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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
TK ABL1 261
TK BMX 422
TK BTK 402
CMGC CDC2 4
TK CSK 195
TK EGFR 712
Other EIF2AK2 267
TK EPHA1 624
TK EPHA2 613
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK FYN 271
TK HCK 241
CMGC MAPK14 24
TK PDGFRB 600
TK PTK6 191
TK RET 724
TK SRC 270
TK SYK 371
TKL TGFBR1 205
TK TNK2 150
TK TXK 271
TK YES1 277
-------LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-Q--GSM-SP---DAFL-AEANLMKQL-QHQRLVRLYAVVT-------------------------------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGR----------IPYPGM-----TNPEVIQNL-ERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
-------ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-E--DTM-EV---EEFL-KEAAVMKEI-KHPNLVQLLGVCT-R-----------------------------EPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----DLSQVYELL-EKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
-------ITLLKELGSGQFGVVQLGKWK------GQYDVAVKMIK-E--GSM-SE---DEFF-QEAQTMMKL-SHPKLVKFYGVCS-K-----------------------------EYPIYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDRDLCVKVSDFGMTRYV-------L--DDQY-VSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK----------QPYDLY-----DNSQVVLKV-SQGHRLYRPHLAS------------------------------DTIYQIMYSCWHELPEKRPTFQQLLSS--I---
-------LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIK-E--GSM-SE---DEFI-EEAKVMMNL-SHEKLVQLYGVCT-K-----------------------------QRPIFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVNDQGVVKVSDFGLSRYV-------L--DDEY-TSSVGSKFPVRWSPPEVLM------YSKFSSKSDIWAFGVLMWEIYSLGK----------MPYERF-----TNSETAEHI-AQGLRLYRPHLAS------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I---
-------YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLE--SEEEGV---PSTAIREISLLKEL-RHPNIVSLQDVLM-Q-----------------------------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLIDDKGTIKLADFGLARAF-------GIPIRVY-TH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KK----------PLFHGD-----SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---
-------LKLLQTIGKGEFGDVMLGDYR-------GNKVAVKCIK-N--DAT-AQ----AFL-AEASVMTQL-RHSNLVQLLGVIVEE-----------------------------KGGLYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEA-------------S-STQDTGKLPVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGR----------VPYPRI-----PLKDVVPRV-EKGYKMDAPDGCP------------------------------PAVYEVMKNCWHLDAAMRPSFLQLREQL-----
------F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-E--ATS-PKA-NKEIL-DEAYVMASV-DNPHVCRLLGICL-------------------------------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKTPQHVKITDFGLAKLL----G--A--EEKE-YHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGS----------KPYDGI-----PASEISSIL-EKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
------F-KEIELIGSGGFGQVFKAKHR-----IDGKTYVIKRVKYN--NEKAER---------EVKALAKL-DHVNIVHYNGCWD-GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGE----------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK--------KLIHRDLKPSNIFLVDTKQVKIGDFGLVTS--------LKNDGKR-TR---SKGTLRYMSPEQIS------SQDYGKEVDLYALGLILAELLH-VC---------DTAFET------------SKF-FTDLRDGIISDIFDK-----------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT
-----LM--VDTVIGEGEFGEVYRGTLR--LPSQDCKTVAIKTLK-D--TSP-GGQ-WWNFL-REATIMGQF-SHPHILHLEGVVT-K-----------------------------RKPIMIITEFMENGALDAFLR----ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVNQNLCCKVSDFGLTRLL----D--D--FDGT-YETQGGKIPIRWTAPEAIA------HRIFTTASDVWSFGIVMWEVLSFGD----------KPYGEM-----SNQEVMKSI-EDGYRLPPPVDCP------------------------------APLYELMKNCWAYDRARRPHFQKLQAHL-----
------V-TRQKVIGAGEFGEVYKGMLKT-SSGKKEVPVAIKTLK-A--GYT-EKQ-RVDFL-GEAGIMGQF-SHHNIIRLEGVIS-K-----------------------------YKPMMIITEYMENGALDKFLR----EK--------------------------------------------------------------------------------------------------DGEFSVLQLVGMLRGIAAGMKYLANM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRVL----E--D--DPEATYTTSGGKIPIRWTAPEAIS------YRKFTSASDVWSFGIVMWEVMTYGE----------RPYWEL-----SNHEVMKAI-NDGFRLPTPMDCP------------------------------SAIYQLMMQCWQQERARRPKFADIVSIL-----
-------IKIEKVIGVGEFGEVCSGRLK--VPGKREICVAIKTLK-A--GYT-DKQ-RRDFL-SEASIMGQF-DHPNIIHLEGVVT-K-----------------------------CKPVMIITEYMENGSLDAFLR----KN--------------------------------------------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDM--------SYVHRDLAARNILVNSNLVCKVSDFGMSRVL----E--D--DPEAAYTTRGGKIPIRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSYGE----------RPYWDM-----SNQDVIKAI-EEGYRLPPPMDCP------------------------------IALHQLMLDCWQKERSDRPKFGQIVNML-----
-------ITIERVIGAGEFGEVCSGRLK--LPGKRELPVAIKTLK-V--GYT-EKQ-RRDFL-GEASIMGQF-DHPNIIHLEGVVT-K-----------------------------SKPVMIVTEYMENGSLDTFLK----KN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDM--------GYVHRDLAARNILINSNLVCKVSDFGLSRVL----E--D--DPEAAYTTRGGKIPIRWTAPEAIA------FRKFTSASDVWSYGIVMWEVVSYGE----------RPYWEM-----TNQDVIKAV-EEGYRLPSPMDCP------------------------------AALYQLMLDCWQKERNSRPKFDEIVNML-----
LPPRIPA--------------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR----KH--------------------------------------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILVNSNLVCKVSDFGLSRVL----E--D--DPEAAYTTTGGKIPIRWTAPEAIA------YRKFSSASDAWSYGIVMWEVMSYGE----------RPYWEM-----SNQDVILSI-EEGYRLPAPMGCP------------------------------ASLHQLMLHCWQKERNHRPKFTDIVSFL-----
------V-KIEEVIGAGEFGEVYKGRLK--LPGKREIYVAIKTLK-A--GYS-EKQ-RRDFL-SEASIMGQF-DHPNIIRLEGVVT-K-----------------------------SRPVMIITEFMENGALDSFLR----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQ-DDT--S--DPTY-TSSLGGKIPVRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSFGE----------RPYWDM-----SNQDVINAI-EQDYRLPPPMDCP------------------------------AALHQLMLDCWQKDRNSRPRFAEIVNTL-----
------V-KIEQVIGAGEFGEVCSGHLK--LPGKREIFVAIKTLK-S--GYT-EKQ-RRDFL-SEASIMGQF-DHPNVIHLEGVVT-K-----------------------------STPVMIITEFMENGSLDSFLR----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRFLE-DDT--S--DPTY-TSALGGKIPIRWTAPEAIQ------YRKFTSASDVWSYGIVMWEVMSYGE----------RPYWDM-----TNQDVINAI-EQDYRLPPPMDCP------------------------------SALHQLMLDCWQKDRNHRPKFGQIVNTL-----
------V-KIEEVIGAGEFGEVCRGRLK--QPGRREVFVAIKTLK-V--GYT-ERQ-RRDFL-SEASIMGQF-DHPNIIRLEGVVT-K-----------------------------SRPVMILTEFMENCALDSFLR----LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLSEM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRFLE-DDP--S--DPTY-TSSLGGKIPIRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSYGE----------RPYWDM-----SNQDVINAV-EQDYRLPPPMDCP------------------------------TALHQLMLDCWVRDRNLRPKFSQIVNTL-----
------V-KIEEVIGAGEFGEVCRGRLK--APGKKESCVAIKTLK-G--GYT-ERQ-RREFL-SEASIMGQF-EHPNIIRLEGVVT-N-----------------------------SMPVMILTEFMENGALDSFLR----LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNSNLVCKVSDFGLSRFLE-ENS--S--DPTY-TSSLGGKIPIRWTAPEAIA------FRKFTSASDAWSYGIVMWEVMSFGE----------RPYWDM-----SNQDVINAI-EQDYRLPPPPDCP------------------------------TSLHQLMLDCWQKDRNARPRFPQVVSAL-----
-------LQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTLK-P--GTM-SP---ESFL-EEAQIMKKL-KHDKLVQLYAVVS-------------------------------EEPIYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGR----------VPYPGM-----NNREVLEQV-ERGYRMPCPQDCP------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL-----
-------LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMK-P--GSM-SV---EAFL-AEANVMKTL-QHDKLVKLHAVVT-------------------------------KEPIYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSASLVCKIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGR----------IPYPGM-----SNPEVIRAL-ERGYRMPRPENCP------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L---
-------YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRP--FQSIIH---AKRTYRELRLLKHM-KHENVIGLLDVFT-PARS-----------------------LEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVNEDCELKILDFGLAR----------HTDDEM-TG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GR----------TLFPGT-----DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---
------L-VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLK-S--TAR-SSE-KQALM-SELKIMSHLGPHLNVVNLLGACT-K-----------------------------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICEGKLVKICDFGLARDI----M--R--DSNY-ISKGSTFLPLKWMAPESIF------NSLYTTLSDVWSFGILLWEIFTLGG----------TPYPEL-P---MNEQFYNAI-KRGYRMAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL--
------F-TLCRKLGSGYFGEVFEGLWK------DRVQVAIKVIS-R--DNL-LH--QQMLQ-SEIQAMKKL-RHKHILALYAVVS-V-----------------------------GDPVYIITELMAKGSLLELLR----DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVGENTLCKVGDFGLARLI----------KEDV-YLSHDHNIPYKWTAPEALS------RGHYSTKSDVWSFGILLHEMFSRGQ----------VPYPGM-----SNHEAFLRV-DAGYRMPCPLECP------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL-----
------L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-E--NAS-PSE-LRDLL-SEFNVLKQV-NHPHVIKLYGACS-Q-----------------------------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAEGRKMKISDFGLSRDV----Y--E--EDSY-VKRSQGRIPVKWMAIESLF------DHIYTTQSDVWSFGVLLWEIVTLGG----------NPYPGI-----PPERLFNLL-KTGHRMERPDNCS------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
------L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-P--GTM-SP---EAFL-QEAQVMKKL-RHEKLVQLYAVVS-------------------------------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR----------VPYPGM-----VNREVLDQV-ERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
----TLE---DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILK-N--EAN-DPALKDELL-AEANVMQQL-DNPYIVRMIGICE-------------------------------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVTQHYAKISDFGLSKAL----R--A--DENYYKAQTHGKWPVKWYAPECIN------YYKFSSKSDVWSFGVLMWEAFSYGQ----------KPYRGM-----KGSEVTAML-EKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL-
-----IV--LQESIGKGRFGEVWRGKWR-----GEE--VAVKIFSSR--EERSWF---REA---EIYQTVML-RHENILGFIAADN-KDN-------------------------GTWTQLWLVSDYHEHGSLFDYLN----RY----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS---ATDTIDIAP-NH---RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVV-CEQKLRPNIPNRWQSCEAL------------------------RVMAKIMRECWYANGAARLTALRIKK----TL-
------L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLK-PDVLSQ-PEA-MDDFI-REVNAMHSL-DHRNLIRLYGVVL-------------------------------TPPMKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLATRDLVKIGDFGLMRAL---PQ--N--DDHY-VMQEHRKVPFAWCAPESLK------TRTFSHASDTWMFGVTLWEMFTYGQ----------EPWIGL-----NGSQILHKIDKEGERLPRPEDCP------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---
------L-AFIKEIGSGQFGVVHLGEWR------SHIQVAIKAIN-E--GSM-SE---EDFI-EEAKVMMKL-SHSKLVQLYGVCI-Q-----------------------------RKPLYIVTEFMENGCLLNYLR----EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVSSTCIVKISDFGMTRYV-------L--DDEY-VSSFGAKFPIKWSPPEVFL------FNKYSSKSDVWSFGVLMWEVFTEGK----------MPFENK-----SNLQVVEAI-SEGFRLYRPHLAP------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV--
------L-RLEVKLGQGCFGEVWMGTWN------GTTKVAIKTLK-P--GTM-MP---EAFL-QEAQIMKKL-RHDKLVPLYAVVS-------------------------------EEPIYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGENLVCKIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGR----------VPYPGM-----VNREVLEQV-ERGYRMPCPQGCP------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL-----
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