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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK10 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CMGC CLK4 159
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
CMGC NLK 126
CAMK PRKD3 576
---YQNLKPIGSGAQGIVCAAYDAV-LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN--HKN----IISLLNVFTPQKT--LEEFQDVYLVMELMDA-NLCQVIQ-----MEL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL-------------------KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
---YTKIEKIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELR--HPN----IVSLQDVLMQ--------DSRLYLIFEFLSM-DLKKYLDSIPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-------------------KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
---FQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELN--HPN----IVKLLDVIHT--------ENKLYLVFEFLHQ-DLKKFMDA-SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-------------------KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
---FQKVEKIGEGTYGVVYKAKNRE-TGQLVALKKIRLDLEMEGVPSTAIREISLLKELK--HPN----IVRLLDVVHN--------ERKLYLVFEFLSQ-DLKKYMDS-TPGSEL--PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAI-------------------KLADFGLARAF----GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
---YEKLEKIGEGTYGTVFKAKNRE-THEIVALKRVRLDDDDEGVPSSALREICLLKELK--HKN----IVRLHDVLHS--------DKKLTLVFEFCDQ-DLKKYFD--SCNGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL-------------------KLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
---YEKLAKIGQGTFGEVFKARHRK-TGQKVALKKVLMENEKEGFPITALREIKILQLLK--HEN----VVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLVKF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL-------------------KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
---YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARS---EIQVLEHLNSTDPNSVFRCVQMLEWFDH--------HGHVCIVFELLGL-STYDFIK---ENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA-------TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
---YQNLSPVGSGAYGSVCAAFDTK-TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK--HEN----VIGLLDVFTPARS--LEEFNDVYLVTHLMGA-DLNNIVK----CQKL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL-------------------KILDFGLAR-------HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
---YQNLKPIGSGAQGIVCAAYDAI-LERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN--HKN----IIGLLNVFTPQKS--LEEFQDVYIVMELMDA-NLCQVIQ-----MEL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL-------------------KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK--LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
---YQQLKPIGSGAQGIVCAAFDTV-LGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVN--HKN----IISLLNVFTPQKT--LEEFQDVYLVMELMDA-NLCQVIH-----MEL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL-------------------KILDFGLART-----ACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE--LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
IEP---DRPIGYGAFGVVWSVTDPR-DGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFK--HDN----VLSALDILQPPH---IDYFEEIYVVTELMQS-DLHKIIV---SPQPL--SSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVL-------------------KICDFGLARVE---ELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP------------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL
FAD----EVLGSGQFGIVYGGKHRK-TGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLH--HPG----IVNLECMFET--------PERVFVVMEKLHGDMLEMILS--SEKSRL--PERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFP----------------QVKLCDFGFARI-----IGEKSFRRSVVGTPAYLAPEVLR-SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS-------------------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL
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