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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK2 203
CMGC CDK5 4
CAMK CHEK2 220
CMGC GSK3A 119
CMGC GSK3B 56
CAMK MAPKAPK3 44
Other NEK2 8
Other PLK1 53
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------R------EVELHWRASQCPHIVRIVDVYENLYAGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI-
---YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR------EICLLKEL-KHKNIVRLHDVLHS----DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLIN-RNGEL---KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKL-NHPCIIKIKNFF-D----AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
---YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR------------ELQIMRKL-DHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQ-----GVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------------ELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-
QLS---KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQ-------------EVDHHWQASGGPHIVCILDVYENMHHGKRCLL--IIMECMEGG--ELFSRIQE--RGDQAFTEREAAEIMRDIGTAIQFLHSH-----NIAHRDVKPENLLYT-SKEKDAVLKLTDFGFAK--ETTQNALQTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVS----------------------EDAKQLIRLLLKTDPTERLTITQFMNHPWI-
---YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS------EVNLLREL-KHPNIVRYYDRIIDR--TNTTLY--IVMEYCEGG--DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV---KLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF----SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMS-----MEISIHRSL-AHQHVVGFHGFFED----NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-
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