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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK8 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK CAMK1G 23
Other CAMKK2 165
CMGC CDK2 4
CAMK CHEK2 220
CMGC CLK2 163
CMGC CLK3 156
CAMK DAPK2 23
CMGC DYRK2 222
CMGC MAPK10 64
CMGC MAPK12 27
CMGC MAPK9 26
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC RPS6KA2 59
CAMK STK33 116
---YQNLKPIGSGAQGIVCAAYDAILER---NVAIKKLSRPF-QNQTHAKRAYR-------------------------ELVLMKCVN------HKN---IIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ----MEL---DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---SDCTL--------------------KILDFGLART--AGTSFMMTPYVVTRYYRAPEVIL---GMG--YKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK-----------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI
---FEIGRPLGKGKFGNVYLAREKQSKF---ILALKVLFKAQLEKAGVEHQLRR-------------------------EVEIQSHLR------HPN---ILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ--KLSKF---DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG---SAGEL--------------------KIADFGWSV---HAPSSRRTTLCGTLDYLPPEMIE---GRM--HDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI
---FEIGRPLGKGKFGNVYLAREKKSHF---IVALKVLFKSQ-IEKEGVEHQLR------------------------REIEIQAHLH------HPN---ILRLYNYFYD------RRRIYLILEYAPRGELYKELQ--KSCTF---DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG---LKGEL--------------------KIADFGWSV---HAPSLRRKTMCGTLDYLPPEMIE---GRM--HNEKVDLWCIGVLCYELLVGNPPFESA---SHNETYRRIVKVDLKFPASVP--------------------------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV
---FEIGRPLGKGKFGNVYLARLKESHF---IVALKVLFKSQ-IEKEGLEHQLR------------------------REIEIQAHLQ------HPN---ILRLYNYFHD------ARRVYLILEYAPRGELYKELQ--KSEKL---DEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG---FRGEV--------------------KIADFGWSV---HTPSLRRKTMCGTLDYLPPEMIE---GRT--YDEKVDLWCIGVLCYELLVGYPPFESA---SHSETYRRILKVDVRFPLSMP--------------------------------------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV
-FI--FMEVLGSGAFSEVFLVKQRLTGK---LFALKCIKKSP-AFRDSSLE--N-------------------------EIAVLKKIK------HEN---IVTLEDIYES------TTHYYLVMQLVSGGELFDRIL--ERGVY---TEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKI--------------------MITDFGLSK---MEQNGIMSTACGTPGYVAPEVLA---QKP--YSKAVDCWSIGVITYILLCGYPPFYEE---TESKLFEKIKEGYYEFESPFWDDIS----------------------------------------------------ESAKDFICHLLEKDPNERYT-----CEKALSHPWI
---YTLKDEIGKGSYGVVKLAYNENDNT---YYAMKVLSKKK-LIRQAGFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLD------HPN---VVKLVEVLDDP----NEDHLYMVFELVNQGPVMEVPT---LKPL---SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHI--------------------KIADFGVSNEF-KGSDALLSNTVGTPAFMAPESLS--ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE---RIMCLHSKIKSQALEFPDQPDIA------------------------------------------------------EDLKDLITRMLDKNPESRIV-----VPEIKLHPWV
---FQKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDT-ETEGVPSTAIR-------------------------EISLLKELN------HPN---IVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDASALTGI---PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN---TEGAI--------------------KLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILL--GCKY--YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
-YI--MSKTLGSGACGEVKLAFERKTCK---KVAIKIISKRK-FAIGSAREADPALN-------------------VETEIEILKKLN------HPC---IIKIKNFF-D------AEDYYIVLELMEGGELFDKVV--GNKRL---KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS---SQEEDC-----------------LIKITDFGHSKI--LGETSLMRTLCGTPTYLAPEVLVSVGTAG--YNRAVDCWSLGVILFICLSGYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS----------------------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL
---YEIVSTLGEGTFGRVVQCVDHRRGG--ARVALKIIKNVE-KYKEAAR---L-------------------------EINVLEKINEK-DPDNKN--LCVQMFDWFDY------HGHMCISFELLGL-STFDFLK--DNNYLP-YPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV---NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT----FDHEHHSTIVSTRHYRAPEVIL---ELG--WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY---------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-----LGEALQHPFF
---YEIVGNLGEGTFGKVVECLDHARGK--SQVALKIIRNVG-KYREAAR---L-------------------------EINVLKKIKE---KDKENKFLCVLMSDWFNF------HGHMCIAFELLGK-NTFEFLK---ENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFV---NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT----FDHEHHTTIVATRHYRPPEVIL---ELG--WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY---------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRIT-----LAEALLHPFF
---YDIGEELGSGQFAIVKKCREKSTGL---EYAAKFIKKRQ-SRASRRGVSREEI---------------------EREVSILRQVL------HHN---VITLHDVYEN------RTDVVLILELVSGGELFDFLA--QKESL---SEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL---DKNIPIP----------------HIKLIDFGLAHE--IEDGVEFKNIFGTPEFVAPEIVN---YEP--LGLEADMWSIGVITYILLSGASPFLGD---TKQETLANITAVSYDFDEEFFSQTS----------------------------------------------------ELAKDFIRKLLVKETRKRLT-----IQEALRHPWI
---YEVLKVIGKGSFGQVVKAYDHKVHQ---HVALKMVRNEK-RFHRQAAE----------------------------EIRILEHLRKQDKDNTMN---VIHMLENFTF------RNHICMTFELLSM-NLYELIKKNKFQGF---SLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLK---QQGRSG------------------IKVIDFGSSC----YEHQRVYTYIQSRFYRAPEVIL---GAR--YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-----PGQALRHPWL
---YQNLKPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPF-QNQTHAKRAYR-------------------------ELVLMKCVN------HKN---IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ----MEL---DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---SDCTL--------------------KILDFGLART--AGTSFMMTPYVVTRYYRAPEVIL---GMG--YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK-----------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI
---YRDLQPVGSGAYGAVCSAVDGRTGA---KVAIKKLYRPF-QSELFAKRAYR-------------------------ELRLLKHMR------HEN---VIGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMK---HEKL---GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN---EDCEL--------------------KILDFGLAR----QADSEMTGYVVTRWYRAPEVIL--NWMR--YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE----------------------------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF
---YQQLKPIGSGAQGIVCAAFDTVLGI---NVAVKKLSRPF-QNQTHAKRAYR-------------------------ELVLLKCVN------HKN---IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH----MEL---DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---SDCTL--------------------KILDFGLART--ACTNFMMTPYVVTRYYRAPEVIL---GMG--YKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE-----------------LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI
-PD----EVLGSGQFGIVYGGKHRKTGR---DVAIKIIDKLR-FPTKQESQLRN-------------------------EVAILQNLH------HPG---VVNLECMFET------PERVFVVMEKLHGDMLEMILS-SEKGRL---PEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA---SADPFP-----------------QVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLR---NKG--YNRSLDMWSVGVIIYVSLSGTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS----------------------------------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL
-PD----EVLGSGQFGVVYGGKHRKTGR---DVAVKVIDKLR-FPTKQESQLRN-------------------------EVAILQSLR------HPG---IVNLECMFET------PEKVFVVMEKLHGDMLEMILS-SEKGRL---PERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLA---SADPFP-----------------QVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLL---NQG--YNRSLDMWSVGVIMYVSLSGTFPFNED-----EDINDQIQNAAFMYPASPWSHIS----------------------------------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL
FAD----EVLGSGQFGIVYGGKHRKTGR---DVAIKVIDKMR-FPTKQESQLRN-------------------------EVAILQNLH------HPG---IVNLECMFET------PERVFVVMEKLHGDMLEMILS-SEKSRL---PERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA---SAEPFP-----------------QVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLR---SKG--YNRSLDMWSVGVIIYVSLSGTFPFNED-----EDINDQIQNAAFMYPPNPWREIS----------------------------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL
---FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKAT-LKVRDRVRSKM-------------------------ERDILAEVN------HPF---IVKLHYAFQT------EGKLYLILDFLRGGDLFTRLS--KEVMF---TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD---EEGHI--------------------KITDFGLSKEA-IDHDKRAYSFCGTIEYMAPEVVN---RRG--HTQSADWWSFGVLMFEMLTGSLPFQGK---DRKETMALILKAKLGMPQFLS--------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
---YTFGRILGKGSFGIVIEATDKETET---KWAIKKVNKEK-AGSSAVKLLER-------------------------EVNILKSVK------HEH---IIHLEQVFET------PKKMYLVMELCEDGELKEILD--RKGHF---SENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVK---SSLIDDNNE-----------INLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVIS---AHD--YSQQCDIWSIGVVMYMLLRGEPPFLAS---SEEKLFELIRKGELHFENAVWNSIS----------------------------------------------------DCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL
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