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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK9 203
Other AURKA 133
CMGC CDK2 4
CMGC MAPK10 64
CMGC MAPK8 26
YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPF-QNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-ACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ--KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELNHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPF-QNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
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