|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MERTK 203
TK ALK 1116
TK FGFR2 481
L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDF-SHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL----------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQ-L
I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSLQSLP-----RFILLELMAGGDLKSFLRETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP-----LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-
|