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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
CAMK CHEK2 220
TK EPHB2 621
CMGC MAPK10 64
CMGC MAPK8 26
--YQNLSPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRPFQSIIH--AKRTYR------ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-CQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
YI--MSKTLGSGACGEVKLAFER---KTCKKVAIKIISKRKFAIGS--AREADPALNVETEIEILKKLNHPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL
-V-KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLK-SGYT-EKQRRDFL-S------EASIMGQFDHPNVIHLEGVVTK------STPVMIITEFMENGSLDSFLR-QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVC---KVSDFGLSRFLEDDTS--DPTYTSALGGKIPIRWTAPEAIQ---YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCP-----------------------------------------SALHQLMLDCWQKDRNHRPKFGQIVNTL--
--YQNLKPIGSGAQGIVCAAYDA---VLDRNVAIKKLSRPFQNQTH--AKRAYR------ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
--YQNLKPIGSGAQGIVCAAYDA---ILERNVAIKKLSRPFQNQTH--AKRAYR------ELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ--M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
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