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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
Other AURKA 133
CAMK PIM2 132
Other PLK2 82
-YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGELPNGTRVPMEVVLLKKVS----SGFSGVIRLLDWFERPDSFVLILER-PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
-FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR----EVEIQSHLR----HPN--ILRLYGYFHDATRVYLILEY-APLG-TVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
-YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNR-VLGWSPLSDSVTCPLEVALLWKVGAGGGHPG--VIRLLDWFETQEGFMLVLERPLPAQ-DLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGA--LLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM
Y-CRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSR-VAKPHQREKID---KEIELHRILH----HKH--VVQFYHYFEDKENIYILLEY-CSRR-SMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN-EAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFF
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