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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
TK EGFR 712
Other EIF2AK2 267
TK EPHA6 631
TK FGFR1 478
TK IGF1R 999
TKL IRAK4 186
TK JAK2 849
CMGC MAPK14 24
AGC PRKCA 339
TK SRC 270
TKL TGFBR1 205
-------LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM-SP--D-AFL-A-EANLMKQL--QHQRLVRLYAVVT--------------------------------QEPIYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSD---TLSCKIADFGLARLI------E--DNEY-TAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--------------
-------ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM-EV--E-EFL-K-EAAVMKEI--KHPNLVQLLGVCT--R-----------------------------EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE---NHLVKVADFGLSRLM------T--GDTY-TAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--------------
------I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EV-CS-EQDEL-DFL-M-EALIISKF--NHQNIVRCIGVSL--Q-----------------------------SLPRFILLELMAGGDLKSFLR----ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y--R--ASYY-RKGGCAMLPVKWMPPEAFM------EGIFTSKTDTWSFGVLLWEIFSLGY----------MP---------------YPSK-----SNQEVLEFVTSGGRMDPPKNCP------------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I--------------
-------FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--E-HQLRR-EVEIQSHL--RHPNILRLYGYFH--D-----------------------------ATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGS---AGELKIADFGWSV--------HAPSSRR-TT---LCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GK----------PP---------------FEAN--------TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--------------
-------YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEEGV--P-STAIR-EISLLKEL--RHPNIVSLQDVLM--Q-----------------------------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLIDD---KGTIKLADFGLARAF------GIPIRVY-TH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KK----------PL---------------FHGD-----SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
-------FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV--P-STAIR-EISLLKEL--NHPNIVKLLDVIH--T-----------------------------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLINT---EGAIKLADFGLARAF------GVPVRTY-TH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RR----------AL---------------FPGD-----SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
------F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKANK-EIL-D-EAYVMASV--DNPHVCRLLGICL--------------------------------TSTVQLITQLMPFGCLLDYVR----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G--A--EEKE-YHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----PASEISSILEKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF------------
------F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRVKYNN-EKAER----------EVKALAKL--DHVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGE-----------------KLDKVLALELFEQITKGVDYIHSK--------KLIHRDLKPSNIFLVD---TKQVKIGDFGLVTS-------LKNDGKR-TR---SKGTLRYMSPEQIS------SQDYGKEVDLYALGLILAELLH-VC---------DTA---------------FET------------SKFFTDLRDGIISDIFDK-----------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT-----------
LPPRIPA------------------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR----KH---------------DGHFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILVNS---NLVCKVSDFGLSRVL---E--D--DPEAAYTTTGGKIPIRWTAPEAIA------YRKFSSASDAWSYGIVMWEVMSYGE----------RP---------------YWEM-----SNQDVILSIEEGYRLPAPMGCP------------------------------ASLHQLMLHCWQKERNHRPKFTDIVSFL----------------
------L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKDLS-DLI-S-EMEMMKMIG-KHKNIINLLGACT--Q-----------------------------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H--H--IDYY-KKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV-----PVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----------------
-------ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EA-AS-MRERI-EFL-N-EASVMKEF--NCHHVVRLLGVVS--Q-----------------------------GQPTLVIMELMTRGDLKSYLR----SLRPEM------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y--E--TDYY-RKGGKGLLPVRWMSPESLK------DGVFTTYSDVWSFGVVLWEIATLAE----------QP---------------YQGL-----SNEQVLRFVMEGGLLDKPDNCP------------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I--------------
----VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAMV-DITTE--ELKQQFDQEIKVMAKC--QHENLVELLGFSS--D-----------------------------GDDLCLVYVYMPNGSLLDRLSCLDGTP-----------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLDE---AFTAKISDFGLARASE----KFAQTVMT-SR---IVGTTAYMAPEALR-------GEITPKSDIYSFGVVLLEIIT-GL----------PA---------------VDEH-----REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD----------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ-----------
-------LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HS-TE--EHLR-DFE-R-EIEILKSL--QHDNIVKYKGVCYSAG-----------------------------RRNLKLIMEYLPYGSLRDYLQ----KH---------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQ--D--KEYY-KVKEPGESPIFWYAPESLT------ESKFSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELLKNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV------------
-------YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPF-QSIIH--A-KRTYR-ELRLLKHM--KHENVIGLLDVFT--PARS-----------------------LEEFNDVYLVTHLMGA-DLNNIVK----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVNE---DCELKILDFGLAR---------HTDDEM-TG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GR----------TL---------------FPGT-----DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--------------
------F-NFLMVLGKGSFGKVMLADRK-------GTEELYAIKILKKDV-VIQDD--D-VECTMVEKRVLALL-DKPPFLTQLHSCFQ--T-----------------------------VDRLYFVMEYVNGGDLMYHIQ---QVG-----------------KFKEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLDS---EGHIKIADFGMCKEH------MMDGVTT-RT---FCGTPDYIAPEIIA------YQPYGKSVDWWAYGVLLYEMLA-GQ----------PP---------------FDGE--------DEDELFQSIMEHNVSYPKSLS----------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
------L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--E-AFL-Q-EAQVMKKL--RHEKLVQLYAVVS--------------------------------EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGE---NLVCKVADFGLARLI------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--------------
-----IV--LQESIGKGRFGEVWRGKWR-------GEE--VAVKIFSSRE-ERSWF--R-EA----EIYQTVML--RHENILGFIAADN--KDN-------------------------GTWTQLWLVSDYHEHGSLFDYLN----RY-----------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKK---NGTCCIADLGLAVRHDS--ATDTIDIAP-NH---RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLP---------------YYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEAL------------------------RVMAKIMRECWYANGAARLTALRIKK----TL------------
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