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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
TK ABL1 261
CMGC CDC2 4
CAMK CHEK1 9
TK EGFR 712
AGC PRKCD 349
AGC PRKCQ 380
-F-KFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRHIIKEN--KVPYVTR-ERDVMSRL-DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR---KIG---SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG-CE-EM------EGYGPLKAHPF
--ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLK-EDTM-EV--EE-FL-K-EAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR----ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPS-FA-EIHQA--F-----------
--YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGV--PS-TAIR-EISLLKEL-RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-GK-MALNHPYF-----------
-W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKRAVDCP--EN-I-KK-EICINKML-NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIE---PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSARIT-IP-DIKKDRW-Y----------
-F-KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATS-PKANKE-IL-D-EAYVMASV-DNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR----EH-KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-G-A--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPK-FR-ELI----IEF---------
FI--FHKVLGKGSFGKVLLGELK----GRGEYFAIKALKKDVVLIDD--DV-ECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQ---DKG---RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKEN---IFGESRAST---FCGTPDYIAPEILQ-GLKYTFSVDWWSFGVLLYEMLI-GQSPFHGD---DEDELFESIRVDTPHYPRWIT--------------------------KESKDILEKLFEREPTKRLGVTG-NIKIHPFF-----------
FI--LHKMLGKGSFGKVFLAEFK----KTNQFFAIKALKKDVVLMDD--DV-ECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQ---SCH---KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKEN---MLGDAKTNT---FCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLI-GQSPFHGQ---DEEELFHSIRMDNPFYPRWLE--------------------------KEAKDLLVKLFVREPEKRLG-VRGDIRQHPLF-----------
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