAQPSRWS---------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV-----------
------L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAI-KTL---K-P--G-TM-SP---EA-FL-QEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE-----NLVC-KVADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ER----GYR----MPCPPECP-----------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L-----------
-----FA--LGRKLGEGYFGEV---WEGLWL-----------------GSL---PVAI-KVI---K-S--A-NM-K---LTD-LA-KEIQTLKGL-RHERLIRLHAVCS--GGEPVYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD-----GLAC-KVADFGLARLL-----------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----YRV---FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM-TNHETLQQI----MR----GYR----LPRPAACP-----------AEVYV-LMLECWRSSPEERPS-----FATLREKL-------------
------F-DVLEKLGEGSYGSV---FKAIHK----------------ESGQ---VVAI-KQV---PVE--S-DLQEI--------IKEISIMQQC-DSPYVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIR-------LRNK----------------------------------------------------------------------------------------------------TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNT-----EGHA-KLADFGVAGQL-----------------TDTMAKR--------------NT---VIGTPFWMAPEVIQ-----EIG---YNCVADIWSLGITSIEMAE-GK-PP---------------YADI-HPMRAIFMI----PT----NPP----PTFRKPELWS---------DDFTD-FVKKCLVKNPEQRAT-----ATQLLQHPFI-----------
----TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAV-KIL---K-N--E-AN-DPALKDE-LL-AEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ---------QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT-----QHYA-KISDFGLSKAL-------------R---A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK---FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM-KGSEVTAML----EK----GER----MGCPAGCP-----------REMYD-LMNLCWTYDVENRPG-----FAAVE----LRL---------
-------LTFMRELGSGLFGVV---RLGKWR-----------------AQY---KVAI-KAI---R-E--G-AM-CE---ED-FI-EEAKVMMKL-THPKLVQLYGVCT--QQKPIYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSE-----AGVV-KVSDFGMARYV-----------------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR---FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY-TNYEVVTMV----TR----GHR----LYQPKLAS-----------NYVYE-VMLRCWQEKPEGRPS-----FEDLLRT--I-----------
----VCR---GELLGSGCFGVV---HRGLWT-------------LPSGKSV---PVAV-KSLRVGP-E--G-PM-GTE-LGD-FL-REVSVMMNL-EHPHVLRLHGLVL---GQPLQMVMELAPLGSLHARLT---------AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS-----PRTI-KVADFGLVRPL------------GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR-----HGA---FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV-PPYLILQRL----ED----RAR----LPRPPLCS-----------RALYS-LALRCWAPHPADRPS-----FSHLE----GLL---------
------L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAV-KCL---K-PDVL-SQ-PEA-MDD-FI-REVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT-----RDLV-KIGDFGLMRAL------------PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-NGSQILHKI---DKE----GER----LPRPEDCP-----------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L-----------
------L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAI-KAI---N-E--G-SM-SE---ED-FI-EEAKVMMKL-SHSKLVQLYGVCI--QRKPLYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS-----TCIV-KISDFGMTRYV-----------------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK---YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-SNLQVVEAI----SE----GFR----LYRPHLAP-----------MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV----------
------L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAI-KTL---K-P--G-TM-MP---EA-FL-QEAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE-----NLVC-KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ER----GYR----MPCPQGCP-----------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL-------------
---LIAD----IELGCGNFGSV---RQGVYR--------------MRKKQI---DVAI-KVL---K-Q--G-TE-KAD-TEE-MM-REAQIMHQL-DNPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN-----RHYA-KISDFGLSKAL------------GA---D--DSYY--------------TARSAGKWPLKWYAPECIN-----FRK---FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM-KGPEVMAFI----EQ----GKR----MECPPECP-----------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M-----------
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