|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
AGC AKT3 148
Other AURKC 43
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK2 165
CMGC CDK2 4
CMGC CDK3 4
CMGC CDKL2 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC ICK 4
CAMK MAPKAPK2 64
CAMK MARK2 53
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK3 268
CMGC PCTK1 165
CAMK PHKG1 20
CAMK PIM2 132
CAMK PIM3 40
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCE 408
AGC PRKCH 355
CAMK PRKD2 551
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
CAMK STK17A 61
STE STK24 24
Other TLK2 440
---YQVGPLLGSGGFGSV---YSGIRVSDNL---PVAIKHVEKDRISDWGELPNGTRV---------------------PMEVVLLKKV-S----SGFSGVIRLLDWFER----PDSFVLILER-PEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHNC--GVLHRDIKDENILIDLNRGEL----KLIDFGSGA---------LLKDTVYTDFDGTRVYSPPEWIR-----YHRY--HGRSAAVWSLGILLYDMVCGDIPFE-HD----------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT-------FEEIQNHPWM--------------
-FD--YLKLLGKGTFGKV---ILVREKASGK---YYAMKILKKEVIIAKDEVAHTL------------------------TESRVLKNT-R----HPF--LTSLKYSFQT----KDRLCFVMEY-VNGG-ELFFHLS--RERVFSEDRTRFYGAEIVSALDYLHSG--KIVYRDLKLENLMLD-KDGHI----KITDFGLCKEG-------ITDAATMKTFCGTPEYLAPEVLE------DND--YGRAVDWWGLGVVMYEMMCGRLPFY-NQ----DHEKLFELILMEDIKFPRTLS----------------------------------SDAKSLLSGLLIKDPNKRLGGG--PDDAKEIMRHSFF--------------
---FEIGRPLGKGKFGNV---YLARLKESHF---IVALKVLFKSQIEKEGLEHQLR------------------------REIEIQAHL-Q----HPN--ILRLYNYFHD----ARRVYLILEY-APRG-ELYKELQ--KSEKLDEQRTATIIEELADALTYCHDK--KVIHRDIKPENLLLG-FRGEV----KIADFGWSV---------HTPSLRRKTMCGTLDYLPPEMIE------GRT--YDEKVDLWCIGVLCYELLVGYPPFE-SA----SHSETYRRILKVDVRFPLSMP----------------------------------LGARDLISRLLRYQPLERLP-------LAQILKHPWV--------------
---YQLFEELGKGAFSVV---RRCMKIPTGQ---EYAAKIINTKKLSARDHQKLER-------------------------EARICRLL-K----HPN--IVRLHDSISE----EGFHYLVFDL-VTGG-ELFEDIV--AREYYSEADASHCIQQILESVNHCHLN--GIVHRDLKPENLLLA-SKSKGA-AVKLADFGLAIEV-------QGDQQAWFGFAGTPGYLSPEVLR------KDP--YGKPVDMWACGVILYILLVGYPPFW-DE----DQHRLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKDLINKMLTINPAKRIT-------ASEALKHPWI--------------
---YQLFEELGKGAFSVV---RRCVKKTSTQ---EYAAKIINTKKLSARDHQKLER-------------------------EARICRLL-K----HPN--IVRLHDSISE----EGFHYLVFDL-VTGG-ELFEDIV--AREYYSEADASHCIHQILESVNHIHQH--DIVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV-------QGEQQAWFGFAGTPGYLSPEVLR------KDP--YGKPVDIWACGVILYILLVGYPPFW-DE----DQHKLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKNLINQMLTINPAKRIT-------ADQALKHPWV--------------
---YTLKDEIGKGSYGVV---KLAYNENDNT---YYAMKVLSKKKLIRQAGFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D----HPN--VVKLVEVLDDP--NEDHLYMVFEL-VNQG-PVMEVPT---LKPLSEDQARFYFQDLIKGIEYLHYQ--KIIHRDIKPSNLLVG-EDGHI----KIADFGVSNEF-------KGSDALLSNTVGTPAFMAPESLS-----ETRKIFSGKALDVWAMGVTLYCFVFGQCPFM-DE----RIMCLHSKIKSQALEFPDQPDIA--------------------------------EDLKDLITRMLDKNPESRIV-------VPEIKLHPWV--------------
---FQKVEKIGEGTYGVV---YKARNKLTGE---VVALKKIRLDTETEGVPSTAIR-------------------------EISLLKEL-N----HPN--IVKLLDVIHT----ENKLYLVFEF-LHQ--DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF-------GVPVRTYTHEVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVTRRALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AKAALAHPFF--------------
---FQKVEKIGEGTYGVV---YKAKNRETGQ---LVALKKIRLDLEMEGVPSTAIR-------------------------EISLLKEL-K----HPN--IVRLLDVVHN----ERKLYLVFEF-LSQ--DLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSH--RVIHRDLKPQNLLIN-ELGAI----KLADFGLARAF-------GVPLRTYTHEVVTLWYRAPEILL-----GSKF--YTTAVDIWSIGCIFAEMVTRKALFP-GD-SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR--------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-------AKTALAHPYF--------------
---YENLGLVGEGSYGMV---MKCRNKDTGR---IVAIKKFLESDDDKMVKKIAMR-------------------------EIKLLKQL-R----HEN--LVNLLEVCKK----KKRWYLVFEF-VDHT-ILDDLEL--FPNGLDYQVVQKYLFQIINGIGFCHSH--NIIHRDIKPENILVS-QSGVV----KLCDFGFARTL-------AAPGEVYTDYVATRWYRAPELLV-----GDVK--YGKAVDVWAIGCLVTEMFMGEPLFP-GD-SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-------CAELLHHDFF--------------
---FEILGVVGEGAYGVV---LKCRHKETHE---IVAIKKFKDSEENEEVKETTLR-------------------------ELKMLRTL-K----QEN--IVELKEAFRR----RGKLYLVFEY-VEK--NMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCHKN--DIVHRDIKPENLLIS-HNDVL----KLCDFGFARNL------SEGNNANYTEYVATRWYRSPELLL------GAP--YGKSVDMWSVGCILGELSDGQPLFP-GE-SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH-----PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-------TEQCLNHPTF--------------
--W-DLVQTLGEGAYGEV---QLAVNRVTEE---AVAVKIVDMKRAVDCPENI-KK-------------------------EICINKML-N----HEN--VVKFYGHRRE----GNIQYLFLEY-CSGG-ELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLHGI--GITHRDIKPENLLLD-ERDNL----KISDFGLATVFR-----YNNRERLLNKMCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLAGELPWD-QP---SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARIT-------IPDIKKDRW-Y-------------
-YI--MSKTLGSGACGEV---KLAFERKTCK---KVAIKIISKRKFAIGSAREADPALN-------------------VETEIEILKKL-N----HPC--IIKIKNFF-D----AEDYYIVLEL-MEGG-ELFDKVV--GNKRLKEATCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI--------LGETSLMRTLCGTPTYLAPEVLVS---VGTAG--YNRAVDCWSLGVILFICLSGYPPFS-EH---RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT-------TEEALRHPWL--------------
---YQLVRKLGRGKYSEV---FEAINITNNE---KVVVKILKPVKKKKIKR------------------------------EIKILENLRG----GPN--IITLADIVKDP--VSRTPALVFEH-VNNT-DFKQLY-----QTLTDYDIRFYMYEILKALDYCHSM--GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF--------YHPGQEYNVRVASRYFKGPELLV-----DYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-------AREAMEHPYF--------------
---YQLVRKLGRGKYSEV---FEAINITNNE---RVVVKILKPVKKKKIKR------------------------------EVKILENLRG----GTN--IIKLIDTVKDP--VSKTPALVFEY-INNT-DFKQLY-----QILTDFDIRFYMYELLKALDYCHSK--GIMHRDVKPHNVMIDHQQKKL----RLIDWGLAEF--------YHPAQEYNVRVASRYFKGPELLV-----DYQM--YDYSLDMWSLGCMLASMIFRREPFFHGQ-DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-------AKEAMEHPYF--------------
---YDTGEELGSGQFAVV---KKCREKSTGL---QYAAKFIKKRRTKSSRRGVSREDI---------------------EREVSILKEI-Q----HPN--VITLHEVYEN----KTDVILILEL-VAGG-ELFDFLA--EKESLTEEEATEFLKQILNGVYYLHSL--QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK--------IDFGNEFKNIFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLSGASPFL-GD----TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMT-------IQDSLQHPWI--------------
---YDIGEELGSGQFAIV---KKCREKSTGL---EYAAKFIKKRQSRASRRGVSREEI---------------------EREVSILRQV-L----HHN--VITLHDVYEN----RTDVVLILEL-VSGG-ELFDFLA--QKESLSEEEATSFIKQILDGVNYLHTK--KIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE--------IEDGVEFKNIFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLSGASPFL-GD----TKQETLANITAVSYDFDEEFFSQTS------------------------------ELAKDFIRKLLVKETRKRLT-------IQEALRHPWI--------------
---YEMGEELGSGQFAIV---RKCRQKGTGK---EYAAKFIKKRRLSSSRRGVSREEI---------------------EREVNILREI-R----HPN--IITLHDIFEN----KTDVVLILEL-VSGG-ELFDFLA--EKESLTEDEATQFLKQILDGVHYLHSK--RIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK--------IEAGNEFKNIFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLSGASPFL-GE----TKQETLTNISAVNYDFDEEYFSNTS------------------------------ELAKDFIRRLLVKDPKRRMT-------IAQSLEHSWI--------------
---YTTIRQLGDGTYGSV---LLGRSIESGE---LIAIKKMKRKFYSWEEC-MNLR-------------------------EVKSLKKL-N----HAN--VVKLKEVIRE----NDHLYFIFEY-MKE--NLYQLIK-ERNKLFPESAIRNIMYQILQGLAFIHKH--GFFHRDLKPENLLCM-GPELV----KIADFGLARE--------IRSKPPYTDYVSTRWYRAPEVLL-----RSTN--YSSPIDVWAVGCIMAEVYTLRPLFP-GA-SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV-------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-------ASQALRYPYF--------------
KVT---SQVLGLGINGKV---LQIFNKRTQE---KFALKMLQDCPKAR-------R-------------------------EVELHWRASQ----CPH--IVRIVDVYENLYAGRKCLLIVMEC-LDGG-ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI--NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE--------TTSHNSLTTPCYTPYYVAPEVLG------PEK--YDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMT-------ITEFMNHPWI--------------
---YRLLKTIGKGNFAKV---KLARHILTGK---EVAVKIIDKTQLNSSSLQKLFR-------------------------EVRIMKVL-N----HPN--IVKLFEVIET----EKTLYLVMEY-ASGG-EVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQK--FIVHRDLKAENLLLD-ADMNI----KIADFGFSNE--------FTFGNKLDTFCGSPPYAAPELFQ-----GKKY--DGPEVDVWSLGVILYTLVSGSLPFD-GQ----NLKELRERVLRGKYRIPFYMS----------------------------------TDCENLLKKFLILNPSKRGT-------LEQIMKDRWM--------------
---YELQETLGKGTYGKV---KRATERFSGR---VVAIKSIRKDKIKDEQDMVHIR------------------------REIEIMSSL-N----HPH--IISIYEVFEN----KDKIVIIMEY-ASKG-ELYDYIS--ERRRLSERETRHFFRQIVSAVHYCHKN--GVVHRDLKLENILLD-DNCNI----KIADFGLSNL--------YQKDKFLQTFCGSPLYASPEIVN-----GRPY--RGPEVDSWALGVLLYTLVYGTMPFD-GF----DHKNLIRQISSGEYREPTQP-----------------------------------SDARGLIRWMLMVNPDRRAT-------IEDIANHWW-V-------------
---YEFLETLGKGTYGKV---KKARESSGR----LVAIKSIRKDKIKDEQDLMHIR------------------------REIEIMSSL-N----HPH--IIAIHEVFEN----SSKIVIVMEY-ASRG-DLYDYIS--ERQQLSEREARHFFRQIVSAVHYCHQN--RVVHRDLKLENILLD-ANGNI----KIADFGLSNL--------YHQGKFLQTFCGSPLYASPEIVN-----GKPY--TGPEVDSWSLGVLLYILVHGTMPFD-GH----DHKILVKQISNGAYREPPK-----P------------------------------SDACGLIRWLLMVNPTRRAT-------LEDVASHWW-V-------------
---YTRFEKIGQGASGTV---YTALDIATGQ---EVAIKQMNLQQQPKKELII--N-------------------------EILVMREN-K----NPN--IVNYLDSYLV----GDELWVVMEY-LAGG-SLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNILLG-MDGSV----KLTDFGFCAQI-------TPEQSKRSTMVGTPYWMAPEVVT------RKA--YGPKVDIWSLGIMAIEMVEGEPPYL-NE-NPLRALYLIATNGTPELQNPERLS----------------------------------AVFRDFLNRCLEMDVDRRGS-------AKELLQHPFL--------------
--Y-IKLDKLGEGTYATV---YKGKSKLTDN---LVALKEIRLEHEEGAPC-TAIR-------------------------EVSLLKDL-K----HAN--IVTLHDIIHT----EKSLTLVFEY-LDK--DLKQYLD-DCGNIINMHNVKLFLFQLLRGLAYCHRQ--KVLHRDLKPQNLLIN-ERGEL----KLADFGLARAK-------SIPTKTYSNEVVTLWYRPPDILL-----GSTD--YSTQIDMWGVGCIFYEMATGRPLFP-GS-TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR-------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-------AEDAMKHPFF--------------
---YEPKEILGRGVSSVV---RRCIHKPTSQ---EYAVKVIDVTGGGSFSPEEVRELRE------------------ATLKEVDILRKVSG----HPN--IIQLKDTYET----NTFFFLVFDL-MKRG-ELFDYLT--EKVTLSEKETRKIMRALLEVICTLHKL--NIVHRDLKPENILLD-DNMNI----KLTDFGFSCQ--------LEPGERLREVCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLAGSPPFW-HR----KQMLMLRMIMSGNYQFGSPEWDDYS------------------------------DTVKDLVSRFLVVQPQNRYT-------AEEALAHPFF--------------
---YRLGPLLGKGGFGTV---FAGHRLTDRL---QVAIKVIPRNRVLGWSPLSDSVTC---------------------PLEVALLWKV-GAGGGHPG--VIRLLDWFET----QEGFMLVLERPLPAQ-DLFDYIT--EKGPLGEGPSRCFFGQVVAAIQHCHSR--GVVHRDIKDENILIDLRRGCA----KLIDFGSGA---------LLHDEPYTDFDGTRVYSPPEWIS-----RHQY--HALPATVWSLGILLYDMVCGDIPFE-RD----------QEILEAELHFPAHVS----------------------------------PDCCALIRRCLAPKPSSRPS-------LEEILLDPWM--------------
---YQVGAVLGSGGFGTV---YAGSRIADGL---PVAVKHVVKERVTEWGSLGGATV----------------------PLEVVLLRKV-GAAGGARG--VIRLLDWFER----PDGFLLVLER-PEPAQDLFDFIT--ERGALDEPLARRFFAQVLAAVRHCHSC--GVVHRDIKDENLLVDLRSGEL----KLIDFGSGA---------LLKDTVYTDFDGTRVYSPPEWIR-----YHRY--HGRSATVWSLGVLLYDMVCGDIPFE-QD----------EEILRGRLLFRRRVS----------------------------------PECQQLIRWCLSLRPSERPS-------LDQIAAHPWM--------------
--F-NFLMVLGKGSFGKV---MLADRKGTEE---LYAIKILKKDVVIQDDDVECTM------------------------VEKRVLALLDK----PPF--LTQLHSCFQT----VDRLYFVMEY-VNGG-DLMYHIQ--QVGKFKEPQAVFYAAEISIGLFFLHKR--GIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEH-------MMDGVTTRTFCGTPDYIAPEIIA------YQP--YGKSVDWWAYGVLLYEMLAGQPPFD-GE----DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLG-------C---------GPEGERDVREHAFF
--F-NFLMVLGKGSFGKV---MLSERKGTDE---LYAVKILKKDVVIQDDDVECTM------------------------VEKRVLALPGK----PPF--LTQLHSCFQT----MDRLYFVMEY-VNGG-DLMYHIQ--QVGRFKEPHAVFYAAEIAIGLFFLQSK--GIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEN-------IWDGVTTKTFCGTPDYIAPEIIA------YQP--YGKSVDWWAFGVLLYEMLAGQAPFE-GE----DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGKRLG-------C---------GPEGERDIKEHAFF
--F-NFIKVLGKGSFGKV---MLAELKGKDE---VYAVKVLKKDVILQDDDVDCTM------------------------TEKRILALARK----HPY--LTQLYCCFQT----KDRLFFVMEY-VNGG-DLMFQIQ--RSRKFDEPRSRFYAAEVTSALMFLHQH--GVIYRDLKLDNILLD-AEGHC----KLADFGMCKEG-------ILNGVTTTTFCGTPDYIAPEILQ------ELE--YGPSVDWWALGVLMYEMMAGQPPFE-AD----NEDDLFESILHDDVLYPVWLS----------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHP--FF------------
---FEFIRVLGKGSFGKV---MLARVKETGD---LYAVKVLKKDVILQDDDVECTM------------------------TEKRILSLARN----HPF--LTQLFCCFQT----PDRLFFVMEF-VNGG-DLMFHIQ--KSRRFDEARARFYAAEIISALMFLHDK--GIIYRDLKLDNVLLD-HEGHC----KLADFGMCKEG-------ICNGVTTATFCGTPDYIAPEILQ------EML--YGPAVDWWAMGVLLYEMLCGHAPFE-AE----NEDDLFEAILNDEVVYPTWLH----------------------------------EDATGILKSFMTKNPTMRLGSLT-QGGEHAILRHPF-F-------------
-PD----EVLGSGQFGVV---YGGKHRKTGR---DVAVKVIDKLRFPTKQESQLRN-------------------------EVAILQSL-R----HPG--IVNLECMFET----PEKVFVVMEK-LHGD-MLEMILS-SEKGRLPERLTKFLITQILVALRHLHFK--NIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI--------IGEKSFRRSVVGTPAYLAPEVLL------NQG--YNRSLDMWSVGVIMYVSLSGTFPFN-ED------EDINDQIQNAAFMYPASPWSHIS------------------------------AGAIDLINNLLQVKMRKRYS-------VDKSLSHPWL--------------
---FELLKVLGQGSFGKVFLVRKVTRPDSGH---LYAMKVLKKATLKVRDRVRTKM-------------------------ERDILADV-N----HPF--VVKLHYAFQT----EGKLYLILDF-LRGG-DLFTRLS--KEVMFTEEDVKFYLAELALGLDHLHSL--GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA-------IDHEKKAYSFCGTVEYMAPEVVN------RQG--HSHSADWWSYGVLMFEMLTGSLPFQ-GK----DRKETMTLILKAKLGMPQFLS----------------------------------TEAQSLLRALFKRNPANRLGSG--PDGAEEIKRHV--FY------------
---FELLKVLGQGSYGKV---FLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-------------------------ERDILAEV-N----HPF--IVKLHYAFQT----EGKLYLILDF-LRGG-DLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSL--GIIYRDLKPENILLD-EEGHI----KITDFGLSKEA-------IDHDKRAYSFCGTIEYMAPEVVN------RRG--HTQSADWWSFGVLMFEMLTGSLPFQ-GK----DRKETMALILKAKLGMPQFLS----------------------------------GEAQSLLRALFKRNPCNRLGAG--IDGVEEIKRHPFF--------------
---FELLKVLGQGSFGKV---FLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM-------------------------ERDILVEV-N----HPF--IVKLHYAFQT----EGKLYLILDF-LRGG-DLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSL--GIIYRDLKPENILLD-EEGHI----KLTDFGLSKES-------IDHEKKAYSFCGTVEYMAPEVVN------RRG--HTQSADWWSFGVLMFEMLTGTLPFQ-GK----DRKETMTMILKAKLGMPQFLS----------------------------------PEAQSLLRMLFKRNPANRLGAG--PDGVEEIKRHSFF--------------
---FELLKVLGQGSFGKV---FLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-------------------------ERDILVEV-N----HPF--IVKLHYAFQT----EGKLYLILDF-LRGG-DVFTRLS--KEVLFTEEDVKFYLAELALALDHLHQL--GIVYRDLKPENILLD-EIGHI----KLTDFGLSKES-------VDQEKKAYSFCGTVEYMAPEVVN------RRG--HSQSADWWSYGVLMFEMLTGTLPFQ-GK----DRNETMNMILKAKLGMPQFLS----------------------------------AEAQSLLRMLFKRNPANRLGS----EGVEEIKRHLFF--------------
LCP---GRELGRGKFAVV---RKCIKKDSGK---EFAAKFMRKRRKGQDCRMEIIH-------------------------EIAVLELAQD----NPW--VINLHEVYET----ASEMILVLEY-AAGG-EIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR--DVVHLDLKPQNILLT-SESPLG-DIKIVDFGLSRI--------LKNSEELREIMGTPEYVAPEILS------YDP--ISMATDMWSIGVLTYVMLTGISPFL-GN----DKQETFLNISQMNLSYSEEEFDVLS------------------------------ESAVDFIRTLLVKKPEDRAT-------AEECLKHPWL--------------
---FTKLEKIGKGSFGEV---FKGIDNRTQK---VVAIKIIDLEEAEDEIEDIQ-Q-------------------------EITVLSQC-D----SPY--VTKYYGSYLK----DTKLWIIMEY-LGGG-SALDLLE---PGPLDETQIATILREILKGLDYLHSE--KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL-------TDTQIKRNTFVGTPFWMAPEVIK------QSA--YDSKADIWSLGITAIELARGEPPHS-EL-HPMKVLFLIPKNNPPTLEGNYS------------------------------------KPLKEFVEACLNKEPSFRPT-------AKELLKHKFI--------------
-YL--LLHLLGRGGFSEV---YKAFDLTEQR---YVAVKIHQLNKNWRDEKKENYHKH--------------------ACREYRIHKEL-D----HPR--IVKLYDYFSL---DTDSFCTVLEY-CEGN-DLDFYLK--QHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLV-NGTACG-EIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVV--GKEPPK--ISNKVDVWSVGVIFYQCLYGRKPFG-HN--QSQQDILQENTILKATEVQFPPKPVVT------------------------------PEAKAFIRRCLAYRKEDRID-------VQQLACDPYL--------------
|