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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK1G 23
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDK5 4
CMGC CDK6 13
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK2 222
Other EIF2AK2 267
AGC GRK1 190
AGC GRK4 187
AGC GRK6 186
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
CAMK HUNK 61
CMGC MAPK8 26
CAMK MAPKAPK3 44
CAMK MAPKAPK5 22
CAMK MARK2 53
CAMK MARK4 59
CAMK MGC42105 74
CAMK MKNK2 84
Other NEK2 8
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK3 268
STE PAK4 321
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
AGC PKN1 615
AGC PKN2 657
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
Other SBK1 53
AGC SGK1 98
AGC SGK3 162
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
CAMK SNRK 16
STE STK10 36
CAMK STK11 49
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
STE STK25 20
CAMK STK33 116
Other STK35 202
Other TLK2 440
CAMK TSSK1B 12
Other ULK3 14
--KVT---SQVLGLGINGKV---LQIFN---K-RTQE---KFALKMLQDCP-KAR--------R-------------------------EVELH-WRA-SQ------CPH--IVRIVDVYENLY---------------------------------AGRKCLL--IVMEC-LDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT---SKRPNA------ILKLTDFGFAKE------------------TTSHNSLTTPCYTPYYVAPEVLG------------------PEK--YDKSCDMWSLGVIMYILLC-GY-PPFY-SN-----------HGLAIS-PGMKTRIRMGQYEFPNPEWSEVS----------------------------------------------------EEVKMLIRNLLKTEPTQRMT-----IT-EFMNHPWI--------------
-----FEIGRPLGKGKFGNV---YLARE---K-QSKF---ILALKVLFKAQLEKAGVEH-QLRR-------------------------EVEIQ-SHL--R------HPN--ILRLYGYFHD-------------------------------------ATRVY--LILEY-APLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG---SAGEL---------KIADFGWSV-------------------HAPSSRRTTLCGTLDYLPPEMIE------------------GRM--HDEKVDLWSLGVLCYEFLV-GK-PPFE-AN---------------TY-QETYKRISRVEFTFPDFVT--------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LR-EVLEHPWI--------------
-----FEIGRPLGKGKFGNV---YLARE---K-KSHF---IVALKVLFKSQ-IEKEGVE-HQLR------------------------REIEIQ-AHL--H------HPN--ILRLYNYFYD-------------------------------------RRRIY--LILEY-APRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGK-----KVIHRDIKPENLLLG---LKGEL---------KIADFGWSV-------------------HAPSLRRKTMCGTLDYLPPEMIE------------------GRM--HNEKVDLWCIGVLCYELLV-GN-PPFE-SA---------------SH-NETYRRIVKVDLKFPASVP--------------------------------------------------------MGAQDLISKLLRHNPSERLP-----LA-QVSAHPWV--------------
-----FEIGRPLGKGKFGNV---YLARL---K-ESHF---IVALKVLFKSQ-IEKEGLE-HQLR------------------------REIEIQ-AHL--Q------HPN--ILRLYNYFHD-------------------------------------ARRVY--LILEY-APRG--ELYKELQ----KSEKLDEQRTATIIEELADALTYCHDK-----KVIHRDIKPENLLLG---FRGEV---------KIADFGWSV-------------------HTPSLRRKTMCGTLDYLPPEMIE------------------GRT--YDEKVDLWCIGVLCYELLV-GY-PPFE-SA---------------SH-SETYRRILKVDVRFPLSMP--------------------------------------------------------LGARDLISRLLRYQPLERLP-----LA-QILKHPWV--------------
-----YRLEKTLGKGQTGLV---KLGVH---C-ITGQ---KVAIKIVNREK-LSESVLM-KVER-------------------------EIAIL-KLI--E------HPH--VLKLHDVYEN-------------------------------------KKYLY--LVLEH-VSGG--ELFDYLV----KKGRLTPKEARKFFRQIVSALDFCHSY-----SICHRDLKPENLLLD---EKNNI---------RIADFGMASL------------------QVGDSLLETSCGSPHYACPEVIK-----------------GEKY--DGRRADMWSCGVILFALLV-GA-LPFD-DD---------------NL-RQLLEKVKRGVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVEPEKRLS-----LE-QIQKHPW-Y-------------
-----YRLEKTLGKGQTGLV---KLGVH---C-VTCQ---KVAIKIVNREK-LSESVLM-KVER-------------------------EIAIL-KLI--E------HPH--VLKLHDVYEN-------------------------------------KKYLY--LVLEH-VSGG--ELFDYLV----KKGRLTPKEARKFFRQIISALDFCHSH-----SICHRDLKPENLLLD---EKNNI---------RIADFGMASL------------------QVGDSLLETSCGSPHYACPEVIR-----------------GEKY--DGRKADVWSCGVILFALLV-GA-LPFD-DD---------------NL-RQLLEKVKRGVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVDAARRLT-----LE-HIQKHIW-Y-------------
---FI--FMEVLGSGAFSEV---FLVKQ---R-LTGK---LFALKCIKKSP-AFRDSSL-E--N-------------------------EIAVL-KKI--K------HEN--IVTLEDIYES-------------------------------------TTHYY--LVMQL-VSGG--ELFDRIL----ERGVYTEKDASLVIQQVLSAVKYLHEN-----GIVHRDLKPENLLYLTPEENSKI---------MITDFGLSK-------------------MEQNGIMSTACGTPGYVAPEVLA------------------QKP--YSKAVDCWSIGVITYILLC-GY-PPFY-EE---------------TE-SKLFEKIKEGYYEFESPFWDDIS----------------------------------------------------ESAKDFICHLLEKDPNERYT-----CE-KALSHPWI--------------
-----YQLYEDIGKGAFSVV---RRCVK---L-CTGH---EYAAKIINTKK-LSARDHQ-KLER-------------------------EARIC-RLL--K------HSN--IVRLHDSISE-------------------------------------EGFHY--LVFDL-VTGG--ELFEDIV----AREYYSEADASHCIQQILEAVLHCHQM-----GVVHRDLKPENLLLA---SKCKGA------AVKLADFGLAIEV-----------------QGDQQAWFGFAGTPGYLSPEVLR------------------KEA--YGKPVDIWACGVILYILLV-GY-PPFW-DE---------------DQ-HKLYQQIKAGAYDFPSPEWDTVT----------------------------------------------------PEAKNLINQMLTINPAKRIT-----AH-EALKHPWV--------------
-----YQLFEELGKGAFSVV---RRCMK---I-PTGQ---EYAAKIINTKK-LSARDHQ-KLER-------------------------EARIC-RLL--K------HPN--IVRLHDSISE-------------------------------------EGFHY--LVFDL-VTGG--ELFEDIV----AREYYSEADASHCIQQILESVNHCHLN-----GIVHRDLKPENLLLA---SKSKGA------AVKLADFGLAIEV-----------------QGDQQAWFGFAGTPGYLSPEVLR------------------KDP--YGKPVDMWACGVILYILLV-GY-PPFW-DE---------------DQ-HRLYQQIKAGAYDFPSPEWDTVT----------------------------------------------------PEAKDLINKMLTINPAKRIT-----AS-EALKHPWI--------------
-----YQLFEELGKGAFSVV---RRCVK---K-TSTQ---EYAAKIINTKK-LSARDHQ-KLER-------------------------EARIC-RLL--K------HPN--IVRLHDSISE-------------------------------------EGFHY--LVFDL-VTGG--ELFEDIV----AREYYSEADASHCIHQILESVNHIHQH-----DIVHRDLKPENLLLA---SKCKGA------AVKLADFGLAIEV-----------------QGEQQAWFGFAGTPGYLSPEVLR------------------KDP--YGKPVDIWACGVILYILLV-GY-PPFW-DE---------------DQ-HKLYQQIKAGAYDFPSPEWDTVT----------------------------------------------------PEAKNLINQMLTINPAKRIT-----AD-QALKHPWV--------------
-----YKLQSEIGKGAYGVV---RLAYN---E-SEDR---HYAMKVLSKKK-LLKQYGF-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAIL-KKL--D------HVN--VVKLIEVLDDP-----------------------------------AEDNLY--LVFDL-LRKG--PVMEVPC-----DKPFSEEQARLYLRDVILGLEYLHCQ-----KIVHRDIKPSNLLLG---DDGHV---------KIADFGVSNQF-----------------EGNDAQLSSTAGTPAFMAPEAISD---------------SGQSF--SGKALDVWATGVTLYCFVY-GK-CPFI-DD---------------FI-LALHRKIKNEPVVFPEEPEIS------------------------------------------------------EELKDLILKMLDKNPETRIG-----VP-DIKLHPWV--------------
-----YTLKDEIGKGSYGVV---KLAYN---E-NDNT---YYAMKVLSKKK-LIRQAGF-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL-KKL--D------HPN--VVKLVEVLDDP-----------------------------------NEDHLY--MVFEL-VNQG--PVMEVPT-----LKPLSEDQARFYFQDLIKGIEYLHYQ-----KIIHRDIKPSNLLVG---EDGHI---------KIADFGVSNEF-----------------KGSDALLSNTVGTPAFMAPESLS-----------------ETRKIFSGKALDVWAMGVTLYCFVF-GQ-CPFM-DE---------------RI-MCLHSKIKSQALEFPDQPDIA------------------------------------------------------EDLKDLITRMLDKNPESRIV-----VP-EIKLHPWV--------------
-----YEKLEKIGEGTYGTV---FKAKN---R-ETHE---IVALKRVRLDD-DDEGVPS-SALR-------------------------EICLL-KEL--K------HKN--IVRLHDVLHS-------------------------------------DKKLT--LVFEF-CDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLIN---RNGEL---------KLADFGLARAF-----------------GIPVRCYSAEVVTLWYRPPDVLF-----------------GAKL--YSTSIDMWSAGCIFAELANAGR-PLFP-GN------------DVDDQ-LKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AE-EALQHPYF--------------
-----YECVAEIGEGAYGKV---FKARD---L-KNGG--RFVALKRVRVQT-GEEGMPL-STIR-------------------------EVAVL-RHL--ET---FEHPN--VVRLFDVCTVSR--------------------------------TDRETKLT--LVFEH-VDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSH-----RVVHRDLKPQNILVT---SSGQI---------KLADFGLARI------------------YSFQMALTSVVVTLWYRAPEVLL------------------QSS--YATPVDLWSVGCIFAEMFR-RK-PLFR-GS------------SDVDQ-LGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ--------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AY-SALSHPYF--------------
-----FEILGVVGEGAYGVV---LKCRH---K-ETHE---IVAIKKFKDSE-ENEEVKE-TTLR-------------------------ELKML-RTL--K------QEN--IVELKEAFRR-------------------------------------RGKLY--LVFEY-VEK---NMLELLE---EMPNGVPPEKVKSYIYQLIKAIHWCHKN-----DIVHRDIKPENLLIS---HNDVL---------KLCDFGFARNL----------------SEGNNANYTEYVATRWYRSPELLL------------------GAP--YGKSVDMWSVGCILGELSD-GQ-PLFP-GE------------SEIDQ-LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH---------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-----TE-QCLNHPTF--------------
----W-DLVQTLGEGAYGEV---QLAVN---R-VTEE---AVAVKIVDMKR-AVDCPEN-I-KK-------------------------EICIN-KML--N------HEN--VVKFYGHRRE-------------------------------------GNIQY--LFLEY-CSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD---ERDNL---------KISDFGLATVFR---------------YNNRERLLNKMCGTLPYVAPELLK-----------------RREF--HAEPVDVWSCGIVLTAMLA-GE-LPWD-QP--------------SDS-CQEYSDWKEKKTYLNPWKKI--D----------------------------------------------------SAPLALLHKILVENPSARIT-----IP-DIKKDRW-Y-------------
---YI--MSKTLGSGACGEV---KLAFE---R-KTCK---KVAIKIISKRK-FAIGSAR-EADPALN-------------------VETEIEIL-KKL--N------HPC--IIKIKNFF-D-------------------------------------AEDYY--IVLEL-MEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS---SQEEDC------LIKITDFGHSKI------------------LGETSLMRTLCGTPTYLAPEVLVS---------------VGTAG--YNRAVDCWSLGVILFICLS-GY-PPFS-EH--------------RTQ-VSLKDQITSGKYNFIPEVWAEVS----------------------------------------------------EKALDLVKKLLVVDPKARFT-----TE-EALRHPWL--------------
-----YQLVRKLGRGKYSEV---FEAIN---I-TNNE---KVVVKILKPVK-KKKIKR-------------------------------EIKIL-ENL-RG------GPN--IITLADIVKDP-----------------------------------VSRTPA--LVFEH-VNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMID--HEHRKL---------RLIDWGLAEF------------------YHPGQEYNVRVASRYFKGPELLV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RK-EPFFHGH------------DNYDQ-LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK----------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AR-EAMEHPYF--------------
-----YQLVRKLGRGKYSEV---FEAIN---I-TNNE---RVVVKILKPVK-KKKIKR-------------------------------EVKIL-ENL-RG------GTN--IIKLIDTVKDP-----------------------------------VSKTPA--LVFEY-INNT--DFKQLY-------QILTDFDIRFYMYELLKALDYCHSK-----GIMHRDVKPHNVMID--HQQKKL---------RLIDWGLAEF------------------YHPAQEYNVRVASRYFKGPELLV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RR-EPFFHGQ------------DNYDQ-LVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK----------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AK-EAMEHPYF--------------
-----YDTGEELGSGQFAVV---KKCRE---K-STGL---QYAAKFIKKRR-TKSSRRG-VSREDI---------------------EREVSIL-KEI--Q------HPN--VITLHEVYEN-------------------------------------KTDVI--LILEL-VAGG--ELFDFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL---DRNVPKP-----RIKIIDFGLAHK------------------IDFGNEFKNIFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GA-SPFL-GD---------------TK-QETLANVSAVNYEFEDEYFSNTS----------------------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQ-DSLQHPWI--------------
-----YDIGEELGSGQFAIV---KKCRE---K-STGL---EYAAKFIKKRQ-SRASRRG-VSREEI---------------------EREVSIL-RQV--L------HHN--VITLHDVYEN-------------------------------------RTDVV--LILEL-VSGG--ELFDFLA----QKESLSEEEATSFIKQILDGVNYLHTK-----KIAHFDLKPENIMLL---DKNIPIP-----HIKLIDFGLAHE------------------IEDGVEFKNIFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GA-SPFL-GD---------------TK-QETLANITAVSYDFDEEFFSQTS----------------------------------------------------ELAKDFIRKLLVKETRKRLT-----IQ-EALRHPWI--------------
-----YEMGEELGSGQFAIV---RKCRQ---K-GTGK---EYAAKFIKKRR-LSSSRRG-VSREEI---------------------EREVNIL-REI--R------HPN--IITLHDIFEN-------------------------------------KTDVV--LILEL-VSGG--ELFDFLA----EKESLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLL---DKNVPNP-----RIKLIDFGIAHK------------------IEAGNEFKNIFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GA-SPFL-GE---------------TK-QETLTNISAVNYDFDEEYFSNTS----------------------------------------------------ELAKDFIRRLLVKDPKRRMT-----IA-QSLEHSWI--------------
-----YEVLKVIGKGSFGQV---VKAYD---H-KVHQ---HVALKMVRNEK-RFHRQAA-E----------------------------EIRIL-EHL--RKQDKDNTMN--VIHMLENFTF-------------------------------------RNHIC--MTFEL-LSM---NLYELIKK--NKFQGFSLPLVRKFAHSILQCLDALHKN-----RIIHCDLKPENILLK---QQGRSG-------IKVIDFGSSC--------------------YEHQRVYTYIQSRFYRAPEVIL------------------GAR--YGMPIDMWSLGCILAELLT-GY-PLLP-GE------------DEGDQ-LACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-----PG-QALRHPWL--------------
----F-KEIELIGSGGFGQV---FKAKH---R-IDGK---TYVIKRVKYNN-EKAER--------------------------------EVKAL-AKL--D------HVN--IVHYNGCWDGFDYDPETSDDSLES--------SDYDPENSKNSSRSKTKCLF--IQMEF-CDKG--TLEQWIEK--RRGEKLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLV---DTKQV---------KIGDFGLVTS------------------LKNDGKRTRSKGTLRYMSPEQIS------------------SQD--YGKEVDLYALGLILAELLH-VCDTAFE-T--------------------SKFFTDLRDGIISDIFDK---------------------------------------------------------KEKTLLQKLLSKKPEDRPN-----TS-EILR----TLT-----------
-FLDF----RVLGKGGFGEV---SACQM---K-ATGK---LYACKKLNKKR-LKKRKGY-QGAM------------------------VEKKIL-MKV--H------SRF--IVSLAYAFET-------------------------------------KADLC--LVMTI-MNGG--DIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQR-----RIVYRDLKPENVLLD---NDGNV---------RISDLGLAVEL-----------------LDGQSKTKGYAGTPGFMAPELLQ------------------GEE--YDFSVDYFALGVTLYEMIA-AR-GPFR-AR-----------GEKVEN-KELKHRIISEPVKYPDKFS--------------------------------------------------------QASKDFCEALLEKDPEKRLG-----FR-D-------ETCDKLRAHPLF--
---FR--HYRVLGKGGFGEV---CACQV---R-ATGK---MYACKKLQKKR-IKKRKGE-AMAL------------------------NEKRIL-EKV--Q------SRF--VVSLAYAYET-------------------------------------KDALC--LVLTI-MNGG--DLKFHIYN--LGNPGFDEQRAVFYAAELCCGLEDLQRE-----RIVYRDLKPENILLD---DRGHI---------RISDLGLATE------------------IPEGQRVRGRVGTVGYMAPEVVN------------------NEK--YTFSPDWWGLGCLIYEMIQ-GH-SPFK-KY------------KEKVK-WEEVDQRIKNDTEEYSE---KFS----------------------------------------------------EDAKSICRMLLTKNPSKRLGCRGEGAA-GVKQHPV-F-------------
----F-RQYRVLGKGGFGEV---CACQV---R-ATGK---MYACKKLEKKR-IKKRKGE-AMAL------------------------NEKQIL-EKV--N------SRF--VVSLAYAYET-------------------------------------KDALC--LVLTL-MNGG--DLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD---DHGHI---------RISDLGLAVH------------------VPEGQTIKGRVGTVGYMAPEVVK------------------NER--YTFSPDWWALGCLLYEMIA-GQ-SPFQ-QR------------KKKIK-REEVERLVK-EVPEEYSER--FS----------------------------------------------------PQARSLCSQLLCKDPAERLGCRGGSAR-EVKEHPLF--------------
----F-TEFRVLGKGGFGEV---CAVQV---K-NTGK---MYACKKLDKKR-LKKKGGE-KMAL------------------------LEKEIL-EKV--S------SPF--IVSLAYAFES-------------------------------------KTHLC--LVMSL-MNGG--DLKFHIYN--VGTRGLDMSRVIFYSAQIACGMLHLHEL-----GIVYRDMKPENVLLD---DLGNC---------RLSDLGLAVE------------------MKGGKPITQRAGTNGYMAPEILM-----------------EKVS--YSYPVDWFAMGCSIYEMVA-GR-TPFK-DY-----------KEKVSK-EDLKQRTLQDEVKFQHDNF---T----------------------------------------------------EEAKDICRLFLAKKPEQRLG-----SR-E-------KSDDPR--------
-----YTDIKVIGNGSFGVV---YQARL---A-ETRE---LVAIKKVLQDK-RFKNR--------------------------------ELQIM-RKL--D------HCN--IVRLRYFFYSSG---------------------------------EKKDELYLNLVLEY-VPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQ-----GVCHRDIKPQNLLVD--PDTAVL---------KLCDFGSAKQ------------------LVRGEPNVSYICSRYYRAPELIF-----------------GATD--YTSSIDVWSAGCVLAELLL-GQ-PIFP-GD------------SGVDQ-LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PL-EACAHSFF--------------
-----YTDTKVIGNGSFGVV---YQAKL---C-DSGE---LVAIKKVLQDK-RFKNR--------------------------------ELQIM-RKL--D------HCN--IVRLRYFFYSSG---------------------------------EKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLD--PDTAVL---------KLCDFGSAKQ------------------LVRGEPNVSYICSRYYRAPELIF-----------------GATD--YTSSIDVWSAGCVLAELLL-GQ-PIFP-GD------------SGVDQ-LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PL-EACAHSFF--------------
--IGS----RKLGEGSFAKV---REGLH---V-LTGE---KVAIKVIDKKR-AKKDTYV-TKNLR-----------------------REGQIQ-QMI--R------HPN--ITQLLDILET-------------------------------------ENSYY--LVMEL-CPGG--NLMHKIY----EKKRLEESEARRYIRQLISAVEHLHRA-----GVVHRDLKIENLLLD---EDNNI---------KLIDFGLSNCAG---------------ILGYSDPFSTQCGSPAYAAPELLA------------------RKK--YGPKIDVWSIGVNMYAMLT-GT-LPFT-VE-------------PFSL-RALYQKMVD-KEMNPLPTQ--LS----------------------------------------------------TGAISFLRSLLEPDPVKRPN-----IQ-QALANRWL--------------
-----YQNLKPIGSGAQGIV---CAAYD---A-ILER---NVAIKKLSRPF-QNQTHAK-RAYR-------------------------ELVLM-KCV--N------HKN--IIGLLNVFTPQKS-------------------------------LEEFQDVY--IVMEL-MDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK---SDCTL---------KILDFGLART------------------AGTSFMMTPYVVTRYYRAPEVIL------------------GMG--YKENVDLWSVGCIMGEMVC-HK-ILFP-GR------------DYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK-----------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VD-EALQHPYI--------------
--QLS---KQVLGLGVNGKV---LECFH---R-RTGQ---KCALKLLYDSP-KARQ---------------------------------EVDHH-WQA-SG------GPH--IVCILDVYENMH---------------------------------HGKRCLL--IIMEC-MEGG--ELFSRIQE--RGDQAFTEREAAEIMRDIGTAIQFLHSH-----NIAHRDVKPENLLYT---SKEKDA------VLKLTDFGFAK-------------------ETTQNALQTPCYTPYYVAPEVLG------------------PEK--YDKSCDMWSLGVIMYILLC-GF-PPFY-SN-----------TGQAIS-PGMKRRIRLGQYGFPNPEWSEVS----------------------------------------------------EDAKQLIRLLLKTDPTERLT-----IT-QFMNHPWI--------------
--INW---TQKLGAGISGPV---RVCVK---K-STQE---RFALKILLDRP-KAR--------N-------------------------EVRLH-MMC-AT------HPN--IVQIIEVFANSVQFP---------------------------HESSPRARLL--IVMEM-MEGG--ELFHRIS----QHRHFTEKQASQVTKQIALALRHCHLL-----NIAHRDLKPENLLFK---DNS-LDA-----PVKLCDFGFAK--------------------IDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYT--YNKSCDLWSLGVIIYVMLC-GY-PPFY-SKH----------HSRTIP-KDMRRKIMTGSFEFPEEEWSQIS----------------------------------------------------EMAKDVVRKLLKVKPEERLT-----IE-GVLDHPWL--------------
-----YRLLKTIGKGNFAKV---KLARH---I-LTGK---EVAVKIIDKTQ-LNSSSLQ-KLFR-------------------------EVRIM-KVL--N------HPN--IVKLFEVIET-------------------------------------EKTLY--LVMEY-ASGG--EVFDYLV----AHGRMKEKEARAKFRQIVSAVQYCHQK-----FIVHRDLKAENLLLD---ADMNI---------KIADFGFSNE------------------FTFGNKLDTFCGSPPYAAPELFQ-----------------GKKY--DGPEVDVWSLGVILYTLVS-GS-LPFD-GQ---------------NL-KELRERVLRGKYRIPFYMS--------------------------------------------------------TDCENLLKKFLILNPSKRGT-----LE-QIMKDRWM--------------
-----YRLLRTIGKGNFAKV---KLARH---I-LTGR---EVAIKIIDKTQ-LNPSSLQ-KLFR-------------------------EVRIM-KGL--N------HPN--IVKLFEVIET-------------------------------------EKTLY--LVMEY-ASAG--EVFDYLV----SHGRMKEKEARAKFRQIVSAVHYCHQK-----NIVHRDLKAENLLLD---AEANI---------KIADFGFSNE------------------FTLGSKLDTFCGSPPYAAPELFQ-----------------GKKY--DGPEVDIWSLGVILYTLVS-GS-LPFD-GH---------------NL-KELRERVLRGKYRVPFYMS--------------------------------------------------------TDCESILRRFLVLNPAKRCT-----LE-QIMKDKWI--------------
-----YRIRGEIGSGNFSQV---KLGIH---S-LTKE---KVAIKILDKTK-LDQKTQR-LLSR-------------------------EISSM-EKL--H------HPN--IIRLYEVVET-------------------------------------LSKLH--LVMEY-AGGG--ELFGKIS----TEGKLSEPESKLIFSQIVSAVKHMHEN-----QIIHRDLKAENVFYT---SNTCV---------KVGDFGFSTV------------------SKKGEMLNTFCGSPPYAAPELFR-----------------DEHY--IGIYVDIWALGVLLYFMVT-GT-MPFR-AE---------------TV-AKLKKSILEGTYSVPPHV----S----------------------------------------------------EPCHRLIRGVLQQIPTERYG-----ID-CIMNDEWM--------------
-QLQE----DVLGEGAHARV---QTCIN---L-ITSQ---EYAVKIIEKQP-GHIRSR---VFR-------------------------EVEML-YQC-QG------HRN--VLELIEFFEE-------------------------------------EDRFY--LVFEK-MRGG--SILSHIH----KRRHFNELEASVVVQDVASALDFLHNK-----GIAHRDLKPENILCE---HPNQVS------PVKICDFDLGSGIKLN----------GDCSPISTPELLTPCGSAEYMAPEVVEAF-------------SEEASI--YDKRCDLWSLGVILYILLS-GY-PPFV-GRCGSDCGWDRGEACPACQ-NMLFESIQEGKYEFPDKDWAHIS----------------------------------------------------CAAKDLISKLLVRDAKQRLS-----AA-QVLQHPWV--------------
-----YEVLYTIGTGSYGRC---QKIRR---K-SDGK---ILVWKELDYGS-MTEAEKQ-MLVS-------------------------EVNLL-REL--K------HPN--IVRYYDRIIDR-----------------------------------TNTTLY--IVMEY-CEGG--DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD---GKQNV---------KLGDFGLARIL-----------------NHDTSFAKTFVGTPYYMSPEQMN------------------RMS--YNEKSDIWSLGCLLYELCA-LM-PPFT-AF---------------SQ-KELAGKIREGKFRRIPYRY---S----------------------------------------------------DELNEIITRMLNLKDYHRPS-----VE-EILENPL-I-------------
-----YELQETLGKGTYGKV---KRATE---R-FSGR---VVAIKSIRKDK-IKDEQDM-VHIR------------------------REIEIM-SSL--N------HPH--IISIYEVFEN-------------------------------------KDKIV--IIMEY-ASKG--ELYDYIS----ERRRLSERETRHFFRQIVSAVHYCHKN-----GVVHRDLKLENILLD---DNCNI---------KIADFGLSNL------------------YQKDKFLQTFCGSPLYASPEIVN-----------------GRPY--RGPEVDSWALGVLLYTLVY-GT-MPFD-GF---------------DH-KNLIRQISSGEYREPTQP---------------------------------------------------------SDARGLIRWMLMVNPDRRAT-----IE-DIANHWW-V-------------
-----YEFLETLGKGTYGKV---KKARE---S-SGR----LVAIKSIRKDK-IKDEQDL-MHIR------------------------REIEIM-SSL--N------HPH--IIAIHEVFEN-------------------------------------SSKIV--IVMEY-ASRG--DLYDYIS----ERQQLSEREARHFFRQIVSAVHYCHQN-----RVVHRDLKLENILLD---ANGNI---------KIADFGLSNL------------------YHQGKFLQTFCGSPLYASPEIVN-----------------GKPY--TGPEVDSWSLGVLLYILVH-GT-MPFD-GH---------------DH-KILVKQISNGAYREPPK-----P----------------------------------------------------SDACGLIRWLLMVNPTRRAT-----LE-DVASHWW-V-------------
-----YTRFEKIGQGASGTV---YTALD---I-ATGQ---EVAIKQMNLQQ-QPKKELI-I--N-------------------------EILVM-REN--K------NPN--IVNYLDSYLV-------------------------------------GDELW--VVMEY-LAGG--SLTDVVT-----ETCMDEGQIAAVCRECLQALDFLHSN-----QVIHRDIKSDNILLG---MDGSV---------KLTDFGFCAQI-----------------TPEQSKRSTMVGTPYWMAPEVVT------------------RKA--YGPKVDIWSLGIMAIEMVE-GE-PPYL-NE------------NPLRA-LYLIATNGTPELQNPERLS--------------------------------------------------------AVFRDFLNRCLEMDVDRRGS-----AK-ELLQHPFL--------------
-DNFI-----KIGEGSTGIV---CIATV---R-SSGK---LVAVKKMDLRK-QQRREL---LFN-------------------------EVVIM-RDY--Q------HEN--VVEMYNSYLV-------------------------------------GDELW--VVMEF-LEGG--ALTDIVT-----HTRMNEEQIAAVCLAVLQALSVLHAQ-----GVIHRDIKSDSILLT---HDGRV---------KLSDFGFCAQV-----------------SKEVPRRKSLVGTPYWMAPELIS------------------RLP--YGPEVDIWSLGIMVIEMVD-GE-PPYF-NE------------PPLKA-MKMIRDNLPPRLKNLHKVS--------------------------------------------------------PSLKGFLDRLLVRDPAQRAT-----AA-ELLKHPFL--------------
----F-KFGKILGEGSFSTV---VLARE---L-ATSR---EYAIKILEKRH-IIKENKVPYVTR-------------------------ERDVM-SRL--D------HPF--FVKLYFTFQD-------------------------------------DEKLY--FGLSY-AKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN---EDMHI---------QITDFGTAKVLS---------------PESKQARANSFVGTAQYVSPELLT------------------EKS--ACKSSDLWALGCIIYQLVA-GL-PPFR-AG---------------NE-YLIFQKIIKLEYDFPEKFF--------------------------------------------------------PKARDLVEKLLVLDATKRLG-----CE-EM------EGYGPLKAHPF---
-----YEPKEILGRGVSSVV---RRCIH---K-PTSQ---EYAVKVIDVTG-GGSFSPE-EVRELRE------------------ATLKEVDIL-RKV-SG------HPN--IIQLKDTYET-------------------------------------NTFFF--LVFDL-MKRG--ELFDYLT----EKVTLSEKETRKIMRALLEVICTLHKL-----NIVHRDLKPENILLD---DNMNI---------KLTDFGFSCQ------------------LEPGERLREVCGTPSYLAPEIIECS------------MNEDHPG--YGKEVDMWSTGVIMYTLLA-GS-PPFW-HR---------------KQ-MLMLRMIMSGNYQFGSPEWDDYS----------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AE-EALAHPFF--------------
--YDP---KDVIGRGVSSVV---RRCVH---R-ATGH---EFAVKIMEVTA-ERLSPEQ-LEEVREA-------------------TRRETHIL-RQV-AG------HPH--IITLIDSYES-------------------------------------SSFMF--LVFDL-MRKG--ELFDYLT----EKVALSEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLD---DNMQI---------RLSDFGFSCH------------------LEPGEKLRELCGTPGYLAPEILKCS------------MDETHPG--YGKEVDLWACGVILFTLLA-GS-PPFW-HR---------------RQ-ILMLRMIMEGQYQFSSPEWDDRS----------------------------------------------------STVKDLISRLLQVDPEARLT-----AE-QALQHPFF--------------
-----YQVGPLLGSGGFGSV---YSGIR---V-SDNL---PVAIKHVEKDR-ISDWGEL-PNGTRV---------------------PMEVVLL-KKV--S------SGFSGVIRLLDWFER-------------------------------------PDSFV--LILER-PEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILID--LNRGEL---------KLIDFGSGA-------------------LLKDTVYTDFDGTRVYSPPEWIR-----------------YHRY--HGRSAAVWSLGILLYDMVC-GD-IPFE-HD----------------------EEIIRGQVFFRQRVS--------------------------------------------------------SECQHLIRWCLALRPSDRPT-----FE-EIQNHPWM--------------
-----YRLGPLLGKGGFGTV---FAGHR---L-TDRL---QVAIKVIPRNR-VLGWSPL-SDSVTC---------------------PLEVALL-WKV--GAG--GGHPG--VIRLLDWFET-------------------------------------QEGFM--LVLERPLPAQ--DLFDYIT----EKGPLGEGPSRCFFGQVVAAIQHCHSR-----GVVHRDIKDENILID--LRRGCA---------KLIDFGSGA-------------------LLHDEPYTDFDGTRVYSPPEWIS-----------------RHQY--HALPATVWSLGILLYDMVC-GD-IPFE-RD----------------------QEILEAELHFPAHVS--------------------------------------------------------PDCCALIRRCLAPKPSSRPS-----LE-EILLDPWM--------------
-----YQVGAVLGSGGFGTV---YAGSR---I-ADGL---PVAVKHVVKER-VTEWGSL-GGATV----------------------PLEVVLL-RKV--GAA--GGARG--VIRLLDWFER-------------------------------------PDGFL--LVLER-PEPA-QDLFDFIT----ERGALDEPLARRFFAQVLAAVRHCHSC-----GVVHRDIKDENLLVD--LRSGEL---------KLIDFGSGA-------------------LLKDTVYTDFDGTRVYSPPEWIR-----------------YHRY--HGRSATVWSLGVLLYDMVC-GD-IPFE-QD----------------------EEILRGRLLFRRRVS--------------------------------------------------------PECQQLIRWCLSLRPSERPS-----LD-QIAAHPWM--------------
----F-KFLAVLGRGHFGKV---LLSEF---R-PSGE---LFAIKALKKGD-IVARDEV-ESLM------------------------CEKRIL-AAV--TS---AGHPF--LVNLFGCFQT-------------------------------------PEHVC--FVMEY-SAGG--DLMLHIH-----SDVFSEPRAIFYSACVVLGLQFLHEH-----KIVYRDLKLDNLLLD---TEGYV---------KIADFGLCKEG-----------------MGYGDRTSTFCGTPEFLAPEVLT------------------DTS--YTRAVDWWGLGVLLYEMLV-GE-SPFP-GD---------------DE-EEVFDSIVNDEVRYPRFLS--------------------------------------------------------AEAIGIMRRLLRRNPERRLGSSERDAE-DVKKQPFF--------------
---FR--CCAVLGRGHFGKV---LLAEY---K-NTNE---MFAIKALKKGD-IVARDEV-DSLM------------------------CEKRIF-ETV--NS---VRHPF--LVNLFACFQT-------------------------------------KEHVC--FVMEY-AAGG--DLMMHIH-----TDVFSEPRAVFYAACVVLGLQYLHEH-----KIVYRDLKLDNLLLD---TEGFV---------KIADFGLCKEG-----------------MGYGDRTSTFCGTPEFLAPEVLT------------------ETS--YTRAVDWWGLGVLIYEMLV-GE-SPFP-GD---------------DE-EEVFDSIVNDEVRYPRFLS--------------------------------------------------------TEAISIMRRLLRRNPERRLGASEKDAE-DVKKHPFF--------------
---YV--RGRFLGKGGFAKC---FEISD---A-DTKE---VFAGKIVPKSL-LLKPHQR-EKMS------------------------MEISIH-RSL--A------HQH--VVGFHGFFED-------------------------------------NDFVF--VVLEL-CRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN---EDLEV---------KIGDFGLATKV-----------------EYDGERKKTLCGTPNYIAPEVLS------------------KKG--HSFEVDVWSIGCIMYTLLV-GK-PPFE-TS---------------CL-KETYLRIKKNEYSIPKHIN--------------------------------------------------------PVAASLIQKMLQTDPTARPT-----IN-ELLNDEFF--------------
----Y-CRGKVLGKGGFAKC---YEMTD---L-TNNK---VYAAKIIPHSR-VAKPHQR-EKID------------------------KEIELH-RIL--H------HKH--VVQFYHYFED-------------------------------------KENIY--ILLEY-CSRR--SMAHILK----ARKVLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFIN---EAMEL---------KVGDFGLAARL-----------------EPLEHRRRTICGTPNYLSPEVLN------------------KQG--HGCESDIWALGCVMYTMLL-GR-PPFE-TT---------------NL-KETYRCIREARYTMPSSLL--------------------------------------------------------APAKHLIASMLSKNPEDRPS-----LD-DIIRHDFF--------------
---YL--KGRLLGKGGFARC---YEATD---T-ETGS---AYAVKVIPQSR-VAKPHQR-EKIL------------------------NEIELH-RDL--Q------HRH--IVRFSHHFED-------------------------------------ADNIY--IFLEL-CSRK--SLAHIWK----ARHTLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFIT---ENMEL---------KVGDFGLAARL-----------------EPPEQRKKTICGTPNYVAPEVLL------------------RQG--HGPEADVWSLGCVMYTLLC-GS-PPFE-TA---------------DL-KETYRCIKQVHYTLPASLS--------------------------------------------------------LPARQLLAAILRASPRDRPS-----ID-QILRHDFF--------------
----F-NFLMVLGKGSFGKV---MLADR---K-GTEE---LYAIKILKKDV-VIQDDDV-ECTM------------------------VEKRVL-ALL-DK------PPF--LTQLHSCFQT-------------------------------------VDRLY--FVMEY-VNGG--DLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHKR-----GIIYRDLKLDNVMLD---SEGHI---------KIADFGMCKEH-----------------MMDGVTTRTFCGTPDYIAPEIIA------------------YQP--YGKSVDWWAYGVLLYEMLA-GQ-PPFD-GE---------------DE-DELFQSIMEHNVSYPKSLS--------------------------------------------------------KEAVSVCKGLMTKHPAKRLG-----C----------GPEGERDVREHAFF
----F-NFLMVLGKGSFGKV---MLSER---K-GTDE---LYAVKILKKDV-VIQDDDV-ECTM------------------------VEKRVL-ALP-GK------PPF--LTQLHSCFQT-------------------------------------MDRLY--FVMEY-VNGG--DLMYHIQ----QVGRFKEPHAVFYAAEIAIGLFFLQSK-----GIIYRDLKLDNVMLD---SEGHI---------KIADFGMCKEN-----------------IWDGVTTKTFCGTPDYIAPEIIA------------------YQP--YGKSVDWWAFGVLLYEMLA-GQ-APFE-GE---------------DE-DELFQSIMEHNVAYPKSMS--------------------------------------------------------KEAVAICKGLMTKHPGKRLG-----C----------GPEGERDIKEHAFF
---FI--LHKMLGKGSFGKV---FLAEF---K-KTNQ---FFAIKALKKDV-VLMDDDV-ECTM------------------------VEKRVL-SLA-WE------HPF--LTHMFCTFQT-------------------------------------KENLF--FVMEY-LNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHSK-----GIVYRDLKLDNILLD---KDGHI---------KIADFGMCKEN-----------------MLGDAKTNTFCGTPDYIAPEILL------------------GQK--YNHSVDWWSFGVLLYEMLI-GQ-SPFH-GQ---------------DE-EELFHSIRMDNPFYPRWLE--------------------------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF--------------
---PD----EVLGSGQFGIV---YGGKH---R-KTGR---DVAIKIIDKLR-FPTKQES-QLRN-------------------------EVAIL-QNL--H------HPG--VVNLECMFET-------------------------------------PERVF--VVMEK-LHGD--MLEMILS---SEKGRLPEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA---SADPFP------QVKLCDFGFARI------------------IGEKSFRRSVVGTPAYLAPEVLR------------------NKG--YNRSLDMWSVGVIIYVSLS-GT-FPFN-ED------------------EDIHDQIQNAAFMYPPNPWKEIS----------------------------------------------------HEAIDLINNLLQVKMRKRYS-----VD-KTLSHPWL--------------
---PD----EVLGSGQFGVV---YGGKH---R-KTGR---DVAVKVIDKLR-FPTKQES-QLRN-------------------------EVAIL-QSL--R------HPG--IVNLECMFET-------------------------------------PEKVF--VVMEK-LHGD--MLEMILS---SEKGRLPERLTKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA---SADPFP------QVKLCDFGFARI------------------IGEKSFRRSVVGTPAYLAPEVLL------------------NQG--YNRSLDMWSVGVIMYVSLS-GT-FPFN-ED------------------EDINDQIQNAAFMYPASPWSHIS----------------------------------------------------AGAIDLINNLLQVKMRKRYS-----VD-KSLSHPWL--------------
--FAD----EVLGSGQFGIV---YGGKH---R-KTGR---DVAIKVIDKMR-FPTKQES-QLRN-------------------------EVAIL-QNL--H------HPG--IVNLECMFET-------------------------------------PERVF--VVMEK-LHGD--MLEMILS---SEKSRLPERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVLLA---SAEPFP------QVKLCDFGFARI------------------IGEKSFRRSVVGTPAYLAPEVLR------------------SKG--YNRSLDMWSVGVIIYVSLS-GT-FPFN-ED------------------EDINDQIQNAAFMYPPNPWREIS----------------------------------------------------GEAIDLINNLLQVKMRKRYS-----VD-KSLSHPWL--------------
-----FELLKVLGQGSFGKVFLVRKVTR---P-DSGH---LYAMKVLKKAT-LKVRDRV-RTKM-------------------------ERDIL-ADV--N------HPF--VVKLHYAFQT-------------------------------------EGKLY--LILDF-LRGG--DLFTRLS----KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KLTDFGLSKEA-----------------IDHEKKAYSFCGTVEYMAPEVVN------------------RQG--HSHSADWWSYGVLMFEMLT-GS-LPFQ-GK---------------DR-KETMTLILKAKLGMPQFLS--------------------------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAE-EIKRHV--FY------------
-----FELLKVLGQGSYGKV---FLVRK---V-KGSDAGQLYAMKVLKKAT-LKVRDRV-RSKM-------------------------ERDIL-AEV--N------HPF--IVKLHYAFQT-------------------------------------EGKLY--LILDF-LRGG--DLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KITDFGLSKEA-----------------IDHDKRAYSFCGTIEYMAPEVVN------------------RRG--HTQSADWWSFGVLMFEMLT-GS-LPFQ-GK---------------DR-KETMALILKAKLGMPQFLS--------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVE-EIKRHPFF--------------
-----FELLKVLGQGSFGKV---FLVKK---I-SGSDARQLYAMKVLKKAT-LKVRDRV-RTKM-------------------------ERDIL-VEV--N------HPF--IVKLHYAFQT-------------------------------------EGKLY--LILDF-LRGG--DLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KLTDFGLSKES-----------------IDHEKKAYSFCGTVEYMAPEVVN------------------RRG--HTQSADWWSFGVLMFEMLT-GT-LPFQ-GK---------------DR-KETMTMILKAKLGMPQFLS--------------------------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVE-EIKRHSFF--------------
-----FELLKVLGQGSFGKV---FLVRK---K-TGPDAGQLYAMKVLKKAS-LKVRDRV-RTKM-------------------------ERDIL-VEV--N------HPF--IVKLHYAFQT-------------------------------------EGKLY--LILDF-LRGG--DVFTRLS----KEVLFTEEDVKFYLAELALALDHLHQL-----GIVYRDLKPENILLD---EIGHI---------KLTDFGLSKES-----------------VDQEKKAYSFCGTVEYMAPEVVN------------------RRG--HSQSADWWSYGVLMFEMLT-GT-LPFQ-GK---------------DR-NETMNMILKAKLGMPQFLS--------------------------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVE-EIKRHLFF--------------
-----FELLRVLGKGGYGKV---FQVRKVTGA-NTGK---IFAMKVLKKAM-IVRNAKD-TAHTK-----------------------AERNIL-EEV--K------HPF--IVDLIYAFQT-------------------------------------GGKLY--LILEY-LSGG--ELFMQLE----REGIFMEDTACFYLAEISMALGHLHQK-----GIIYRDLKPENIMLN---HQGHV---------KLTDFGLCKES-----------------IHDGTVTHTFCGTIEYMAPEILM------------------RSG--HNRAVDWWSLGALMYDMLT-GA-PPFT-GE---------------NR-KKTIDKILKCKLNLPPYLT--------------------------------------------------------QEARDLLKKLLKRNAASRLGAGPGDAG-EVQAHPFF--------------
-----YELVRELGKGTYGKV---DLVVY---K-GTGT---KMALKFVNKSK-TKLKNF----LR-------------------------EVSIT-NSL-SS------SPF--IIKVFDVVFE------------------------------------TEDCYV--FAQEY-APAG--DLFDIIP----PQVGLPEDTVKRCVQQLGLALDFMHGR-----QLVHRDIKPENVLLFD-RECRRV---------KLADFGMTR--------------------RVGCRVKRVSGTIPYTAPEVCQAG-------------RADGLA--VDTGVDVWAFGVLIFCVLT-GN-FPWE-AA------------SGADAFFEEFVRWQRGRLPGLPSQWRRFT----------------------------------------------------EPALRMFQRLLALEPERRGP-----AK-EVF-----RFLKH---------
-----FHFLKVIGKGSFGKV---LLARH---K-AEEV---FYAVKVLQKKA-ILKKKEE-KHIM------------------------SERNVLLKNV--K------HPF--LVGLHFSFQT-------------------------------------ADKLY--FVLDY-INGG--ELFYHLQ----RERCFLEPRARFYAAEIASALGYLHSL-----NIVYRDLKPENILLD---SQGHI---------VLTDFGLCKEN-----------------IEHNSTTSTFCGTPEYLAPEVLH------------------KQP--YDRTVDWWCLGAVLYEMLY-GL-PPFY-SR---------------NT-AEMYDNILNKPLQLKPNIT--------------------------------------------------------NSARHLLEGLLQKDRTKRLGAK-DDFM-EIKSHV--FF------------
----F-DFLKVIGKGSFGKV---LLAKR---K-LDGK---FYAVKVLQKKI-VLNRKEQ-KHIM------------------------AERNVLLKNV--K------HPF--LVGLHYSFQT-------------------------------------TEKLY--FVLDF-VNGG--ELFFHLQ----RERSFPEHRARFYAAEIASALGYLHSI-----KIVYRDLKPENILLD---SVGHV---------VLTDFGLCKEG-----------------IAISDTTTTFCGTPEYLAPEVIR------------------KQP--YDNTVDWWCLGAVLYEMLY-GL-PPFY-CR---------------DV-AEMYDNILHKPLSLRPGVS--------------------------------------------------------LTAWSILEELLEKDRQNRLGAK-EDFL-EIQNHPFF--------------
-----YDIERTLGKGNFAVV---KLARH---R-VTKT---QVAIKIIDKTR-LDSSNLE-KIYR-------------------------EVQLM-KLL--N------HPH--IIKLYQVMET-------------------------------------KDMLY--IVTEF-AKNG--EMFDYLT----SNGHLSENEARKKFWQILSAVEYCHDH-----HIVHRDLKTENLLLD---GNMDI---------KLADFGFGNF------------------YKSGEPLSTWCGSPPYAAPEVFE-----------------GKEY--EGPQLDIWSLGVVLYVLVC-GS-LPFD-GP---------------NL-PTLRQRVLEGRFRIPFFMS--------------------------------------------------------QDCESLIRRMLVVDPARRIT-----IA-QIRQHRWM--------------
-----YDIEGTLGKGNFAVV---KLGRH---R-ITKT---EVAIKIIDKSQ-LDAVNLE-KIYR-------------------------EVQIM-KML--D------HPH--IIKLYQVMET-------------------------------------KSMLY--LVTEY-AKNG--EIFDYLA----NHGRLNESEARRKFWQILSAVDYCHGR-----KIVHRDLKAENLLLD---NNMNI---------KIADFGFGNF------------------FKSGELLATWCGSPPYAAPEVFE-----------------GQQY--EGPQLDIWSMGVVLYVLVC-GA-LPFD-GP---------------TL-PILRQRVLEGRFRIPYFMS--------------------------------------------------------EDCEHLIRRMLVLDPSKRLT-----IA-QIKEHKWM--------------
-----WEIIGELGDGAFGKV---YKAQN---K-ETSV---LAAAKVIDTKS-EEELEDY-M--V-------------------------EIDIL-ASC--D------HPN--IVKLLDAFYY-------------------------------------ENNLW--ILIEF-CAGG--AVDAVML---ELERPLTESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNILFT---LDGDI---------KLADFGVSAKN-----------------TRTIQRRDSFIGTPYWMAPEVVMCE-------------TSKDRP--YDYKADVWSLGITLIEMAE-IE-PPHH-EL------------NPMRV-LLKIAKSEPPTLAQPSRWS--------------------------------------------------------SNFKDFLKKCLEKNVDARWT-----TS-QLLQHPFV--------------
-----YDLDKTLGRGHFAVV---KLARH---V-FTGE---KVAVKVIDKTK-LDTLATG-HLFQ-------------------------EVRCM-KLV--Q------HPN--IVRLYEVIDT-------------------------------------QTKLY--LILEL-GDGG--DMFDYIM---KHEEGLNEDLAKKYFAQIVHAISYCHKL-----HVVHRDLKPENVVFF--EKQGLV---------KLTDFGFSNK------------------FQPGKKLTTSCGSLAYSAPEILL-----------------GDEY--DAPAVDIWSLGVILFMLVC-GQ-PPFQ-EA---------------ND-SETLTMIMDCKYTVPSHVS--------------------------------------------------------KECKDLITRMLQRDPKRRAS-----LE-EIENHPWL--------------
-----WEIVGELGDGAFGKV---YKAKN---K-ETGA---LAAAKVIETKS-EEELEDY-I--V-------------------------EIEIL-ATC--D------HPY--IVKLLGAYYH-------------------------------------DGKLW--IMIEF-CPGG--AVDAIML---ELDRGLTEPQIQVVCRQMLEALNFLHSK-----RIIHRDLKAGNVLMT---LEGDI---------RLADFGVSAKN-----------------LKTLQKRDSFIGTPYWMAPEVVMCE-------------TMKDTP--YDYKADIWSLGITLIEMAQ-IE-PPHH-EL------------NPMRV-LLKIAKSDPPTLLTPSKWS--------------------------------------------------------VEFRDFLKIALDKNPETRPS-----AA-QLLEHPFV--------------
--YLM---GDLLGEGSYGKV---KEVLD---S-ETLC---RRAVKILKKKK-LRRIPNG-EANVK-----------------------KEIQLL-RRL--R------HKN--VIQLVDVLYNE-----------------------------------EKQKMY--MVMEY-CVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLT---TGGTL---------KISDLGVAEALH---------------PFAADDTCRTSQGSPAFQPPEIAN----------------GLDTF--SGFKVDIWSAGVTLYNITT-GL-YPFE-GD---------------NI-YKLFENIGKGSYAIPGDCG--------------------------------------------------------PPLSDLLKGMLEYEPAKRFS-----IR-QIRQHSWF--------------
--LCP---GRELGRGKFAVV---RKCIK---K-DSGK---EFAAKFMRKRR-KGQDCRM-EIIH-------------------------EIAVL-ELA-QD------NPW--VINLHEVYET-------------------------------------ASEMI--LVLEY-AAGG--EIFDQCVA--DREEAFKEKDVQRLMRQILEGVHFLHTR-----DVVHLDLKPQNILLT---SESPLG------DIKIVDFGLSRI------------------LKNSEELREIMGTPEYVAPEILS------------------YDP--ISMATDMWSIGVLTYVMLT-GI-SPFL-GN---------------DK-QETFLNISQMNLSYSEEEFDVLS----------------------------------------------------ESAVDFIRTLLVKKPEDRAT-----AE-ECLKHPWL--------------
--ILT---SKELGRGKFAVV---RQCIS---K-STGQ---EYAAKFLKKRR-RGQDCRA-EILH-------------------------EIAVL-ELA-KS------CPR--VINLHEVYEN-------------------------------------TSEII--LILEY-AAGG--EIFSLCLP--ELAEMVSENDVIRLIKQILEGVYYLHQN-----NIVHLDLKPQNILLS---SIYPLG------DIKIVDFGMSRK------------------IGHACELREIMGTPEYLAPEILN------------------YDP--ITTATDMWNIGIIAYMLLT-HT-SPFV-GE---------------DN-QETYLNISQVNVDYSEETFSSVS----------------------------------------------------QLATDFIQSLLVKNPEKRPT-----AE-ICLSHSWL--------------
-----FTKLEKIGKGSFGEV---FKGID---N-RTQK---VVAIKIIDLEE-AEDEIED-IQ-Q-------------------------EITVL-SQC--D------SPY--VTKYYGSYLK-------------------------------------DTKLW--IIMEY-LGGG--SALDLLE-----PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS---EHGEV---------KLADFGVAGQL-----------------TDTQIKRNTFVGTPFWMAPEVIK------------------QSA--YDSKADIWSLGITAIELAR-GE-PPHS-EL------------HPMKV-LFLIPKNNPPTLEGNYS----------------------------------------------------------KPLKEFVEACLNKEPSFRPT-----AK-ELLKHKFI--------------
----F-TKLDRIGKGSFGEV---YKGID---N-HTKE---VVAIKIIDLEE-AEDEIED-IQ-Q-------------------------EITVL-SQC--D------SPY--ITRYFGSYLK-------------------------------------STKLW--IIMEY-LGGG--SALDLLK-----PGPLEETYIATILREILKGLDYLHSE-----RKIHRDIKAANVLLS---EQGDV---------KLADFGVAGQL-----------------TDTQIKRNTFVGTPFWMAPEVIK------------------QSA--YDFKADIWSLGITAIELAK-GE-PPNS-DL------------HPMRV-LFLIPKNSPPTLEGQHS----------------------------------------------------------KPFKEFVEACLNKDPRFRPT-----AK-ELLKHKFI--------------
-----YTFGRILGKGSFGIV---IEATD---K-ETET---KWAIKKVNKEK-AGSSAVK-LLER-------------------------EVNIL-KSV--K------HEH--IIHLEQVFET-------------------------------------PKKMY--LVMEL-CEDG--ELKEILD----RKGHFSENETRWIIQSLASAIAYLHNN-----DIVHRDLKLENIMVK---SSLIDDNNEINLNIKVTDFGLAVKK----------------QSRSEAMLQATCGTPIYMAPEVIS------------------AHD--YSQQCDIWSIGVVMYMLLR-GE-PPFL-AS---------------SE-EKLFELIRKGELHFENAVWNSIS----------------------------------------------------DCAKSVLKQLMKVDPAHRIT-----AK-ELLDNQWL--------------
-----YSLLAEIGRGSYGVV---YEAVA---G-RSGA---RVAVKKIRCDA-PENVEL---ALA-------------------------EFWAL-TSLKRR------HQN--VVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLW--FVMEF-CEGG--DLNQYVL-----SRRPDPATNKSFMLQLTSAIAFLHKN-----HIVHRDLKPDNILIT---ERSGTP------ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWE-------------------GH--YTAKADIFALGIIIWAMIE-RI-TFID-SE------------TKKEL-LGTYIKQGTEIVPVGEALLENPKMELHIPQ--------------------------------------KRRTSMSEGIKQLLKDMLAANPQDRPD-----AF-EL------ETRM----------
---YL--LLHLLGRGGFSEV---YKAFD---L-TEQR---YVAVKIHQLNK-NWRDEKK-ENYHKH--------------------ACREYRIH-KEL--D------HPR--IVKLYDYFSL------------------------------------DTDSFC--TVLEY-CEGN--DLDFYLK----QHKLMSEKEARSIIMQIVNALKYLNEIK---PPIIHYDLKPGNILLV---NGTACG------EIKITDFGLSKIMDDD----------SYNSVDGMELTSQGAGTYWYLPPECFVV--------------GKEPPK--ISNKVDVWSVGVIFYQCLY-GR-KPFG-HN-------------QSQQ-DILQENTILKATEVQFPPKPVVT----------------------------------------------------PEAKAFIRRCLAYRKEDRID-----VQ-QLACDPYL--------------
YLLGI-----NLGEGSYAKV---KSAYS---E-RLKF---NVAIKIIDRKK-APADFLE-KFLP------------------------REIEIL-AML--N------HCS--IIKTYEIFET------------------------------------SHGKVY--IVMEL-AVQG--DLLELIK----TRGALHEDEARKKFHQLSLAIKYCHDL-----DVVHRDLKCDNLLLD---KDFNI---------KLSDFSFSKRCLR-------------DDSGRMALSKTFCGSPAYAAPEVLQ-----------------GIPY--QPKVYDIWSLGVILYIMVC-GS-MPYD-DS---------------NI-KKMLRIQKEHRVNFPRSKHLT------------------------------------------------------GECKDLIYHMLQPDVNRRLH-----ID-EILSHCWM--------------
---FI--LTERLGSGTYATV---YKAYA---KKDTRE---VVAIKCVAKKS-LNKASVE-NLLT-------------------------EIEIL-KGI--R------HPH--IVQLKDFQWD-------------------------------------SDNIY--LIMEF-CAGG--DLSRFIH----TRRILPEKVARVFMQQLASALQFLHER-----NISHLDLKPQNILLSS-LEKPHL---------KLADFGFAQH------------------MSPWDEKHVLRGSPLYMAPEMVC------------------QRQ--YDARVDLWSMGVILYEALF-GQ-PPFA-SR------------SFSEL-EEKIRSNRVIELPLRPLLS--------------------------------------------------------RDCRDLLQRLLERDPSRRIS-----FQ-DFFAHPWV--------------
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