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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CMGC CDK5 4
CMGC GSK3B 56
AGC PDPK1 82
Other PLK1 53
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR--------R-EVELHWRASQCPHIVRIVDVYENLYAGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMT-IT-EFMNHPWI--------------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR-EVEIQSHL-RHPNILRLYGYFHD----ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM-LR-EVLEHPWI--------------
---FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVE-HQLRREIEIQAHL-HHPNILRLYNYFYD----RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLP-LA-QVSAHPWV--------------
---FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQ-IEKEGLE-HQLRREIEIQAHL-QHPNILRLYNYFHD----ARRVY--LILEYAPRG--ELYKELQ----KSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEV---KIADFGWSV----HTPSLRRKTMCGTLDYLPPEMIE-GRTYDEKVDLWCIGVLCYELLV-GYPPFESA----SHSETYRRILKVDVRFPLSMP--------------------------LGARDLISRLLRYQPLERLP-LA-QILKHPWV--------------
---YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPS-SALR-EICLLKEL-KHKNIVRLHDVLHS----DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-AE-EALQHPYF--------------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR--------ELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT-PL-EACAHSFF--------------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR-ERDVMSRL-DHPFFVKLYFTFQD----DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG----NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG-CE-EM------EGYGPLKAHPF---
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQR-EKMSMEISIHRSL-AHQHVVGFHGFFED----NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPT-IN-ELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV-VIQDDDV-ECTMVEKRVLALLDKPPFLTQLHSCFQT----VDRLY--FVMEYVNGG--DLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEH--MMDGVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLA-GQPPFDGE----DEDELFQSIMEHNVSYPKSLS--------------------------KEAVSVCKGLMTKHPAKRLG-C----------GPEGERDVREHAFF
-FI--FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDV-VLIDDDV-ECTMVEKRVLTLAAENPFLTHLICTFQT----KDHLF--FVMEFLNGG--DLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI---KIADFGMCKEN--IFGESRASTFCGTPDYIAPEILQ-GLKYTFSVDWWSFGVLLYEMLI-GQSPFHGD----DEDELFESIRVDTPHYPRWIT--------------------------KESKDILEKLFEREPTKRLGVTG-NIKIHPFF--------------
-FI--LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDV-VLMDDDV-ECTMVEKRVLSLAWEHPFLTHMFCTFQT----KENLF--FVMEYLNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHI---KIADFGMCKEN--MLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLI-GQSPFHGQ----DEEELFHSIRMDNPFYPRWLE--------------------------KEAKDLLVKLFVREPEKRLG-VRGDIRQHPLF--------------
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