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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK2 203
Other AURKA 133
CMGC CDK6 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC GSK3A 119
CMGC GSK3B 56
CMGC MAPK8 26
CAMK MAPKAPK3 44
CAMK MAPKAPK5 22
Other NEK2 8
CAMK PIM1 38
Other PLK1 53
AGC PRKCA 339
AGC PRKCZ 252
CAMK PRKD1 583
CAMK STK11 49
KVT---SQVLGLGINGKVLQIFNKRTQE-KFALKMLQDCP-KAR-------R------EVELHWRASQ---CPH--IVRIVDVYENLY------AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG------------------PEKYDKSCDMWSLGVIMYILLCGYPPFY-SN---HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI--------------
---FEIGRPLGKGKFGNVYLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRR------EVEIQSHL-R---HPN--ILRLYGYFHD----------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE------------------GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN-------TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI--------------
---YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIR------EVAVLRHL-ETFEHPN--VVRLFDVCTVSR-----TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSH-----RVVHRDLKPQNILVT-SSGQI----KLADFGLARI---YSFQMALTSVVVTLWYRAPEVLL------------------QSSYATPVDLWSVGCIFAEMFRRKPLFR-GS----SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AYSALSHPYF--------------
--W-DLVQTLGEGAYGEVQLAVNRVTEE-AVAVKIVDMKR-AVDCPENI-KK------EICINKML-N---HEN--VVKFYGHRRE----------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD-ERDNL----KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK-----------------RREFHAEPVDVWSCGIVLTAMLAGELPWD-QP------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT------IPDIKKDRW-Y-------------
-YI--MSKTLGSGACGEVKLAFERKTCK-KVAIKIISKRK-FAIGSAREADPALNVETEIEILKKL-N---HPC--IIKIKNFF-D----------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVS---------------VGTAGYNRAVDCWSLGVILFICLSGYPPFS-EH------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL--------------
---YQLVRKLGRGKYSEVFEAINITNNE-KVVVKILKPVK-KKKIKR-----------EIKILENLRG---GPN--IITLADIVKDP--------VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV-----------------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH----DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AREAMEHPYF--------------
---YTDIKVIGNGSFGVVYQARLAETRE-LVAIKKVLQDK-RFKNR------------ELQIMRKL-D---HCN--IVRLRYFFYSSG------EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQ-----GVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF-----------------GATDYTSSIDVWSAGCVLAELLLGQPIFP-GD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PLEACAHSFF--------------
---YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDK-RFKNR------------ELQIMRKL-D---HCN--IVRLRYFFYSSG------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF-----------------GATDYTSSIDVWSAGCVLAELLLGQPIFP-GD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF--------------
---YQNLKPIGSGAQGIVCAAYDAILER-NVAIKKLSRPF-QNQTHAKRAYR------ELVLMKCV-N---HKN--IIGLLNVFTPQKS----LEEFQDVY--IVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL----KILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL------------------GMGYKENVDLWSVGCIMGEMVCHKILFP-GR----DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS------VDEALQHPYI--------------
QLS---KQVLGLGVNGKVLECFHRRTGQ-KCALKLLYDSP-KARQ-------------EVDHHWQASG---GPH--IVCILDVYENMH------HGKRCLL--IIMECMEGG--ELFSRIQE--RGDQAFTEREAAEIMRDIGTAIQFLHSH-----NIAHRDVKPENLLYT-SKEKDA-VLKLTDFGFAK----ETTQNALQTPCYTPYYVAPEVLG------------------PEKYDKSCDMWSLGVIMYILLCGFPPFY-SN---TGQAISPGMKRRIRLGQYGFPNPEWSEVS-----------------------------------EDAKQLIRLLLKTDPTERLT------ITQFMNHPWI--------------
INW---TQKLGAGISGPVRVCVKKSTQE-RFALKILLDRP-KAR-------N------EVRLHMMCAT---HPN--IVQIIEVFANSVQFPHESSPRARLL--IVMEMMEGG--ELFHRIS----QHRHFTEKQASQVTKQIALALRHCHLL-----NIAHRDLKPENLLFK-DNS-LDAPVKLCDFGFAK-----IDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY-SKH--HSRTIPKDMRRKIMTGSFEFPEEEWSQIS-----------------------------------EMAKDVVRKLLKVKPEERLT------IEGVLDHPWL--------------
---YEVLYTIGTGSYGRCQKIRRKSDGK-ILVWKELDYGS-MTEAEKQMLVS------EVNLLREL-K---HPN--IVRYYDRIIDR--------TNTTLY--IVMEYCEGG--DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN------------------RMSYNEKSDIWSLGCLLYELCALMPPFT-AF-------SQKELAGKIREGKFRRIPYRY---S-----------------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I-------------
---YQVGPLLGSGGFGSVYSGIRVSDNL-PVAIKHVEKDR-ISDWGELPNGTRV--PMEVVLLKKV-S---SGFSGVIRLLDWFER----------PDSFV--LILERPEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR-----------------YHRYHGRSAAVWSLGILLYDMVCGDIPFE-HD-------------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM--------------
-YV--RGRFLGKGGFAKCFEISDADTKE-VFAGKIVPKSL-LLKPHQREKMS-----MEISIHRSL-A---HQH--VVGFHGFFED----------NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS------------------KKGHSFEVDVWSIGCIMYTLLVGKPPFE-TS-------CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLADRKGTEE-LYAIKILKKDV-VIQDDDVECTM-----VEKRVLALLDK---PPF--LTQLHSCFQT----------VDRLY--FVMEYVNGG--DLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHKR-----GIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEH--MMDGVTTRTFCGTPDYIAPEIIA------------------YQPYGKSVDWWAYGVLLYEMLAGQPPFD-GE-------DEDELFQSIMEHNVSYPKSLS---------------------------------------KEAVSVCKGLMTKHPAKRLG------C---------GPEGERDVREHAFF
--F-DLIRVIGRGSYAKVLLVRLKKNDQ-IYAMKVVKKEL-VHDDEDIDWVQ-----TEKHVFEQASS---NPF--LVGLHSCFQT----------TSRLF--LVIEYVNGG--DLMFHMQ----RQRKLPEEHARFYAAEICIALNFLHER-----GIIYRDLKLDNVLLD-ADGHI----KLTDYGMCKEG--LGPGDTTSTFCGTPNYIAPEILR------------------GEEYGFSVDWWALGVLMFEMMAGRSPFD-IITDNPDMNTEDYLFQVILEKPIRIPRFLS---------------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF---------SDIKSHAFF-----
-PD----EVLGSGQFGIVYGGKHRKTGR-DVAIKIIDKLR-FPTKQESQLRN------EVAILQNL-H---HPG--VVNLECMFET----------PERVF--VVMEKLHGD--MLEMILS---SEKGRLPEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI---IGEKSFRRSVVGTPAYLAPEVLR------------------NKGYNRSLDMWSVGVIIYVSLSGTFPFN-ED---------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS------VDKTLSHPWL--------------
YLM---GDLLGEGSYGKVKEVLDSETLC-RRAVKILKKKK-LRRIPNGEANVK----KEIQLLRRL-R---HKN--VIQLVDVLYNE--------EKQKMY--MVMEYCVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLT-TGGTL----KISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIAN----------------GLDTFSGFKVDIWSAGVTLYNITTGLYPFE-GD-------NIYKLFENIGKGSYAIPGDCG---------------------------------------PPLSDLLKGMLEYEPAKRFS------IRQIRQHSWF--------------
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