|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MERTK 203
TK ALK 1116
TK BTK 402
TK INSR 1023
TK INSRR 979
TK MUSK 575
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
-L-ILGKILGEGEFGSVMEGNLK--QEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKIYSGDYY--------------RQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQ-L-
-I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLP-----RFILLELMAGGDLKSFLRETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY--------------RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I-
--LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIK-EGSMSE--DEFIEEAKVMMNLSHEKLVQLYGVCTKQRP-----IFIITEYMANGCLLNYLREM-----------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVVKVSDFGLSRYV-LDDEY--------------TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSN-I-
--ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQP-----TLVVMELMAHGDLKSYLRSLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDIYETDYY--------------RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL--
-I-SIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN-ELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQP-----TLVIMELMTRGDLKSHLRSLRPEA--------------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ---DFTVKIGDFGMTRDVYETDYY--------------RKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILD--SI
-I-EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK-EEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKP-----MCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE---NMVVKIADFGLSRNIYSADYY--------------KANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL--
IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESA-RQDFQREAELLTMLQHQHIVRFFGVCTEGRP-----LLMVFEYMRHGDLNRFLRSHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDIYSTDYY--------------RVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL--
-I-VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNA-RKDFHREAELLTNLQHEHIVKFYGVCVEGDP-----LIMVFEYMKHGDLNKFLRAHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDVYSTDYY--------------RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L-
-I-VLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK-DPTLAA-RKDFQREAELLTNLQHEHIVKFYGVCGDGDP-----LIMVFEYMKHGDLNKFLRAHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL--
|