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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other NEK2 203
CAMK CHEK1 9
CAMK CHEK2 220
Other NEK1 4
--YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS------EVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV---KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCALMPPFTAF-SQKELAGKIREGKFRRIPYRY---SDELNEIITRMLNLKDYHRPSVEEILENPL-I
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK------EICINKMLNHENVVKFYGHRRE--GNIQYLFLEYCSGGELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLDERDNL---KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKI--DSAPLALLHKILVENPSARITIPDIKKDRW-Y
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-D--AEDYYIVLELMEGGELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL-
-Y-VRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRR------EVAVLANMKHPNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINA--QKGVLFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLTKDGTV---QLGDFGIARVL--NSTVELARTCIGTPYYLSPEICE---NKPYNNKSDIWALGCVLYELCTLKHAFEAG-SMKNLVLKIISGSFPPVSLHYS---YDLRSLVSQLFKRNPRDRPSVNSILEKGF-I
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