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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PKN1 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK1G 23
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK1 128
Other CAMKK2 165
AGC CDC42BPA 77
AGC CDC42BPB 76
AGC CDC42BPG 71
CMGC CDK5 4
CMGC CDK6 13
CMGC CDKL1 5
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK2 222
Other EIF2AK2 267
AGC GRK1 190
AGC GRK4 187
AGC GRK5 186
AGC GRK6 186
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
CAMK HUNK 61
CAMK KIAA0999 66
CMGC MAPK6 20
CMGC MAPK8 26
CAMK MAPKAPK2 64
CAMK MAPKAPK5 22
CAMK MARK2 53
CAMK MARK4 59
CAMK MGC42105 74
CAMK MKNK2 84
Other NEK1 4
Other NEK2 8
Other NEK4 6
Other NEK5 4
Other NEK8 4
Other NEK9 52
CMGC NLK 126
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK1 270
STE PAK2 249
STE PAK3 268
STE PAK4 321
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
AGC PKN2 657
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
AGC PRKCI 245
AGC PRKCQ 380
AGC PRKCZ 252
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
AGC RPS6KB2 67
Other SBK1 53
AGC SGK1 98
AGC SGK2 35
AGC SGK3 162
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
CAMK SNRK 16
STE STK10 36
CAMK STK11 49
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
STE STK25 20
AGC STK32A 23
AGC STK32C 93
CAMK STK33 116
Other STK35 202
Other STK36 4
Other TLK2 440
CAMK TSSK1B 12
CAMK TSSK2 12
Other ULK3 14
----F-KFLAVLGRGHFGKV---LLSEF---R-PSGE---LFAIKALKKGD-IVARDEV-ESLM------------------------CEKRI-L-AAV--TS---AGHPF--LVNLFGCFQT-------------------------------------PEHVC--FVMEY-SAGG--DLMLHIH-----SDVFSEPRAIFYSACVVLGLQFLHEH-----KIVYRDLKLDNLLLD---TEGYV---------KIADFGLCKEG-----------------MGYGD-RTSTFCGTPEFLAPEV----LT------------------DTS--YTRAVDWWGLGVLLYEMLV-GE-SPFP-GD---------------DE-EEVFDSIVNDEVRYPRFLS----------------------------------------------------------AEAIGIMRRLLRRNPER--RLGSS--ERDAE-DVKKQPFF--------------
-----FEIGRPLGKGKFGNV---YLARE---K-QSKF---ILALKVLFKAQLEKAGVEH-QLRR-------------------------EVEI-Q-SHL--R------HPN--ILRLYGYFHD-------------------------------------ATRVY--LILEY-APLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG---SAGEL---------KIADFGWSV-------------------HAPSS-RRTTLCGTLDYLPPEM----IE------------------GRM--HDEKVDLWSLGVLCYEFLV-GK-PPFE-AN---------------TY-QETYKRISRVEFTFPDFVT----------------------------------------------------------EGARDLISRLLKHNPSQ--RPM-------LR-EVLEHPWI--------------
-----FEIGRPLGKGKFGNV---YLARE---K-KSHF---IVALKVLFKSQ-IEKEGVE-HQLR------------------------REIEI-Q-AHL--H------HPN--ILRLYNYFYD-------------------------------------RRRIY--LILEY-APRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGK-----KVIHRDIKPENLLLG---LKGEL---------KIADFGWSV-------------------HAPSL-RRKTMCGTLDYLPPEM----IE------------------GRM--HNEKVDLWCIGVLCYELLV-GN-PPFE-SA---------------SH-NETYRRIVKVDLKFPASVP----------------------------------------------------------MGAQDLISKLLRHNPSE--RLP-------LA-QVSAHPWV--------------
-----FEIGRPLGKGKFGNV---YLARL---K-ESHF---IVALKVLFKSQ-IEKEGLE-HQLR------------------------REIEI-Q-AHL--Q------HPN--ILRLYNYFHD-------------------------------------ARRVY--LILEY-APRG--ELYKELQ----KSEKLDEQRTATIIEELADALTYCHDK-----KVIHRDIKPENLLLG---FRGEV---------KIADFGWSV-------------------HTPSL-RRKTMCGTLDYLPPEM----IE------------------GRT--YDEKVDLWCIGVLCYELLV-GY-PPFE-SA---------------SH-SETYRRILKVDVRFPLSMP----------------------------------------------------------LGARDLISRLLRYQPLE--RLP-------LA-QILKHPWV--------------
-----YRLEKTLGKGQTGLV---KLGVH---C-ITGQ---KVAIKIVNREK-LSESVLM-KVER-------------------------EIAI-L-KLI--E------HPH--VLKLHDVYEN-------------------------------------KKYLY--LVLEH-VSGG--ELFDYLV----KKGRLTPKEARKFFRQIVSALDFCHSY-----SICHRDLKPENLLLD---EKNNI---------RIADFGMASL------------------QVGDS-LLETSCGSPHYACPEV----IK-----------------GEKY--DGRRADMWSCGVILFALLV-GA-LPFD-DD---------------NL-RQLLEKVKRGVFHMPHFIP----------------------------------------------------------PDCQSLLRGMIEVEPEK--RLS-------LE-QIQKHPW-Y-------------
-----YRLEKTLGKGQTGLV---KLGVH---C-VTCQ---KVAIKIVNREK-LSESVLM-KVER-------------------------EIAI-L-KLI--E------HPH--VLKLHDVYEN-------------------------------------KKYLY--LVLEH-VSGG--ELFDYLV----KKGRLTPKEARKFFRQIISALDFCHSH-----SICHRDLKPENLLLD---EKNNI---------RIADFGMASL------------------QVGDS-LLETSCGSPHYACPEV----IR-----------------GEKY--DGRKADVWSCGVILFALLV-GA-LPFD-DD---------------NL-RQLLEKVKRGVFHMPHFIP----------------------------------------------------------PDCQSLLRGMIEVDAAR--RLT-------LE-HIQKHIW-Y-------------
---FI--FMEVLGSGAFSEV---FLVKQ---R-LTGK---LFALKCIKKSP-AFRDSSL-E--N-------------------------EIAV-L-KKI--K------HEN--IVTLEDIYES-------------------------------------TTHYY--LVMQL-VSGG--ELFDRIL----ERGVYTEKDASLVIQQVLSAVKYLHEN-----GIVHRDLKPENLLYLTPEENSKI---------MITDFGLSK-------------------MEQNG-IMSTACGTPGYVAPEV----LA------------------QKP--YSKAVDCWSIGVITYILLC-GY-PPFY-EE---------------TE-SKLFEKIKEGYYEFESPFW-D-DIS----------------------------------------------------ESAKDFICHLLEKDPNE--RYT-------CE-KALSHPWI--------------
-----YQLYEDIGKGAFSVV---RRCVK---L-CTGH---EYAAKIINTKK-LSARDHQ-KLER-------------------------EARI-C-RLL--K------HSN--IVRLHDSISE-------------------------------------EGFHY--LVFDL-VTGG--ELFEDIV----AREYYSEADASHCIQQILEAVLHCHQM-----GVVHRDLKPENLLLA---SKCKGA------AVKLADFGLAIEV-----------------QGDQQ-AWFGFAGTPGYLSPEV----LR------------------KEA--YGKPVDIWACGVILYILLV-GY-PPFW-DE---------------DQ-HKLYQQIKAGAYDFPSPEW-D-TVT----------------------------------------------------PEAKNLINQMLTINPAK--RIT-------AH-EALKHPWV--------------
-----YQLFEELGKGAFSVV---RRCMK---I-PTGQ---EYAAKIINTKK-LSARDHQ-KLER-------------------------EARI-C-RLL--K------HPN--IVRLHDSISE-------------------------------------EGFHY--LVFDL-VTGG--ELFEDIV----AREYYSEADASHCIQQILESVNHCHLN-----GIVHRDLKPENLLLA---SKSKGA------AVKLADFGLAIEV-----------------QGDQQ-AWFGFAGTPGYLSPEV----LR------------------KDP--YGKPVDMWACGVILYILLV-GY-PPFW-DE---------------DQ-HRLYQQIKAGAYDFPSPEW-D-TVT----------------------------------------------------PEAKDLINKMLTINPAK--RIT-------AS-EALKHPWI--------------
-----YQLFEELGKGAFSVV---RRCVK---K-TSTQ---EYAAKIINTKK-LSARDHQ-KLER-------------------------EARI-C-RLL--K------HPN--IVRLHDSISE-------------------------------------EGFHY--LVFDL-VTGG--ELFEDIV----AREYYSEADASHCIHQILESVNHIHQH-----DIVHRDLKPENLLLA---SKCKGA------AVKLADFGLAIEV-----------------QGEQQ-AWFGFAGTPGYLSPEV----LR------------------KDP--YGKPVDIWACGVILYILLV-GY-PPFW-DE---------------DQ-HKLYQQIKAGAYDFPSPEW-D-TVT----------------------------------------------------PEAKNLINQMLTINPAK--RIT-------AD-QALKHPWV--------------
-----YKLQSEIGKGAYGVV---RLAYN---E-SEDR---HYAMKVLSKKK-LLKQYGF-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAI-L-KKL--D------HVN--VVKLIEVLDDP-----------------------------------AEDNLY--LVFDL-LRKG--PVMEVPC-----DKPFSEEQARLYLRDVILGLEYLHCQ-----KIVHRDIKPSNLLLG---DDGHV---------KIADFGVSNQF-----------------EGNDA-QLSSTAGTPAFMAPEA----ISD---------------SGQSF--SGKALDVWATGVTLYCFVY-GK-CPFI-DD---------------FI-LALHRKIKNEPVVFPEEPE-I-S------------------------------------------------------EELKDLILKMLDKNPET--RIG-------VP-DIKLHPWV--------------
-----YTLKDEIGKGSYGVV---KLAYN---E-NDNT---YYAMKVLSKKK-LIRQAGF-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAI-L-KKL--D------HPN--VVKLVEVLDDP-----------------------------------NEDHLY--MVFEL-VNQG--PVMEVPT-----LKPLSEDQARFYFQDLIKGIEYLHYQ-----KIIHRDIKPSNLLVG---EDGHI---------KIADFGVSNEF-----------------KGSDA-LLSNTVGTPAFMAPES----LS-----------------ETRKIFSGKALDVWAMGVTLYCFVF-GQ-CPFM-DE---------------RI-MCLHSKIKSQALEFPDQPD-I-A------------------------------------------------------EDLKDLITRMLDKNPES--RIV-------VP-EIKLHPWV--------------
-----FEILKVIGRGAFGEV---AVVKL---K-NADK---VFAMKILNKWE-MLKRAET-ACFR------------------------EERDV-L-VNG--D------NKW--ITTLHYAFQD-------------------------------------DNNLY--LVMDY-YVGG--DLLTLLS---KFEDRLPEDMARFYLAEMVIAIDSVHQL-----HYVHRDIKPDNILMD---MNGHI---------RLADFGSCLKL----------------MEDGTV-QSSVAVGTPDYISPEI----LQAM-------------EDGKGR--YGPECDWWSLGVCMYEMLY-GE-TPFY-AE------------SLV----ETYGKIMNHKERFQFPAQVT-DVS----------------------------------------------------ENAKDLIRRLICSREHR---LGQ----NGIE-DFKKHPFF--------------
-----FEIIKVIGRGAFGEV---AVVKM---K-NTER---IYAMKILNKWE-MLKRAET-ACFR------------------------EERDV-L-VNG--D------CQW--ITALHYAFQD-------------------------------------ENHLY--LVMDY-YVGG--DLLTLLS---KFEDKLPEDMARFYIGEMVLAIDSIHQL-----HYVHRDIKPDNVLLD---VNGHI---------RLADFGSCLKM-----------------NDDGTVQSSVAVGTPDYISPEI----LQAM-------------EDGMGK--YGPECDWWSLGVCMYEMLY-GE-TPFY-AE---------------SL-VETYGKIMNHEERFQFPSHVT-DVS----------------------------------------------------EEAKDLIQRLICSRE-R--RLGQ----NGIE-DFKKHAF-F-------------
-----FEILKVIGRGAFGEV---TVVRQ---R-DTGQ---IFAMKMLHKWE-MLKRAET-ACFR------------------------EERDV-L-VKG--D------SRW--VTTLHYAFQD-------------------------------------EEYLY--LVMDY-YAGG--DLLTLLS---RFEDRLPPELAQFYLAEMVLAIHSLHQL-----GYVHRDVKPDNVLLD---VNGHI---------RLADFGSCLRL-----------------NTNGMVDSSVAVGTPDYISPEI----LQAM-------------EEGKGH--YGPQCDWWSLGVCAYELLF-GE-TPFY-AE------------SLVET-YGKIM---NHEDHLQFPPD-VPDVP----------------------------------------------------ASAQDLIRQLLCRQEERLGRGG-------LD-DFRNHPFF--------------
-----YEKLEKIGEGTYGTV---FKAKN---R-ETHE---IVALKRVRLDD-DDEGVPS-SALR-------------------------EICL-L-KEL--K------HKN--IVRLHDVLHS-------------------------------------DKKLT--LVFEF-CDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLIN---RNGEL---------KLADFGLARAF-----------------GIPVR-CYSAEVVTLWYRPPDV----LF-----------------GAKL--YSTSIDMWSAGCIFAELANAGR-PLFP-GN------------DVDDQ-LKRIFRLLGTPTEEQWPSM-T-KLPDYKPYPMYPAT------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS-------AE-EALQHPYF--------------
-----YECVAEIGEGAYGKV---FKARD---L-KNGG--RFVALKRVRVQT-GEEGMPL-STIR-------------------------EVAV-L-RHL--ET---FEHPN--VVRLFDVCTVSR--------------------------------TDRETKLT--LVFEH-VDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSH-----RVVHRDLKPQNILVT---SSGQI---------KLADFGLARI------------------YSFQM-ALTSVVVTLWYRAPEV----LL------------------QSS--YATPVDLWSVGCIFAEMFR-RK-PLFR-GS------------SDVDQ-LGKILDVIGLPGEEDWPRD-V-ALPRQAFHSKSAQ--------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAK--RIS-------AY-SALSHPYF--------------
-----YEKIGKIGEGSYGVV---FKCRN---R-DTGQ---IVAIKKFLESE-DDPVIKK-IALR-------------------------EIRM-L-KQL--K------HPN--LVNLLEVFRR-------------------------------------KRRLH--LVFEY-CDHT--VLHELDR----YQRGVPEHLVKSITWQTLQAVNFCHKH-----NCIHRDVKPENILIT---KHSVI---------KLCDFGFARLL-----------------AGPSD-YYTDYVATRWYRSPEL----LV-----------------GDTQ--YGPPVDVWAIGCVFAELLS-GV-PLWP-GK------------SDVDQ-LYLIRKTLGDLIPRHQQVF-S-TNQYFSGVKIPDPED----------------------------MEPLELKFPNISYPALGLLKGCLHMDPTQ--RLT-------CE-QLLHHPYF--------------
-----YETLGKVGEGSYGTV---MKCKH---K-NTGQ---IVAIKIFYERP-EQSVNK--IAMR-------------------------EIKF-L-KQF--H------HEN--LVNLIEVFRQ-------------------------------------KKKIH--LVFEF-IDHT--VLDELQH----YCHGLESKRLRKYLFQILRAIDYLHSN-----NIIHRDIKPENILVS---QSGIT---------KLCDFGFARTL-----------------AAPGD-IYTDYVATRWYRAPEL----VL-----------------KDTS--YGKPVDIWALGCMIIEMAT-GN-PYLP-SS------------SDLDL-LHKIVLKVGN-LSPHLQNI-F-SKSPIFAGVVLPQVQ---------------------------HPKNARKKYPKLNGLLADIVHACLQIDPAD--RIS-------SS-DLLHHEYF--------------
-----FEILGVVGEGAYGVV---LKCRH---K-ETHE---IVAIKKFKDSE-ENEEVKE-TTLR-------------------------ELKM-L-RTL--K------QEN--IVELKEAFRR-------------------------------------RGKLY--LVFEY-VEK---NMLELLE---EMPNGVPPEKVKSYIYQLIKAIHWCHKN-----DIVHRDIKPENLLIS---HNDVL---------KLCDFGFARNL----------------SEGNNA-NYTEYVATRWYRSPEL----LL------------------GAP--YGKSVDMWSVGCILGELSD-GQ-PLFP-GE------------SEIDQ-LFTIQKVLGPLPSEQMKLF-Y-SNPRFHGLRFPAVNH---------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPAD--RYL-------TE-QCLNHPTF--------------
----W-DLVQTLGEGAYGEV---QLAVN---R-VTEE---AVAVKIVDMKR-AVDCPEN-I-KK-------------------------EICI-N-KML--N------HEN--VVKFYGHRRE-------------------------------------GNIQY--LFLEY-CSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD---ERDNL---------KISDFGLATVFR---------------YNNRER-LLNKMCGTLPYVAPEL----LK-----------------RREF--HAEPVDVWSCGIVLTAMLA-GE-LPWD-QP--------------SDS-CQEYSDWKEKKTYLNPWKK-I---D----------------------------------------------------SAPLALLHKILVENPSA--RIT-------IP-DIKKDRW-Y-------------
---YI--MSKTLGSGACGEV---KLAFE---R-KTCK---KVAIKIISKRK-FAIGSAR-EADPALN-------------------VETEIEI-L-KKL--N------HPC--IIKIKNFF-D-------------------------------------AEDYY--IVLEL-MEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS---SQEEDC------LIKITDFGHSKI------------------LGETS-LMRTLCGTPTYLAPEV----LVS---------------VGTAG--YNRAVDCWSLGVILFICLS-GY-PPFS-EH--------------RTQ-VSLKDQITSGKYNFIPEVW-A-EVS----------------------------------------------------EKALDLVKKLLVVDPKA--RFT-------TE-EALRHPWL--------------
-----YQLVRKLGRGKYSEV---FEAIN---I-TNNE---KVVVKILKPVK-KKKIKR-------------------------------EIKI-L-ENL-RG------GPN--IITLADIVKDP-----------------------------------VSRTPA--LVFEH-VNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMID--HEHRKL---------RLIDWGLAEF------------------YHPGQ-EYNVRVASRYFKGPEL----LV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RK-EPFFHGH------------DNYDQ-LVRIAKVLGTEDLYDYIDK-Y-NIELDPRFNDILGRHSRK----------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-------AR-EAMEHPYF--------------
-----YQLVRKLGRGKYSEV---FEAIN---I-TNNE---RVVVKILKPVK-KKKIKR-------------------------------EVKI-L-ENL-RG------GTN--IIKLIDTVKDP-----------------------------------VSKTPA--LVFEY-INNT--DFKQLY-------QILTDFDIRFYMYELLKALDYCHSK-----GIMHRDVKPHNVMID--HQQKKL---------RLIDWGLAEF------------------YHPAQ-EYNVRVASRYFKGPEL----LV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RR-EPFFHGQ------------DNYDQ-LVRIAKVLGTEELYGYLKK-Y-HIDLDPHFNDILGQHSRK----------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQ--RLT-------AK-EAMEHPYF--------------
-----YDTGEELGSGQFAVV---KKCRE---K-STGL---QYAAKFIKKRR-TKSSRRG-VSREDI---------------------EREVSI-L-KEI--Q------HPN--VITLHEVYEN-------------------------------------KTDVI--LILEL-VAGG--ELFDFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL---DRNVPKP-----RIKIIDFGLAHK------------------IDFGN-EFKNIFGTPEFVAPEI----VN------------------YEP--LGLEADMWSIGVITYILLS-GA-SPFL-GD---------------TK-QETLANVSAVNYEFEDEYF-S-NTS----------------------------------------------------ALAKDFIRRLLVKDPKK--RMT-------IQ-DSLQHPWI--------------
-----YDIGEELGSGQFAIV---KKCRE---K-STGL---EYAAKFIKKRQ-SRASRRG-VSREEI---------------------EREVSI-L-RQV--L------HHN--VITLHDVYEN-------------------------------------RTDVV--LILEL-VSGG--ELFDFLA----QKESLSEEEATSFIKQILDGVNYLHTK-----KIAHFDLKPENIMLL---DKNIPIP-----HIKLIDFGLAHE------------------IEDGV-EFKNIFGTPEFVAPEI----VN------------------YEP--LGLEADMWSIGVITYILLS-GA-SPFL-GD---------------TK-QETLANITAVSYDFDEEFF-S-QTS----------------------------------------------------ELAKDFIRKLLVKETRK--RLT-------IQ-EALRHPWI--------------
-----YEMGEELGSGQFAIV---RKCRQ---K-GTGK---EYAAKFIKKRR-LSSSRRG-VSREEI---------------------EREVNI-L-REI--R------HPN--IITLHDIFEN-------------------------------------KTDVV--LILEL-VSGG--ELFDFLA----EKESLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLL---DKNVPNP-----RIKLIDFGIAHK------------------IEAGN-EFKNIFGTPEFVAPEI----VN------------------YEP--LGLEADMWSIGVITYILLS-GA-SPFL-GE---------------TK-QETLTNISAVNYDFDEEYF-S-NTS----------------------------------------------------ELAKDFIRRLLVKDPKR--RMT-------IA-QSLEHSWI--------------
-----YEVLKVIGKGSFGQV---VKAYD---H-KVHQ---HVALKMVRNEK-RFHRQAA-E----------------------------EIRI-L-EHL--RKQDKDNTMN--VIHMLENFTF-------------------------------------RNHIC--MTFEL-LSM---NLYELIKK--NKFQGFSLPLVRKFAHSILQCLDALHKN-----RIIHCDLKPENILLK---QQGRSG-------IKVIDFGSSC--------------------YEHQ-RVYTYIQSRFYRAPEV----IL------------------GAR--YGMPIDMWSLGCILAELLT-GY-PLLP-GE------------DEGDQ-LACMIELLGMPSQKLLDAS-K-RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAV--RMT-------PG-QALRHPWL--------------
----F-KEIELIGSGGFGQV---FKAKH---R-IDGK---TYVIKRVKYNN-EKAER--------------------------------EVKA-L-AKL--D------HVN--IVHYNGCWDGFDYDPETSDDSLES--------SDYDPENSKNSSRSKTKCLF--IQMEF-CDKG--TLEQWIEK--RRGEKLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLV---DTKQV---------KIGDFGLVTS------------------LKNDG-KRTRSKGTLRYMSPEQ----IS------------------SQD--YGKEVDLYALGLILAELLH-VCDTAFE-T--------------------SKFFTDLRDGIISDIFDK-----------------------------------------------------------KEKTLLQKLLSKKPED--RPN-------TS-EILR----TLT-----------
-FLDF----RVLGKGGFGEV---SACQM---K-ATGK---LYACKKLNKKR-LKKRKGY-QGAM------------------------VEKKI-L-MKV--H------SRF--IVSLAYAFET-------------------------------------KADLC--LVMTI-MNGG--DIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQR-----RIVYRDLKPENVLLD---NDGNV---------RISDLGLAVEL-----------------LDGQS-KTKGYAGTPGFMAPEL----LQ------------------GEE--YDFSVDYFALGVTLYEMIA-AR-GPFR-AR-----------GEKVEN-KELKHRIISEPVKYPDKFS----------------------------------------------------------QASKDFCEALLEKDPEK--RLG-------FR-D-------ETCDKLRAHPLF--
---FR--HYRVLGKGGFGEV---CACQV---R-ATGK---MYACKKLQKKR-IKKRKGE-AMAL------------------------NEKRI-L-EKV--Q------SRF--VVSLAYAYET-------------------------------------KDALC--LVLTI-MNGG--DLKFHIYN--LGNPGFDEQRAVFYAAELCCGLEDLQRE-----RIVYRDLKPENILLD---DRGHI---------RISDLGLATE------------------IPEGQ-RVRGRVGTVGYMAPEV----VN------------------NEK--YTFSPDWWGLGCLIYEMIQ-GH-SPFK-KY------------KEKVK-WEEVDQRIKNDTEEYSE-----KFS----------------------------------------------------EDAKSICRMLLTKNPSK--RLGCR--GEGAA-GVKQHPV-F-------------
----F-RQYRVLGKGGFGEV---CACQV---R-ATGK---MYACKRLEKKR-IKKRKGE-SMAL------------------------NEKQI-L-EKV--N------SQF--VVNLAYAYET-------------------------------------KDALC--LVLTI-MNGG--DLKFHIYN--MGNPGFEEERALFYAAEILCGLEDLHRE-----NTVYRDLKPENILLD---DYGHI---------RISDLGLAVK------------------IPEGD-LIRGRVGTVGYMAPEV----LN------------------NQR--YGLSPDYWGLGCLIYEMIE-GQ-SPFR-GR---------------KE-KVKREEVDRRVLETEEVYS-H-KFS----------------------------------------------------EEAKSICKMLLTKDAKQ--RLGCQ--EEGAA-EVKRHPFF--------------
----F-RQYRVLGKGGFGEV---CACQV---R-ATGK---MYACKKLEKKR-IKKRKGE-AMAL------------------------NEKQI-L-EKV--N------SRF--VVSLAYAYET-------------------------------------KDALC--LVLTL-MNGG--DLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD---DHGHI---------RISDLGLAVH------------------VPEGQ-TIKGRVGTVGYMAPEV----VK------------------NER--YTFSPDWWALGCLLYEMIA-GQ-SPFQ-QR------------KKKIK-REEVERLVK-EVPEEYSER----FS----------------------------------------------------PQARSLCSQLLCKDPAE--RLGCR--GGSAR-EVKEHPLF--------------
----F-TEFRVLGKGGFGEV---CAVQV---K-NTGK---MYACKKLDKKR-LKKKGGE-KMAL------------------------LEKEI-L-EKV--S------SPF--IVSLAYAFES-------------------------------------KTHLC--LVMSL-MNGG--DLKFHIYN--VGTRGLDMSRVIFYSAQIACGMLHLHEL-----GIVYRDMKPENVLLD---DLGNC---------RLSDLGLAVE------------------MKGGK-PITQRAGTNGYMAPEI----LM-----------------EKVS--YSYPVDWFAMGCSIYEMVA-GR-TPFK-DY-----------KEKVSK-EDLKQRTLQDEVKFQHDNF-----T----------------------------------------------------EEAKDICRLFLAKKPEQ--RLG-------SR-E-------KSDDPR--------
-----YTDIKVIGNGSFGVV---YQARL---A-ETRE---LVAIKKVLQDK-RFKNR--------------------------------ELQI-M-RKL--D------HCN--IVRLRYFFYSSG---------------------------------EKKDELYLNLVLEY-VPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQ-----GVCHRDIKPQNLLVD--PDTAVL---------KLCDFGSAKQ------------------LVRGE-PNVSYICSRYYRAPEL----IF-----------------GATD--YTSSIDVWSAGCVLAELLL-GQ-PIFP-GD------------SGVDQ-LVEIIKVLGTPTREQIREM-N-PNYTEFKFPQIKAH------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-------PL-EACAHSFF--------------
-----YTDTKVIGNGSFGVV---YQAKL---C-DSGE---LVAIKKVLQDK-RFKNR--------------------------------ELQI-M-RKL--D------HCN--IVRLRYFFYSSG---------------------------------EKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLD--PDTAVL---------KLCDFGSAKQ------------------LVRGE-PNVSYICSRYYRAPEL----IF-----------------GATD--YTSSIDVWSAGCVLAELLL-GQ-PIFP-GD------------SGVDQ-LVEIIKVLGTPTREQIREM-N-PNYTEFKFPQIKAH------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-------PL-EACAHSFF--------------
--IGS----RKLGEGSFAKV---REGLH---V-LTGE---KVAIKVIDKKR-AKKDTYV-TKNLR-----------------------REGQI-Q-QMI--R------HPN--ITQLLDILET-------------------------------------ENSYY--LVMEL-CPGG--NLMHKIY----EKKRLEESEARRYIRQLISAVEHLHRA-----GVVHRDLKIENLLLD---EDNNI---------KLIDFGLSNCAG---------------ILGYSD-PFSTQCGSPAYAAPEL----LA------------------RKK--YGPKIDVWSIGVNMYAMLT-GT-LPFT-VE-------------PFSL-RALYQKMVD-KEMNPLPTQ----LS----------------------------------------------------TGAISFLRSLLEPDPVK--RPN-------IQ-QALANRWL--------------
-----YEIDRTIGKGNFAVV---KRATH---L-VTKA---KVAIKIIDKTQ-LDEENLK-KIFR-------------------------EVQI-M-KML--C------HPH--IIRLYQVMET-------------------------------------ERMIY--LVTEY-ASGG--EIFDHLV----AHGRMAEKEARRKFKQIVTAVYFCHCR-----NIVHRDLKAENLLLD---ANLNI---------KIADFGFSNL------------------FTPGQ-LLKTWCGSPPYAAPEL----FE-----------------GKEY--DGPKVDIWSLGVVLYVLVC-GA-LPFD-GS---------------TL-QNLRARVLSGKFRIPFFMS----------------------------------------------------------TECEHLIRHMLVLDPNK--RLS-------ME-QICKHKWM--------------
---YM--DLKPLGCGGNGLV---FSAVD---N-DCDK---RVAIKKIVLTD-PQSVKH---ALR-------------------------EIKI-I-RRL--D------HDN--IVKVFEILGPSGSQLTD-----------------------DVGSLTELNSVY--IVQEY-MET---DLANVLE-----QGPLLEEHARLFMYQLLRGLKYIHSA-----NVLHRDLKPANLFIN--TEDLVL---------KIGDFGLARIMD--------------PHYSHKG-HLSEGLVTKWYRSPRL----LL-----------------SPNN--YTKAIDMWAAGCIFAEMLT-GK-TLFA-GA------------HELEQ-MQLILESIPVVHEEDRQEL-L-SVIPVYIRNDMTEP-----------------------------HKPLTQLLPGISREALDFLEQILTFSPMD--RLT-------AE-EALSHPYM--------------
-----YQNLKPIGSGAQGIV---CAAYD---A-ILER---NVAIKKLSRPF-QNQTHAK-RAYR-------------------------ELVL-M-KCV--N------HKN--IIGLLNVFTPQKS-------------------------------LEEFQDVY--IVMEL-MDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK---SDCTL---------KILDFGLART------------------AGTSF-MMTPYVVTRYYRAPEV----IL------------------GMG--YKENVDLWSVGCIMGEMVC-HK-ILFP-GR------------DYIDQ-WNKVIEQLGTPCPEFMKKL-Q-PTVRTYVENRPKYAGYSFEK-----------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASK--RIS-------VD-EALQHPYI--------------
--KVT---SQVLGLGINGKV---LQIFN---K-RTQE---KFALKMLQDCP-KAR--------R-------------------------EVEL-H-WRA-SQ------CPH--IVRIVDVYENLY---------------------------------AGRKCLL--IVMEC-LDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT---SKRPNA------ILKLTDFGFAKE------------------TTSHN-SLTTPCYTPYYVAPEV----LG------------------PEK--YDKSCDMWSLGVIMYILLC-GY-PPFY-SN-----------HGLAIS-PGMKTRIRMGQYEFPNPEW-S-EVS----------------------------------------------------EEVKMLIRNLLKTEPTQ--RMT-------IT-EFMNHPWI--------------
--INW---TQKLGAGISGPV---RVCVK---K-STQE---RFALKILLDRP-KAR--------N-------------------------EVRL-H-MMC-AT------HPN--IVQIIEVFANSVQFP---------------------------HESSPRARLL--IVMEM-MEGG--ELFHRIS----QHRHFTEKQASQVTKQIALALRHCHLL-----NIAHRDLKPENLLFK---DNS-LDA-----PVKLCDFGFAK--------------------IDQG-DLMTPQFTPYYVAPQV----LEAQRRHQKEKSGIIPTSPTPYT--YNKSCDLWSLGVIIYVMLC-GY-PPFY-SKH----------HSRTIP-KDMRRKIMTGSFEFPEEEW-S-QIS----------------------------------------------------EMAKDVVRKLLKVKPEE--RLT-------IE-GVLDHPWL--------------
-----YRLLKTIGKGNFAKV---KLARH---I-LTGK---EVAVKIIDKTQ-LNSSSLQ-KLFR-------------------------EVRI-M-KVL--N------HPN--IVKLFEVIET-------------------------------------EKTLY--LVMEY-ASGG--EVFDYLV----AHGRMKEKEARAKFRQIVSAVQYCHQK-----FIVHRDLKAENLLLD---ADMNI---------KIADFGFSNE------------------FTFGN-KLDTFCGSPPYAAPEL----FQ-----------------GKKY--DGPEVDVWSLGVILYTLVS-GS-LPFD-GQ---------------NL-KELRERVLRGKYRIPFYMS----------------------------------------------------------TDCENLLKKFLILNPSK--RGT-------LE-QIMKDRWM--------------
-----YRLLRTIGKGNFAKV---KLARH---I-LTGR---EVAIKIIDKTQ-LNPSSLQ-KLFR-------------------------EVRI-M-KGL--N------HPN--IVKLFEVIET-------------------------------------EKTLY--LVMEY-ASAG--EVFDYLV----SHGRMKEKEARAKFRQIVSAVHYCHQK-----NIVHRDLKAENLLLD---AEANI---------KIADFGFSNE------------------FTLGS-KLDTFCGSPPYAAPEL----FQ-----------------GKKY--DGPEVDIWSLGVILYTLVS-GS-LPFD-GH---------------NL-KELRERVLRGKYRVPFYMS----------------------------------------------------------TDCESILRRFLVLNPAK--RCT-------LE-QIMKDKWI--------------
-----YRIRGEIGSGNFSQV---KLGIH---S-LTKE---KVAIKILDKTK-LDQKTQR-LLSR-------------------------EISS-M-EKL--H------HPN--IIRLYEVVET-------------------------------------LSKLH--LVMEY-AGGG--ELFGKIS----TEGKLSEPESKLIFSQIVSAVKHMHEN-----QIIHRDLKAENVFYT---SNTCV---------KVGDFGFSTV------------------SKKGE-MLNTFCGSPPYAAPEL----FR-----------------DEHY--IGIYVDIWALGVLLYFMVT-GT-MPFR-AE---------------TV-AKLKKSILEGTYSVPPHV------S----------------------------------------------------EPCHRLIRGVLQQIPTE--RYG-------ID-CIMNDEWM--------------
-QLQE----DVLGEGAHARV---QTCIN---L-ITSQ---EYAVKIIEKQP-GHIRSR---VFR-------------------------EVEM-L-YQC-QG------HRN--VLELIEFFEE-------------------------------------EDRFY--LVFEK-MRGG--SILSHIH----KRRHFNELEASVVVQDVASALDFLHNK-----GIAHRDLKPENILCE---HPNQVS------PVKICDFDLGSGIKLN----------GDCSPISTP-ELLTPCGSAEYMAPEV----VEAF-------------SEEASI--YDKRCDLWSLGVILYILLS-GY-PPFV-GRCGSDCGWDRGEACPACQ-NMLFESIQEGKYEFPDKDW-A-HIS----------------------------------------------------CAAKDLISKLLVRDAKQ--RLS-------AA-QVLQHPWV--------------
----Y-VRLQKIGEGSFGKA---ILVKS---T-EDGR---QYVIKEINISR-MSSKERE-ESRR-------------------------EVAV-L-ANM--K------HPN--IVQYRESFEE-------------------------------------NGSLY--IVMDY-CEGG--DLFKRINA--QKGVLFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLT---KDGTV---------QLGDFGIARVL-----------------NSTVE-LARTCIGTPYYLSPEI----CE------------------NKP--YNNKSDIWALGCVLYELCT-LK-HAFE-AG---------------SM-KNLVLKIISGSFPPVSLHY-S--------------------------------------------------------YDLRSLVSQLFKRNPRD--RPS-------VN-SILEKGF-I-------------
-----YEVLYTIGTGSYGRC---QKIRR---K-SDGK---ILVWKELDYGS-MTEAEKQ-MLVS-------------------------EVNL-L-REL--K------HPN--IVRYYDRIIDR-----------------------------------TNTTLY--IVMEY-CEGG--DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD---GKQNV---------KLGDFGLARIL-----------------NHDTS-FAKTFVGTPYYMSPEQ----MN------------------RMS--YNEKSDIWSLGCLLYELCA-LM-PPFT-AF---------------SQ-KELAGKIREGKFRRIPYRY-----S----------------------------------------------------DELNEIITRMLNLKDYH--RPS-------VE-EILENPL-I-------------
----Y-CYLRVVGKGSYGEV---TLVKH---R-RDGK---QYVIKKLNLRN-ASSRERR-AAEQ-------------------------EAQL-L-SQL--K------HPN--IVTYKESWEG------------------------------------GDGLLY--IVMGF-CEGG--DLYRKLKE--QKGQLLPENQVVEWFVQIAMALQYLHEK-----HILHRDLKTQNVFLT---RTNII---------KVGDLGIARVL-----------------ENHCD-MASTLIGTPYYMSPEL----FS------------------NKP--YNYKSDVWALGCCVYEMAT-LK-HAFN-AK---------------DM-NSLVYRIIEGKLPPMPRDY-----S----------------------------------------------------PELAELIRTMLSKRPEE--RPS-------VR-SILRQPYI--------------
-----YDVIKAIGQGAFGKA---YLAKG---K-SDSK---HCVIKEINFEK-MPIQEKE-ASKK-------------------------EVIL-L-EKM--K------HPN--IVAFFNSFQE-------------------------------------NGRLF--IVMEY-CDGG--DLMKRINR--QRGVLFSEDQILGWFVQISLGLKHIHDR-----KILHRDIKAQNIFLS---KNGMV--------AKLGDFGIARVL-----------------NNSME-LARTCIGTPYYLSPEI----CQ------------------NKP--YNNKTDIWSLGCVLYELCT-LK-HPFE-GN---------------NL-QQLVLKICQAHFAPISPGF-----S----------------------------------------------------RELHSLISQLFQVSPRD--RPS-------IN-SILKRPFL--------------
-----YERIRVVGRGAFGIV---HLCLR---K-ADQK---LVIIKQIPVEQ-MTKEERQ-AAQN-------------------------ECQV-L-KLL--N------HPN--VIEYYENFLE-------------------------------------DKALM--IAMEY-APGG--TLAEFIQK--RCNSLLEEETILHFFVQILLALHHVHTH-----LILHRDLKTQNILLD--KHRMVV---------KIGDFGISKI------------------LSSKS-KAYTVVGTPCYISPEL----CE------------------GKP--YNQKSDIWALGCVLYELAS-LK-RAFE-AA---------------NL-PALVLKIMSGTFAPISDRY-----S----------------------------------------------------PELRQLVLSLLSLEPAQ--RPP-------LS-HIMAQP--LC------------
--YIP---IRVLGRGAFGEA---TLYRR---T-EDDS---LVVWKEVDLTR-LSEKERR-DALN-------------------------EIVI-L-ALL--Q------HDN--IIAYYNHFMD-------------------------------------NTTLL--IELEY-CNGG--NLYDKILR--QKDKLFEEEMVVWYLFQIVSAVSCIHKA-----GILHRDIKTLNIFLT---KANLI---------KLGDYGLAKKL-----------------NSEYS-MAETLVGTPYYMSPEL----CQ------------------GVK--YNFKSDIWAVGCVIFELLT-LK-RTFD-AT---------------NP-LNLCVKIVQGIRAMEVDSS---QYS----------------------------------------------------LELIQMVHSCLDQDPEQ--RPT-------AD-ELLDRPL-L-------------
--IEP---DRPIGYGAFGVV---WSVTD---P-RDGK---RVALKKMPNVF-QNLVSCK-RVFR-------------------------ELKM-L-CFF--K------HDN--VLSALDILQPPH--------------------------------IDYFEEIY--VVTEL-MQS---DLHKIIV----SPQPLSSDHVKVFLYQILRGLKYLHSA-----GILHRDIKPGNLLVN---SNCVL---------KICDFGLARVE----------------ELDESR-HMTQEVVTQYYRAPEI----LM-----------------GSRH--YSNAIDIWSVGCIFAELLG-RR-ILFQ-AQ------------SPIQQ-LDLITDLLGTPSLEAMRTA-C-EGAKAHILRGPHKQP---------------------------SLPVLYTLSSQATHEAVHLLCRMLVFDPSK--RIS-------AK-DALAHPYL--------------
-----YELQETLGKGTYGKV---KRATE---R-FSGR---VVAIKSIRKDK-IKDEQDM-VHIR------------------------REIEI-M-SSL--N------HPH--IISIYEVFEN-------------------------------------KDKIV--IIMEY-ASKG--ELYDYIS----ERRRLSERETRHFFRQIVSAVHYCHKN-----GVVHRDLKLENILLD---DNCNI---------KIADFGLSNL------------------YQKDK-FLQTFCGSPLYASPEI----VN-----------------GRPY--RGPEVDSWALGVLLYTLVY-GT-MPFD-GF---------------DH-KNLIRQISSGEYREPTQP-----------------------------------------------------------SDARGLIRWMLMVNPDR--RAT-------IE-DIANHWW-V-------------
-----YEFLETLGKGTYGKV---KKARE---S-SGR----LVAIKSIRKDK-IKDEQDL-MHIR------------------------REIEI-M-SSL--N------HPH--IIAIHEVFEN-------------------------------------SSKIV--IVMEY-ASRG--DLYDYIS----ERQQLSEREARHFFRQIVSAVHYCHQN-----RVVHRDLKLENILLD---ANGNI---------KIADFGLSNL------------------YHQGK-FLQTFCGSPLYASPEI----VN-----------------GKPY--TGPEVDSWSLGVLLYILVH-GT-MPFD-GH---------------DH-KILVKQISNGAYREPPK-------P----------------------------------------------------SDACGLIRWLLMVNPTR--RAT-------LE-DVASHWW-V-------------
-----YTRFEKIGQGASGTV---YTAMD---V-ATGQ---EVAIKQMNLQQ-QPKKELI-I--N-------------------------EILV-M-REN--K------NPN--IVNYLDSYLV-------------------------------------GDELW--VVMEY-LAGG--SLTDVVT-----ETCMDEGQIAAVCRECLQALEFLHSN-----QVIHRDIKSDNILLG---MDGSV---------KLTDFGFCAQI-----------------TPEQS-KRSTMVGTPYWMAPEV----VT------------------RKA--YGPKVDIWSLGIMAIEMIE-GE-PPYL-NE------------NPLRA-LYLIATNGTPELQNPEKLS----------------------------------------------------------AIFRDFLNRCLEMDVEK--RGS-------AK-ELLQHQFL--------------
-----YTRYEKIGQGASGTV---FTATD---V-ALGQ---EVAIKQINLQK-QPKKELI-I--N-------------------------EILV-M-KEL--K------NPN--IVNFLDSYLV-------------------------------------GDELF--VVMEY-LAGG--SLTDVVT-----ETCMDEAQIAAVCRECLQALEFLHAN-----QVIHRDIKSDNVLLG---MEGSV---------KLTDFGFCAQI-----------------TPEQS-KRSTMVGTPYWMAPEV----VT------------------RKA--YGPKVDIWSLGIMAIEMVE-GE-PPYL-NE------------NPLRA-LYLIATNGTPELQNPEKLS----------------------------------------------------------PIFRDFLNRCLEMDVEK--RGS-------AK-ELLQHPFL--------------
-----YTRFEKIGQGASGTV---YTALD---I-ATGQ---EVAIKQMNLQQ-QPKKELI-I--N-------------------------EILV-M-REN--K------NPN--IVNYLDSYLV-------------------------------------GDELW--VVMEY-LAGG--SLTDVVT-----ETCMDEGQIAAVCRECLQALDFLHSN-----QVIHRDIKSDNILLG---MDGSV---------KLTDFGFCAQI-----------------TPEQS-KRSTMVGTPYWMAPEV----VT------------------RKA--YGPKVDIWSLGIMAIEMVE-GE-PPYL-NE------------NPLRA-LYLIATNGTPELQNPERLS----------------------------------------------------------AVFRDFLNRCLEMDVDR--RGS-------AK-ELLQHPFL--------------
-DNFI-----KIGEGSTGIV---CIATV---R-SSGK---LVAVKKMDLRK-QQRREL---LFN-------------------------EVVI-M-RDY--Q------HEN--VVEMYNSYLV-------------------------------------GDELW--VVMEF-LEGG--ALTDIVT-----HTRMNEEQIAAVCLAVLQALSVLHAQ-----GVIHRDIKSDSILLT---HDGRV---------KLSDFGFCAQV-----------------SKEVP-RRKSLVGTPYWMAPEL----IS------------------RLP--YGPEVDIWSLGIMVIEMVD-GE-PPYF-NE------------PPLKA-MKMIRDNLPPRLKNLHKVS----------------------------------------------------------PSLKGFLDRLLVRDPAQ--RAT-------AA-ELLKHPFL--------------
----F-KFGKILGEGSFSTV---VLARE---L-ATSR---EYAIKILEKRH-IIKENKVPYVTR-------------------------ERDV-M-SRL--D------HPF--FVKLYFTFQD-------------------------------------DEKLY--FGLSY-AKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN---EDMHI---------QITDFGTAKVLS---------------PESKQA-RANSFVGTAQYVSPEL----LT------------------EKS--ACKSSDLWALGCIIYQLVA-GL-PPFR-AG---------------NE-YLIFQKIIKLEYDFPEKFF----------------------------------------------------------PKARDLVEKLLVLDATK--RLG-------CE-EM------EGYGPLKAHPF---
-----YEPKEILGRGVSSVV---RRCIH---K-PTSQ---EYAVKVIDVTG-GGSFSPE-EVRELRE------------------ATLKEVDI-L-RKV-SG------HPN--IIQLKDTYET-------------------------------------NTFFF--LVFDL-MKRG--ELFDYLT----EKVTLSEKETRKIMRALLEVICTLHKL-----NIVHRDLKPENILLD---DNMNI---------KLTDFGFSCQ------------------LEPGE-RLREVCGTPSYLAPEI----IECS------------MNEDHPG--YGKEVDMWSTGVIMYTLLA-GS-PPFW-HR---------------KQ-MLMLRMIMSGNYQFGSPEW-D-DYS----------------------------------------------------DTVKDLVSRFLVVQPQN--RYT-------AE-EALAHPFF--------------
--YDP---KDVIGRGVSSVV---RRCVH---R-ATGH---EFAVKIMEVTA-ERLSPEQ-LEEVREA-------------------TRRETHI-L-RQV-AG------HPH--IITLIDSYES-------------------------------------SSFMF--LVFDL-MRKG--ELFDYLT----EKVALSEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLD---DNMQI---------RLSDFGFSCH------------------LEPGE-KLRELCGTPGYLAPEI----LKCS------------MDETHPG--YGKEVDLWACGVILFTLLA-GS-PPFW-HR---------------RQ-ILMLRMIMEGQYQFSSPEW-D-DRS----------------------------------------------------STVKDLISRLLQVDPEA--RLT-------AE-QALQHPFF--------------
-----YQVGPLLGSGGFGSV---YSGIR---V-SDNL---PVAIKHVEKDR-ISDWGEL-PNGTRV---------------------PMEVVL-L-KKV--S------SGFSGVIRLLDWFER-------------------------------------PDSFV--LILER-PEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILID--LNRGEL---------KLIDFGSGA-------------------LLKDT-VYTDFDGTRVYSPPEW----IR-----------------YHRY--HGRSAAVWSLGILLYDMVC-GD-IPFE-HD----------------------EEIIRGQVFFRQRVS----------------------------------------------------------SECQHLIRWCLALRPSD--RPT-------FE-EIQNHPWM--------------
-----YRLGPLLGKGGFGTV---FAGHR---L-TDRL---QVAIKVIPRNR-VLGWSPL-SDSVTC---------------------PLEVAL-L-WKV--GAG--GGHPG--VIRLLDWFET-------------------------------------QEGFM--LVLERPLPAQ--DLFDYIT----EKGPLGEGPSRCFFGQVVAAIQHCHSR-----GVVHRDIKDENILID--LRRGCA---------KLIDFGSGA-------------------LLHDE-PYTDFDGTRVYSPPEW----IS-----------------RHQY--HALPATVWSLGILLYDMVC-GD-IPFE-RD----------------------QEILEAELHFPAHVS----------------------------------------------------------PDCCALIRRCLAPKPSS--RPS-------LE-EILLDPWM--------------
-----YQVGAVLGSGGFGTV---YAGSR---I-ADGL---PVAVKHVVKER-VTEWGSL-GGATV----------------------PLEVVL-L-RKV--GAA--GGARG--VIRLLDWFER-------------------------------------PDGFL--LVLER-PEPA-QDLFDFIT----ERGALDEPLARRFFAQVLAAVRHCHSC-----GVVHRDIKDENLLVD--LRSGEL---------KLIDFGSGA-------------------LLKDT-VYTDFDGTRVYSPPEW----IR-----------------YHRY--HGRSATVWSLGVLLYDMVC-GD-IPFE-QD----------------------EEILRGRLLFRRRVS----------------------------------------------------------PECQQLIRWCLSLRPSE--RPS-------LD-QIAAHPWM--------------
---FR--CCAVLGRGHFGKV---LLAEY---K-NTNE---MFAIKALKKGD-IVARDEV-DSLM------------------------CEKRI-F-ETV--NS---VRHPF--LVNLFACFQT-------------------------------------KEHVC--FVMEY-AAGG--DLMMHIH-----TDVFSEPRAVFYAACVVLGLQYLHEH-----KIVYRDLKLDNLLLD---TEGFV---------KIADFGLCKEG-----------------MGYGD-RTSTFCGTPEFLAPEV----LT------------------ETS--YTRAVDWWGLGVLIYEMLV-GE-SPFP-GD---------------DE-EEVFDSIVNDEVRYPRFLS----------------------------------------------------------TEAISIMRRLLRRNPER--RLGAS--EKDAE-DVKKHPFF--------------
---YV--RGRFLGKGGFAKC---FEISD---A-DTKE---VFAGKIVPKSL-LLKPHQR-EKMS------------------------MEISI-H-RSL--A------HQH--VVGFHGFFED-------------------------------------NDFVF--VVLEL-CRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN---EDLEV---------KIGDFGLATKV-----------------EYDGE-RKKTLCGTPNYIAPEV----LS------------------KKG--HSFEVDVWSIGCIMYTLLV-GK-PPFE-TS---------------CL-KETYLRIKKNEYSIPKHIN----------------------------------------------------------PVAASLIQKMLQTDPTA--RPT-------IN-ELLNDEFF--------------
----Y-CRGKVLGKGGFAKC---YEMTD---L-TNNK---VYAAKIIPHSR-VAKPHQR-EKID------------------------KEIEL-H-RIL--H------HKH--VVQFYHYFED-------------------------------------KENIY--ILLEY-CSRR--SMAHILK----ARKVLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFIN---EAMEL---------KVGDFGLAARL-----------------EPLEH-RRRTICGTPNYLSPEV----LN------------------KQG--HGCESDIWALGCVMYTMLL-GR-PPFE-TT---------------NL-KETYRCIREARYTMPSSLL----------------------------------------------------------APAKHLIASMLSKNPED--RPS-------LD-DIIRHDFF--------------
---YL--KGRLLGKGGFARC---YEATD---T-ETGS---AYAVKVIPQSR-VAKPHQR-EKIL------------------------NEIEL-H-RDL--Q------HRH--IVRFSHHFED-------------------------------------ADNIY--IFLEL-CSRK--SLAHIWK----ARHTLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFIT---ENMEL---------KVGDFGLAARL-----------------EPPEQ-RKKTICGTPNYVAPEV----LL------------------RQG--HGPEADVWSLGCVMYTLLC-GS-PPFE-TA---------------DL-KETYRCIKQVHYTLPASLS----------------------------------------------------------LPARQLLAAILRASPRD--RPS-------ID-QILRHDFF--------------
----F-NFLMVLGKGSFGKV---MLADR---K-GTEE---LYAIKILKKDV-VIQDDDV-ECTM------------------------VEKRV-L-ALL-DK------PPF--LTQLHSCFQT-------------------------------------VDRLY--FVMEY-VNGG--DLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHKR-----GIIYRDLKLDNVMLD---SEGHI---------KIADFGMCKEH-----------------MMDGV-TTRTFCGTPDYIAPEI----IA------------------YQP--YGKSVDWWAYGVLLYEMLA-GQ-PPFD-GE---------------DE-DELFQSIMEHNVSYPKSLS----------------------------------------------------------KEAVSVCKGLMTKHPAK--RLG-------C----------GPEGERDVREHAFF
----F-NFLMVLGKGSFGKV---MLSER---K-GTDE---LYAVKILKKDV-VIQDDDV-ECTM------------------------VEKRV-L-ALP-GK------PPF--LTQLHSCFQT-------------------------------------MDRLY--FVMEY-VNGG--DLMYHIQ----QVGRFKEPHAVFYAAEIAIGLFFLQSK-----GIIYRDLKLDNVMLD---SEGHI---------KIADFGMCKEN-----------------IWDGV-TTKTFCGTPDYIAPEI----IA------------------YQP--YGKSVDWWAFGVLLYEMLA-GQ-APFE-GE---------------DE-DELFQSIMEHNVAYPKSMS----------------------------------------------------------KEAVAICKGLMTKHPGK--RLG-------C----------GPEGERDIKEHAFF
---FI--FHKVLGKGSFGKV---LLGEL---K-GRGE---YFAIKALKKDV-VLIDDDV-ECTM------------------------VEKRV-L-TLA-AE------NPF--LTHLICTFQT-------------------------------------KDHLF--FVMEF-LNGG--DLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHSK-----GIIYRDLKLDNVLLD---RDGHI---------KIADFGMCKEN-----------------IFGES-RASTFCGTPDYIAPEI----LQ------------------GLK--YTFSVDWWSFGVLLYEMLI-GQ-SPFH-GD---------------DE-DELFESIRVDTPHYPRWIT----------------------------------------------------------KESKDILEKLFEREPTK--RLG------VTG-NIKIHPFF--------------
----F-NFIKVLGKGSFGKV---MLAEL---K-GKDE---VYAVKVLKKDV-ILQDDDV-DCTM------------------------TEKRI-L-ALA-RK------HPY--LTQLYCCFQT-------------------------------------KDRLF--FVMEY-VNGG--DLMFQIQ----RSRKFDEPRSRFYAAEVTSALMFLHQH-----GVIYRDLKLDNILLD---AEGHC---------KLADFGMCKEG-----------------ILNGV-TTTTFCGTPDYIAPEI----LQ------------------ELE--YGPSVDWWALGVLMYEMMA-GQ-PPFE-AD---------------NE-DDLFESILHDDVLYPVWLS----------------------------------------------------------KEAVSILKAFMTKNPHK--RLGCVASQNGED-AIKQHP--FF------------
-----FEFIRVLGKGSFGKV---MLARV---K-ETGD---LYAVKVLKKDV-ILQDDDV-ECTM------------------------TEKRI-L-SLA-RN------HPF--LTQLFCCFQT-------------------------------------PDRLF--FVMEF-VNGG--DLMFHIQ----KSRRFDEARARFYAAEIISALMFLHDK-----GIIYRDLKLDNVLLD---HEGHC---------KLADFGMCKEG-----------------ICNGV-TTATFCGTPDYIAPEI----LQ------------------EML--YGPAVDWWAMGVLLYEMLC-GH-APFE-AE---------------NE-DDLFEAILNDEVVYPTWLH----------------------------------------------------------EDATGILKSFMTKNPTM--RLGSLT-QGGEH-AILRHPF-F-------------
----F-DLLRVIGRGSYAKV---LLVRL---K-KTDR---IYAMKVVKKEL-VNDDEDI-DWVQ------------------------TEKHV-F-EQA-SN------HPF--LVGLHSCFQT-------------------------------------ESRLF--FVIEY-VNGG--DLMFHMQ----RQRKLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLD---SEGHI---------KLTDYGMCKEG-----------------LRPGD-TTSTFCGTPNYIAPEI----LR------------------GED--YGFSVDWWALGVLMFEMMA-GR-SPFD-IVGSS------DNPDQNTE-DYLFQVILEKQIRIPRSLS----------------------------------------------------------VKAASVLKSFLNKDPKE--RLGCHP-QTGFA-DIQGHPF-F-------------
---FI--LHKMLGKGSFGKV---FLAEF---K-KTNQ---FFAIKALKKDV-VLMDDDV-ECTM------------------------VEKRV-L-SLA-WE------HPF--LTHMFCTFQT-------------------------------------KENLF--FVMEY-LNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHSK-----GIVYRDLKLDNILLD---KDGHI---------KIADFGMCKEN-----------------MLGDA-KTNTFCGTPDYIAPEI----LL------------------GQK--YNHSVDWWSFGVLLYEMLI-GQ-SPFH-GQ---------------DE-EELFHSIRMDNPFYPRWLE----------------------------------------------------------KEAKDLLVKLFVREPEK--RLG-------VRGDIRQHPLF--------------
----F-DLIRVIGRGSYAKV---LLVRL---K-KNDQ---IYAMKVVKKEL-VHDDEDI-DWVQ------------------------TEKHV-F-EQA-SS------NPF--LVGLHSCFQT-------------------------------------TSRLF--LVIEY-VNGG--DLMFHMQ----RQRKLPEEHARFYAAEICIALNFLHER-----GIIYRDLKLDNVLLD---ADGHI---------KLTDYGMCKEG-----------------LGPGD-TTSTFCGTPNYIAPEI----LR------------------GEE--YGFSVDWWALGVLMFEMMA-GR-SPFD-IITD--------NPDMNTE-DYLFQVILEKPIRIPRFLS----------------------------------------------------------VKASHVLKGFLNKDPKE--RLGCRP-QTGF----------SDIKSHAFF-----
---PD----EVLGSGQFGIV---YGGKH---R-KTGR---DVAIKIIDKLR-FPTKQES-QLRN-------------------------EVAI-L-QNL--H------HPG--VVNLECMFET-------------------------------------PERVF--VVMEK-LHGD--MLEMILS---SEKGRLPEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA---SADPFP------QVKLCDFGFARI------------------IGEKS-FRRSVVGTPAYLAPEV----LR------------------NKG--YNRSLDMWSVGVIIYVSLS-GT-FPFN-ED------------------EDIHDQIQNAAFMYPPNPW-K-EIS----------------------------------------------------HEAIDLINNLLQVKMRK--RYS-------VD-KTLSHPWL--------------
---PD----EVLGSGQFGVV---YGGKH---R-KTGR---DVAVKVIDKLR-FPTKQES-QLRN-------------------------EVAI-L-QSL--R------HPG--IVNLECMFET-------------------------------------PEKVF--VVMEK-LHGD--MLEMILS---SEKGRLPERLTKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA---SADPFP------QVKLCDFGFARI------------------IGEKS-FRRSVVGTPAYLAPEV----LL------------------NQG--YNRSLDMWSVGVIMYVSLS-GT-FPFN-ED------------------EDINDQIQNAAFMYPASPW-S-HIS----------------------------------------------------AGAIDLINNLLQVKMRK--RYS-------VD-KSLSHPWL--------------
--FAD----EVLGSGQFGIV---YGGKH---R-KTGR---DVAIKVIDKMR-FPTKQES-QLRN-------------------------EVAI-L-QNL--H------HPG--IVNLECMFET-------------------------------------PERVF--VVMEK-LHGD--MLEMILS---SEKSRLPERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVLLA---SAEPFP------QVKLCDFGFARI------------------IGEKS-FRRSVVGTPAYLAPEV----LR------------------SKG--YNRSLDMWSVGVIIYVSLS-GT-FPFN-ED------------------EDINDQIQNAAFMYPPNPW-R-EIS----------------------------------------------------GEAIDLINNLLQVKMRK--RYS-------VD-KSLSHPWL--------------
-----FELLKVLGQGSFGKVFLVRKVTR---P-DSGH---LYAMKVLKKAT-LKVRDRV-RTKM-------------------------ERDI-L-ADV--N------HPF--VVKLHYAFQT-------------------------------------EGKLY--LILDF-LRGG--DLFTRLS----KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KLTDFGLSKEA-----------------IDHEK-KAYSFCGTVEYMAPEV----VN------------------RQG--HSHSADWWSYGVLMFEMLT-GS-LPFQ-GK---------------DR-KETMTLILKAKLGMPQFLS----------------------------------------------------------TEAQSLLRALFKRNPAN--RLGSG--PDGAE-EIKRHV--FY------------
-----FELLKVLGQGSYGKV---FLVRK---V-KGSDAGQLYAMKVLKKAT-LKVRDRV-RSKM-------------------------ERDI-L-AEV--N------HPF--IVKLHYAFQT-------------------------------------EGKLY--LILDF-LRGG--DLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KITDFGLSKEA-----------------IDHDK-RAYSFCGTIEYMAPEV----VN------------------RRG--HTQSADWWSFGVLMFEMLT-GS-LPFQ-GK---------------DR-KETMALILKAKLGMPQFLS----------------------------------------------------------GEAQSLLRALFKRNPCN--RLGAG--IDGVE-EIKRHPFF--------------
-----FELLKVLGQGSFGKV---FLVKK---I-SGSDARQLYAMKVLKKAT-LKVRDRV-RTKM-------------------------ERDI-L-VEV--N------HPF--IVKLHYAFQT-------------------------------------EGKLY--LILDF-LRGG--DLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KLTDFGLSKES-----------------IDHEK-KAYSFCGTVEYMAPEV----VN------------------RRG--HTQSADWWSFGVLMFEMLT-GT-LPFQ-GK---------------DR-KETMTMILKAKLGMPQFLS----------------------------------------------------------PEAQSLLRMLFKRNPAN--RLGAG--PDGVE-EIKRHSFF--------------
-----FELLKVLGQGSFGKV---FLVRK---K-TGPDAGQLYAMKVLKKAS-LKVRDRV-RTKM-------------------------ERDI-L-VEV--N------HPF--IVKLHYAFQT-------------------------------------EGKLY--LILDF-LRGG--DVFTRLS----KEVLFTEEDVKFYLAELALALDHLHQL-----GIVYRDLKPENILLD---EIGHI---------KLTDFGLSKES-----------------VDQEK-KAYSFCGTVEYMAPEV----VN------------------RRG--HSQSADWWSYGVLMFEMLT-GT-LPFQ-GK---------------DR-NETMNMILKAKLGMPQFLS----------------------------------------------------------AEAQSLLRMLFKRNPAN--RLGS----EGVE-EIKRHLFF--------------
-----FELLRVLGKGGYGKV---FQVRKVTGA-NTGK---IFAMKVLKKAM-IVRNAKD-TAHTK-----------------------AERNI-L-EEV--K------HPF--IVDLIYAFQT-------------------------------------GGKLY--LILEY-LSGG--ELFMQLE----REGIFMEDTACFYLAEISMALGHLHQK-----GIIYRDLKPENIMLN---HQGHV---------KLTDFGLCKES-----------------IHDGT-VTHTFCGTIEYMAPEI----LM------------------RSG--HNRAVDWWSLGALMYDMLT-GA-PPFT-GE---------------NR-KKTIDKILKCKLNLPPYLT----------------------------------------------------------QEARDLLKKLLKRNAAS--RLGAG--PGDAG-EVQAHPFF--------------
-----FELLRVLGKGGYGKV---FQVRK---V-QGTNLGKIYAMKVLRKAK-IVRNAKD-TAHTR-----------------------AERNI-L-ESV--K------HPF--IVELAYAFQT-------------------------------------GGKLY--LILEC-LSGG--ELFTHLE----REGIFLEDTACFYLAEITLALGHLHSQ-----GIIYRDLKPENIMLS---SQGHI---------KLTDFGLCKES-----------------IHEGA-VTHTFCGTIEYMAPEI----LV------------------RSG--HNRAVDWWSLGALMYDMLT-GS-PPFT-AE---------------NR-KKTMDKIIRGKLALPPYLT----------------------------------------------------------PDARDLVKKFLKRNPSQ--RIGGG--PGDAA-DVQRHPFF--------------
-----YELVRELGKGTYGKV---DLVVY---K-GTGT---KMALKFVNKSK-TKLKNF----LR-------------------------EVSI-T-NSL-SS------SPF--IIKVFDVVFE------------------------------------TEDCYV--FAQEY-APAG--DLFDIIP----PQVGLPEDTVKRCVQQLGLALDFMHGR-----QLVHRDIKPENVLLFD-RECRRV---------KLADFGMTR--------------------RVGC-RVKRVSGTIPYTAPEV----CQAG-------------RADGLA--VDTGVDVWAFGVLIFCVLT-GN-FPWE-AA------------SGADAFFEEFVRWQRGRLPGLPSQW-R-RFT----------------------------------------------------EPALRMFQRLLALEPER--RGP-------AK-EVF-----RFLKH---------
-----FHFLKVIGKGSFGKV---LLARH---K-AEEV---FYAVKVLQKKA-ILKKKEE-KHIM------------------------SERNV-LLKNV--K------HPF--LVGLHFSFQT-------------------------------------ADKLY--FVLDY-INGG--ELFYHLQ----RERCFLEPRARFYAAEIASALGYLHSL-----NIVYRDLKPENILLD---SQGHI---------VLTDFGLCKEN-----------------IEHNS-TTSTFCGTPEYLAPEV----LH------------------KQP--YDRTVDWWCLGAVLYEMLY-GL-PPFY-SR---------------NT-AEMYDNILNKPLQLKPNIT----------------------------------------------------------NSARHLLEGLLQKDRTK--RLGAK---DDFM-EIKSHV--FF------------
----F-DFLKVIGKGNYGKV---LLAKR---K-SDGA---FYAVKVLQKKS-ILKKKEQ-SHIM------------------------AERSVLL-KNV--R------HPF--LVGLRYSFQT-------------------------------------PEKLY--FVLDY-VNGG--ELFFHLQ----RERRFLEPRARFYAAEVASAIGYLHSL-----NIIYRDLKPENILLD---CQGHV---------VLTDFGLCKEG-----------------VEPED-TTSTFCGTPEYLAPEV----LR------------------KEP--YDRAVDWWCLGAVLYEMLH-GL-PPFY-SQ---------------DV-SQMYENILHQPLQIPGGRT----------------------------------------------------------VAACDLLQSLLHKDQRQ--RLGSK---ADFL-EIKNHVFF--------------
----F-DFLKVIGKGSFGKV---LLAKR---K-LDGK---FYAVKVLQKKI-VLNRKEQ-KHIM------------------------AERNV-LLKNV--K------HPF--LVGLHYSFQT-------------------------------------TEKLY--FVLDF-VNGG--ELFFHLQ----RERSFPEHRARFYAAEIASALGYLHSI-----KIVYRDLKPENILLD---SVGHV---------VLTDFGLCKEG-----------------IAISD-TTTTFCGTPEYLAPEV----IR------------------KQP--YDNTVDWWCLGAVLYEMLY-GL-PPFY-CR---------------DV-AEMYDNILHKPLSLRPGVS----------------------------------------------------------LTAWSILEELLEKDRQN--RLGAK---EDFL-EIQNHPFF--------------
-----YDIERTLGKGNFAVV---KLARH---R-VTKT---QVAIKIIDKTR-LDSSNLE-KIYR-------------------------EVQL-M-KLL--N------HPH--IIKLYQVMET-------------------------------------KDMLY--IVTEF-AKNG--EMFDYLT----SNGHLSENEARKKFWQILSAVEYCHDH-----HIVHRDLKTENLLLD---GNMDI---------KLADFGFGNF------------------YKSGE-PLSTWCGSPPYAAPEV----FE-----------------GKEY--EGPQLDIWSLGVVLYVLVC-GS-LPFD-GP---------------NL-PTLRQRVLEGRFRIPFFMS----------------------------------------------------------QDCESLIRRMLVVDPAR--RIT-------IA-QIRQHRWM--------------
-----YDIEGTLGKGNFAVV---KLGRH---R-ITKT---EVAIKIIDKSQ-LDAVNLE-KIYR-------------------------EVQI-M-KML--D------HPH--IIKLYQVMET-------------------------------------KSMLY--LVTEY-AKNG--EIFDYLA----NHGRLNESEARRKFWQILSAVDYCHGR-----KIVHRDLKAENLLLD---NNMNI---------KIADFGFGNF------------------FKSGE-LLATWCGSPPYAAPEV----FE-----------------GQQY--EGPQLDIWSMGVVLYVLVC-GA-LPFD-GP---------------TL-PILRQRVLEGRFRIPYFMS----------------------------------------------------------EDCEHLIRRMLVLDPSK--RLT-------IA-QIKEHKWM--------------
-----WEIIGELGDGAFGKV---YKAQN---K-ETSV---LAAAKVIDTKS-EEELEDY-M--V-------------------------EIDI-L-ASC--D------HPN--IVKLLDAFYY-------------------------------------ENNLW--ILIEF-CAGG--AVDAVML---ELERPLTESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNILFT---LDGDI---------KLADFGVSAKN-----------------TRTIQ-RRDSFIGTPYWMAPEV----VMCE-------------TSKDRP--YDYKADVWSLGITLIEMAE-IE-PPHH-EL------------NPMRV-LLKIAKSEPPTLAQPSRWS----------------------------------------------------------SNFKDFLKKCLEKNVDA--RWT-------TS-QLLQHPFV--------------
-----YDLDKTLGRGHFAVV---KLARH---V-FTGE---KVAVKVIDKTK-LDTLATG-HLFQ-------------------------EVRC-M-KLV--Q------HPN--IVRLYEVIDT-------------------------------------QTKLY--LILEL-GDGG--DMFDYIM---KHEEGLNEDLAKKYFAQIVHAISYCHKL-----HVVHRDLKPENVVFF--EKQGLV---------KLTDFGFSNK------------------FQPGK-KLTTSCGSLAYSAPEI----LL-----------------GDEY--DAPAVDIWSLGVILFMLVC-GQ-PPFQ-EA---------------ND-SETLTMIMDCKYTVPSHVS----------------------------------------------------------KECKDLITRMLQRDPKR--RAS-------LE-EIENHPWL--------------
-----WEIVGELGDGAFGKV---YKAKN---K-ETGA---LAAAKVIETKS-EEELEDY-I--V-------------------------EIEI-L-ATC--D------HPY--IVKLLGAYYH-------------------------------------DGKLW--IMIEF-CPGG--AVDAIML---ELDRGLTEPQIQVVCRQMLEALNFLHSK-----RIIHRDLKAGNVLMT---LEGDI---------RLADFGVSAKN-----------------LKTLQ-KRDSFIGTPYWMAPEV----VMCE-------------TMKDTP--YDYKADIWSLGITLIEMAQ-IE-PPHH-EL------------NPMRV-LLKIAKSDPPTLLTPSKWS----------------------------------------------------------VEFRDFLKIALDKNPET--RPS-------AA-QLLEHPFV--------------
--YLM---GDLLGEGSYGKV---KEVLD---S-ETLC---RRAVKILKKKK-LRRIPNG-EANVK-----------------------KEIQL-L-RRL--R------HKN--VIQLVDVLYNE-----------------------------------EKQKMY--MVMEY-CVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLT---TGGTL---------KISDLGVAEALH---------------PFAADD-TCRTSQGSPAFQPPEI----AN----------------GLDTF--SGFKVDIWSAGVTLYNITT-GL-YPFE-GD---------------NI-YKLFENIGKGSYAIPGDCG----------------------------------------------------------PPLSDLLKGMLEYEPAK--RFS-------IR-QIRQHSWF--------------
--LCP---GRELGRGKFAVV---RKCIK---K-DSGK---EFAAKFMRKRR-KGQDCRM-EIIH-------------------------EIAV-L-ELA-QD------NPW--VINLHEVYET-------------------------------------ASEMI--LVLEY-AAGG--EIFDQCVA--DREEAFKEKDVQRLMRQILEGVHFLHTR-----DVVHLDLKPQNILLT---SESPLG------DIKIVDFGLSRI------------------LKNSE-ELREIMGTPEYVAPEI----LS------------------YDP--ISMATDMWSIGVLTYVMLT-GI-SPFL-GN---------------DK-QETFLNISQMNLSYSEEEF-D-VLS----------------------------------------------------ESAVDFIRTLLVKKPED--RAT-------AE-ECLKHPWL--------------
--ILT---SKELGRGKFAVV---RQCIS---K-STGQ---EYAAKFLKKRR-RGQDCRA-EILH-------------------------EIAV-L-ELA-KS------CPR--VINLHEVYEN-------------------------------------TSEII--LILEY-AAGG--EIFSLCLP--ELAEMVSENDVIRLIKQILEGVYYLHQN-----NIVHLDLKPQNILLS---SIYPLG------DIKIVDFGMSRK------------------IGHAC-ELREIMGTPEYLAPEI----LN------------------YDP--ITTATDMWNIGIIAYMLLT-HT-SPFV-GE---------------DN-QETYLNISQVNVDYSEETF-S-SVS----------------------------------------------------QLATDFIQSLLVKNPEK--RPT-------AE-ICLSHSWL--------------
-----FTKLEKIGKGSFGEV---FKGID---N-RTQK---VVAIKIIDLEE-AEDEIED-IQ-Q-------------------------EITV-L-SQC--D------SPY--VTKYYGSYLK-------------------------------------DTKLW--IIMEY-LGGG--SALDLLE-----PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS---EHGEV---------KLADFGVAGQL-----------------TDTQI-KRNTFVGTPFWMAPEV----IK------------------QSA--YDSKADIWSLGITAIELAR-GE-PPHS-EL------------HPMKV-LFLIPKNNPPTLEGNYS------------------------------------------------------------KPLKEFVEACLNKEPSF--RPT-------AK-ELLKHKFI--------------
----F-TKLDRIGKGSFGEV---YKGID---N-HTKE---VVAIKIIDLEE-AEDEIED-IQ-Q-------------------------EITV-L-SQC--D------SPY--ITRYFGSYLK-------------------------------------STKLW--IIMEY-LGGG--SALDLLK-----PGPLEETYIATILREILKGLDYLHSE-----RKIHRDIKAANVLLS---EQGDV---------KLADFGVAGQL-----------------TDTQI-KRNTFVGTPFWMAPEV----IK------------------QSA--YDFKADIWSLGITAIELAK-GE-PPNS-DL------------HPMRV-LFLIPKNSPPTLEGQHS------------------------------------------------------------KPFKEFVEACLNKDPRF--RPT-------AK-ELLKHKFI--------------
-----FEILRAIGKGSFGKV---CIVQK---N-DTKK---MYAMKYMNKQK-CVERNEV-RNVF------------------------KELQI-M-QGL--E------HPF--LVNLWYSFQD-------------------------------------EEDMF--MVVDL-LLGG--DLRYHLQ----QNVHFKEETVKLFICELVMALDYLQNQ-----RIIHRDMKPDNILLD---EHGHV---------HITDFNIAAM------------------LPRET-QITTMAGTKPYMAPEMF--SSR-----------------KGAG--YSFAVDWWSLGVTAYELLR-GR-RPYH-IR------------SSTSS-KEIVHTFETTVVTYPSAWS----------------------------------------------------------QEMVSLLKKLLEPNPDQ--RFS------QLS-DVQNFPY-M-------------
-----FQILRAIGKGSFGKV---CIVQK---R-DTEK---MYAMKYMNKQQ-CIERDEV-RNVF------------------------RELEI-L-QEI--E------HVF--LVNLWYSFQD-------------------------------------EEDMF--MVVDL-LLGG--DLRYHLQ----QNVQFSEDTVRLYICEMALALDYLRGQ-----HIIHRDVKPDNILLD---ERGHA---------HLTDFNIATI------------------IKDGE-RATALAGTKPYMAPEIFHSFVN-----------------GGTG--YSFEVDWWSVGVMAYELLR-GW-RPYD-IH------------SSNAV-ESLVQLFSTVSVQYVPTWS----------------------------------------------------------KEMVALLRKLLTVNPEH--RLS-------SL-Q-------DVQAAPA-------
-----YTFGRILGKGSFGIV---IEATD---K-ETET---KWAIKKVNKEK-AGSSAVK-LLER-------------------------EVNI-L-KSV--K------HEH--IIHLEQVFET-------------------------------------PKKMY--LVMEL-CEDG--ELKEILD----RKGHFSENETRWIIQSLASAIAYLHNN-----DIVHRDLKLENIMVK---SSLIDDNNEINLNIKVTDFGLAVKK----------------QSRSEA-MLQATCGTPIYMAPEV----IS------------------AHD--YSQQCDIWSIGVVMYMLLR-GE-PPFL-AS---------------SE-EKLFELIRKGELHFENAVW-N-SIS----------------------------------------------------DCAKSVLKQLMKVDPAH--RIT-------AK-ELLDNQWL--------------
-----YSLLAEIGRGSYGVV---YEAVA---G-RSGA---RVAVKKIRCDA-PENVEL---ALA-------------------------EFWA-L-TSLKRR------HQN--VVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLW--FVMEF-CEGG--DLNQYVL-----SRRPDPATNKSFMLQLTSAIAFLHKN-----HIVHRDLKPDNILIT---ERSGTP------ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKY-WLSSACGSDFYMAPEV----WE-------------------GH--YTAKADIFALGIIIWAMIE-RI-TFID-SE------------TKKEL-LGTYIKQGTEIVPVGEALL-E-NPKMELHIPQ--------------------------------------KRRTSMSEGIKQLLKDMLAANPQD--RPD-------AF-EL------ETRM----------
-----YHVLEMIGEGSFGRV---YKGRR---K-YSAQ---VVALKFIPKLG-RSEKELR-NLQR-------------------------EIEI-M-RGL--R------HPN--IVHMLDSFET-------------------------------------DKEVV--VVTDY-AEG---ELFQILE----DDGKLPEDQVQAIAAQLVSALYYLHSH-----RILHRDMKPQNILLA---KGGGI---------KLCDFGFARAM-----------------STNTM-VLTSIKGTPLYMSPEL----VE------------------ERP--YDHTADLWSVGCILYELAV-GT-PPFY-AT---------------SI-FQLVSLILKDPVRWPSTIS----------------------------------------------------------PCFKNFLQGLLTKDPRQ--RLS-------WP-DLLYHPFI--------------
---YL--LLHLLGRGGFSEV---YKAFD---L-TEQR---YVAVKIHQLNK-NWRDEKK-ENYHKH--------------------ACREYRI-H-KEL--D------HPR--IVKLYDYFSL------------------------------------DTDSFC--TVLEY-CEGN--DLDFYLK----QHKLMSEKEARSIIMQIVNALKYLNEIK---PPIIHYDLKPGNILLV---NGTACG------EIKITDFGLSKIMDDD----------SYNSVDGME-LTSQGAGTYWYLPPEC----FVV--------------GKEPPK--ISNKVDVWSVGVIFYQCLY-GR-KPFG-HN-------------QSQQ-DILQENTILKATEVQFPPK-P-VVT----------------------------------------------------PEAKAFIRRCLAYRKED--RID-------VQ-QLACDPYL--------------
YLLGI-----NLGEGSYAKV---KSAYS---E-RLKF---NVAIKIIDRKK-APADFLE-KFLP------------------------REIEI-L-AML--N------HCS--IIKTYEIFET------------------------------------SHGKVY--IVMEL-AVQG--DLLELIK----TRGALHEDEARKKFHQLSLAIKYCHDL-----DVVHRDLKCDNLLLD---KDFNI---------KLSDFSFSKRCLR-------------DDSGRMA-LSKTFCGSPAYAAPEV----LQ-----------------GIPY--QPKVYDIWSLGVILYIMVC-GS-MPYD-DS---------------NI-KKMLRIQKEHRVNFPRSKH-L-T------------------------------------------------------GECKDLIYHMLQPDVNR--RLH-------ID-EILSHCWM--------------
YIVGI-----NLGKGSYAKV---KSAYS---E-RLKF---NVAVKIIDRKK-TPTDFVE-RF-LP-----------------------REMDI-L-ATV--N------HGS--IIKTYEIFET------------------------------------SDGRIY--IIMEL-GVQG--DLLEFIK----CQGALHEDVARKMFRQLSSAVKYCHDL-----DIVHRDLKCENLLLD---KDFNI---------KLSDFGFSKRCLR-------------DSNGRII-LSKTFCGSAAYAAPEV----LQ-----------------SIPY--QPKVYDIWSLGVILYIMVC-GS-MPYD-DS---------------DI-RKMLRIQKEHRVDFPRSKN-L-T------------------------------------------------------CECKDLIYRMLQPDVSQ--RLH-------ID-EILSHSWL--------------
---FI--LTERLGSGTYATV---YKAYA---KKDTRE---VVAIKCVAKKS-LNKASVE-NLLT-------------------------EIEI-L-KGI--R------HPH--IVQLKDFQWD-------------------------------------SDNIY--LIMEF-CAGG--DLSRFIH----TRRILPEKVARVFMQQLASALQFLHER-----NISHLDLKPQNILLSS-LEKPHL---------KLADFGFAQH------------------MSPWD-EKHVLRGSPLYMAPEM----VC------------------QRQ--YDARVDLWSMGVILYEALF-GQ-PPFA-SR------------SFSEL-EEKIRSNRVIELPLRPLLS----------------------------------------------------------RDCRDLLQRLLERDPSR--RIS-------FQ-DFFAHPWV--------------
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