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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
CMGC CDK2 4
TK EGFR 712
TK INSR 1023
TK KDR 834
TK RET 724
TKL RIPK2 18
---VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLN-RITD-IGEVSQFL-T-EGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR---NE-----------------------------------------------------------------THNP---TVKDLIGFGLQVAKGMKYLASK--KFVHRDLAARNCMLDEKFTVKVADFGLARDM--Y---D--KEYYSVHNKTGAKLPVKWMALESLQ---TQKFTTKSDVWSFGVLLWELMTRGAPPYPDV---NTFDITVYLLQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I---
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIH-TENKLYLVFEFLHQ-DLKKFMDASALT-------------------------------------------------------------------GI---PLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLLINTEGAIKLADFGLARAF------GVPVRTY--TH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD---SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
--F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EATS-PKANKEIL-D-EAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVR---EH-----------------------------------------------------------------KDNI---GSQYLLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVKTPQHVKITDFGLAKLL--G---A--EEKE--YHAEGGKVPIKWMALESIL---HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI---PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESAS-LRERIEFL-N-EASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLR---SLRPEA--------------------------------------------------------ENNPGRPPP---TLQEMIQMAAEIADGMAYLNAK--KFVHRDLAARNCMVAHDFTVKIGDFGMTRDI--Y---E--TDYY--RKGGKGLLPVRWMAPESLK---DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL---SNEQVLKFVMDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
---LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGAT-HSEHRALM-S-ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLR---SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFL---TLEHLICYSFQVAKGMEFLASR--KCIHRDLAARNILLSEKNVVKICDFGLARDI--Y---K--DPDY--VRKGDARLPLKWMAPETIF---DRVYTIQSDVWSFGVLLWEIFSLGASPYPGV-K-IDEEFCRRLKEGTRMRAPDYTT----------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL-----
--L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELRDLL-S-EFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAEM--KLVHRDLAARNILVAEGRKMKISDFGLSRDV--Y---E--EDSY--VKRSQGRIPVKWMAIESLF---DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI---PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
LAD---LRYLSRGASGTVSSARHA-----DWRVQVAVKHLHIHTPLLDS--ERKDVLREAEILHKA-RFSYILPILGICN-EPEFLGIVTEYMPNGSLNELLH--RKT-------------------------------------------------------------------EYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMM-SLSQSRSSKS--AP---EGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLS-RKQPFEDVT-NPLQIMYSVSQGHRPVINEESLPYDIPHR----------------------ARMISLIESGWAQNPDERPSFLKCL-----IEL
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