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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK1 203
CMGC CDC2L6 20
CMGC CDK2 4
CMGC CDK8 2.7.11.23
CAMK CHEK1 9
CMGC GSK3B 56
TK LCK 245
CMGC MAPK10 64
CMGC MAPK14 24
Other PLK1 53
Other PLK2 82
Other PLK3 62
---YTNLSYIGEGAYGMVCSAYDNVNKV--RVAIKKISPFEHQTYCQRT-LR-EIKILLRFRHENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK----------TQ---HL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN----TTCDLKICDFGLARVADPDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGK---------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL-
EGC-----KVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSAC----R-EIALLRELKHPNVIALQKVFLSH----SDRKVW--LLFDYAEH---DLWHIIKFHR--ASKANKK---PMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDP---VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYA----NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF-
---FQKVEKIGEGTYGVVYKARNKLTGE--VVALKKIRLDTETEGVPSTAIR-EISLLKELNHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT---GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN----TEGAIKLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD---------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
EGC-----KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSAC----R-EIALLRELKHPNVISLQKVFLSH----ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV---QL--PRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDP---VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT----NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF-
--W-DLVQTLGEGAYGEVQLAVNRVTEE--AVAVKIVDMKRAVDCPENI-KK-EICINKMLNHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE---------PDI---GM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD----ERDNLKISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP-----------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
---YTDTKVIGNGSFGVVYQAKLCDSGE--LVAIKKVLQDKRFKNR-------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ---TL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD---PDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD---------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-
---LKLVERLGAGQFGEVWMGYYN-GHT--KVAVKSLK-QGSM-SPDAFL-A-EANLMKQLQHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK----------TPSGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS----DTLSCKIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM---------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
---YQNLKPIGSGAQGIVCAAYDAVLDR--NVAIKKLSRPFQNQTHAKRAYR-ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ-----------M---EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGR---------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-
---YQNLSPVGSGAYGSVCAAFDTKTGL--RVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK----------CQ---KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN----EDCELKILDFGLAR------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT---------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
-YV--RGRFLGKGGFAKCFEISDADTKE--VFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK---------RRK---AL--TEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN----EDLEVKIGDFGLATKV---EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS------------CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-
--Y-CRGKVLGKGGFAKCYEMTDLTNNK--VYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFED------KENIY--ILLEYCSRR--SMAHILK---------ARK---VL--TEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN----EAMELKVGDFGLAARL---EPLEHRRRT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPPFETT------------NLKETYRCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF-
-YL--KGRLLGKGGFARCYEATDTETGS--AYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFED------ADNIY--IFLELCSRK--SLAHIWK---------ARH---TL--LEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT----ENMELKVGDFGLAARL---EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPPFETA------------DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF-
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