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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other NEK2 203
CAMK CHEK1 9
CAMK CHEK2 220
CAMK MAPKAPK2 64
Other NEK1 4
CAMK PIM1 38
TK PTK2 422
TK SRC 270
---YEVLYTIGTGSYGRCQKIRRK---SDGKILVWKELDYGSMTEAE--KQMLVS------EVNLLREL-KHPN--IVRYYDRIIDR--TNTTLYIVMEYCEGG-DLASVITKGTKERQ---YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV---KLGDFGLARIL--NHDTSFAKT---FVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF----SQKELAGKIREGKFRRIPYRY---SDELNEIITRMLNLKDYHRPSVEEILENPL-I
--W-DLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMKRAVDCP--ENI-KK------EICINKML-NHEN--VVKFYGHRRE----GNIQYLFLEYCSGG-ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP---SDSCQEYSDWKEKKTYLNPWKKI--DSAPLALLHKILVENPSARITIPDIKKDRW-Y
-YI--MSKTLGSGACGEVKLAFER---KTCKKVAIKIISKRKFAIGS--AREADPALNVETEIEILKKL-NHPC--IIKIKNFF-D----AEDYYIVLELMEGG-ELFDKVV----GNK---RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI---LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL-
KVT---SQVLGLGINGKVLQIFNK---RTQEKFALKMLQDCPKAR---------R------EVELHWRASQCPH--IVRIVDVYENLYAGRKCLLIVMECLDGG-ELFSRIQD--RGDQ---AFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE---TTSHNSLTT---PCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-
--Y-VRLQKIGEGSFGKAILVKST---EDGRQYVIKEINISRMSSKE--REESRR------EVAVLANM-KHPN--IVQYRESFEE----NGSLYIVMDYCEGG-DLFKRINA--QKGV---LFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLT-KDGTV---QLGDFGIARVL--NSTVELART---CIGTPYYLSPEICE---NKPYNNKSDIWALGCVLYELCT-LKHAFEAG----SMKNLVLKIISGSFPPVSLHYS---YDLRSLVSQLFKRNPRDRPSVNSILEKGF-I
---YQVGPLLGSGGFGSVYSGIRV---SDNLPVAIKHVEKDRISDWG--ELPNGTRV--PMEVVLLKKV-SSGFSGVIRLLDWFER----PDSFVLILERPEPVQDLFDFIT----ERG---ALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL---KLIDFGSGA----LLKDTVYTD---FDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD----------EEIIRGQVFFRQRVS----SECQHLIRWCLALRPSDRPTFEEIQNHPWM-
---IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTS-DSVREKFL-Q------EALTMRQF-DHPH--IVKLIGVIT-----ENPVWIIMELCTLG-ELRSFLQ-----VR-KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVS-SNDCV---KLGDFGLSRYM--E--DSTYYKASKGKLPIKWMAPESIN---FRRFTSASDVWMFGVCMWEILMHGVKPFQGV-KNNDVIGRIENGERLPMPPNCP------PTLYSLMTKCWAYDPSRRPRFTELKAQL---
--L-RLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLK-PGTM-SP--EAFL-Q------EAQVMKKL-RHEK--LVQLYAVVS-----EEPIYIVTEYMSKG-SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVG-ENLVC---KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCPPECP------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-
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