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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE MST4 203
TK JAK2 849
TK JAK3 822
STE MAP3K8 136
----FTKLERIGKGSFGEVFKGIDN----RTQQVVAIKIIDLEEAEDEI--EDIQQEITVLSQCDSSYVTKYYGSYL--KGSKLWIIMEYLGGGSALDLLR-AG--PFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQL--TDTQIKRNT---FVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAK-GEPP---------------NSDM-HPMRVLFLIPKNNPPTLVGDFT------KSFKEFIDACLNKDPSFRPTAKELLKHKFI--
----LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE--EHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
---L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGP-DQ-QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
GSDF------IPRGAFGKVYLAQDI----KTKKRMACKLIPVDQFKPSD--------VEIQACFRHENIAELYGAVL--WGETVHLFMEAGEGGSVLEKLESCG--PMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFM-STKAVLVDFGLSVQM--TEDVYFPKD---LRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQT-GTPP---------------WVKR-YPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHE--AL
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