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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
Other AURKA 133
TK BLK 241
TK ERBB2 720
TK ERBB4 718
TK IGF1R 999
TK INSR 1023
TK JAK2 849
TK LCK 245
TK LYN 247
STE PAK1 270
TK SRC 270
STE STK3 27
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EA-TS-PKANKEIL-DEAYVMASVDNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR--EH---------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GA--EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGIPASEISSILEKGERLPQPPICT--IDVYM-IMVKCWMIDADSRPKFRELI----IEF
-FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRREVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ-KLS-----------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN---TYQETYKRISRVEFTFPDFVTEGARD-LISRLLKHNPSQRPMLREVLEHPWI--
L-RLVRKLGSGQFGEVWMGYYK------NNMKVAIKTLK-EG-TM-SP--EAFL-GEANVMKALQHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK--TD--------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-----DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVP---------------YPGMSNPEVIRNLERGYRMPRPDTCP--PELYRGVIAECWRSRPEERPTFEFLQSV--L--
L-RKVKVLGSGAFGTVYKGIWIP-DGENVKIPVAIKVLR-EN-TS-PKANKEIL-DEAYVMAGVGSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHVR--EN---------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL-DI--DETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKP---------------YDGIPAREIPDLLEKGERLPQPPICT--IDVYM-IMVKCWMIDSECRPRFRELVSE--F--
L-KRVKVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILN-ET-TG-PKANVEFM-DEALIMASMDHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYVH--EH---------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL-EG--DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKP---------------YDGIPTREIPDLLEKGERLPQPPICT--IDVYM-VMVKCWMIDADSRPKFKELAAE--F--
-ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EA-AS-MRERIEFL-NEASVMKEFNCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR--SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-YE--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGLSNEQVLRFVMEGGLLDKPDNCP--DMLFE-LMRMCWQYNPKMRPSFLEIISS--I--
-ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ES-AS-LRERIEFL-NEASVMKGFTCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR--SLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-YE--TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGLSNEQVLKFVMDGGYLDQPDNCP--ERVTD-LMRMCWQFNPKMRPTFLEIVNLL----
-LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-REIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ--KH---------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP--DEIYM-IMTECWNNNVNQRPSFRDLA----LRV
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QG-SM-SP--DAFL-AEANLMKQLQHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK--TP--------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGMTNPEVIQNLERGYRMVRPDNCP--EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
-IKLVKRLGAGQFGEVWMGYYN------NSTKVAVKTLK-PG-TM-SV--QAFL-EEANLMKTLQHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLK--SD--------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI--E--DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIP---------------YPGRTNADVMTALSQGYRMPRVENCP--DELYD-IMKMCWKEKAEERPTFDYLQSV--L--
-YTRFEKIGQGASGTVYTAMDV-----ATGQEVAIKQMNLQQ-QPKKE--LII--NEILVMRENKNPNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVVT--ET-----------CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI--TPEQSKRST---MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIE-GEPP---------------YLNENPLRALYLIATNGTPELQNPEKLSAIFRD-FLNRCLEMDVEKRGSAKELLQHQFL--
L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-PG-TM-SP--EAFL-QEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK--GE--------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGMVNREVLDQVERGYRMPCPPECP--ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--
F-DVLEKLGEGSYGSVFKAIHK-----ESGQVVAIKQVPVES-DLQEI------IKEISIMQQCDSPYVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIRLRNK-----------TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL--TDTMAKRNT---VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAE-GKPP---------------YADIHPMRAIFMIPTNPPPTFRKPELWSDDFTD-FVKKCLVKNPEQRATATQLLQHPFI--
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