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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL MAP3K9 203
CMGC CDK2 4
TKL MAP3K10 98
TKL MAP3K11 117
TK RET 724
TK TEK 824
L-TLEEIIGIGGFGKVYRAFWI-----GDE--VAVKAA---RHDPDEDISQ-----TIENVRQEAKLFAML-KHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS---GK-------------------------RIPPDILVNWAVQIARGMNYLHDEAIVP---IIHRDLKSSNILILQ--------KVENGDLSNKILKITDFGLAR---EWHRTTKMS---AAGTYAWMAPEVIR-ASMFSKGSDVWSYGVLLWELLT-GEVPFRGI---DGLAVA-YGVAMNKLALPIPSTCP------------------------EPFAKLMEDCWNPDPHSRPSFTNILDQ---LT
-FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKI---RLD-TETEGV-----PSTAIR-EISLLKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSH---R---VLHRDLKPQNLLINT--------EGAI--------KLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-LQLEEIIGVGGFGKVYRALWR-------GEEVAVKAARLDP-E-KDP-AVT---AEQVC-Q-EARLFGAL-QHPNIIALRGACLNPPHLCLVMEYARGGALSRVLA---GR-------------------------RVPPHVLVNWAVQVARGMNYLHND---APVPIIHRDLKSINILILEAIENHNLADTVL--------KITDFGLAREW------HKTTKMSAAGTYAWMAPEVIR-LSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPSTCP----------------------------EPFARLLEECWDPDPHGRPDFGSILKRL----
-LRLEEVIGIGGFGKVYRGSWR-------GELVAVKAA---R-Q-DPD-EDISVTAESVR-Q-EARLFAML-AHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA---GR-------------------------RVPPHVLVNWAVQIARGMHYLHCE---ALVPVIHRDLKSNNILLLQPIESDDMEHKTL--------KITDFGLAREW------HKTTQMSAAGTYAWMAPEVIK-ASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP----------------------------EPFAQLMADCWAQDPHRRPDFASILQQL----
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML---K-E-NAS-PSE---LRDLL-S-EFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM---K---LVHRDLAARNILVAE--------GRKM--------KISDFGLSRDVYE--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL-KTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
-IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRM---K-E-YAS-KDD---HRDFA-G-ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLR---KSRVLETDP--------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQK---Q---FIHRDLAARNILVGE--------NYVA--------KIADFGLSRGQ-----EVYVKKTMGRLPVRWMAIESLN-YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL-PQGYRLEKPLNCD----------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL-
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