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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK2 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CAMK DAPK1 13
TK EGFR 712
CMGC GSK3A 119
TK JAK3 822
TK KIT 589
STE MAP3K5 677
TK PDGFRB 600
AGC PDPK1 82
TK SRC 270
TK SYK 371
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EH-LRD-FE-R----EIEILKSL-QHDNIVKYKGVCYSAG----RRNLK--LIMEYLPYG--SLRDYLQ---KH--------------------------------------------------------------------------------------------------KERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV----KIGDFGLTKVL-PQ-D--KEYY-KVKEPGESPIFWYAPESLT--ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV---------
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-ED-TM-EV---EE-FL-K----EAAVMKEI-KHPNLVQLLGVCT--R----EPPFY--IITEFMTYG--NLLDYLR---EC-------------------------------------------------------------------------------------------------NRQEV--NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV----KVADFGLSRLM----T--GDTY-TAHAGAKFPIKWTAPESLA--YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
---FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV---EH-QLRR----EVEIQSHL-RHPNILRLYGYFH--D----ATRVY--LILEYAPLG--TVYRELQ--KLS----------------------------------------------------------------------------------------------------KF--DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV------HAPSSRR-TT---LCGTLDYLPPEMIE--GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
---FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG---VE-HQLR---REIEIQAHL-HHPNILRLYNYFY--D----RRRIY--LILEYAPRG--ELYKELQ--KSC----------------------------------------------------------------------------------------------------TF--DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL----KIADFGWSV------HAPSLRR-KT---MCGTLDYLPPEMIE--GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV---PS-TAIR----EISLLKEL-NHPNIVKLLDVIH--T----ENKLY--LVFEFLHQ---DLKKFMDASALT----------------------------------------------------------------------------------------------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTY-TH---EVVTLWYRAPEILL-GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
---YDTGEELGSGQFAVVKKCREK-----STGLQYAAKFIKKRR-TKSSR---RG-VSREDIEREVSILKEI-QHPNVITLHEVYE--N----KTDVI--LILELVAGG--ELFDFLA--EKE----------------------------------------------------------------------------------------------------SL--TEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEF-KN---IFGTPEFVAPEIVN--YEPLGLEADMWSIGVITYILLS-GASP---------------FLGD----TKQETLANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI-----------
--F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EA-TS-PKA-NKE-IL-D----EAYVMASV-DNPHVCRLLGICL-------TSTVQ--LITQLMPFG--CLLDYVR---EH--------------------------------------------------------------------------------------------------KDNI--GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHV----KITDFGLAKLL--G-A--EEKE-YHAEGGKVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
---YTDIKVIGNGSFGVVYQARLA-----ETRELVAIKKVLQDK-RFKNR--------------ELQIMRKL-DHCNIVRLRYFFY--SSGEKKDELYLNLVLEYVPETVYRVARHFT-KAKL----------------------------------------------------------------------------------------------------TI--PILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ-----LVRGEPN-VS---YICSRYYRAPELIF-GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-----------
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HS-GP-DQ--QRD-FQ-R----EIQILKAL-HSDFIVKYRGVSYGPG----RQSLR--LVMEYLPSG--CLRDFLQ---RH--------------------------------------------------------------------------------------------------RARL--DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV----KIADFGLAKLL-PL-D--KDYY-VVREPGQSPIFWYAPESLS--DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL----------
---LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-PS-AH-LTE-REA-LM-S----ELKVLSYLGNHMNIVNLLGACT--I----GGPTL--VITEYCCYG--DLLNFLR---RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELAL--DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLT-HGRIT----KICDFGLARDI--K-N--DSNY-VVKGNARLPVKWMAPESIF--NCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMIKEGFRMLSPEHAP----------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-----------
DRV-----VLGKGTYGIVYAGRDL-----SNQVRIAIKEIPERD-SRYSQ---PL-H--E----EIALHKHL-KHKNIVQYLGSFS--E----NGFIK--IFMEQVPGG--SLSALLR-SKWG----------------------------------------------------------------------------------------------------PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVL----KISDFGTSKRL----AGINPCT-ET---FTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMAT-GKPP---------------FYEL---GEPQAAMFKVGMFKVHPEIPESMS------------------------AEAKAFILKCFEPDPDKRACANDLLVDEF-L----------
--L-VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLK-ST-AR-SSE-KQA-LM-S----ELKIMSHLGPHLNVVNLLGACT--K----GGPIY--IITEYCRYG--DLVDYLH---RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVL--SYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLIC-EGKLV----KICDFGLARDI--M-R--DSNY-ISKGSTFLPLKWMAPESIF--NSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAIKRGYRMAQPAHAS----------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL----------
--F-KFGKILGEGSFSTVVLAREL-----ATSREYAIKILEKRH-IIKEN---KVPYVTR----ERDVMSRL-DHPFFVKLYFTFQ--D----DEKLY--FGLSYAKNG--ELLKYIR--KIG----------------------------------------------------------------------------------------------------SF--DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS--PESKQARA-NS---FVGTAQYVSPELLT--EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
--L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-PG-TM-SP---EA-FL-Q----EAQVMKKL-RHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK---GE-------------------------------------------------------------------------------------------------TGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC----KVADFGLARLI----E--DNEY-TARQGAKFPIKWTAPEAAL--YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
TLE---DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILK-NE-AN-DPALKDE-LL-A----EANVMQQL-DNPYIVRMIGICE-------AESWM--LVMEMAELG--PLNKYLQ---QN---------------------------------------------------------------------------------------------------RHV--KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-TQHYA----KISDFGLSKAL--R-A--DENYYKAQTHGKWPVKWYAPECIN--YYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAMLEKGERMGCPAGCP----------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL---------
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