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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
CMGC CDK2 4
TK EGFR 712
TK KDR 834
TK RET 724
-VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLN-RITD-IGEVSQFL-TEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR---NE-----------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYLLQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I--
-FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV--PSTAIREISLLKEL-NHPNIVKLLDVIH-TENKLYLVFEFLHQ-DLKKFMDASALT-------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVR---EH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
-LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLR---SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK--DPDY--VRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTT----------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
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