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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
TK ABL2 288
TK LCK 245
TKL LIMK1 339
CMGC MAPK11 24
CMGC MAPK9 26
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH--AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEM------------TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
---ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEIKHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTY------------TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
---ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEIKHPNLVQLLGVCTL------EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM-T--GDTY------------TAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYDLLEKGYRMEQPEGCP-----------------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F-
---LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQLQHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-E--DNEY------------TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
-LI--HGEVLGKGCFGQAIKVTHRETGEVMVMKELI--RFD-EETQRTFL-KEVKVMRCLEHPNVLKFIGVLYK------DKRLNFITEYIKGGTLRGIIKSM-DSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVD--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN-GRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCP-----------------------------------------PSFFPITVRCCDLDPEKRPSFVKLEH---WL
LQG---LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH--ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR----QADEEM------------TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGS-DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF-
---YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTH--AKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH-M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMM------------TP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGT-DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI-
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