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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK10 203
CMGC CDK2 4
CMGC CDKL2 4
CMGC DYRK1B 111
AGC GRK1 190
AGC GRK4 187
AGC GRK7 191
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CMGC ICK 4
CMGC MAPK14 24
CMGC MAPK8 26
AGC PDPK1 82
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC SGK3 162
STE STK24 24
----YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYR-ELVLM-KCV-N-----HKN-----IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ------MEL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL----KILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VD-DALQHPYI------------
----FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIR-EISLL-KEL-N-----HPN-----IVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA--SALTGI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI----KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AK-AALAHPFF------------
----YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKK-IAMR-EIKLL-KQL-R-----HEN-----LVNLLEVCKK------KKRWYLVFEFVDHTILDDLEL----FPNGL---DYQVVQKYLFQIINGIGFCHS--HNIIHRDIKPENILVS--QSGVV----KLCDFGFARTL--AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGD-SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-----CA-ELLHHDFF------------
----YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQ-I----ELRLL-ELMNQ-----HDTEMKYYIVHLKRHFMF------RNHLCLVFELLSY-NLYDLLR-----NTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQ-----LGQRIYQYIQSRFYRSPEVLL-GTPYDLAIDMWSLGCILVEMHTGEPLFSGS-NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-----PL-GALQHGFF------------
FLDF----RVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGY-QGAMVEKKIL-MKV-H-----SRF-----IVSLAYAFET------KADLCLVMTIMNGGDIRYHIYNVNEENPGF---PEPRALFYTAQIICGLEHLHQ--RRIVYRDLKPENVLLD--NDGNV----RISDLGLAVEL--LDGQSKTKGYAGTPGFMAPELLQ-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS---------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG-----FR-D-------ETCDKLRAHPLF
--FR--HYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGE-AMALNEKRIL-EKV-Q-----SRF-----VVSLAYAYET------KDALCLVLTIMNGGDLKFHIYN--LGNPGF---DEQRAVFYAAELCCGLEDLQR--ERIVYRDLKPENILLD--DRGHI----RISDLGLATE---IPEGQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKY-KEKVKWEEVDQRIKNDTEEYSE---KFS-----------------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCRGEGAA-GVKQHPV-F-----------
---F-TEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGE-KMALLEKEIL-EKV-S-----SPF-----IVSLAYAFES------KTHLCLVMSLMNGGDLKFHIYN--VGTRGL---DMSRVIFYSAQIACGMLHLHE--LGIVYRDMKPENVLLD--DLGNC----RLSDLGLAVE---MKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-----SR-E-------KSDDPR------
----YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQ-I----EVSIL-SRL-S-----SENADEYNFVRSYECFQH------KNHTCLVFEMLEQ-NLYDFLKQ--NKFSPL---PLKYIRPILQQVATALMKLKS--LGLIHADLKPENIMLV--DPVRQPYRVKVIDFGSAS----HVSKAVCSTYLQSRYYRAPEIIL-GLPFCEAIDMWSLGCVIAELFLGWPLYPGA-SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT-----PL-KTLNHQFV------------
----YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQ-I----EVSIL-ARL-STESADDYN-----FVRAYECFQH------KNHTCLVFEMLEQ-NLYDFLKQ--NKFSPL---PLKYIRPVLQQVATALMKLKS--LGLIHADLKPENIMLV--DPSRQPYRVKVIDFGSAS----HVSKAVCSTYLQSRYYRAPEIIL-GLPFCEAIDMWSLGCVIAELFLGWPLYPGA-SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT-----PI-ETLNHPFV------------
----YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQ-I----EVSIL-ARL-S-----TENADEYNFVRAYECFQH------RNHTCLVFEMLEQ-NLYDFLKQ--NKFSPL---PLKVIRPILQQVATALKKLKS--LGLIHADLKPENIMLV--DPVRQPYRVKVIDFGSAS----HVSKTVCSTYLQSRYYRAPEIIL-GLPFCEAIDMWSLGCVIAELFLGWPLYPGA-LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT-----PA-ETLNHPFV------------
----YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIK-N----ELKLL-HCM-RGLDPEEAH-----VIRFLEFFHD------ALKFYLVFELLEQ-NLFEFQK-----ENNFAPLPARHIRTVTLQVLTALARLKE--LAIIHADLKPENIMLV--DQTRCPFRVKVIDFGSASIF--SEVRYVKEPYIQSRFYRAPEILL-GLPFCEKVDVWSLGCVMAELHLGWPLYPGN-NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-----PS-AALRHPFV------------
----YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEEC--MNLR-EVKSL-KKL-N-----HAN-----VVKLKEVIRE------NDHLYFIFEYMKE-NLYQLIK---ERNKLF---PESAIRNIMYQILQGLAFIHK--HGFFHRDLKPENLLCM--GPELV----KIADFGLARE---IRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGA-SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-----AS-QALRYPYF------------
----YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYR-ELRLL-KHM-K-----HEN-----VIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-----CQKL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCEL----KILDFGLAR-----HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AA-QALAHAYF------------
----YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAK-RAYR-ELVLM-KCV-N-----HKN-----IIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ------MEL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL----KILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VD-EALQHPYI------------
---F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR-ERDVM-SRL-D-----HPF-----FVKLYFTFQD------DEKLYFGLSYAKNGELLKYIR----KIGSF---DETCTRFYTAEIVSALEYLHG--KGIIHRDLKPENILLN--EDMHI----QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVAGLPPFRAG----NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG-----CE-EM------EGYGPLKAHPF-
--FI--LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDV-ECTMVEKRVL-SLAWE-----HPF-----LTHMFCTFQT------KENLFFVMEYLNGGDLMYHIQ----SCHKF---DLSRATFYAAEIILGLQFLHS--KGIVYRDLKLDNILLD--KDGHI----KIADFGMCKEN--MLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQ----DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF------------
--PD----EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQES-QLRN-EVAIL-QNL-H-----HPG-----VVNLECMFET------PERVFVVMEKLHGDMLEMILS---SEKGRL---PEHITKFLITQILVALRHLHF--KNIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI---IGEKSFRRSVVGTPAYLAPEVLR-NKGYNRSLDMWSVGVIIYVSLSGTFPFNED------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------------HEAIDLINNLLQVKMRKRYS-----VD-KTLSHPWL------------
--PD----EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQES-QLRN-EVAIL-QSL-R-----HPG-----IVNLECMFET------PEKVFVVMEKLHGDMLEMILS---SEKGRL---PERLTKFLITQILVALRHLHF--KNIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI---IGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIMYVSLSGTFPFNED------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS-----VD-KSLSHPWL------------
-FAD----EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQES-QLRN-EVAIL-QNL-H-----HPG-----IVNLECMFET------PERVFVVMEKLHGDMLEMILS---SEKSRL---PERITKFMVTQILVALRNLHF--KNIVHCDLKPENVLLA--SAEPFP-QVKLCDFGFARI---IGEKSFRRSVVGTPAYLAPEVLR-SKGYNRSLDMWSVGVIIYVSLSGTFPFNED------EDINDQIQNAAFMYPPNPWREIS-----------------------------------------------------------------------GEAIDLINNLLQVKMRKRYS-----VD-KSLSHPWL------------
---F-DFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQ-KHIMAERNVLLKNV-K-----HPF-----LVGLHYSFQT------TEKLYFVLDFVNGGELFFHLQ----RERSF---PEHRARFYAAEIASALGYLHS--IKIVYRDLKPENILLD--SVGHV----VLTDFGLCKEG--IAISDTTTTFCGTPEYLAPEVIR-KQPYDNTVDWWCLGAVLYEMLYGLPPFYCR----DVAEMYDNILHKPLSLRPGVS---------------------------------------------------------------------------LTAWSILEELLEKDRQNRLGAK-EDFL-EIQNHPFF------------
----FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIED-IQ-Q-EITVL-SQC-D-----SPY-----VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLE-----PGPL---DETQIATILREILKGLDYLHS--EKKIHRDIKAANVLLS--EHGEV----KLADFGVAGQL--TDTQIKRNTFVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELARGEPPHSEL-HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT-----AK-ELLKHKFI------------
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