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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
Other AURKA 133
Other AURKB 77
CAMK BRSK1 50
CAMK BRSK2 19
CMGC CDK2 4
CMGC CDK5 4
CMGC CDK6 13
CAMK CHEK2 220
CMGC GSK3A 119
CMGC GSK3B 56
CAMK MELK 11
CAMK NUAK1 55
CAMK PHKG1 20
TK RET 724
AGC RPS6KA1 62
AGC RPS6KA2 59
CAMK STK11 49
CAMK STK17A 61
CAMK STK33 116
--F-KFGKILGEGSFSTV---VLAREL-----ATSR---EYAIKILEKRH-IIKEN--KVPYVTR-------ERDVMSRL-D---HPFFVKLYFTFQD-----DEKLY--FGLSYAKNG--ELLKYIR----KIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---------QITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---FEIGRPLGKGKFGNV---YLAREK-----QSKF---ILALKVLFKAQLEKAGV--EH-QLRR-------EVEIQSHL-R---HPNILRLYGYFHD-----ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---------KIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
---FEIGRPLGKGKFGNV---YLAREK-----KSHF---IVALKVLFKSQ-IEKEG--VE-HQLR------REIEIQAHL-H---HPNILRLYNYFYD-----RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---------KIADFGWSV-----HAPSLRRKT---MCGTLDYLPPEMIE------GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV-----------
---YRLEKTLGKGQTGLV---KLGVHC-----ITGQ---KVAIKIVNREK-LSESV--LM-KVER-------EIAILKLI-E---HPHVLKLHDVYEN-----KKYLY--LVLEHVSGG--ELFDYLV----KKG-------------------------RLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-EKNNI---------RIADFGMASL----QVGDSLLET---SCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP--------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
---YRLEKTLGKGQTGLV---KLGVHC-----VTCQ---KVAIKIVNREK-LSESV--LM-KVER-------EIAILKLI-E---HPHVLKLHDVYEN-----KKYLY--LVLEHVSGG--ELFDYLV----KKG-------------------------RLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLD-EKNNI---------RIADFGMASL----QVGDSLLET---SCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP--------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
---FQKVEKIGEGTYGVV---YKARNK-----LTGE---VVALKKIRLDT-ETEGV--PS-TAIR-------EISLLKEL-N---HPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---------KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
---YEKLEKIGEGTYGTV---FKAKNR-----ETHE---IVALKRVRLDD-DDEGV--PS-SALR-------EICLLKEL-K---HKNIVRLHDVLHS-----DKKLT--LVFEFCDQ---DLKKYFD---SCNG-------------------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---------KLADFGLARAF---GIPVRCYSA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF-----------
---YECVAEIGEGAYGKV---FKARDL-----KNGG--RFVALKRVRVQT-GEEGM--PL-STIR-------EVAVLRHL-ETFEHPNVVRLFDVCTVSRTDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-------------------------GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI---------KLADFGLARI----YSFQMALTS---VVVTLWYRAPEVLL------QSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ--PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF-----------
-YI--MSKTLGSGACGEV---KLAFER-----KTCK---KVAIKIISKRK-FAIGS--AR-EADPALN-VETEIEILKKL-N---HPCIIKIKNFF-D-----AEDYY--IVLELMEGG--ELFDKVV----GNK-------------------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC------LIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
---YTDIKVIGNGSFGVV---YQARLA-----ETRE---LVAIKKVLQDK-RFKNR----------------ELQIMRKL-D---HCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---------KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-----------
---YTDTKVIGNGSFGVV---YQAKLC-----DSGE---LVAIKKVLQDK-RFKNR----------------ELQIMRKL-D---HCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---------KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
---YELHETIGTGGFAKV---KLACHI-----LTGE---MVAIKIMDKNT-LGSDL--PR-IKT--------EIEALKNL-R---HQHICQLYHVLET-----ANKIF--MVLEYCPGG--ELFDYII----SQD-------------------------RLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFD-EYHKL---------KLIDFGLCAKP--KGNKDYHLQT---CCGSLAYAAPELIQ-----GKSYLGSEADVWSMGILLYVLMC-GFLPFDDD---NVMALYKKIMRGKYDVPKWLS--------------------------PSSILLLQQMLQVDPKKRIS-----MKNLLNHPWI-----------
---YELQETLGKGTYGKV---KRATER-----FSGR---VVAIKSIRKDK-IKDEQ--DM-VHIR------REIEIMSSL-N---HPHIISIYEVFEN-----KDKIV--IIMEYASKG--ELYDYIS----ERR-------------------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI---------KIADFGLSNL----YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMPFDGF---DHKNLIRQISSGEYREPTQP---------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V----------
---YEPKEILGRGVSSVV---RRCIHK-----PTSQ---EYAVKVIDVTG-GGSFS--PE-EVRELREATLKEVDILRKVSG---HPNIIQLKDTYET-----NTFFF--LVFDLMKRG--ELFDYLT----EKV-------------------------TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD-DNMNI---------KLTDFGFSCQ----LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHR---KQMLMLRMIMSGNYQFGSPEWDDYS----------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF-----------
--L-VLGKTLGEGEFGKV---VKATAFHLKGRAGYT---TVAVKMLK-EN-AS-PSELRD-LL-S-------EFNVLKQV-N---HPHVIKLYGACSQ-----DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKM---------KISDFGLSRDV-Y-E--EDSYVKRSQGRIPVKWMAIESLF------DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-------------
---FELLKVLGQGSFGKVFLVRKVTRP-----DSGH---LYAMKVLKKAT-LKVRD--RV-RTKM-------ERDILADV-N---HPFVVKLHYAFQT-----EGKLY--LILDFLRGG--DLFTRLS----KEV-------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHI---------KLTDFGLSKEA---IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS--------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
---FELLKVLGQGSYGKV---FLVRKV-----KGSDAGQLYAMKVLKKAT-LKVRD--RV-RSKM-------ERDILAEV-N---HPFIVKLHYAFQT-----EGKLY--LILDFLRGG--DLFTRLS----KEV-------------------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI---------KITDFGLSKEA---IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLPFQGK---DRKETMALILKAKLGMPQFLS--------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
YLM---GDLLGEGSYGKV---KEVLDS-----ETLC---RRAVKILKKKK-LRRIP--NG-EANVK-----KEIQLLRRL-R---HKNVIQLVDVLYNE---EKQKMY--MVMEYCVCGMQEMLDSVP-----EK-------------------------RFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLT-TGGTL---------KISDLGVAEALH-PFAADDTCRT---SQGSPAFQPPEIAN----GLDTFSGFKVDIWSAGVTLYNITT-GLYPFEGD---NIYKLFENIGKGSYAIPGDCG--------------------------PPLSDLLKGMLEYEPAKRFS-----IRQIRQHSWF-----------
LCP---GRELGRGKFAVV---RKCIKK-----DSGK---EFAAKFMRKRR-KGQDC--RM-EIIH-------EIAVLELAQD---NPWVINLHEVYET-----ASEMI--LVLEYAAGG--EIFDQCVA--DREE-------------------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT-SESPLG------DIKIVDFGLSRI----LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GISPFLGN---DKQETFLNISQMNLSYSEEEFDVLS----------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL-----------
---YTFGRILGKGSFGIV---IEATDK-----ETET---KWAIKKVNKEK-AGSSA--VK-LLER-------EVNILKSV-K---HEHIIHLEQVFET-----PKKMY--LVMELCEDG--ELKEILD----RKG-------------------------HFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVK-SSLIDDNNEINLNIKVTDFGLAVKK--QSRSEAMLQA---TCGTPIYMAPEVIS------AHDYSQQCDIWSIGVVMYMLLR-GEPPFLAS---SEEKLFELIRKGELHFENAVWNSIS----------------------DCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL-----------
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