|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK15 203
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDK11A 438
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
Other CHUK 15
CMGC CSNK2A1 39
CAMK DCLK3 356
CMGC DYRK2 222
Other ERN1 571
CMGC HIPK4 -1
CMGC MAPK6 20
CMGC MAPK7 55
CMGC MAPK8 26
CMGC PCTK1 165
Other PLK1 53
AGC PRKCD 349
AGC PRKCQ 380
CAMK PRKD1 583
AGC ROCK1 76
AGC ROCK2 92
Other STK36 4
TK ZAP70 338
--YL--LRRQLGQGAYGIV-WKAVDR--RTGE-VVAIKKIFDAFRDK---TD--AQRTFR---EITLLQEFGD------HPNIISLLDVIRAE------------NDRDIYLVFEFMDT-DLNAVIR---KGG--LL---QDV--HVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLD-ANCTV-----KLCDFGLARSLGD--LPEGPEDQAVTE---YVATRWYRAPEVLL---SSHRYTLGVDMWSLGCILGEMLR-GRPLFP-GT-----------STLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRP----------------------------------------------RQTLDALLPPDTSPEALDLLRRLLVFAPDK--RLS-AT-QALQHPYV---------
----YTKIEKIGEGTYGVV-YKGRHK--TTGQ-VVAMKKIRLESEEE---GV--PSTAIR---EISLLKEL-R------HPNIVSLQDVLMQ--------------DSRLYLIFEFLSM-DLKKYLDSIPPGQ--YM---DSS--LVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-----KLADFGLARAF-------GIPIRVYTH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-GK-MALNHPYF---------
---F-DIIGIIGEGTYGQV-YKARDK--DTGE-MVALKKVRLDNEKE---GF--PITAIR---EIKILRQL-T------HQSIINMKEIVTDKEDAL----DFKKDKGAFYLVFEYMDH-DLMGLLE--SGLV--HF---NEN--HIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLN-NRGQI-----KLADFGLARLY------SSEESRPYTN---KVITLWYRPPELLL---GEERYTPAIDVWSCGCILGELFT-KKPIFQ-AN-----------QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY------------------------------------------------RRKLREEFVFIPAAALDLFDYMLALDPSK--RCT-AE-QALQCEF-L--------
----FQCLNRIEEGTYGVV-YRAKDK--KTDE-IVALKRLKMEKEKE---GF--PITSLR---EINTILKA-Q------HPNIVTVREIVVGS------------NMDKIYIVMNYVEH-DLKSLME--TMKQ--PF---LPG--EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLS-HAGIL-----KVGDFGLAREY-------GSPLKAYTP---VVVTLWYRAPELLL---GAKEYSTAVDMWSVGCIFGELLT-QKPLFP-GK-----------SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPY-----------------------------------------------NNLRKRFGALLSDQGFDLMNKFLTYFPGR--RIS-AE-DGLKHEYF---------
----FQKVEKIGEGTYGVV-YKARNK--LTGE-VVALKKIRLDTETE---GV--PSTAIR---EISLLKEL-N------HPNIVKLLDVIHT--------------ENKLYLVFEFLHQ-DLKKFMDA-SALT--GI---PLP--LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-----KLADFGLARAF-------GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-AK-AALAHPFF---------
---Y-EPVAEIGVGAYGTV-YKARDP--HSGH-FVALKSVRVPNGGGGGGGL--PISTVR---EVALLRRL-EA---FEHPNVVRLMDVCATSR---------TDREIKVTLVFEHVDQ-DLRTYLDK-APPP--GL---PAE--TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV-----KLADFGLARI--------YSYQMALTP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RKPLFC-GN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-AF-RALQHSYL---------
----YECVAEIGEGAYGKV-FKARDL--KNGGRFVALKRVRVQTGEE---GM--PLSTIR---EVAVLRHL-ET---FEHPNVVRLFDVCTVSR---------TDRETKLTLVFEHVDQ-DLTTYLDK-VPEP--GV---PTE--TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI-----KLADFGLARI--------YSFQMALTS---VVVTLWYRAPEVLL----QSSYATPVDLWSVGCIFAEMFR-RKPLFR-GS-----------SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAK--RIS-AY-SALSHPYF---------
----YEKLDFLGEGQFATV-YKARDK--NTNQ-IVAIKKIKLGHRSE---AK--DGINRTALREIKLLQEL-S------HPNIIGLLDAFGH--------------KSNISLVFDFMET-DLEVIIK--DNSL--VL---TPS--HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD-ENGVL-----KLADFGLAKSF-------GSPNRAYTH---QVVTRWYRAPELLF---GARMYGVGVDMWAVGCILAELLL-RVPFLP-GD-----------SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG--------------------------------------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCA--RIT-AT-QALKMKYF---------
----YEKLAKIGQGTFGEV-FKARHR--KTGQ-KVALKKVLMENEKE---GF--PITALR---EIKILQLL-K------HENVVNLIEICRTKASP------YNRCKGSIYLVFDFCEH-DLAGLLS--NVLV--KF---TLS--EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-----KLADFGLARAFSL---AKNSQPNRYTN---RVVTLWYRPPELLL---GERDYGPPIDLWGAGCIMAEMWT-RSPIMQ-GN-----------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------------------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RID-SD-DALNHDFF---------
---W-DLVQTLGEGAYGEV-QLAVNR--VTEE-AVAVKIVDMKRAVD---CP--ENI-KK---EICINKML-N------HENVVKFYGHRRE--------------GNIQYLFLEYCSGGELFDRIE---PDI--GM---PEP--DAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL-----KISDFGLATVFR-----YNNRERLLNK---MCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSA--RIT-IP-DIKKDRW-Y--------
---W-EMRERLGTGGFGNV-CLYQHR--ELDL-KIAIKSCRLELSTK---NR--ER-WCH---EIQIMKKL-N------HANVVKACDVPEELN---------ILIHDVPLLAMEYCSGGDLRKLLNKPENCC--GL---KES--QILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKI--IHKIIDLGYAKD--------VDQGSLCTS---FVGTLQYLAPELFE----NKPYTATVDYWSFGTMVFECIA-GYRPFL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------------------------------------------LVVEPMENWLQLMLNWDPQQ--RG-------------GPVDLTLKQ
----YQLVRKLGRGKYSEV-FEAINI--TNNE-KVVVKILKPVKKKK---IK--R--------EIKILENLRG------GPNIITLADIVKDP------------VSRTPALVFEHVNNTDFKQLY------Q--TL---TDY--DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL-----RLIDWGLAEF--------YHPGQEYNV---RVASRYFKGPELLV---DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-AR-EAMEHPYF---------
----YETGRVIGDGNFAVV-KECRHR--ETRQ-AYAMKIIDKSRLKG---KE--DMV-DS---EILIIQSL-S------HPNIVKLHEVYET--------------DMEIYLILEYVQGGDLFDAII---ESV--KF---PEP--DAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQ-RNEDKST-TLKLADFGLAK----------HVVRPIFT---VCGTPTYVAPEILS----EKGYGLEVDMWAAGVILYILLC-GFPPFR-SP------------ERDQDELFNIIQLGHFEFLPPYWDNIS-----------------------------------------------------------------------DAAKDLVSRLLVVDPKK--RYT-AH-QVLQHPWI---------
----YEVLKVIGKGSFGQV-VKAYDH--KVHQ-HVALKMVRNEKRFH---RQ--AAE------EIRILEHL-RKQDKDNTMNVIHMLENFTF--------------RNHICMTFELLSM-NLYELIKK-NKFQ--GF---SLP--LVRKFAHSILQCLDALHKNRIIHCDLKPENILLK-QQGRSG---IKVIDFGSSC----------YEHQRVYT---YIQSRFYRAPEVIL----GARYGMPIDMWSLGCILAELLT-GYPLLP-GE-----------DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAV--RMT-PG-QALRHPWL---------
-FCP---KDVLGHGAEGTIVYRGMFD--NRD---VAVKRILPECFSF---AD--R--------EVQLLRESDE------HPNVIRYFCTEKD--------------RQFQYIAIELCAA-TLQEYVE----QK--DF---AHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILIS-MPNAHGKIKAMISDFGLCKKLA----VGRHSFSRRSG---VPGTEGWIAPEMLSE-DCKENPTYTVDIFSAGCVFYYVISEGSHPFG-KS------------LQRQANILLGACSLDCLHPEKHE---D-----------------------------------------------------------------------VIARELIEKMIAMDPQK--RPS-AK-HVLKHPFF---------
----YDIIEVLGKGTFGEV-AKGWRR--STGE-MVAIKILKNDAYRN---RI--IKN------ELKLLHCM-RGL-DPEEAHVIRFLEFFHD--------------ALKFYLVFELLEQ-NLFEFQK----EN--NFAPLPAR--HIRTVTLQVLTALARLKELAIIHADLKPENIMLV-DQTRCPF-RVKVIDFGSASIF-------SEVRYVKEP---YIQSRFYRAPEILL----GLPFCEKVDVWSLGCVMAELHL-GWPLYP-GN-----------NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHE--RIS-PS-AALRHPFV---------
--YM--DLKPLGCGGNGLV-FSAVDN--DCDK-RVAIKKIVLTDPQS---VK--H--ALR---EIKIIRRL-D------HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVLE----QG--PL---LEE--HARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVL-----KIGDFGLARIMD----PHYSHKGHLSE---GLVTKWYRSPRLLL---SPNNYTKAIDMWAAGCIFAEMLT-GKTLFA-GA-----------HELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEP------------------------------------------------HKPLTQLLPGISREALDFLEQILTFSPMD--RLT-AE-EALSHPYM---------
----YEIIETIGNGAYGVV-SSARRR--LTGQ-QVAIKKIPNAFDVV---TN--AKRTLR---ELKILKHF-K------HDNIIAIKDILRPTVP--------YGEFKSVYVVLDLMES-DLHQIIH---SSQ--PL---TLE--HVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCEL-----KIGDFGMARGLCT---SPAEHQYFMTE---YVATRWYRAPELML---SLHEYTQAIDLWSVGCIFGEMLA-RRQLFP-GK-----------NYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQ-----------------------------------------------PVPWETVYPGADRQALSLLGRMLRFEPSA--RIS-AA-AALRHPFL---------
----YQNLKPIGSGAQGIV-CAAYDA--ILER-NVAIKKLSRPFQNQ---TH--AKRAYR---ELVLMKCV-N------HKNIIGLLNVFTPQKS--------LEEFQDVYIVMELMDA-NLCQVIQ-----M--EL---DHE--RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-----KILDFGLART--------AGTSFMMTP---YVVTRYYRAPEVIL----GMGYKENVDLWSVGCIMGEMVC-HKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASK--RIS-VD-EALQHPYI---------
---Y-IKLDKLGEGTYATV-YKGKSK--LTDN-LVALKEIRLEHEEG---AP--C-TAIR---EVSLLKDL-K------HANIVTLHDIIHT--------------EKSLTLVFEYLDK-DLKQYLD--DCGN--II---NMH--NVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLIN-ERGEL-----KLADFGLARAK-------SIPTKTYSN---EVVTLWYRPPDILL---GSTDYSTQIDMWGVGCIFYEMAT-GRPLFP-GS-----------TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRN--RIS-AE-DAMKHPFF---------
--YV--RGRFLGKGGFAKC-FEISDA--DTKE-VFAGKIVPKSLLLK---PH--QREKMS--MEISIHRSL-A------HQHVVGFHGFFED--------------NDFVFVVLELCRRRSLLELHK---RRK--AL---TEP--EARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV-----KIGDFGLATKV-------EYDGERKKT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS--------------CLKETYLRIKKNEYSIPKHIN---------------------------------------------------------------------------PVAASLIQKMLQTDPTA--RPT-IN-ELLNDEFF---------
--FI--FHKVLGKGSFGKV-LLGELK--GRGE-YFAIKALKKDVVLI---DD--DVECTM--VEKRVLTLAAE------NPFLTHLICTFQT--------------KDHLFFVMEFLNGGDLMYHIQ---DKG--RF---ELY--RATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI-----KIADFGMCKEN-------IFGESRAST---FCGTPDYIAPEILQ----GLKYTFSVDWWSFGVLLYEMLI-GQSPFH-GD--------------DEDELFESIRVDTPHYPRWIT---------------------------------------------------------------------------KESKDILEKLFEREPTK--RLGVTG-NIKIHPFF---------
--FI--LHKMLGKGSFGKV-FLAEFK--KTNQ-FFAIKALKKDVVLM---DD--DVECTM--VEKRVLSLAWE------HPFLTHMFCTFQT--------------KENLFFVMEYLNGGDLMYHIQ---SCH--KF---DLS--RATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHI-----KIADFGMCKEN-------MLGDAKTNT---FCGTPDYIAPEILL----GQKYNHSVDWWSFGVLLYEMLI-GQSPFH-GQ--------------DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEK--RLG-VRGDIRQHPLF---------
--PD----EVLGSGQFGIV-YGGKHR--KTGR-DVAIKIIDKLRFPT---KQ--ESQLRN---EVAILQNL-H------HPGVVNLECMFET--------------PERVFVVMEKLHGDMLEMILS--SEKG--RL---PEH--ITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP--QVKLCDFGFARI--------IGEKSFRRS---VVGTPAYLAPEVLR----NKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED----------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------------HEAIDLINNLLQVKMRK--RYS-VD-KTLSHPWL---------
----YEVVKVIGRGAFGEV-QLVRHK--STRK-VYAMKLLSKFEMIK---RS--DSAFFW--EERDIMAFA-N------SPWVVQLFYAFQD--------------DRYLYMVMEYMPGGDLVNLMS----NY--DV---PEK--WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLD-KSGHL-----KLADFGTCMKM------NKEGMVRCDT---AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLV-GDTPFY-AD--------------SLVGTYSKIMNHKNSLTFPDDNDIS-----------------------------------------------------------------------KEAKNLICAFLTDREVRLGRNG-VE-EIKRHLFF---------
----YDVVKVIGRGAFGEV-QLVRHK--ASQK-VYAMKLLSKFEMIK---RS--DSAFFW--EERDIMAFA-N------SPWVVQLFYAFQD--------------DRYLYMVMEYMPGGDLVNLMS----NY--DV---PEK--WAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHL-----KLADFGTCMKM------DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTPFY-AD--------------SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------------------------------------------KHAKNLICAFLTDREVRLGRNG-VE-EIRQHPFF---------
----YHVLEMIGEGSFGRV-YKGRRK--YSAQ-VVALKFIPKLGRSE---KE--LRNLQR---EIEIMRGL-R------HPNIVHMLDSFET--------------DKEVVVVTDYAEG-ELFQILE---DDG--KL---PED--QVQAIAAQLVSALYYLHSHRILHRDMKPQNILLA-KGGGI-----KLCDFGFARAM-------STNTMVLTS---IKGTPLYMSPELVE----ERPYDHTADLWSVGCILYELAV-GTPPFY-AT--------------SIFQLVSLILKDPVRWPSTIS---------------------------------------------------------------------------PCFKNFLQGLLTKDPRQ--RLS-WP-DLLYHPFI---------
LIAD----IELGCGNFGSV-RQGVYRMRKKQI-DVAIKVLK-QGTE----KADTEEMM-R---EAQIMHQL-D------NPYIVRLIGVCQ---------------AEALMLVMEMAGGGPLHKFLV----GKREEI---PVS--NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-NRHYA-----KISDFGLSKAL--GA---D--DSYYTARSAGKWPLKWYAPECIN----FRKFSSRSDVWSYGVTMWEALSYGQKPYK-KM-----------KGPEVMAFIEQGKRMECPPECP-----------------------------------------------------------------------------PELYALMSDCWIYKWED--RPD-FL-TVEQR--M---------
|