|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
TK ABL1 261
Other AURKA 133
TKL BRAF 456
CMGC CDK2 4
TK FYN 271
TK HCK 241
TK JAK2 849
CMGC MAPK14 24
TK PDGFRA 593
AGC PRKCA 339
TK SRC 270
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-Q-G-SM-SP--DAFL-A-EANLMKQL--QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK---TP------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYR----MVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--------------
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-E-D-TM-EV--EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR---EC------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--------------
-FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKA-QLEKAGV--EHQLRR-EVEIQSHL--RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ--KLS---------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISR----VEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--------------
-ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLN-VTA-PT-PQQLQAFK-N-EVGVLRKT--RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH---II-------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-SR--WSGSHQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI-------------
-FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLD-T-ETEGV--PSTAIR-EISLLKEL--NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDASALT---------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
-LQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTLK-P-G-TM-SP--ESFL-E-EAQIMKKL--KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK---DG------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGR---FTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQVERGYR----MPCPQDCP------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL----------------
-LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMK-P-G-SM-SV--EAFL-A-EANVMKTL--QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK---SD------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI--E--DNEYTAREGAKFPIKWTAPEAIN-FGS---FTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRALERGYR----MPRPENCP------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L--------------
-LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-H-S-TE--EHLRDFE-R-EIEILKSL--QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ---KH-------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV------------
-YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRP-F-QSIIH--AKRTYR-ELRLLKHM--KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK---CQ---------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--------------
L-VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK-P-T-AR-SSEKQALM-S-ELKIMTHLG-PHLNIVNLLGACT--K------SGPIYIITEYCFYGDLVNYLH---KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-MH--DSNYVSKGSTFLPVKWMAPESIF-DNL---YTTLSDVWSYGILLWEIFSLGGTP---------------YPGMMVDSTFYNKIKSGYR----MAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV-------------
F-NFLMVLGKGSFGKVMLADRK-----GTEELYAIKILKKD-V-VIQDD--DVECTMVEKRVLALL-DKPPFLTQLHSCFQ--T------VDRLYFVMEYVNGGDLMYHIQ--QVG---------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEH--MMDGVTTRT---FCGTPDYIAPEIIA-YQP---YGKSVDWWAYGVLLYEMLA-GQPP---------------FDGE----DEDELFQSIME----HNVSYPKSLS----------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-P-G-TM-SP--EAFL-Q-EAQVMKKL--RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK---GE------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYR----MPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--------------
|