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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC GRK6 203
Other AURKA 133
CAMK CASK 12
CMGC CDK2 4
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
CMGC GSK3B 56
STE MAP2K1 68
CMGC MAPK10 64
CMGC MAPK12 27
CAMK MAPKAPK2 64
Other NEK7 34
STE OXSR1 17
AGC PDPK1 82
Other PLK1 53
AGC PRKCI 245
AGC ROCK1 76
AGC SGK1 98
CAMK STK11 49
STE STK24 24
Other TTK 525
--F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGE-AMAL-----NEKQIL-EKV-N-SRFVVSLAYAYET------KDALC--LVLTLMNGG--DLK-FHIYH------MGQAGFPEARAVFYAAEICCGLEDLHR-ERIVYRDLKPENILLD-DHGHI----RISDLGLAVH------VPEGQTIKGRVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIAGQSPFQ-QR------KKKIKREEVERLVK-EVPEEYSER--FS-------------------------------------PQARSLCSQLLCKDPAE--RLGCR-GGSAREVKEHPLF-----------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQ-SHL-R-HPNILRLYGYFHD------ATRVY--LILEYAPLG--TVY-RELQ--------KLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGEL----KIADFGWSV-------HAPSSRRTTLCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN---------TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPM------LREVLEHPWI-----------
---YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAK-FTSSPGL-STEDL---KREASIC-HML-K-HPHIVELLETYSS------DGMLY--MVFEFMDGA--DLCFEIVKR-----ADAGFVYSEAVASHYMRQILEALRYCHD-NNIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL-----GESGLVAGGRVGTPHFMAPEVVK-----------REPYGKPVDVWGCGVILFILLSGCLPFY-GT----------KERLFEGIIKGKYKMNPRQWSHIS-------------------------------------ESAKDLVRRMLMLDPAE--RIT------VYEALNHPWL-----------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPS-TAIR------EISLL-KEL-N-HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLK-KFMDA------SALTGIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF-----GVPVRTYTHEVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS------AKAALAHPFF-----------
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEIL-KKL-N-HPCIIKIKNFF-D------AEDYY--IVLELMEGG--ELF-DKVV--------GNKRLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI------LGETSLMRTLCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLSGYPPFS-EH--------RTQVSLKDQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKA--RFT------TEEALRHPWL-----------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKR------------EIKIL-ENLRG-GPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFK-QLY-----------QTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF------YHPGQEYNVRVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT------AREAMEHPYF-----------
---YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRR-TKSSRRG-VSREDI--EREVSIL-KEI-Q-HPNVITLHEVYEN------KTDVI--LILELVAGG--ELF-DFLA--------EKESLTEEEATEFLKQILNGVYYLHS-LQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK------IDFGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLSGASPFL-GD---------TKQETLANVSAVNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKK--RMT------IQDSLQHPWI-----------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIM-RKL-D-HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA----RHY----SRAKQTLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ------LVRGEPNVSYICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLLGQPIFP-GD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT------PLEACAHSFF-----------
---FEKISELGAGNGGVVFKVSHKPSGL-VMARKLIHLE-IKPAIRN-QIIR------ELQVL-HEC-N-SPYIVGFYGAFYS------DGEIS--ICMEHMDGG--SLD-QVLK--------KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEI----KLCDFGVSG-------QLIDSMANSFVGTRSYMSPERLQ-----------GTHYSVQSDIWSMGLSLVEMAVGRYPIP-PP------DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE--RAD------LKQLMVHAFI-----------
---YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAK-RAYR------ELVLM-KCV-N-HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLC-QVIQ----------MELDHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK-SDCTL----KILDFGLART------AGTSFMMTPYVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVRHKILFP-GR------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS------VDDALQHPYI-----------
---YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAK-RAYR------ELRLL-KHM-R-HENVIGLLDVFTPDETLDDFTDFY--LVMPFMGT---DLG-KLMK---------HEKLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVN-EDCEL----KILDFGLAR--------QADSEMTGYVVTRWYRAPEVIL----------NWMRYTQTVDIWSVGCIMAEMITGKTLFK-GS------DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-------------KKDFASILTNASPLAVNLLEKMLVLDAEQ--RVT------AGEALAHPYF-----------
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR--------R------EVELH-WRASQ-CPHIVRIVDVYENLY--AGRKCLL--IVMECLDGG--ELF-SRIQD------RGDQAFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE------TTSHNSLTTPCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLCGYPPFY-SN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS-------------------------------------EEVKMLIRNLLKTEPTQ--RMT------ITEFMNHPWI-----------
---FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFD-LMDAKAR-ADCI-----KEIDLL-KQL-N-HPNVIKYYASFIE------DNELN--IVLELADAG--DLS-RMIKHF----KKQKRLIPERTVWKYFVQLCSALEHMHS-RRVMHRDIKPANVFIT-ATGVV----KLGDLGLGRFF-----SSKTTAAHSLVGTPYYMSPERIH-----------ENGYNFKSDIWSLGCLLYEMAALQSPFY-GD-------KMNLYSLCKKIEQCDYPPLPSDHYS---------------------------------------EELRQLVNMCINPDPEK--RPD------VTYV------YDVA-------
---YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEK-CQTSMDE--LLK------EIQAM-SQC-H-HPNIVSYYTSFVV------KDELW--LVMKLLSGG--SVL-DIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHK-NGQIHRDVKAGNILLG-EDGSV----QIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME----------QVRGYDFKADIWSFGITAIELATGAAPYH-KY------PPMKVLMLTLQNDPPSLETGVQDKE--MLK--------------------------------KYGKSFRKMISLCLQKDPEK--RPT------AAELLRHKFF-----------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVM-SRL-D-HPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELL-KYIR--------KIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS---PESKQARANSFVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVAGLPPFR-AG---------NEYLIFQKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATK--RLG------CEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQR-EKMS-----MEISIH-RSL-A-HQHVVGFHGFFED------NDFVF--VVLELCRRR--SLL-ELHK--------RRKALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV-----EYDGERKKTLCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLVGKPPFE-TS---------CLKETYLRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTA--RPT------INELLNDEFF-----------
--F-DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKEL-VNDDEDI-DWVQ-----TEKHVF-EQASN-HPFLVGLHSCFQT------ESRLF--FVIEYVNGG--DLM-FHMQ--------RQRKLPEEHARFYSAEISLALNYLHE-RGIIYRDLKLDNVLLD-SEGHI----KLTDYGMCKEG-----LRPGDTTSTFCGTPNYIAPEILR-----------GEDYGFSVDWWALGVLMFEMMAGRSPFD-IVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS-----------------------------------------VKAASVLKSFLNKDPKE--RLGCHPQTGFADIQGHPF-F----------
---YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFE-MIKRSDS-AFFW-----EERDIM-AFA-N-SPWVVQLFYAFQD------DRYLY--MVMEYMPGG--DLV-NLMS---------NYDVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLD-KSGHL----KLADFGTCMKM----NKEGMVRCDTAVGTPDYISPEVLKS-------QGGDGYYGRECDWWSVGVFLYEMLVGDTPFY-AD---------SLVGTYSKIMNHKNSLTFPDDNDIS-------------------------------------KEAKNLICAFLTDREVRLGRNG------VEEIKRHLFF-----------
---FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA-ILKKKEE-KHIM-----SERNVLLKNV-K-HPFLVGLHFSFQT------ADKLY--FVLDYINGG--ELF-YHLQ--------RERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLD-SQGHI----VLTDFGLCKEN-----IEHNSTTSTFCGTPEYLAPEVLH-----------KQPYDRTVDWWCLGAVLYEMLYGLPPFY-SR---------NTAEMYDNILNKPLQLKPNIT-----------------------------------------NSARHLLEGLLQKDRTK--RLGAK--DDFMEIKSHV--FF---------
YLM---GDLLGEGSYGKVKEVLDSETLCRRAVKILKKKK-LRRIPNG-EANVK----KEIQLL-RRL-R-HKNVIQLVDVLYNE----EKQKMY--MVMEYCVCGMQEML-DSVP---------EKRFPVCQAHGYFCQLIDGLEYLHS-QGIVHKDIKPGNLLLT-TGGTL----KISDLGVAEALH---PFAADDTCRTSQGSPAFQPPEIAN---------GLDTFSGFKVDIWSAGVTLYNITTGLYPFE-GD---------NIYKLFENIGKGSYAIPGDCG-----------------------------------------PPLSDLLKGMLEYEPAK--RFS------IRQIRQHSWF-----------
---FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE-AEDEIED-IQ-Q------EITVL-SQC-D-SPYVTKYYGSYLK------DTKLW--IIMEYLGGG--SAL-DLLE---------PGPLDETQIATILREILKGLDYLHS-EKKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL-----TDTQIKRNTFVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELARGEPPHS-EL------HPMKVLFLIPKNNPPTLEGNYS-------------------------------------------KPLKEFVEACLNKEPSF--RPT------AKELLKHKFI-----------
---YSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEE-ADNQTLD-SYRN------EIAYL-NKLQQHSDKIIRLYDYEIT------DQYIY--MVMECGNI---DLN-SWLK--------KKKSIDPWERKSYWKNMLEAVHTIHQ-HGIVHSDLKPANFLIV--DGML----KLIDFGIANQMQ---PDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-QI--------INQISKLHAIIDPNHEIEFPDIPE---------------------------------------KDLQDVLKCCLKRDPKQ--RIS------IPELLAHPYV-----------
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