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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGFR1 203
TK ALK 1116
Other AURKA 133
TK EGFR 712
TK ERBB3 709
TK FGFR2 481
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK LCK 245
TK MERTK 587
TK PTK2 422
TK ZAP70 338
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKDLS-DLI-S-EMEMMKMIGKHKNIINLLGACTQDGP-----LYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EV-CS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSLQSLP-----RFILLELMAGGDLKSFLR----ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--E-HQLRR-EVEIQSHL-RHPNILRLYGYFHDATR-----VYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKANK-EIL-D-EAYVMASV-DNPHVCRLLGICL-TST-----VQLITQLMPFGCLLDYVR----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT--------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-DK-SG-RQSFQ-AVT-D-HMLAIGSL-DHAHIVRLLGLCP-GSS-----LQLVTQYLPLGSLLDHVR----QH---------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL--P-P--DDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICT--------------IDVYMVMVKCWMIDENIRPTFKELANE--F---
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLS-DLV-S-EMEMMKMIGKHKNIINLLGACTQDGP-----LYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI--N-N--IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EA-AS-MRERI-EFL-N-EASVMKEF-NCHHVVRLLGVVSQGQP-----TLVIMELMTRGDLKSYLR----SLRPEM------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI--Y-E--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP--------------DMLFELMRMCWQYNPKMRPSFLEIISS--I---
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ES-AS-LRERI-EFL-N-EASVMKGF-TCHHVVRLLGVVSKGQP-----TLVVMELMAHGDLKSYLR----SLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI--Y-E--TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP--------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAMV-DITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSSDGDD-----LCLVYVYMPNGSLLDRLSCLDGTP-----------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM-SP--D-AFL-A-EANLMKQL-QHQRLVRLYAVVT-QEP-----IYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP--------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
---L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLDN-SS-QREIE-EFL-S-EAACMKDF-SHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLL----YSRL----------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKI--Y-S--GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL--------------DELYEIMYSCWRTDPLDRPTFSVLRLQ--L---
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSVRE-KFL-Q-EALTMRQF-DHPHIVKLIGVIT-ENP-----VWIIMELCTLGELRSFLQ----VR---------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP--------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-----
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-QG-TE-KADTE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ-AEA-----LMLVMEMAGGGPLHKFLV----GK---------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL-GA-D--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP--------------PELYALMSDCWIYKWEDRPDFLTVEQR--M---
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