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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK KDR 203
TK ABL1 261
TKL BRAF 456
TK FLT1 827
TK KIT 589
TK MET 1078
TK PDGFRA 593
TK PDGFRB 600
TK TEK 824
-LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY--VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTY--TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
-ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGS--HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
-LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKE-GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDY--VRKGDTRLPLKWMAPESIFDKI---YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMR----MRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL--
-LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNY--VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
-VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK---FTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYLLQGRR----LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I-
L-VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY--VSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR----MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
L-VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY--ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYR----MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
-IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVY--VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
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