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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
TK BLK 241
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK2D 14
CMGC CDC2L6 20
CMGC CDK2 4
CMGC CDK8 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CLK2 163
CMGC CSNK2A1 39
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK1B 111
TK FGFR1 478
TK FGFR2 481
TK FGR 263
TK FYN 271
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
TK LCK 245
TK LYN 247
CMGC MAPK10 64
CMGC MAPK8 26
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
CAMK MKNK2 84
CAMK NUAK1 55
CAMK NUAK2 97
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
Other PLK1 53
AGC PRKACA 44
AGC PRKACB 44
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
TK SRC 270
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
CAMK TSSK1B 12
TK YES1 277
-----YQNLSPVGSGAYGSV---CAAFDT-------KTGL---RVAVKKLSRPFQSIIH--AK-RTYR-------ELRLLKHM--K-----HEN-----VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK------------------------CQ-----------------KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN----EDCEL-------------------KILDFGLAR-----------HTDDEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GT------------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AAQALAHAYF-----------
-----ITMKHKLGGGQYGEV---YEGVWK-------KYSL---TVAVKTLK-EDTM-EV--EE-FL-K-------EAAVMKEI--K-----HPN-----LVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR------------------------EC--------------NRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG----ENHLV-------------------KVADFGLSRLM--------T--GDTYTAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GI------------DLSQVYELLEKDYRMERPEGCP---------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F-----------
----L-RLVRKLGSGQFGEV---WMGYYK--------NNM---KVAIKTLK-EGTM-SP--EA-FL-G-------EANVMKAL--Q-----HER-----LVRLYAVVT-------KEPIY--IVTEYMARG--CLLDFLK------------------------TD--------------EGSRL---SLPRLIDMSAQIAEGMAYIER--MNSIHRDLRAANILVS----EALCC-------------------KIADFGLARII-----------DSEYTAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGRVPYP-GM------------SNPEVIRNLERGYRMPRPDTCP---------------------------------------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L-----------
-----YRLEKTLGKGQTGLV---KLGVHC-------ITGQ---KVAIKIVNREKLSESV--LM-KVER-------EIAILKLI--E-----HPH-----VLKLHDVYEN------KKYLY--LVLEHVSGG--ELFDYLV-----------------------KKG-----------------RL---TPKEARKFFRQIVSALDFCHS--YSICHRDLKPENLLLD----EKNNI-------------------RIADFGMASL---------QVGDSLLET---SCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GALPFD-DD---------------NLRQLLEKVKRGVFHMPHFIP-------------------------------------------------------------PDCQS-LLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
-----YRLEKTLGKGQTGLV---KLGVHC-------VTCQ---KVAIKIVNREKLSESV--LM-KVER-------EIAILKLI--E-----HPH-----VLKLHDVYEN------KKYLY--LVLEHVSGG--ELFDYLV-----------------------KKG-----------------RL---TPKEARKFFRQIISALDFCHS--HSICHRDLKPENLLLD----EKNNI-------------------RIADFGMASL---------QVGDSLLET---SCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GALPFD-DD---------------NLRQLLEKVKRGVFHMPHFIP-------------------------------------------------------------PDCQS-LLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
-----YQLFEELGKGAFSVV---RRCMKI-------PTGQ---EYAAKIINTKKLSARD--HQ-KLER-------EARICRLL--K-----HPN-----IVRLHDSISE------EGFHY--LVFDLVTGG--ELFEDIV-----------------------ARE-----------------YY---SEADASHCIQQILESVNHCHL--NGIVHRDLKPENLLLA----SKSKGA----------------AVKLADFGLAIEV--------QGDQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GYPPFW-DE---------------DQHRLYQQIKAGAYDFPSPEWDTVT---------------------------------------------------------PEAKD-LINKMLTINPAKRIT-----ASEALKHPWI-----------
--EGC-----KVGRGTYGHV---YKARRK-------DGKDE-KEYALKQIEGTGISMSA--C-----R-------EIALLREL--K-----HPN-----VIALQKVFLSH----SDRKVW--LLFDYAEH---DLWHIIKFHR----------------ASKANKK-----------------PMQ-LPRSMVKSLLYQILDGIHYLHA--NWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN-----SPLKPLADLDP---VVVTFWYRAPELLL-----GARHYTKAIDIWAIGCIFAELLT-SEPIFH-CRQEDI---KTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYA--------------------------NSSLIKYMEKHKVKPDSKVFL-LLQKLLTMDPTKRIT-----SEQALQDPYF-----------
-----FQKVEKIGEGTYGVV---YKARNK-------LTGE---VVALKKIRLDTETEGV--PS-TAIR-------EISLLKEL--N-----HPN-----IVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA---------------------SALT-----------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN----TEGAI-------------------KLADFGLARAF--------GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD------------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AKAALAHPFF-----------
--EGC-----KVGRGTYGHV---YKAKRK-------DGKDD-KDYALKQIEGTGISMSA--C-----R-------EIALLREL--K-----HPN-----VISLQKVFLSH----ADRKVW--LLFDYAEH---DLWHIIKFHRA--------------SKANKKPV-----------------QL---PRGMVKSLLYQILDGIHYLHA--NWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN-----SPLKPLADLDP---VVVTFWYRAPELLL-----GARHYTKAIDIWAIGCIFAELLT-SEPIFH-CRQEDI---KTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT--------------------------NCSLIKYMEKHKVKPDSKAFH-LLQKLLTMDPIKRIT-----SEQAMQDPYF-----------
----W-DLVQTLGEGAYGEV---QLAVNR-------VTEE---AVAVKIVDMKRAVDCP--EN-I-KK-------EICINKML--N-----HEN-----VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE-----------------------PDI-----------------GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD----ERDNL-------------------KISDFGLATVFR------YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP--------------SDSCQEYSDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLA-LLHKILVENPSARIT-----IPDIKKDRW-Y----------
---YI--MSKTLGSGACGEV---KLAFER-------KTCK---KVAIKIISKRKFAIGS--AR-EADPALN-VETEIEILKKL--N-----HPC-----IIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV-----------------------GNK-----------------RL---KEATCKLYFYQMLLAVQYLHE--NGIIHRDLKPENVLLS----SQEEDC----------------LIKITDFGHSKI---------LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH--------------RTQVSLKDQITSGKYNFIPEVWAEVS---------------------------------------------------------EKALD-LVKKLLVVDPKARFT-----TEEALRHPWL-----------
-----YEIVSTLGEGTFGRV---VQCVDH-------RRGG--ARVALKIIKNVEKYKEA--AR----L-------EINVLEKI--NEKDPDNKN----LCVQMFDWFDY------HGHMC--ISFELLGL---STFDFLK-----------------------DNN-----------------YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV----NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-----------FDHEHHST---IVSTRHYRAPEVIL------ELGWSQPCDVWSIGCIIFEYYV-GFTLFQ-TH------------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFD-LIESMLEYEPAKRLT-----LGEALQHPFF-----------
-----YQLVRKLGRGKYSEV---FEAINI-------TNNE---KVVVKILKPVKKKKIK--R-------------EIKILENL-RG-----GPN-----IITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY--------------------------Q-----------------TL---TDYDIRFYMYEILKALDYCHS--MGIMHRDVKPHNVMID---HEHRKL-------------------RLIDWGLAEF---------YHPGQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH------------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK---------------------------RWERFVHSENQHLVSPEALD-FLDKLLRYDHQSRLT-----AREAMEHPYF-----------
-----YDTGEELGSGQFAVV---KKCREK-------STGL---QYAAKFIKKRRTKSSR--RG-VSREDI---EREVSILKEI--Q-----HPN-----VITLHEVYEN------KTDVI--LILELVAGG--ELFDFLA-----------------------EKE-----------------SL---TEEEATEFLKQILNGVYYLHS--LQIAHFDLKPENIMLL----DRNVPKP---------------RIKIIDFGLAHK---------IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GD---------------TKQETLANVSAVNYEFEDEYFSNTS---------------------------------------------------------ALAKD-FIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
-----YDIGEELGSGQFAIV---KKCREK-------STGL---EYAAKFIKKRQSRASR--RG-VSREEI---EREVSILRQV--L-----HHN-----VITLHDVYEN------RTDVV--LILELVSGG--ELFDFLA-----------------------QKE-----------------SL---SEEEATSFIKQILDGVNYLHT--KKIAHFDLKPENIMLL----DKNIPIP---------------HIKLIDFGLAHE---------IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GD---------------TKQETLANITAVSYDFDEEFFSQTS---------------------------------------------------------ELAKD-FIRKLLVKETRKRLT-----IQEALRHPWI-----------
-----YEMGEELGSGQFAIV---RKCRQK-------GTGK---EYAAKFIKKRRLSSSR--RG-VSREEI---EREVNILREI--R-----HPN-----IITLHDIFEN------KTDVV--LILELVSGG--ELFDFLA-----------------------EKE-----------------SL---TEDEATQFLKQILDGVHYLHS--KRIAHFDLKPENIMLL----DKNVPNP---------------RIKLIDFGIAHK---------IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GE---------------TKQETLTNISAVNYDFDEEYFSNTS---------------------------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IAQSLEHSWI-----------
-----YEIDSLIGKGSFGQV---VKAYDH-------QTQE---LVAIKIIKNKKAFLNQ--AQ-I----------ELRLLELM-NQ-----HDTEMKYYIVHLKRHFMF------RNHLC--LVFELLSY---NLYDLLR------------------------NT-----------------HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCN--PKRSAI-------------------KIVDFGSSCQ-----------LGQRIYQ---YIQSRFYRSPEVLL------GTPYDLAIDMWSLGCILVEMHT-GEPLFS-GS------------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD-LVLRMLEYEPAARIS-----PLGALQHGFF-----------
----L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVT---KVAVKMLK-SDAT-EKDLSD-LI-S-------EMEMMKMIG-K-----HKN-----IINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ------------------------ARRPPGLEYCYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS--KKCIHRDLAARNVLVT----EDNVM-------------------KIADFGLARDI---H----H--IDYYKKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GV------------PVEELFKLLKEGHRMDKPSNCT---------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAV---TVAVKMLK-DDAT-EKDLSD-LV-S-------EMEMMKMIG-K-----HKN-----IINLLGACTQ------DGPLY--VIVEYASKG--NLREYLR------------------------ARRPPGMEYSYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--QKCIHRDLAARNVLVT----ENNVM-------------------KIADFGLARDI---N----N--IDYYKKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGGSPYP-GI------------PVEELFKLLKEGHRMDKPANCT---------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----ITLERRLGTGCFGDV---WLGTWN--------GST---KVAVKTLK-PGTM-SP--KA-FL-E-------EAQVMKLL--R-----HDK-----LVQLYAVVS-------EEPIY--IVTEFMCHG--SLLDFLK------------------------NP--------------EGQDL---RLPQLVDMAAQVAEGMAYMER--MNYIHRDLRAANILVG----ERLAC-------------------KIADFGLARLI--------K--DDEYNPCQGSKFPIKWTAPEAAL------FGRFTIKSDVWSFGILLTELITKGRIPYP-GM------------NKREVLEQVEQGYHMPCPPGCP---------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL-------------
-----LQLIKRLGNGQFGEV---WMGTWN--------GNT---KVAIKTLK-PGTM-SP--ES-FL-E-------EAQIMKKL--K-----HDK-----LVQLYAVVS-------EEPIY--IVTEYMNKG--SLLDFLK------------------------DG--------------EGRAL---KLPNLVDMAAQVAAGMAYIER--MNYIHRDLRSANILVG----NGLIC-------------------KIADFGLARLI--------E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGRVPYP-GM------------NNREVLEQVERGYRMPCPQDCP---------------------------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL-------------
-----YTDIKVIGNGSFGVV---YQARLA-------ETRE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--D-----HCN-----IVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT----------------------KAKL-----------------TI---PILYVKVYMYQLFRSLAYIHS--QGVCHRDIKPQNLLVD---PDTAVL-------------------KLCDFGSAKQ---------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD------------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS-----PLEACAHSFF-----------
-----YTDTKVIGNGSFGVV---YQAKLC-------DSGE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--D-----HCN-----IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHY-------------------SRAKQ-----------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD---PDTAVL-------------------KLCDFGSAKQ---------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD------------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PLEACAHSFF-----------
-----LKLEKKLGAGQFGEV---WMATYN--------KHT---KVAVKTMK-PGSM-SV--EA-FL-A-------EANVMKTL--Q-----HDK-----LVKLHAVVT-------KEPIY--IITEFMAKG--SLLDFLK------------------------SD--------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--RNYIHRDLRAANILVS----ASLVC-------------------KIADFGLARVI--------E--DNEYTAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGRIPYP-GM------------SNPEVIRALERGYRMPRPENCP---------------------------------------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L-----------
-----LKLVERLGAGQFGEV---WMGYYN--------GHT---KVAVKSLK-QGSM-SP--DA-FL-A-------EANLMKQL--Q-----HQR-----LVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK------------------------TP--------------SGIKL---TINKLLDMAAQIAEGMAFIEE--RNYIHRDLRAANILVS----DTLSC-------------------KIADFGLARLI--------E--DNEYTAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GM------------TNPEVIQNLERGYRMVRPDNCP---------------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L-----------
-----IKLVKRLGAGQFGEV---WMGYYN--------NST---KVAVKTLK-PGTM-SV--QA-FL-E-------EANLMKTL--Q-----HDK-----LVRLYAVVTR------EEPIY--IITEYMAKG--SLLDFLK------------------------SD--------------EGGKV---LLPKLIDFSAQIAEGMAYIER--KNYIHRDLRAANVLVS----ESLMC-------------------KIADFGLARVI--------E--DNEYTAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGKIPYP-GR------------TNADVMTALSQGYRMPRVENCP---------------------------------------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L-----------
-----YQNLKPIGSGAQGIV---CAAYDA-------VLDR---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--N-----HKN-----IISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ-------------------------M-----------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK----SDCTL-------------------KILDFGLART---------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGEMVR-HKILFP-GR------------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-----VDDALQHPYI-----------
-----YQNLKPIGSGAQGIV---CAAYDA-------ILER---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--N-----HKN-----IIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ-------------------------M-----------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK----SDCTL-------------------KILDFGLART---------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDLWSVGCIMGEMVC-HKILFP-GR------------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK----------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS-----VDEALQHPYI-----------
-----YRLQKTIGKGNFAKV---KLARHV-------LTGR---EVAVKIIDKTQLNPTS--LQ-KLFR-------EVRIMKIL--N-----HPN-----IVKLFEVIET------EKTLY--LVMEYASGG--EVFDYLV-----------------------AHG-----------------RM---KEKEARAKFRQIVSAVQYCHQ--KYIVHRDLKAENLLLD----GDMNI-------------------KIADFGFSNE---------FTVGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ---------------NLKELRERVLRGKYRIPFYMS-------------------------------------------------------------TDCEN-LLKKLLVLNPIKRGS-----LEQIMKDRWM-----------
-----YRLLKTIGKGNFAKV---KLARHI-------LTGK---EVAVKIIDKTQLNSSS--LQ-KLFR-------EVRIMKVL--N-----HPN-----IVKLFEVIET------EKTLY--LVMEYASGG--EVFDYLV-----------------------AHG-----------------RM---KEKEARAKFRQIVSAVQYCHQ--KFIVHRDLKAENLLLD----ADMNI-------------------KIADFGFSNE---------FTFGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ---------------NLKELRERVLRGKYRIPFYMS-------------------------------------------------------------TDCEN-LLKKFLILNPSKRGT-----LEQIMKDRWM-----------
-----YRLLKTIGKGNFAKV---KLARHI-------LTGR---EVAIKIIDKTQLNPTS--LQ-KLFR-------EVRIMKIL--N-----HPN-----IVKLFEVIET------EKTLY--LIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV-----------------QV---SFDLLSLMFTFIVSAVQYCHQ--KRIVHRDLKAENLLLD----ADMNI-------------------KIADFGFSNE---------FTVGGKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ---------------NLKELRERVLRGKYRIPFYMS-------------------------------------------------------------TDCEN-LLKRFLVLNPIKRGT-----LEQIMKDRWI-----------
-----YRLLRTIGKGNFAKV---KLARHI-------LTGR---EVAIKIIDKTQLNPSS--LQ-KLFR-------EVRIMKGL--N-----HPN-----IVKLFEVIET------EKTLY--LVMEYASAG--EVFDYLV-----------------------SHG-----------------RM---KEKEARAKFRQIVSAVHYCHQ--KNIVHRDLKAENLLLD----AEANI-------------------KIADFGFSNE---------FTLGSKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDIWSLGVILYTLVS-GSLPFD-GH---------------NLKELRERVLRGKYRVPFYMS-------------------------------------------------------------TDCES-ILRRFLVLNPAKRCT-----LEQIMKDKWI-----------
-QLQE----DVLGEGAHARV---QTCINL-------ITSQ---EYAVKIIEKQPGHIRS--R---VFR-------EVEMLYQC-QG-----HRN-----VLELIEFFEE------EDRFY--LVFEKMRGG--SILSHIH-----------------------KRR-----------------HF---NELEASVVVQDVASALDFLHN--KGIAHRDLKPENILCE----HPNQVS----------------PVKICDFDLGSGIKLN-GDCSPISTPELLT---PCGSAEYMAPEVVEAF-SEEASIYDKRCDLWSLGVILYILLS-GYPPFV-GRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHIS---------------------------------------------------------CAAKD-LISKLLVRDAKQRLS-----AAQVLQHPWV-----------
-----YELQETLGKGTYGKV---KRATER-------FSGR---VVAIKSIRKDKIKDEQ--DM-VHIR------REIEIMSSL--N-----HPH-----IISIYEVFEN------KDKIV--IIMEYASKG--ELYDYIS-----------------------ERR-----------------RL---SERETRHFFRQIVSAVHYCHK--NGVVHRDLKLENILLD----DNCNI-------------------KIADFGLSNL---------YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMPFD-GF---------------DHKNLIRQISSGEYREPTQP--------------------------------------------------------------SDARG-LIRWMLMVNPDRRAT-----IEDIANHWW-V----------
-----YEFLETLGKGTYGKV---KKARES-------SGR----LVAIKSIRKDKIKDEQ--DL-MHIR------REIEIMSSL--N-----HPH-----IIAIHEVFEN------SSKIV--IVMEYASRG--DLYDYIS-----------------------ERQ-----------------QL---SEREARHFFRQIVSAVHYCHQ--NRVVHRDLKLENILLD----ANGNI-------------------KIADFGLSNL---------YHQGKFLQT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GTMPFD-GH---------------DHKILVKQISNGAYREPPK-----P---------------------------------------------------------SDACG-LIRWLLMVNPTRRAT-----LEDVASHWW-V----------
----F-KFGKILGEGSFSTV---VLAREL-------ATSR---EYAIKILEKRHIIKEN--KVPYVTR-------ERDVMSRL--D-----HPF-----FVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR-----------------------KIG-----------------SF---DETCTRFYTAEIVSALEYLHG--KGIIHRDLKPENILLN----EDMHI-------------------QITDFGTAKVLS------PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG---------------NEYLIFQKIIKLEYDFPEKFF-------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-----YEPKEILGRGVSSVV---RRCIHK-------PTSQ---EYAVKVIDVTGGGSFS--PE-EVRELREATLKEVDILRKV-SG-----HPN-----IIQLKDTYET------NTFFF--LVFDLMKRG--ELFDYLT-----------------------EKV-----------------TL---SEKETRKIMRALLEVICTLHK--LNIVHRDLKPENILLD----DNMNI-------------------KLTDFGFSCQ---------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFW-HR---------------KQMLMLRMIMSGNYQFGSPEWDDYS---------------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-----AEEALAHPFF-----------
--YDP---KDVIGRGVSSVV---RRCVHR-------ATGH---EFAVKIMEVTAERLSP--EQ-LEEVREA-TRRETHILRQV-AG-----HPH-----IITLIDSYES------SSFMF--LVFDLMRKG--ELFDYLT-----------------------EKV-----------------AL---SEKETRSIMRSLLEAVSFLHA--NNIVHRDLKPENILLD----DNMQI-------------------RLSDFGFSCH---------LEPGEKLRE---LCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFW-HR---------------RQILMLRMIMEGQYQFSSPEWDDRS---------------------------------------------------------STVKD-LISRLLQVDPEARLT-----AEQALQHPFF-----------
---YV--RGRFLGKGGFAKC---FEISDA-------DTKE---VFAGKIVPKSLLLKPH--QR-EKMS------MEISIHRSL--A-----HQH-----VVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK-----------------------RRK-----------------AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLFLN----EDLEV-------------------KIGDFGLATKV--------EYDGERKKT---LCGTPNYIAPEVLS------KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS---------------CLKETYLRIKKNEYSIPKHIN-------------------------------------------------------------PVAAS-LIQKMLQTDPTARPT-----INELLNDEFF-----------
----F-ERIKTLGTGSFGRV---MLVKHK-------ETGN---HYAMKILDKQKVVKLK--QI-EHTL------NEKRILQAV--N-----FPF-----LVKLEFSFKD------NSNLY--MVMEYVPGG--EMFSHLR-----------------------RIG-----------------RF---SEPHARFYAAQIVLTFEYLHS--LDLIYRDLKPENLLID----QQGYI-------------------QVTDFGFAK-----------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPPFF-AD---------------QPIQIYEKIVSGKVRFPSHFS-------------------------------------------------------------SDLKD-LLRNLLQVDLTKRFGNLKNGVNDIKNHKWF-----------
----F-ERKKTLGTGSFGRV---MLVKHK-------ATEQ---YYAMKILDKQKVVKLK--QI-EHTL------NEKRILQAV--N-----FPF-----LVRLEYAFKD------NSNLY--MVMEYVPGG--EMFSHLR-----------------------RIG-----------------RF---SEPHARFYAAQIVLTFEYLHS--LDLIYRDLKPENLLID----HQGYI-------------------QVTDFGFAK-----------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPPFF-AD---------------QPIQIYEKIVSGKVRFPSHFS-------------------------------------------------------------SDLKD-LLRNLLQVDLTKRFGNLKNGVSDIKTHKWF-----------
---PD----EVLGSGQFGVV---YGGKHR-------KTGR---DVAVKVIDKLRFPTKQ--ES-QLRN-------EVAILQSL--R-----HPG-----IVNLECMFET------PEKVF--VVMEKLHGD--MLEMILS----------------------SEKG-----------------RL---PERLTKFLITQILVALRHLHF--KNIVHCDLKPENVLLA----SADPFP----------------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFPFN-ED-----------------EDINDQIQNAAFMYPASPWSHIS---------------------------------------------------------AGAID-LINNLLQVKMRKRYS-----VDKSLSHPWL-----------
--FAD----EVLGSGQFGIV---YGGKHR-------KTGR---DVAIKVIDKMRFPTKQ--ES-QLRN-------EVAILQNL--H-----HPG-----IVNLECMFET------PERVF--VVMEKLHGD--MLEMILS----------------------SEKS-----------------RL---PERITKFMVTQILVALRNLHF--KNIVHCDLKPENVLLA----SAEPFP----------------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED-----------------EDINDQIQNAAFMYPPNPWREIS---------------------------------------------------------GEAID-LINNLLQVKMRKRYS-----VDKSLSHPWL-----------
----F-NIIDTLGVGGFGRV---ELVQLKS------EESK---TFAMKILKKRHIVDTR--QQ-EHIR------SEKQIMQGA--H-----SDF-----IVRLYRTFKD------SKYLY--MLMEACLGG--ELWTILR-----------------------DRG-----------------SF---EDSTTRFYTACVVEAFAYLHS--KGIIYRDLKPENLILD----HRGYA-------------------KLVDFGFAKK---------IGFGKKTWT---FCGTPEYVAPEIIL------NKGHDISADYWSLGILMYELLT-GSPPFS-GP---------------DPMKTYNIILRGIDMIEFPKKIA-----------------------------------------------------------KNAAN-LIKKLCRDNPSERLGNLKNGVKDIQKHKWF-----------
----L-EIIATLGVGGFGRV---ELVKVK-------NENV---AFAMKCIRKKHIVDTK--QQ-EHVY------SEKRILEEL--C-----SPF-----IVKLYRTFKD------NKYVY--MLLEACLGG--ELWSILR-----------------------DRG-----------------SF---DEPTSKFCVACVTEAFDYLHR--LGIIYRDLKPENLILD----AEGYL-------------------KLVDFGFAKK---------IGSGQKTWT---FCGTPEYVAPEVIL------NKGHDFSVDFWSLGILVYELLT-GNPPFS-GV---------------DQMMTYNLILKGIEKMDFPRKIT-----------------------------------------------------------RRPED-LIRRLCRQNPTERLGNLKNGINDIKKHRWL-----------
---FD--TLATVGTGTFGRV---HLVKEK-------TAKH---FFALKVMSIPDVIRLK--QE-QHVH------NEKSVLKEV--S-----HPF-----LIRLFWTWHD------ERFLY--MLMEYVPGG--ELFSYLR-----------------------NRG-----------------RF---SSTTGLFYSAEIICAIEYLHS--KEIVYRDLKPENILLD----RDGHI-------------------KLTDFGFAKK-----------LVDRTWT---LCGTPEYLAPEVIQ------SKGHGRAVDWWALGILIFEMLS-GFPPFF-DD---------------NPFGIYQKILAGKIDFPRHLD-------------------------------------------------------------FHVKD-LIKKLLVVDRTRRLGNMKNGANDVKHHRWF-----------
-----FELLKVLGQGSFGKVFLVRKVTRP-------DSGH---LYAMKVLKKATLKVRD--RV-RTKM-------ERDILADV--N-----HPF-----VVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF---TEEDVKFYLAELALGLDHLHS--LGIIYRDLKPENILLD----EEGHI-------------------KLTDFGLSKEA--------IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLPFQ-GK---------------DRKETMTLILKAKLGMPQFLS-------------------------------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
-----FELLKVLGQGSYGKV---FLVRKV-------KGSDAGQLYAMKVLKKATLKVRD--RV-RSKM-------ERDILAEV--N-----HPF-----IVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF---TEEDVKFYLAELALALDHLHS--LGIIYRDLKPENILLD----EEGHI-------------------KITDFGLSKEA--------IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLPFQ-GK---------------DRKETMALILKAKLGMPQFLS-------------------------------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
-----FELLKVLGQGSFGKV---FLVKKI-------SGSDARQLYAMKVLKKATLKVRD--RV-RTKM-------ERDILVEV--N-----HPF-----IVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF---TEEDVKFYLAELALALDHLHS--LGIIYRDLKPENILLD----EEGHI-------------------KLTDFGLSKES--------IDHEKKAYS---FCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GTLPFQ-GK---------------DRKETMTMILKAKLGMPQFLS-------------------------------------------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
-----FELLKVLGQGSFGKV---FLVRKK-------TGPDAGQLYAMKVLKKASLKVRD--RV-RTKM-------ERDILVEV--N-----HPF-----IVKLHYAFQT------EGKLY--LILDFLRGG--DVFTRLS-----------------------KEV-----------------LF---TEEDVKFYLAELALALDHLHQ--LGIVYRDLKPENILLD----EIGHI-------------------KLTDFGLSKES--------VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLPFQ-GK---------------DRNETMNMILKAKLGMPQFLS-------------------------------------------------------------AEAQS-LLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
-----YDIERTLGKGNFAVV---KLARHR-------VTKT---QVAIKIIDKTRLDSSN--LE-KIYR-------EVQLMKLL--N-----HPH-----IIKLYQVMET------KDMLY--IVTEFAKNG--EMFDYLT-----------------------SNG-----------------HL---SENEARKKFWQILSAVEYCHD--HHIVHRDLKTENLLLD----GNMDI-------------------KLADFGFGNF---------YKSGEPLST---WCGSPPYAAPEVFE-----GKEYEGPQLDIWSLGVVLYVLVC-GSLPFD-GP---------------NLPTLRQRVLEGRFRIPFFMS-------------------------------------------------------------QDCES-LIRRMLVVDPARRIT-----IAQIRQHRWM-----------
-----YDIEGTLGKGNFAVV---KLGRHR-------ITKT---EVAIKIIDKSQLDAVN--LE-KIYR-------EVQIMKML--D-----HPH-----IIKLYQVMET------KSMLY--LVTEYAKNG--EIFDYLA-----------------------NHG-----------------RL---NESEARRKFWQILSAVDYCHG--RKIVHRDLKAENLLLD----NNMNI-------------------KIADFGFGNF---------FKSGELLAT---WCGSPPYAAPEVFE-----GQQYEGPQLDIWSMGVVLYVLVC-GALPFD-GP---------------TLPILRQRVLEGRFRIPYFMS-------------------------------------------------------------EDCEH-LIRRMLVLDPSKRLT-----IAQIKEHKWM-----------
-----WEIIGELGDGAFGKV---YKAQNK-------ETSV---LAAAKVIDTKSEEELE--DY-M--V-------EIDILASC--D-----HPN-----IVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML----------------------ELER-----------------PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT----LDGDI-------------------KLADFGVSAKN--------TRTIQRRDS---FIGTPYWMAPEVVMCE-TSKDRPYDYKADVWSLGITLIEMAE-IEPPHH-EL------------NPMRVLLKIAKSEPPTLAQPSRWS-------------------------------------------------------------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV-----------
----L-RLEVKLGQGCFGEV---WMGTWN--------GTT---RVAIKTLK-PGTM-SP--EA-FL-Q-------EAQVMKKL--R-----HEK-----LVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK------------------------GE--------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG----ENLVC-------------------KVADFGLARLI--------E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGRVPYP-GM------------VNREVLDQVERGYRMPCPPECP---------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L-----------
-----WEIVGELGDGAFGKV---YKAKNK-------ETGA---LAAAKVIETKSEEELE--DY-I--V-------EIEILATC--D-----HPY-----IVKLLGAYYH------DGKLW--IMIEFCPGG--AVDAIML----------------------ELDR-----------------GL---TEPQIQVVCRQMLEALNFLHS--KRIIHRDLKAGNVLMT----LEGDI-------------------RLADFGVSAKN--------LKTLQKRDS---FIGTPYWMAPEVVMCE-TMKDTPYDYKADIWSLGITLIEMAQ-IEPPHH-EL------------NPMRVLLKIAKSDPPTLLTPSKWS-------------------------------------------------------------VEFRD-FLKIALDKNPETRPS-----AAQLLEHPFV-----------
--LCP---GRELGRGKFAVV---RKCIKK-------DSGK---EFAAKFMRKRRKGQDC--RM-EIIH-------EIAVLELA-QD-----NPW-----VINLHEVYET------ASEMI--LVLEYAAGG--EIFDQCVA---------------------DREE-----------------AF---KEKDVQRLMRQILEGVHFLHT--RDVVHLDLKPQNILLT----SESPLG----------------DIKIVDFGLSRI---------LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GISPFL-GN---------------DKQETFLNISQMNLSYSEEEFDVLS---------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-----AEECLKHPWL-----------
--ILT---SKELGRGKFAVV---RQCISK-------STGQ---EYAAKFLKKRRRGQDC--RA-EILH-------EIAVLELA-KS-----CPR-----VINLHEVYEN------TSEII--LILEYAAGG--EIFSLCLP---------------------ELAE-----------------MV---SENDVIRLIKQILEGVYYLHQ--NNIVHLDLKPQNILLS----SIYPLG----------------DIKIVDFGMSRK---------IGHACELRE---IMGTPEYLAPEILN------YDPITTATDMWNIGIIAYMLLT-HTSPFV-GE---------------DNQETYLNISQVNVDYSEETFSSVS---------------------------------------------------------QLATD-FIQSLLVKNPEKRPT-----AEICLSHSWL-----------
YLLGI-----NLGEGSYAKV---KSAYSE-------RLKF---NVAIKIIDRKKAPADF--LE-KFLP------REIEILAML--N-----HCS-----IIKTYEIFET-----SHGKVY--IVMELAVQG--DLLELIK-----------------------TRG-----------------AL---HEDEARKKFHQLSLAIKYCHD--LDVVHRDLKCDNLLLD----KDFNI-------------------KLSDFSFSKRCLR----DDSGRMALSKT---FCGSPAYAAPEVLQ-----GIPYQPKVYDIWSLGVILYIMVC-GSMPYD-DS---------------NIKKMLRIQKEHRVNFPRSKHLT-----------------------------------------------------------GECKD-LIYHMLQPDVNRRLH-----IDEILSHCWM-----------
----L-RLEVKLGQGCFGEV---WMGTWN--------GTT---KVAIKTLK-PGTM-MP--EA-FL-Q-------EAQIMKKL--R-----HDK-----LVPLYAVVS-------EEPIY--IVTEFMSKG--SLLDFLK------------------------EG--------------DGKYL---KLPQLVDMAAQIADGMAYIER--MNYIHRDLRAANILVG----ENLVC-------------------KIADFGLARLI--------E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGRVPYP-GM------------VNREVLEQVERGYRMPCPQGCP---------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL-------------
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