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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK2 203
Other AURKA 133
CMGC CDK4 6
CMGC CDK6 13
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CSNK2A1 39
CMGC GSK3A 119
CMGC GSK3B 56
STE MAP3K5 677
CMGC MAPK8 26
CAMK MAPKAPK3 44
Other NEK2 8
CAMK PIM1 38
Other PLK1 53
AGC PRKCA 339
AGC PRKCZ 252
CAMK PRKD1 583
CAMK STK11 49
KVT---SQVLGLGINGKVLQIFNKRTQE-KFALKMLQDCP-KAR----------R------EVELHWRASQ---CPH--IVRIVDVYENLY--AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAF--TEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFY-SN----------HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI--------------
---FEIGRPLGKGKFGNVYLAREKQSKF-ILALKVLFKAQLEKA---GVEHQLRR------EVEIQSHL-R---HPN--ILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKF--DEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN--------------TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI--------------
--Y-EPVAEIGVGAYGTVYKARDPHSGH-FVALKSVRVPN-GGGGGGGLPISTVR------EVALLRRL-EAFEHPN--VVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPPGL--PAETIKDLMRQFLRGLDFLHAN-----CIVHRDLKPENILVT-SGGTV---KLADFGLARI---YSYQMALTPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFC-GN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AFRALQHSYL--------------
---YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEE---GMPLSTIR------EVAVLRHL-ETFEHPN--VVRLFDVCTVSR-TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGV--PTETIKDMMFQLLRGLDFLHSH-----RVVHRDLKPQNILVT-SSGQI---KLADFGLARI---YSFQMALTSVVVTLWYRAPEVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFR-GS-----------SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AYSALSHPYF--------------
--W-DLVQTLGEGAYGEVQLAVNRVTEE-AVAVKIVDMKR-AVD---CPENI-KK------EICINKML-N---HEN--VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDIGM--PEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLAGELPWD-QP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT------IPDIKKDRW-Y-------------
-YI--MSKTLGSGACGEVKLAFERKTCK-KVAIKIISKRK-FAI---GSAREADPALNVETEIEILKKL-N---HPC--IIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNKRL--KEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS-EH-------------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL--------------
--W-EMRERLGTGGFGNVCLYQHRELDL-KIAIKSCRLEL-STK---NRER-WCH------EIQIMKKL-N---HAN--VVKACDVPEELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCCGL--KESQILSLLSDIGSGIRYLHEN-----KIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD---VDQGSLCTSFVGTLQYLAPELFE---NKPYTATVDYWSFGTMVFECIAGYRPFL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------LVVEPMENWLQLMLNWDPQQRG-----------------GPVDLTLKQ-----
---YQLVRKLGRGKYSEVFEAINITNNE-KVVVKILKPVK-KKK---IKR-----------EIKILENLRG---GPN--IITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------QTL--TDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AREAMEHPYF--------------
---YTDIKVIGNGSFGVVYQARLAETRE-LVAIKKVLQDK-RFK---NR------------ELQIMRKL-D---HCN--IVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTI--PILYVKVYMYQLFRSLAYIHSQ-----GVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLLGQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PLEACAHSFF--------------
---YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDK-RFK---NR------------ELQIMRKL-D---HCN--IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL--PVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLLGQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF--------------
DRV-----VLGKGTYGIVYAGRDLSNQV-RIAIKEIPERD-SRY---SQPLH--E------EIALHKHL-K---HKN--IVQYLGSFSE------NGFIK--IFMEQVPGG--SLSALLR---SKWGPLKDNEQTIGFYTKQILEGLKYLHDN-----QIVHRDIKGDNVLINTYSGVL---KISDFGTSKRL--AGINPCTETFTGTLQYMAPEIID-KGPRGYGKAADIWSLGCTIIEMATGKPPFY-EL-------------GEPQAAMFKVGMFKVHPEIPESMS-------------------------------------AEAKAFILKCFEPDPDKRAC------ANDLLVDEF-L-------------
---YQNLKPIGSGAQGIVCAAYDAILER-NVAIKKLSRPF-QNQ---THAKRAYR------ELVLMKCV-N---HKN--IIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------MEL--DHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL---KILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVCHKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS------VDEALQHPYI--------------
QLS---KQVLGLGVNGKVLECFHRRTGQ-KCALKLLYDSP-KAR---Q-------------EVDHHWQASG---GPH--IVCILDVYENMH--HGKRCLL--IIMECMEGG--ELFSRIQE--RGDQAF--TEREAAEIMRDIGTAIQFLHSH-----NIAHRDVKPENLLYT-SKEKDAVLKLTDFGFAK----ETTQNALQTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGFPPFY-SN----------TGQAISPGMKRRIRLGQYGFPNPEWSEVS-----------------------------------EDAKQLIRLLLKTDPTERLT------ITQFMNHPWI--------------
---YEVLYTIGTGSYGRCQKIRRKSDGK-ILVWKELDYGS-MTE---AEKQMLVS------EVNLLREL-K---HPN--IVRYYDRIIDR----TNTTLY--IVMEYCEGG--DLASVITKGTKERQYL--DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV---KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCALMPPFT-AF--------------SQKELAGKIREGKFRRIPYRY---S-----------------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I-------------
---YQVGPLLGSGGFGSVYSGIRVSDNL-PVAIKHVEKDR-ISD---WGELPNGTRV--PMEVVLLKKV-S---SGFSGVIRLLDWFER------PDSFV--LILERPEPV-QDLFDFIT----ERGAL--QEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL---KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVCGDIPFE-HD--------------------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM--------------
-YV--RGRFLGKGGFAKCFEISDADTKE-VFAGKIVPKSL-LLK---PHQREKMS-----MEISIHRSL-A---HQH--VVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRKAL--TEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLVGKPPFE-TS--------------CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLADRKGTEE-LYAIKILKKDV-VIQ---DDDVECTM-----VEKRVLALLDK---PPF--LTQLHSCFQT------VDRLY--FVMEYVNGG--DLMYHIQ----QVGKF--KEPQAVFYAAEISIGLFFLHKR-----GIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEH--MMDGVTTRTFCGTPDYIAPEIIA---YQPYGKSVDWWAYGVLLYEMLAGQPPFD-GE--------------DEDELFQSIMEHNVSYPKSLS---------------------------------------KEAVSVCKGLMTKHPAKRLG------C---------GPEGERDVREHAFF
--F-DLIRVIGRGSYAKVLLVRLKKNDQ-IYAMKVVKKEL-VHD---DEDIDWVQ-----TEKHVFEQASS---NPF--LVGLHSCFQT------TSRLF--LVIEYVNGG--DLMFHMQ----RQRKL--PEEHARFYAAEICIALNFLHER-----GIIYRDLKLDNVLLD-ADGHI---KLTDYGMCKEG--LGPGDTTSTFCGTPNYIAPEILR---GEEYGFSVDWWALGVLMFEMMAGRSPFD-IITD-------NPDMNTEDYLFQVILEKPIRIPRFLS---------------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF---------SDIKSHAFF-----
-PD----EVLGSGQFGIVYGGKHRKTGR-DVAIKIIDKLR-FPT---KQESQLRN------EVAILQNL-H---HPG--VVNLECMFET------PERVF--VVMEKLHGD--MLEMILS---SEKGRL--PEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI---IGEKSFRRSVVGTPAYLAPEVLR---NKGYNRSLDMWSVGVIIYVSLSGTFPFN-ED----------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS------VDKTLSHPWL--------------
YLM---GDLLGEGSYGKVKEVLDSETLC-RRAVKILKKKK-LRR---IPNGEANVK----KEIQLLRRL-R---HKN--VIQLVDVLYNE----EKQKMY--MVMEYCVCGMQEMLDSVP-----EKRF--PVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLT-TGGTL---KISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIAN-GLDTFSGFKVDIWSAGVTLYNITTGLYPFE-GD--------------NIYKLFENIGKGSYAIPGDCG---------------------------------------PPLSDLLKGMLEYEPAKRFS------IRQIRQHSWF--------------
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