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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHA3 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK EPHA1 624
TK KDR 834
TK LCK 245
TK TEK 824
TK TIE1 839
-I-SIDKVVGAGEFGEVCSGRLK--LPSKKEISVAIKTLKV-GYTEKQRRDFLGEASIMGQF-DHPNIIRLEGVVT-KSKPVMIVTEYMENGSLDSFLRKH-----------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK---FTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAVDEGYR----LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL--
--ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC----------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTY-TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
--ITMKHKLGGGQYGEVYVGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPPFYIVTEYMPYGNLLDYLREC----------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM-TGDTY-TAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYDLLEKGYR----MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F-
--ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS-HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
LM--VDTVIGEGEFGEVYRGTLR--LPSQDCKTVAIKTLKD-TSPGGQWWNFLREATIMGQF-SHPHILHLEGVVT-KRKPIMIITEFMENGALDAFLRER-----------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGT-YETQGGKIPIRWTAPEAIAHRI---FTTASDVWSFGIVMWEVLSFGDKPYGEM-SNQEVMKSIEDGYR----LPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHL--
--LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY-VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
--LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEY-TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
--IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY-VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
--ITFEDLIGEGNFGQVIRAMIK---KDGLKMNAAIKMLKE-YASENDHRDFAGELEVLCKLGHHPNIINLLGACK-NRGYLYIAIEYAPYGNLLDFLRKSRVLETDP--------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVY-VKKTMGRLPVRWMAIESLNYSV---YTTKSDVWSFGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----MEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ-L-
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