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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK1 203
TK ABL1 261
CMGC CDK2 4
TK FYN 271
TK JAK2 849
TK JAK3 822
TK RET 724
TK TNK1 116
--L-KRIRDLGEGHFGKVELCRYDP-EGDNTGEQVAVKSL---K-PESG-GNHIADLK-KEIEILRNLYHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLP---KN-----------------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD--KEYYTVKDDRDSPVFWYAPECLM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP----------------------------DEVYQLMRKCWEFQPSNRTSFQNLIE---GF-
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTL---K-EDTM-EV--EEFL-KEAAVMKEIKHPNLVQLLGVCT--REPP--FYIITEFMTYGNLLDYLR---EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKI---RLDTETEGV--PSTAIREISLLKELNHPNIVKLLDVIH--TENK--LYLVFEFLHQ-DLKKFMDASALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
---LQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTL---K-PGTM-SP--ESFL-EEAQIMKKLKHDKLVQLYAVVS---EEP--IYIVTEYMNKGSLLDFLK---DG----------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQVERGYRMPCPQDCP----------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL----
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKL---Q-HSTE--EHLRDFE-REIEILKSLQHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQ---KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQL---Q-HSGP-DQ-QRDFQ-REIQILKALHSDFIVKYRGVSYGPGRQS--LRLVMEYLPSGCLRDFLQ---RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
--L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML---K-ENAS-PSELRDLL-SEFNVLKQVNHPHVIKLYGACS--QDGP--LLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YE--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
VCR---GELLGSGCFGVVHRGLWT--LPSGKSVPVAVKSLRVGP-EGPM-GTELGDFL-REVSVMMNLEHPHVLRLHGLVL---GQP--LQMVMELAPLGSLHARLT---AP---------------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGA--RGRYVMGGPRPIPYAWCAPESLR-HGAFSSASDVWMFGVTLWEMFSGGEEP---------------WAGV-PPYLILQRLEDRARLPRPPLCS----------------------------RALYSLALRCWAPHPADRPSFSHLE----GLL
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