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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK2 203
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
TK EGFR 712
TK FGFR3 472
CMGC GSK3B 56
TK JAK3 822
TK LCK 245
TK MUSK 575
TK NTRK1 510
TK NTRK2 538
TK PDGFRB 600
TK RET 724
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HSTE-----EHLRDFE-R-EIEILKSL-Q---HDNIVKYKGVCYSAG-----RRNLK--LIMEYLPYG--SLRDYLQ-----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQIEK---EG--VEHQLRREIEIQAHL-H---HPNILRLYNYFY--D-----RRRIY--LILEYAPRG--ELYKELQ----KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
--YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEE---GV--PSTAIR-EISLLKEL-R---HPNIVSLQDVLM--Q-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
--FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETE---GV--PSTAIR-EISLLKEL-N---HPNIVKLLDVIH--T-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVPNGGGGGGGL--PISTVR-EVALLRRL-EAFEHPNVVRLMDVCA--TSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP----------------------------------------------------------------------------------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
-F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EATS----PKANKEIL-D-EAYVMASV-D---NPHVCRLLGICL--------TSTVQ--LITQLMPFG--CLLDYVR-----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHVKITDFGLAKLL-GA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
--LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK-DDAT----DKDLSDLV-S-EMEMMKMIGK---HKNIINLLGACT--Q-----GGPLY--VLVEYAAKG--NLREFLR-----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT-EDNVMKIADFGLARDV-HN--LDYYKKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHRMDKPANCT----------------------------HDLYMIMRECWHAAPSQRPTFKQLVEDL----
--YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDKRFK---NR---------ELQIMRKL-D---HCNIVRLRYFFY--SSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ----------------------------------------------------------------------------------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--
-L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HSGP----DQ-QRDFQ-R-EIQILKAL-H---SDFIVKYRGVSYGPG-----RQSLR--LVMEYLPSG--CLRDFLQ-----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
--LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM----SP--DAFL-A-EANLMKQL-Q---HQRLVRLYAVVT--------QEPIY--IITEYMENG--SLVDFLK-----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
-I-EYVRDIGEGAFGRVFQARAPG--LLPYEPFTMVAVKMLK-EEAS----ADMQADFQ-R-EAALMAEF-D---NPNIVKLLGVCA--V-----GKPMC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFGLSRNI-YS--ADYYKANENDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQP---------------YYGM-AHEEVIYYVRDGNILSCPENCP----------------------------VELYNLMRLCWSKLPADRPSFTSIHRIL----
IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-EASE----SA-RQDFQ-R-EAELLTML-Q---HQHIVRFFGVCT--E-----GRPLL--MVFEYMRHG--DLNRFLR-----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-QGLVVKIGDFGMSRDI-YS--TDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-SNTEAIDCITQGRELERPRACP----------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL----
-I-VLKRELGEGAFGKVFLAECYN--LCPEQDKILVAVKTLK-DASD----NA-RKDFH-R-EAELLTNL-Q---HEHIVKFYGVCV--E-----GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLVKIGDFGMSRDV-YS--TDYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQP---------------WYQL-SNNEVIECITQGRVLQRPRTCP----------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L--
-L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-STAR----SSEKQALM-S-ELKIMSHLGP---HLNVVNLLGACT--K-----GGPIY--IITEYCRYG--DLVDYLH-----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLIC-EGKLVKICDFGLARDI-MR--DSNYISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAIKRGYRMAQPAHAS----------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL-
-L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-ENAS----PSELRDLL-S-EFNVLKQV-N---HPHVIKLYGACS--Q-----DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKMKISDFGLSRDV-YE--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
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