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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
AGC AKT3 148
Other AURKC 43
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK2 165
CMGC CDK2 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC ICK 4
CAMK MARK2 53
CAMK NUAK1 55
CAMK NUAK2 97
CMGC PCTK1 165
CAMK PHKG1 20
CAMK PIM2 132
CAMK PIM3 40
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCE 408
AGC PRKCH 355
CAMK PRKD2 551
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
STE STK24 24
--YQVGPLLGSGGFGSV---YSGIRVSDNL---PVAIKHVEKDRISDWGELPNGTRV---------------------PMEVVLLKKV-S----SGFSGVIRLLDWFER--PDSFVLILER-PEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR-----YHRY--HGRSAAVWSLGILLYDMVCGDIPFE-HD---------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT-------FEEIQNHPWM--------------
FD--YLKLLGKGTFGKV---ILVREKASGK---YYAMKILKKEVIIAKDEVAHTL------------------------TESRVLKNT-R----HPF--LTSLKYSFQT--KDRLCFVMEY-VNGG-ELFFHLS--RERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD-KDGHI----KITDFGLCKEG--ITDAATMKTFCGTPEYLAPEVLE------DND--YGRAVDWWGLGVVMYEMMCGRLPFY-NQ---DHEKLFELILMEDIKFPRTLS----------------------------------SDAKSLLSGLLIKDPNKRLGGG--PDDAKEIMRHSFF--------------
--FEIGRPLGKGKFGNV---YLARLKESHF---IVALKVLFKSQIEKEGLEHQLR------------------------REIEIQAHL-Q----HPN--ILRLYNYFHD--ARRVYLILEY-APRG-ELYKELQ--KSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEV----KIADFGWSV----HTPSLRRKTMCGTLDYLPPEMIE------GRT--YDEKVDLWCIGVLCYELLVGYPPFE-SA---SHSETYRRILKVDVRFPLSMP----------------------------------LGARDLISRLLRYQPLERLP-------LAQILKHPWV--------------
--YQLFEELGKGAFSVV---RRCMKIPTGQ---EYAAKIINTKKLSARDHQKLER-------------------------EARICRLL-K----HPN--IVRLHDSISE--EGFHYLVFDL-VTGG-ELFEDIV--AREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLA-SKSKGA-AVKLADFGLAIEV--QGDQQAWFGFAGTPGYLSPEVLR------KDP--YGKPVDMWACGVILYILLVGYPPFW-DE---DQHRLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKDLINKMLTINPAKRIT-------ASEALKHPWI--------------
--YQLFEELGKGAFSVV---RRCVKKTSTQ---EYAAKIINTKKLSARDHQKLER-------------------------EARICRLL-K----HPN--IVRLHDSISE--EGFHYLVFDL-VTGG-ELFEDIV--AREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV--QGEQQAWFGFAGTPGYLSPEVLR------KDP--YGKPVDIWACGVILYILLVGYPPFW-DE---DQHKLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKNLINQMLTINPAKRIT-------ADQALKHPWV--------------
--YTLKDEIGKGSYGVV---KLAYNENDNT---YYAMKVLSKKKLIRQAGFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D----HPN--VVKLVEVLDDPNEDHLYMVFEL-VNQG-PVMEVPT---LKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHI----KIADFGVSNEF--KGSDALLSNTVGTPAFMAPESLS-----ETRKIFSGKALDVWAMGVTLYCFVFGQCPFM-DE---RIMCLHSKIKSQALEFPDQPDIA--------------------------------EDLKDLITRMLDKNPESRIV-------VPEIKLHPWV--------------
--FQKVEKIGEGTYGVV---YKARNKLTGE---VVALKKIRLDTETEGVPSTAIR-------------------------EISLLKEL-N----HPN--IVKLLDVIHT--ENKLYLVFEF-LHQ--DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AKAALAHPFF--------------
--FEILGVVGEGAYGVV---LKCRHKETHE---IVAIKKFKDSEENEEVKETTLR-------------------------ELKMLRTL-K----QEN--IVELKEAFRR--RGKLYLVFEY-VEK--NMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS-HNDVL----KLCDFGFARNL-SEGNNANYTEYVATRWYRSPELLL------GAP--YGKSVDMWSVGCILGELSDGQPLFP-GESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH-----PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-------TEQCLNHPTF--------------
-W-DLVQTLGEGAYGEV---QLAVNRVTEE---AVAVKIVDMKRAVDCPENI-KK-------------------------EICINKML-N----HEN--VVKFYGHRRE--GNIQYLFLEY-CSGG-ELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL----KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLAGELPWD-QP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARIT-------IPDIKKDRW-Y-------------
YI--MSKTLGSGACGEV---KLAFERKTCK---KVAIKIISKRKFAIGSAREADPALN-------------------VETEIEILKKL-N----HPC--IIKIKNFF-D--AEDYYIVLEL-MEGG-ELFDKVV--GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVS---VGTAG--YNRAVDCWSLGVILFICLSGYPPFS-EH--RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT-------TEEALRHPWL--------------
--YQLVRKLGRGKYSEV---FEAINITNNE---KVVVKILKPVKKKKIKR------------------------------EIKILENLRG----GPN--IITLADIVKDPVSRTPALVFEH-VNNT-DFKQLY-----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV-----DYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-------AREAMEHPYF--------------
--YQLVRKLGRGKYSEV---FEAINITNNE---RVVVKILKPVKKKKIKR------------------------------EVKILENLRG----GTN--IIKLIDTVKDPVSKTPALVFEY-INNT-DFKQLY-----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL----RLIDWGLAEF---YHPAQEYNVRVASRYFKGPELLV-----DYQM--YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-------AKEAMEHPYF--------------
--YDTGEELGSGQFAVV---KKCREKSTGL---QYAAKFIKKRRTKSSRRGVSREDI---------------------EREVSILKEI-Q----HPN--VITLHEVYEN--KTDVILILEL-VAGG-ELFDFLA--EKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK---IDFGNEFKNIFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLSGASPFL-GD---TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMT-------IQDSLQHPWI--------------
--YDIGEELGSGQFAIV---KKCREKSTGL---EYAAKFIKKRQSRASRRGVSREEI---------------------EREVSILRQV-L----HHN--VITLHDVYEN--RTDVVLILEL-VSGG-ELFDFLA--QKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE---IEDGVEFKNIFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLSGASPFL-GD---TKQETLANITAVSYDFDEEFFSQTS------------------------------ELAKDFIRKLLVKETRKRLT-------IQEALRHPWI--------------
--YEMGEELGSGQFAIV---RKCRQKGTGK---EYAAKFIKKRRLSSSRRGVSREEI---------------------EREVNILREI-R----HPN--IITLHDIFEN--KTDVVLILEL-VSGG-ELFDFLA--EKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK---IEAGNEFKNIFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLSGASPFL-GE---TKQETLTNISAVNYDFDEEYFSNTS------------------------------ELAKDFIRRLLVKDPKRRMT-------IAQSLEHSWI--------------
--YTTIRQLGDGTYGSV---LLGRSIESGE---LIAIKKMKRKFYSWEEC-MNLR-------------------------EVKSLKKL-N----HAN--VVKLKEVIRE--NDHLYFIFEY-MKE--NLYQLIK-ERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCM-GPELV----KIADFGLARE---IRSKPPYTDYVSTRWYRAPEVLL-----RSTN--YSSPIDVWAVGCIMAEVYTLRPLFP-GASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV-------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-------ASQALRYPYF--------------
--YRLLKTIGKGNFAKV---KLARHILTGK---EVAVKIIDKTQLNSSSLQKLFR-------------------------EVRIMKVL-N----HPN--IVKLFEVIET--EKTLYLVMEY-ASGG-EVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNI----KIADFGFSNE---FTFGNKLDTFCGSPPYAAPELFQ-----GKKY--DGPEVDVWSLGVILYTLVSGSLPFD-GQ---NLKELRERVLRGKYRIPFYMS----------------------------------TDCENLLKKFLILNPSKRGT-------LEQIMKDRWM--------------
--YELQETLGKGTYGKV---KRATERFSGR---VVAIKSIRKDKIKDEQDMVHIR------------------------REIEIMSSL-N----HPH--IISIYEVFEN--KDKIVIIMEY-ASKG-ELYDYIS--ERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI----KIADFGLSNL---YQKDKFLQTFCGSPLYASPEIVN-----GRPY--RGPEVDSWALGVLLYTLVYGTMPFD-GF---DHKNLIRQISSGEYREPTQP-----------------------------------SDARGLIRWMLMVNPDRRAT-------IEDIANHWW-V-------------
--YEFLETLGKGTYGKV---KKARESSGR----LVAIKSIRKDKIKDEQDLMHIR------------------------REIEIMSSL-N----HPH--IIAIHEVFEN--SSKIVIVMEY-ASRG-DLYDYIS--ERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLD-ANGNI----KIADFGLSNL---YHQGKFLQTFCGSPLYASPEIVN-----GKPY--TGPEVDSWSLGVLLYILVHGTMPFD-GH---DHKILVKQISNGAYREPPK-----P------------------------------SDACGLIRWLLMVNPTRRAT-------LEDVASHWW-V-------------
-Y-IKLDKLGEGTYATV---YKGKSKLTDN---LVALKEIRLEHEEGAPC-TAIR-------------------------EVSLLKDL-K----HAN--IVTLHDIIHT--EKSLTLVFEY-LDK--DLKQYLD-DCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLIN-ERGEL----KLADFGLARAK--SIPTKTYSNEVVTLWYRPPDILL-----GSTD--YSTQIDMWGVGCIFYEMATGRPLFP-GSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR-------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-------AEDAMKHPFF--------------
--YEPKEILGRGVSSVV---RRCIHKPTSQ---EYAVKVIDVTGGGSFSPEEVRELRE------------------ATLKEVDILRKVSG----HPN--IIQLKDTYET--NTFFFLVFDL-MKRG-ELFDYLT--EKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD-DNMNI----KLTDFGFSCQ---LEPGERLREVCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLAGSPPFW-HR---KQMLMLRMIMSGNYQFGSPEWDDYS------------------------------DTVKDLVSRFLVVQPQNRYT-------AEEALAHPFF--------------
--YRLGPLLGKGGFGTV---FAGHRLTDRL---QVAIKVIPRNRVLGWSPLSDSVTC---------------------PLEVALLWKV-GAGGGHPG--VIRLLDWFET--QEGFMLVLERPLPAQ-DLFDYIT--EKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCA----KLIDFGSGA----LLHDEPYTDFDGTRVYSPPEWIS-----RHQY--HALPATVWSLGILLYDMVCGDIPFE-RD---------QEILEAELHFPAHVS----------------------------------PDCCALIRRCLAPKPSSRPS-------LEEILLDPWM--------------
--YQVGAVLGSGGFGTV---YAGSRIADGL---PVAVKHVVKERVTEWGSLGGATV----------------------PLEVVLLRKV-GAAGGARG--VIRLLDWFER--PDGFLLVLER-PEPAQDLFDFIT--ERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR-----YHRY--HGRSATVWSLGVLLYDMVCGDIPFE-QD---------EEILRGRLLFRRRVS----------------------------------PECQQLIRWCLSLRPSERPS-------LDQIAAHPWM--------------
-F-NFLMVLGKGSFGKV---MLADRKGTEE---LYAIKILKKDVVIQDDDVECTM------------------------VEKRVLALLDK----PPF--LTQLHSCFQT--VDRLYFVMEY-VNGG-DLMYHIQ--QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEH--MMDGVTTRTFCGTPDYIAPEIIA------YQP--YGKSVDWWAYGVLLYEMLAGQPPFD-GE---DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLG-------C---------GPEGERDVREHAFF
-F-NFLMVLGKGSFGKV---MLSERKGTDE---LYAVKILKKDVVIQDDDVECTM------------------------VEKRVLALPGK----PPF--LTQLHSCFQT--MDRLYFVMEY-VNGG-DLMYHIQ--QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEN--IWDGVTTKTFCGTPDYIAPEIIA------YQP--YGKSVDWWAFGVLLYEMLAGQAPFE-GE---DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGKRLG-------C---------GPEGERDIKEHAFF
-F-NFIKVLGKGSFGKV---MLAELKGKDE---VYAVKVLKKDVILQDDDVDCTM------------------------TEKRILALARK----HPY--LTQLYCCFQT--KDRLFFVMEY-VNGG-DLMFQIQ--RSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLD-AEGHC----KLADFGMCKEG--ILNGVTTTTFCGTPDYIAPEILQ------ELE--YGPSVDWWALGVLMYEMMAGQPPFE-AD---NEDDLFESILHDDVLYPVWLS----------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHP--FF------------
--FEFIRVLGKGSFGKV---MLARVKETGD---LYAVKVLKKDVILQDDDVECTM------------------------TEKRILSLARN----HPF--LTQLFCCFQT--PDRLFFVMEF-VNGG-DLMFHIQ--KSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD-HEGHC----KLADFGMCKEG--ICNGVTTATFCGTPDYIAPEILQ------EML--YGPAVDWWAMGVLLYEMLCGHAPFE-AE---NEDDLFEAILNDEVVYPTWLH----------------------------------EDATGILKSFMTKNPTMRLGSLT-QGGEHAILRHPF-F-------------
PD----EVLGSGQFGVV---YGGKHRKTGR---DVAVKVIDKLRFPTKQESQLRN-------------------------EVAILQSL-R----HPG--IVNLECMFET--PEKVFVVMEK-LHGD-MLEMILS-SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI---IGEKSFRRSVVGTPAYLAPEVLL------NQG--YNRSLDMWSVGVIMYVSLSGTFPFN-ED-----EDINDQIQNAAFMYPASPWSHIS------------------------------AGAIDLINNLLQVKMRKRYS-------VDKSLSHPWL--------------
--FELLKVLGQGSFGKVFLVRKVTRPDSGH---LYAMKVLKKATLKVRDRVRTKM-------------------------ERDILADV-N----HPF--VVKLHYAFQT--EGKLYLILDF-LRGG-DLFTRLS--KEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA--IDHEKKAYSFCGTVEYMAPEVVN------RQG--HSHSADWWSYGVLMFEMLTGSLPFQ-GK---DRKETMTLILKAKLGMPQFLS----------------------------------TEAQSLLRALFKRNPANRLGSG--PDGAEEIKRHV--FY------------
--FELLKVLGQGSYGKV---FLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-------------------------ERDILAEV-N----HPF--IVKLHYAFQT--EGKLYLILDF-LRGG-DLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI----KITDFGLSKEA--IDHDKRAYSFCGTIEYMAPEVVN------RRG--HTQSADWWSFGVLMFEMLTGSLPFQ-GK---DRKETMALILKAKLGMPQFLS----------------------------------GEAQSLLRALFKRNPCNRLGAG--IDGVEEIKRHPFF--------------
--FELLKVLGQGSFGKV---FLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM-------------------------ERDILVEV-N----HPF--IVKLHYAFQT--EGKLYLILDF-LRGG-DLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI----KLTDFGLSKES--IDHEKKAYSFCGTVEYMAPEVVN------RRG--HTQSADWWSFGVLMFEMLTGTLPFQ-GK---DRKETMTMILKAKLGMPQFLS----------------------------------PEAQSLLRMLFKRNPANRLGAG--PDGVEEIKRHSFF--------------
--FELLKVLGQGSFGKV---FLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM-------------------------ERDILVEV-N----HPF--IVKLHYAFQT--EGKLYLILDF-LRGG-DVFTRLS--KEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHI----KLTDFGLSKES--VDQEKKAYSFCGTVEYMAPEVVN------RRG--HSQSADWWSYGVLMFEMLTGTLPFQ-GK---DRNETMNMILKAKLGMPQFLS----------------------------------AEAQSLLRMLFKRNPANRLGS----EGVEEIKRHLFF--------------
--FTKLEKIGKGSFGEV---FKGIDNRTQK---VVAIKIIDLEEAEDEIEDIQ-Q-------------------------EITVLSQC-D----SPY--VTKYYGSYLK--DTKLWIIMEY-LGGG-SALDLLE---PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL--TDTQIKRNTFVGTPFWMAPEVIK------QSA--YDSKADIWSLGITAIELARGEPPHS-ELHPMKVLFLIPKNNPPTLEGNYS------------------------------------KPLKEFVEACLNKEPSFRPT-------AKELLKHKFI--------------
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