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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK CSF1R 582
TK FRK 234
TK KIT 589
TK LYN 247
TK PDGFRA 593
TK PDGFRB 600
TK SRC 270
TK YES1 277
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI---EDNEYTAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
-ITMKHKLGGGQYGEVYVGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYDLLEKGYR----MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F-
-ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST-KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK--SRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
-LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKS-TAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI--MNDSNYIVKGNARLPVKWMAPESIFDCV---YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ----MAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL--
-IQLLKRLGSGQFGEVWEGLWN------NTTPVAVKTLKP-GSMDP--NDFLREAQIMKNL-RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNK---FSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQMLAQNYR----LPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWK-L-
-LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI--KNDSNYVVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
-IKLVKRLGAGQFGEVWMGYYN------NSTKVAVKTLKP-GTMSV--QAFLEEANLMKTL-QHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI---EDNEYTAREGAKFPIKWTAPEAINFGC---FTIKSDVWSFGILLYEIVTYGKIPYPGR-TNADVMTALSQGYR----MPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSV-L-
L-VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI--MHDSNYVSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR----MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
L-VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI--MRDSNYISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYR----MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLKP-GTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI---EDNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYR----MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L-
L-RLEVKLGQGCFGEVWMGTWN------GTTKVAIKTLKP-GTMMP--EAFLQEAQIMKKL-RHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI---EDNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYR----MPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL--
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