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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
CMGC GSK3B 56
TK LCK 245
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK12 27
CMGC MAPK8 26
CMGC MAPK9 26
CMGC NLK 126
AGC PRKACA 44
AGC PRKACB 44
TK PTK6 191
AGC RPS6KA1 62
AGC RPS6KA6 73
STE SLK 34
TK SRC 270
AGC STK32B 23
Other STK36 4
---YQNLSPVGSGAYGSV---CAAFDTKTGL---RVAVKKLSRPFQSIIH-AKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR----HTDDEMTG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF----
---YTDTKVIGNGSFGVV---YQAKLCDSGE---LVAIKKVLQDKRFKNR--------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF----
---LKLVERLGAGQFGEV---WMGYYN-GHT---KVAVKSLK-QGSM-SP-DAFL-A-EANLMKQLQHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI-E--DNEYTAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L----
---YQNLKPIGSGAQGIV---CAAYDAVLDR---NVAIKKLSRPFQNQTH-AKRAYR-ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART--AGTSFMMTP---YVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI----
LQG---LRPVGSGAYGSV---CSAYDARLRQ---KVAVKKLSRPFQSLIH-ARRTYR-ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR----QADEEMTG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF----
---YRDLQPVGSGAYGAV---CSAVDGRTGA---KVAIKKLYRPFQSELF-AKRAYR-ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFY--LVMPFMGT---DLGKLMK-----HE---KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR----QADSEMTG---YVVTRWYRAPEVIL----NWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF----
---YQNLKPIGSGAQGIV---CAAYDAILER---NVAIKKLSRPFQNQTH-AKRAYR-ELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART--AGTSFMMTP---YVVTRYYRAPEVIL-----GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI----
---YQQLKPIGSGAQGIV---CAAFDTVLGI---NVAVKKLSRPFQNQTH-AKRAYR-ELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART--ACTNFMMTP---YVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI----
IEP---DRPIGYGAFGVV---WSVTDPRDGK---RVALKKMPNVFQNLVS-CKRVFR-ELKMLCFFKHDNVLSALDILQPPH-IDYFEEIY--VVTELMQS---DLHKIIV----SPQ---PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN-SNCVLKICDFGLARVEELDESRHMTQ---EVVTQYYRAPEILM----GSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL----
--F-ERIKTLGTGSFGRV---MLVKHKETGN---HYAMKILDKQKVVKLK-QIEHTLNEKRILQAVNFPFLVKLEFSFKD------NSNLY--MVMEYVPGG--EMFSHLR----RIG---RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAK----RVKGRTWT---LCGTPEYLAPEIIL-----SKGYNKAVDWWALGVLIYEMAA-GYPPFFAD---QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF----
--F-ERKKTLGTGSFGRV---MLVKHKATEQ---YYAMKILDKQKVVKLK-QIEHTLNEKRILQAVNFPFLVRLEYAFKD------NSNLY--MVMEYVPGG--EMFSHLR----RIG---RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-HQGYIQVTDFGFAK----RVKGRTWT---LCGTPEYLAPEIIL-----SKGYNKAVDWWALGVLIYEMAA-GYPPFFAD---QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWF----
--F-TLCRKLGSGYFGEV---FEGLWK-DRV---QVAIKVIS-RDNL-LHQQMLQ-S-EIQAMKKLRHKHILALYAVVSV------GDPVY--IITELMAKG--SLLELLR-----DSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLI----KEDVYLSHDHNIPYKWTAPEALS-----RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL------
---FELLKVLGQGSFGKVFLVRKVTRPDSGH---LYAMKVLKKATLKVRD-RVRTKM-ERDILADVNHPFVVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV---MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKEA-IDHEKKAYS---FCGTVEYMAPEVVN-----RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS---------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY--
---FELLKVLGQGSFGKV---FLVRKKTGPDAGQLYAMKVLKKASLKVRD-RVRTKM-ERDILVEVNHPFIVKLHYAFQT------EGKLY--LILDFLRGG--DVFTRLS----KEV---LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHIKLTDFGLSKES-VDQEKKAYS---FCGTVEYMAPEVVN-----RRGHSQSADWWSYGVLMFEMLT-GTLPFQGK---DRNETMNMILKAKLGMPQFLS---------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF----
---WEIIGELGDGAFGKV---YKAQNKETSV---LAAAKVIDTKSEEELE-DYM--V-EIDILASCDHPNIVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML---ELER---PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDIKLADFGVSAKN-TRTIQRRDS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHHELNPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV----
--L-RLEVKLGQGCFGEV---WMGTWN-GTT---RVAIKTLK-PGTM-SP-EAFL-Q-EAQVMKKLRHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI-E--DNEYTARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L----
---FQILRAIGKGSFGKV---CIVQKRDTKK---MYAMKYMNKQKCIERD-EVRNVFRELQIMQGLEHPFLVNLWYSFQD------EEDMF--MVVDLLLGG--DLRYHLQ----QNV---HFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLD-EHGHVHITDFNIATV--VKGAERASS---MAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLR-GWRPYEIHSVTPIDEILNMFKVERVHYSSTWC---------------------------------------KGMVALLRKLLTKDPESRVS----SLHDIQS----VPYL
---YHVLEMIGEGSFGRV---YKGRRKYSAQ---VVALKFIPKLGRSEKE-LRNLQR-EIEIMRGLRHPNIVHMLDSFET------DKEVV--VVTDYAEG---ELFQILE----DDG---KLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLA-KGGGIKLCDFGFARAM-STNTMVLTS---IKGTPLYMSPELVE-----ERPYDHTADLWSVGCILYELAV-GTPPFYAT---SIFQLVSLILKDPVRWPSTIS---------------------------------------PCFKNFLQGLLTKDPRQRLS-----WPDLLYHPFI----
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