|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK3 13
AGC PRKCA 339
AGC PRKCB 342
--YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV--PMEVVLLKKV-SSGFSGVIRLLDWFER--PDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVC-GDIPFE-HD---------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM--------------
--YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR------EICLLKEL-KHKN--IVRLHDVLHS--DKKLTLVFEFCDQ--DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL----KLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--------------
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK------EICINKML-NHEN--VVKFYGHRRE--GNIQYLFLEYCSGG-ELFDRIE-PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL----KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-------------
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKL-NHPC--IIKIKNFF-D--AEDYYIVLELMEGG-ELFDKVV-GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH--RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL--------------
--YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-----------EIKILENLRGGPN--IITLADIVKDPVSRTPALVFEHVNNT-DFKQLY----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF--------------
--YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEI--EREVNILREI-RHPN--IITLHDIFEN--KTDVVLILELVSGG-ELFDFLA-EKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK---IEAGNEFKNIFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLS-GASPFL-GE---TKQETLTNISAVNYDFDEEYFSNTS------------------------------ELAKDFIRRLLVKDPKRRMTIAQSLEHSWI--------------
-F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM-----VEKRVLALLDKPPF--LTQLHSCFQT--VDRLYFVMEYVNGG-DLMYHIQ-QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEH--MMDGVTTRTFCGTPDYIAPEIIA---YQPYGKSVDWWAYGVLLYEMLA-GQPPFD-GE---DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
-F-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTM-----VEKRVLALPGKPPF--LTQLHSCFQT--MDRLYFVMEYVNGG-DLMYHIQ-QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEN--IWDGVTTKTFCGTPDYIAPEIIA---YQPYGKSVDWWAFGVLLYEMLA-GQAPFE-GE---DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGKRLGC---------GPEGERDIKEHAFF
|