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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PKN1 203
TK ABL1 261
TK ABL2 288
AGC AKT1 150
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
TKL BMPR1B 204
TK BMX 422
TKL BRAF 456
TK BTK 402
CMGC CDC2 4
CMGC CDKL2 4
TK CSF1R 582
TK CSK 195
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK DDR1 572
TK DDR2 563
Other DSTYK 651
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHB1 619
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FRK 234
TK FYN 271
TK HCK 241
CMGC ICK 4
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
TKL LIMK2 331
TK LTK 510
TK LYN 247
TK MATK 235
TK MERTK 587
TK MET 1078
TK MUSK 575
Other NEK1 4
Other NEK2 8
Other NEK3 4
Other NEK4 6
Other NEK5 4
Other NEK9 52
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
STE OXSR1 17
STE PAK4 321
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
AGC PRKCA 339
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK RET 724
TKL RIPK1 17
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK10 36
CAMK STK17B 33
STE STK24 24
STE STK39 63
TK SYK 371
TK TNK1 116
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
TK ZAP70 338
---F-KFLAVLGRGHFGKV---LLSEFR----------------PSGE---LFAI-KAL---KKG--D-IVARD---E-V-ESLM---CEKRILAAV--TSAGHPFLVNLFGCFQ--T-------PEH------VCFVMEYSAGGDLMLHIH---------SD----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHE-H--------KIVYRDLKLDNLLLDT---EGYV----KIADFGLCKEG-----------------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS---YTRAVDWWGLGVLLYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DS----IVN----DE---VRYPRFLS----------------------------AEAIG-IMRRLLRRNPERRLGSSERDAEDVKKQPFF--------------
----ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---E-E-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--R-------EPP------FYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEK-K--------NFIHRDLAARNCLVGE---NHLV----KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EK----DYR----ME---RPEGCP------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F--------------
----ITMKHKLGGGQYGEV---YVGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---E-E-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--L-------EPP------FYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEK-K--------NFIHRDLAARNCLVGE---NHVV----KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EK----GYR----ME---QPEGCP------------------------------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F--------------
---F-EYLKLLGKGTFGKV---ILVKEK----------------ATGR---YYAM-KIL---KKE--V-IVAKD---E-V-AHTL---TENRVLQNS--R---HPFLTALKYSFQ--T-------HDR------LCFVMEYANGGELFFHLS--------RER----------------------------------------------------------------------------------------------------VFSEDRARFYGAEIVSALDYLHSEK--------NVVYRDLKLENLMLDK---DGHI----KITDFGLCKEG-----------------IKDGATM--------------KT---FCGTPEYLAPEVLE------DND---YGRAVDWWGLGVVMYEMMC-GR--------------LP---------------FYNQ--------DHEKLF----EL----ILM----EE---IRFPRTLG----------------------------PEAKS-LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF--------------
---I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAV-KTL---P-E--V-CS-EQD-EL-D-FL-M----EALIISKF--N---HQNIVRCIGVSL--Q-------SLP------RFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEE-N--------HFIHRDIAARNCLLTCPGPGRVA----KIGDFGMARDI-------------Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGI---FTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----SNQEVLEFV----TS----GGR----MD---PPKNCP------------------------------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I--------------
----FEIGRPLGKGKFGNV---YLAREK----------------QSKF---ILAL-KVL---FKA--QLEKAGV---E-H-QLRR----EVEIQSHL--R---HPNILRLYGYFH--D-------ATR------VYLILEYAPLGTVYRELQ--------KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHS-K--------RVIHRDIKPENLLLGS---AGEL----KIADFGWSV-------------------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK--------------PP---------------FEAN--------TYQETY----KR----ISR----VE---FTFPDFVT----------------------------EGARD-LISRLLKHNPSQRPM-----LREVLEHPWI--------------
----FEIGRPLGKGKFGNV---YLAREK----------------KSHF---IVAL-KVL---FKS--Q-IEKEG---V-E-HQLR---REIEIQAHL--H---HPNILRLYNYFY--D-------RRR------IYLILEYAPRGELYKELQ--------KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHG-K--------KVIHRDIKPENLLLGL---KGEL----KIADFGWSV-------------------HAPSLRR--------------KT---MCGTLDYLPPEMIE------GRM---HNEKVDLWCIGVLCYELLV-GN--------------PP---------------FESA--------SHNETY----RR----IVK----VD---LKFPASVP----------------------------MGAQD-LISKLLRHNPSERLP-----LAQVSAHPWV--------------
----FEIGRPLGKGKFGNV---YLARLK----------------ESHF---IVAL-KVL---FKS--Q-IEKEG---L-E-HQLR---REIEIQAHL--Q---HPNILRLYNYFH--D-------ARR------VYLILEYAPRGELYKELQ--------KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHD-K--------KVIHRDIKPENLLLGF---RGEV----KIADFGWSV-------------------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRT---YDEKVDLWCIGVLCYELLV-GY--------------PP---------------FESA--------SHSETY----RR----ILK----VD---VRFPLSMP----------------------------LGARD-LISRLLRYQPLERLP-----LAQILKHPWV--------------
---V-ALGKTLGEGEFGAV---MEGQLN--------------QDDSIL---KVAV-KTM---K-I-AI-CT-RSE-LE-D-FL-S----EAVCMKEF--D---HPNVMRLIGVCF--Q-------GSERESFPAPVVILPFMKHGDLHSFLL---------YSRL---------------------------------------------------------------------------------------------GDQPVYLPTQMLVKFMADIASGMEYLST-K--------RFIHRDLAARNCMLNE---NMSV----CVADFGLSKKI-------------Y---N--GDYY--------------RQGRIAKMPVKWIAIESLA------DRV---YTSKSDVWSFGVTMWEIATRGQ--------------TP---------------YPGV-----ENSEIYDYL----RQ----GNR----LK---QPADCL------------------------------DGLYA-LMSRCWELNPQDRPS-----FTELREDL----------------
---L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAI-KTL---K-E--G-TM-SP---E-A-FL-G----EANVMKAL--Q---HERLVRLYAVVT----------KEP------IYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIER-M--------NSIHRDLRAANILVSE---ALCC----KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ER----GYR----MP---RPDTCP------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L--------------
---I-QMVKQIGKGRYGEV---WMGKWR----------------GEK-----VAV-KVF---FTT--E-EASWF---R-E-T-------EIYQTVLM--R---HENILGFIAADI--KGT---GSWTQ------LYLITDYHENGSLYDYLK---------ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHT-EIFSTQGKPAIAHRDLKSKNILVKK---NGTC----CIADLGLAVKFIS-------------DTNEVDIPP--------------NT---RVGTKRYMPPEVLDESLNRNHFQ---SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CI----KKL----RP---SFPNRWSSDECL------------------------RQMGK-LMTECWAHNPASRLT-----ALRVKK----TL------------
----ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAV-KMI---K-E--G-SM-SE---D-E-FF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K-------EYP------IYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLES-H--------QFIHRDLAARNCLVDR---DLCV----KVSDFGMTRYV-----------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFK---YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQ----GHR----LY---RPHLAS------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I--------------
----ITVGQRIGSGSFGTV---YKGKWH-------------------G---DVAV-KML---N-V-TA-PT-PQQ-LQ-A-FK-N----EVGVLRKT--R---HVNILLFMGYST----------KPQ------LAIVTQWCEGSSLYHHLH---------II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHA-K--------SIIHRDLKSNNIFLHE---DLTV----KIGDFGLATVK-------------S---R--WSGS--------------HQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ--------------LP---------------YSNI-N---NRDQIIFMV----GR----GYLSPDLSK---VRSNCP------------------------------KAMKR-LMAECLKKKRDERPL-----FPQILA---SI-------------
----LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAI-KMI---K-E--G-SM-SE---D-E-FI-E----EAKVMMNL--S---HEKLVQLYGVCT--K-------QRP------IFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLES-K--------QFLHRDLAARNCLVND---QGVV----KVSDFGLSRYV-----------------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSK---FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQ----GLR----LY---RPHLAS------------------------------EKVYT-IMYSCWHEKADERPT-----FKILLSN--I--------------
----YTKIEKIGEGTYGVV---YKGRHK----------------TTGQ---VVAM-KKI---RLE--S-EEEGV---P-S-TAIR----EISLLKEL--R---HPNIVSLQDVLM--Q-------DSR------LYLIFEFLSM-DLKKYLDS-----IPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHS-R--------RVLHRDLKPQNLLIDD---KGTI----KLADFGLARAF-----------------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSAR---YSTPVDIWSIGTIFAELAT-KK--------------PL---------------FHGD-----SEIDQLFRI----FR----ALG----TP---NNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GKMALNHPYF--------------
----YENLGLVGEGSYGMV---MKCRNK----------------DTGR---IVAI-KKF---LES--D-DDKMV---K-K-IAMR----EIKLLKQL--R---HENLVNLLEVCK--K-------KKR------WYLVFEFVDHTILDDLEL--------FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHS-H--------NIIHRDIKPENILVSQ---SGVV----KLCDFGFARTL-----------------AAPGEVY--------------TD---YVATRWYRAPELLV-----GDVK---YGKAVDVWAIGCLVTEMFM-GE--------------PL---------------FPGD-----SDIDQLYHI----MM----CLG----NL---IPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CAELLHHDFF--------------
----LQFGKTLGAGAFGKV---VEATAFG-----------LGKEDAVL---KVAV-KML---K-S--T-AH-ADE-KE-A-LM-S----ELKIMSHLG-Q---HENIVNLLGACT--H-------GGP------VLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLAS-K--------NCIHRDVAARNVLLTN---GHVA----KIGDFGLARDI-------------M---N--DSNY--------------IVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ----MA---QPAFAP------------------------------KNIYS-IMQACWALEPTHRPT-----FQQICSFL----------------
----LKLLQTIGKGEFGDV---MLGDYR------------------GN---KVAV-KCI---K-N--D-AT-AQ-----A-FL-A----EASVMTQL--R---HSNLVQLLGVIV-EE-------KGG------LYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEG-N--------NFVHRDLAARNVLVSE---DNVA----KVSDFGLTKEA-----------------------S--------------STQDTGKLPVKWTAPEALR------EKK---FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EK----GYK----MD---APDGCP------------------------------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL----------------
----YDTGEELGSGQFAVV---KKCREK----------------STGL---QYAA-KFI---KKR--R-TKSSR---R-G-VSREDIEREVSILKEI--Q---HPNVITLHEVYE--N-------KTD------VILILELVAGGELFDFLA--------EKE----------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHS-L--------QIAHFDLKPENIMLLD---RNVPKPRIKIIDFGLAHK------------------IDFGNEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGD--------TKQETL----AN----VSA----VN---YEFEDEYFSNTS------------------------ALAKD-FIRRLLVKDPKKRMT-----IQDSLQHPWI--------------
----YDIGEELGSGQFAIV---KKCREK----------------STGL---EYAA-KFI---KKR--Q-SRASR---R-G-VSREEIEREVSILRQV--L---HHNVITLHDVYE--N-------RTD------VVLILELVSGGELFDFLA--------QKE----------------------------------------------------------------------------------------------------SLSEEEATSFIKQILDGVNYLHT-K--------KIAHFDLKPENIMLLD---KNIPIPHIKLIDFGLAHE------------------IEDGVEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGD--------TKQETL----AN----ITA----VS---YDFDEEFFSQTS------------------------ELAKD-FIRKLLVKETRKRLT-----IQEALRHPWI--------------
----YEMGEELGSGQFAIV---RKCRQK----------------GTGK---EYAA-KFI---KKR--R-LSSSR---R-G-VSREEIEREVNILREI--R---HPNIITLHDIFE--N-------KTD------VVLILELVSGGELFDFLA--------EKE----------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHS-K--------RIAHFDLKPENIMLLD---KNVPNPRIKLIDFGIAHK------------------IEAGNEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGE--------TKQETL----TN----ISA----VN---YDFDEEYFSNTS------------------------ELAKD-FIRRLLVKDPKRRMT-----IAQSLEHSWI--------------
----LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAV-KIL---R-P--D-AT-KNA-RN-D-FL-K----EVKIMSRL--K---DPNIIRLLGVCV--Q-------DDP------LCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLAT-L--------NFVHRDLATRNCLVGE---NFTI----KIADFGMSRNL-------------Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGK---FTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQ-VYLS---RPPACP------------------------------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL----------------
----LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAV-KML---R-A--D-AN-KNA-RN-D-FL-K----EIKIMSRL--K---DPNIIHLLAVCI--T-------DDP------LCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSS-L--------NFVHRDLATRNCLVGK---NYTI----KIADFGMSRNL-------------Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL------LGK---FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQ-TYLP---QPAICP------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQEIHL---LL-------------
---K--LGQELGRGQYGVV---YLCDNW----------------GGHF---PCAL-KSV---VPP--D-EKHWN---D----LAL----EFHYMRSL-PK---HERLVDLHGSVI--DYNYGGGSSIA------VLLIMERLHR-DLYTGLK----------A----------------------------------------------------------------------------------------------------GLTLETRLQIALDVVEGIRFLHS-Q--------GLVHRDIKLKNVLLDK---QNRA----KITDLGFCK--------------------PEAMMS--------------GS---IVGTPIHMAPELFT-------GK---YDNSVDVYAFGILFWYICS-GS--------------VK---------------LPEAF---ERCASKDHLW----NN----VRR----GA---RPERLPVF---D------------------------EECWQ-LMEACWDGDPLKRP----------------LLGIVQPML-----
---F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAI-KEL---R-E--A-TS-PKA-NK-E-IL-D----EAYVMASV--D---NPHVCRLLGICL----------TST------VQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLED-R--------RLVHRDLAARNVLVKT---PQHV----KITDFGLAKLL-------------G---A--EEKE--------------YHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEISSIL----EK----GER----LP---QPPICT------------------------------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF------------
--LM--VDTVIGEGEFGEV---YRGTLR-------------LPSQDCK---TVAI-KTL---K-D--T-SP-GGQ-WW-N-FL-R----EATIMGQF--S---HPHILHLEGVVT--K-------RKP------IMIITEFMENGALDAFLR---------ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSN-H--------NYVHRDLAARNILVNQ---NLCC----KVSDFGLTRLL-------------D---D--FDGT--------------YETQGGKIPIRWTAPEAIA------HRI---FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI----ED----GYR----LP---PPVDCP------------------------------APLYE-LMKNCWAYDRARRPH-----FQKLQAHL----------------
---I-SIDKVVGAGEFGEV---CSGRLK-------------LPSKKEI---SVAI-KTL---K-V--G-YT-EKQ-RR-D-FL-G----EASIMGQF--D---HPNIIRLEGVVT--K-------SKP------VMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSD-M--------GYVHRDLAARNILINS---NLVC----KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTSPEAIA------YRK---FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV----DE----GYR----LP---PPMDCP------------------------------AALYQ-LMLDCWQKDRNNRPK-----FEQIVSIL----------------
---V-KIEEVIGAGEFGEV---YKGRLK-------------LPGKREI---YVAI-KTL---K-A--G-YS-EKQ-RR-D-FL-S----EASIMGQF--D---HPNIIRLEGVVT--K-------SRP------VMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAE-M--------NYVHRDLAARNILVNS---NLVC----KVSDFGLSRYLQ----------DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LP---PPMDCP------------------------------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL----------------
---V-KIEEVIGAGEFGEV---CRGRLK-------------APGKKES---CVAI-KTL---K-G--G-YT-ERQ-RR-E-FL-S----EASIMGQF--E---HPNIIRLEGVVT--N-------SMP------VMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAE-M--------SYVHRDLAARNILVNS---NLVC----KVSDFGLSRFLE----------ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA------FRK---FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LP---PPPDCP------------------------------TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL----------------
----IKIEEVIGTGSFGEV---RQGRLQ-------------PRGRREQ---TVAI-QAL---W-A--G-GA-ESL-QM-T-FL-G----RAAVLGQF--Q---HPNILRLEGVVT--K-------SRP------LMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSS-F--------AFVHRSLSAHSVLVNS---HLVC----KVARLGHSPQG-------------------------------------------PSCLLRWAAPEVIA------HGK---HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQ----EFR----LP---PPPGCP------------------------------PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF-------------
---L-RKVKVLGSGAFGTV---YKGIWIP------------DGENVKI---PVAI-KVL---R-E--N-TS-PKA-NK-E-IL-D----EAYVMAGV--G---SPYVSRLLGICL----------TST------VQLVTQLMPYGCLLDHVR---------EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLED-V--------RLVHRDLAARNVLVKS---PNHV----KITDFGLARLL-------------D---I--DETE--------------YHADGGKVPIKWMALESIL------RRR---FTHQSDVWSYGVTVWELMTFGA--------------KP---------------YDGI-----PAREIPDLL----EK----GER----LP---QPPICT------------------------------IDVYM-IMVKCWMIDSECRPR-----FRELVSE--F--------------
---L-KRVKVLGSGAFGTV---YKGIWVP------------EGETVKI---PVAI-KIL---N-E--T-TG-PKA-NV-E-FM-D----EALIMASM--D---HPHLVRLLGVCL----------SPT------IQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEE-R--------RLVHRDLAARNVLVKS---PNHV----KITDFGLARLL-------------E---G--DEKE--------------YNADGGKMPIKWMALECIH------YRK---FTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREIPDLL----EK----GER----LP---QPPICT------------------------------IDVYM-VMVKCWMIDADSRPK-----FKELAAE--F--------------
--VI--LGELLGKGNFGEV---YKGTLK-----------------DKT---SVAV-KTC---K-E--D-LP-QEL-KI-K-FL-Q----EAKILKQY--D---HPNIVKLIGVCT--Q-------RQP------VYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLES-K--------NCIHRDLAARNCLVGE---NNVL----KISDFGMSRQE-----------------D--GGVY--------------SSSGLKQIPIKWTAPEALN------YGR---YSSESDVWSFGILLWETFSLGV--------------CP---------------YPGM-----TNQQAREQV----ER----GYR----MS---APQHCP------------------------------EDISK-IMMKCWDYKPENRPK-----FSELQKEL----------------
---L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAV-KSC---R-E--T-LP-PDL-KA-K-FL-Q----EARILKQY--S---HPNIVRLIGVCT--Q-------KQP------IYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLES-K--------CCIHRDLAARNCLVTE---KNVL----KISDFGMSREE-------------A---D--GVYA--------------ASGGLRQVPVKWTAPEALN------YGR---YSSESDVWSFGILLWETFSLGA--------------SP---------------YPNL-----SNQQTREFV----EK----GGR----LP---CPELCP------------------------------DAVFR-LMEQCWAYEPGQRPS-----FSTIYQEL----------------
----LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAV-KML---K-D--D-AT-EKD-LS-D-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q-------DGP------LYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS-Q--------KCIHRDLAARNVLVTE---NNVM----KIADFGLARDI-------------N---N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MD---KPANCT------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----------------
----LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAV-KML---K-D--D-AT-DKD-LS-D-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q-------GGP------LYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS-Q--------KCIHRDLAARNVLVTE---DNVM----KIADFGLARDV-------------H---N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MD---KPANCT------------------------------HDLYM-IMRECWHAAPSQRPT-----FKQLVEDL----------------
---L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPDQAS---TVAV-KML---K-D--N-AS-DKD-LA-D-LV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q-------EGP------LYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLES-R--------KCIHRDLAARNVLVTE---DNVM----KIADFGLARGV-------------H---H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEELFSLL----RE----GHR----MD---RPPHCP------------------------------PELYG-LMRECWHAAPSQRPT-----FKQLVEAL----------------
----ITLERRLGTGCFGDV---WLGTWN-----------------GST---KVAV-KTL---K-P--G-TM-SP---K-A-FL-E----EAQVMKLL--R---HDKLVQLYAVVS----------EEP------IYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMER-M--------NYIHRDLRAANILVGE---RLAC----KIADFGLARLI-----------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQ----GYH----MP---CPPGCP------------------------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL----------------
----LHLGRVLGYGAFGKV---VEASAFG-----------IHKGSSCD---TVAV-KML---K-E--G-AT-ASE-HR-A-LM-S----ELKILIHIG-N---HLNVVNLLGACT-KP-------QGP------LMVIVEFCKYGNLSNFLR---------AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLAS-R--------KCIHRDLAARNILLSE---SDVV----KICDFGLARDI-------------Y---K--DPDY--------------VRKGSARLPLKWMAPESIF------DKV---YTTQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-Q---INEEFCQRL----RD----GTR----MR---APELAT------------------------------PAIRR-IMLNCWSGDPKARPA-----FSELVEIL----------------
----IQLLKRLGSGQFGEV---WEGLWN-----------------NTT---PVAV-KTL---K-P--G-SM-DP---N-D-FL-R----EAQIMKNL--R---HPKLIQLYAVCT--L-------EDP------IYIITELMRHGSLQEYLQ---------ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLES-R--------NYIHRDLAARNVLVGE---HNIY----KVADFGLARVFK-----------VD---N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNK---FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQ----NYR----LP---QPSNCP------------------------------QQFYN-IMLECWNAEPKERPT-----FETLRWK--L--------------
----LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAI-KTL---K-P--G-TM-SP---E-S-FL-E----EAQIMKKL--K---HDKLVQLYAVVS----------EEP------IYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIER-M--------NYIHRDLRSANILVGN---GLIC----KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ER----GYR----MP---CPQDCP------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL----------------
----LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAV-KTM---K-P--G-SM-SV---E-A-FL-A----EANVMKTL--Q---HDKLVKLHAVVT----------KEP------IYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-R--------NYIHRDLRAANILVSA---SLVC----KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ER----GYR----MP---RPENCP------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L--------------
----YTTIRQLGDGTYGSV---LLGRSI----------------ESGE---LIAI-KKM---KRK--F-YSWEE---C---MNLR----EVKSLKKL--N---HANVVKLKEVIR--E-------NDH------LYFIFEYMKE-NLYQLIK-------ERNK----------------------------------------------------------------------------------------------------LFPESAIRNIMYQILQGLAFIHK-H--------GFFHRDLKPENLLCMG---PELV----KIADFGLARE------------------IRSKPPY--------------TD---YVSTRWYRAPEVLL-----RSTN---YSSPIDVWAVGCIMAEVYT-LR--------------PL---------------FPGA-----SEIDTIFKI----CQ----VLG----TP---KKTDWPEGYQLSSAMNFRWPQCV-PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-----ASQALRYPYF--------------
----ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAI-KTV---N-E--A-AS-MRE-RI-E-FL-N----EASVMKEF--N---CHHVVRLLGVVS--Q-------GQP------TLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNA-N--------KFVHRDLAARNCMVAE---DFTV----KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK------DGV---FTTYSDVWSFGVVLWEIATLAE--------------QP---------------YQGL-----SNEQVLRFV----ME----GGL----LD---KPDNCP------------------------------DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I--------------
----ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAV-KTV---N-E--S-AS-LRE-RI-E-FL-N----EASVMKGF--T---CHHVVRLLGVVS--K-------GQP------TLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNA-K--------KFVHRDLAARNCMVAH---DFTV----KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGY----LD---QPDNCP------------------------------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL----------------
---I-SIIRELGQGSFGMV---YEGLARG-----------LEAGEEST---PVAL-KTV---N-E--L-AS-PRE-CI-E-FL-K----EASVMKAF--K---CHHVVRLLGVVS--Q-------GQP------TLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAA-N--------KFVHRDLAARNCMVSQ---DFTV----KIGDFGMTRDV-------------Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGI---FTTHSDVWSFGVVLWEIVTLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGV----LE---ELEGCP------------------------------LQLQE-LMSRCWQPNPRLRPS-----FTHILD---SI-------------
-VGG----NKMGEGGFGVV---YKGYVN----------------NTT-----VAV-KKL---AAM--V-DITTE---ELK-QQFD---QEIKVMAKC--Q---HENLVELLGFSS--D-------GDD------LCLVYVYMPNGSLLDRLSC-----LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHE-N--------HHIHRDIKSANILLDE---AFTA----KISDFGLARASE---------------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GE---ITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----REPQLLLDI----KE----EIE----DE---EKTIEDYIDKKMNDAD----------------STSVEAMYS-VASQCLHEKKNKRPD-----IKKVQQ----LLQ-----------
----LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAI-KTI---R-E--G-AM-SE---E-D-FI-E----EAEVMMKL--S---HPKLVQLYGVCL--E-------QAP------ICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEE-A--------CVIHRDLAARNCLVGE---NQVI----KVSDFGMTRFV-----------------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSR---YSSKSDVWSFGVLMWEVFSEGK--------------IP---------------YENR-----SNSEVVEDI----ST----GFR----LY---KPRLAS------------------------------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL----------------
---L-KRIRDLGEGHFGKV---ELCRYDP------------EGDNTGE---QVAV-KSL---K-P--E-SG-GNH-IA-D-LK-K----EIEILRNL--Y---HENIVKYKGICT-ED--------GGN----GIKLIMEFLPSGSLKEYLP---------KN--------------------------------------------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGS-R--------QYVHRDLAARNVLVES---EHQV----KIGDFGLTKAI------------ET---D--KEYY--------------TVKDDRDSPVFWYAPECLM------QSK---FYIASDVWSFGVTLHELLTYCD--------------SDSSPMALF-LKMIGPTHGQM-----TVTRLVNTL----KE----GKR----LP---CPPNCP------------------------------DEVYQ-LMRKCWEFQPSNRTS-----FQNLIE---GF-------------
----LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAV-KKL---Q-H--S-TE--EH-LR-D-FE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG-------RRN------LKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGT-K--------RYIHRDLATRNILVEN---ENRV----KIGDFGLTKVL------------PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR----LP---RPDGCP------------------------------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV------------
---L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAV-KQL---Q-H--S-GP-DQ--QR-D-FQ-R----EIQILKAL--H---SDFIVKYRGVSYGPG-------RQS------LRLVMEYLPSGCLRDFLQ---------RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGS-R--------RCVHRDLAARNILVES---EAHV----KIADFGLAKLL------------PL---D--KDYY--------------VVREPGQSPIFWYAPESLS------DNI---FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR----LP---APPACP------------------------------AEVHE-LMKLCWAPSPQDRPS-----FSALGP---QL-------------
----LKLGKPLGRGAFGQV---IEADAFG-----------IDKTATCR---TVAV-KML---K-E--G-AT-HSE-HR-A-LM-S----ELKILIHIG-H---HLNVVNLLGACT-KP-------GGP------LMVIVEFCKFGNLSTYLR---------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLAS-R--------KCIHRDLAARNILLSE---KNVV----KICDFGLARDI-------------Y---K--DPDY--------------VRKGDARLPLKWMAPETIF------DRV---YTIQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-K---IDEEFCRRL----KE----GTR----MR---APDYTT------------------------------PEMYQ-TMLDCWHGEPSQRPT-----FSELVEHL----------------
----LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAV-KML---K-P--S-AH-LTE-RE-A-LM-S----ELKVLSYLG-N---HMNIVNLLGACT--I-------GGP------TLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLAS-K--------NCIHRDLAARNILLTH---GRIT----KICDFGLARDI-------------K---N--DSNY--------------VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KE----GFR----ML---SPEHAP------------------------------AEMYD-IMKTCWDADPLKRPT-----FKQIVQL--I--------------
----LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAV-KSL---K-Q--G-SM-SP---D-A-FL-A----EANLMKQL--Q---HQRLVRLYAVVT----------QEP------IYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEE-R--------NYIHRDLRAANILVSD---TLSC----KIADFGLARLI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ER----GYR----MV---RPDNCP------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L--------------
--LI--HGEVLGKGFFGQA---IKVTHK-----------------ATG---KVMVMKEL-----I--R-CD-EET-QK-T-FL-T----EVKVMRSL--D---HPNVLKFIGVLY--K-------DKK------LNLLTEYIEGGTLKDFLR---------SM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHS-M--------CIIHRDLNSHNCLIKL---DKTV----VVADFGLSRLIVEERKRAPMEKATT---------KKRTL-----RKNDRKKRYTVVGNPYWMAPEMLN------GKS---YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---RTLDFGLNV----KL----FWE----KF---VPTDCP------------------------------PAFFP-LAAICCRLEPESRPA-----FSKLED---SF-------------
---V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAI-KTL---P-E--L-CS-PQD-EL-D-FL-M----EALIISKF--R---HQNIVRCVGLSL--R-------ATP------RLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEE-N--------HFIHRDIAARNCLLSCAGPSRVA----KIGDFGMARDI-------------Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL------EGI---FTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----TNQEVLDFV----VG----GGR----MD---PPRGCP------------------------------GPVYR-IMTQCWQHEPELRPS-----FASILERL----------------
----IKLVKRLGAGQFGEV---WMGYYN-----------------NST---KVAV-KTL---K-P--G-TM-SV---Q-A-FL-E----EANLMKTL--Q---HDKLVRLYAVVT--R-------EEP------IYIITEYMAKGSLLDFLK---------SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIER-K--------NYIHRDLRAANVLVSE---SLMC----KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQ----GYR----MP---RVENCP------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L--------------
----LTLGAQIGEGEFGAV---LQGEYL------------------GQ---KVAV-KNI---K-C--D-VT-AQ-----A-FL-D----ETAVMTKM--Q---HENLVRLLGVIL----------HQG------LYIVMEHVSKGNLVNFLR---------TR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLES-K--------KLVHRDLAARNILVSE---DLVA----KVSDFGLAKAE-----------------------R--------------KGLDSSRLPVKWTAPEALK------HGK---FTSKSDVWSFGVLLWEVFSYGR--------------AP---------------YPKM-----SLKEVSEAV----EK----GYR----ME---PPEGCP------------------------------GPVHV-LMSSCWEAEPARRPP-----FRKLAEKL----------------
---L-ILGKILGEGEFGSV---MEGNLK-------------QEDGTSL---KVAV-KTM---KLD--N-SS-QRE-IE-E-FL-S----EAACMKDF--S---HPNVIRLLGVCI--E-------MSSQG-IPKPMVILPFMKYGDLHTYLL---------YSRL---------------------------------------------------------------------------------------------ETGPKHIPLQTLLKFMVDIALGMEYLSN-R--------NFLHRDLAARNCMLRD---DMTV----CVADFGLSKKI-------------Y---S--GDYY--------------RQGRIAKMPVKWIAIESLA------DRV---YTSKSDVWAFGVTMWEIATRGM--------------TP---------------YPGV-----QNHEMYDYL----LH----GHR----LK---QPEDCL------------------------------DELYE-IMYSCWRTDPLDRPT-----FSVLRLQ--L--------------
----VHFNEVIGRGHFGCV---YHGTLL-------------DNDGKKI---HCAV-KSL---N-R--I-TD-IGE-VS-Q-FL-T----EGIIMKDF--S---HPNVLSLLGICL-RS-------EGS------PLVVLPYMKHGDLRNFIR---------NE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLAS-K--------KFVHRDLAARNCMLDE---KFTV----KVADFGLARDM-------------Y---D--KEYYS------------VHNKTGAKLPVKWMALESLQ------TQK---FTTKSDVWSFGVLLWELMTRGA--------------PP---------------YPDV-----NTFDITVYL----LQ----GRR----LL---QPEYCP------------------------------DPLYE-VMLKCWHPKAEMRPS-----FSELVSR--I--------------
---I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYEPFT---MVAV-KML---K-E--E-AS-ADM-QA-D-FQ-R----EAALMAEF--D---NPNIVKLLGVCA--V-------GKP------MCLLFEYMAYGDLNEFLR---------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSE-R--------KFVHRDLATRNCLVGE---NMVV----KIADFGLSRNI-------------Y---S--ADYY--------------KANENDAIPIRWMPPESIF------YNR---YTTESDVWAYGVVLWEIFSYGL--------------QP---------------YYGM-----AHEEVIYYV----RD----GNI----LS---CPENCP------------------------------VELYN-LMRLCWSKLPADRPS-----FTSIHRIL----------------
---Y-VRLQKIGEGSFGKA---ILVKST----------------EDGR---QYVI-KEI---NIS--R-MSSKE---R-E-ESRR----EVAVLANM--K---HPNIVQYRESFE--E-------NGS------LYIVMDYCEGGDLFKRINA------QKGV----------------------------------------------------------------------------------------------------LFQEDQILDWFVQICLALKHVHD-R--------KILHRDIKSQNIFLTK---DGTV----QLGDFGIARVL-----------------NSTVELA--------------RT---CIGTPYYLSPEICE------NKP---YNNKSDIWALGCVLYELCT-LK--------------HA---------------FEAG--------SMKNLV----LK----IIS----GS---FPPVSLHYS---------------------------YDLRS-LVSQLFKRNPRDRPS-----VNSILEKGF-I-------------
----YEVLYTIGTGSYGRC---QKIRRK----------------SDGK---ILVW-KEL---DYG--S-MTEAE---K-Q-MLVS----EVNLLREL--K---HPNIVRYYDRII--DR-----TNTT------LYIVMEYCEGGDLASVITKG----TKERQ----------------------------------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHR-RSD---GGHTVLHRDLKPANVFLDG---KQNV----KLGDFGLARIL-----------------NHDTSFA--------------KT---FVGTPYYMSPEQMN------RMS---YNEKSDIWSLGCLLYELCA-LM--------------PP---------------FTAF--------SQKELA----GK----IRE----GK---FRRIPYRY---S------------------------DELNE-IITRMLNLKDYHRPS-----VEEILENPL-I-------------
---Y-MVLRMIGEGSFGRA---LLVQHE----------------SSNQ---MFAM-KEI---RLP--K-SFSNT---Q-N--SRK----EAVLLAKM--K---HPNIVAFKESFE--A-------EGH------LYIVMEYCDGGDLMQKIKQ------QKGK----------------------------------------------------------------------------------------------------LFPEDMILNWFTQMCLGVNHIHK-K--------RVLHRDIKSKNIFLTQ---NGKV----KLGDFGSARLL-----------------SNPMAFA--------------CT---YVGTPYYVPPEIWE------NLP---YNNKSDIWSLGCILYELCT-LK--------------HP---------------FQAN-----SWKNLILKV----CQ----GCI----SP---LPSHYS------------------------------YELQF-LVKQMFKRNPSHRPS-----ATTLLS----RGIV----------
---Y-CYLRVVGKGSYGEV---TLVKHR----------------RDGK---QYVI-KKL---NLR--N-ASSRE---R-R-AAEQ----EAQLLSQL--K---HPNIVTYKESWE--G------GDGL------LYIVMGFCEGGDLYRKLKE------QKGQ----------------------------------------------------------------------------------------------------LLPENQVVEWFVQIAMALQYLHE-K--------HILHRDLKTQNVFLTR---TNII----KVGDLGIARVL-----------------ENHCDMA--------------ST---LIGTPYYMSPELFS------NKP---YNYKSDVWALGCCVYEMAT-LK--------------HA---------------FNAK--------DMNSLV----YR----IIE----GK---LPPMPRDY---S------------------------PELAE-LIRTMLSKRPEERPS-----VRSILRQPYI--------------
----YDVIKAIGQGAFGKA---YLAKGK----------------SDSK---HCVI-KEI---NFE--K-MPIQE---K-E-ASKK----EVILLEKM--K---HPNIVAFFNSFQ--E-------NGR------LFIVMEYCDGGDLMKRINR------QRGV----------------------------------------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHD-R--------KILHRDIKAQNIFLSK---NGMV---AKLGDFGIARVL-----------------NNSMELA--------------RT---CIGTPYYLSPEICQ------NKP---YNNKTDIWSLGCVLYELCT-LK--------------HP---------------FEGN--------NLQQLV----LK----ICQ----AH---FAPISPGF---S------------------------RELHS-LISQLFQVSPRDRPS-----INSILKRPFL--------------
-YIP---IRVLGRGAFGEA---TLYRRT----------------EDDS---LVVW-KEV---DLT--R-LSEKE---R-R-DALN----EIVILALL--Q---HDNIIAYYNHFM--D-------NTT------LLIELEYCNGGNLYDKILR------QKDK----------------------------------------------------------------------------------------------------LFEEEMVVWYLFQIVSAVSCIHK-A--------GILHRDIKTLNIFLTK---ANLI----KLGDYGLAKKL-----------------NSEYSMA--------------ET---LVGTPYYMSPELCQ------GVK---YNFKSDIWAVGCVIFELLT-LK--------------RT---------------FDAT--------NPLNLC----VK----IVQ----GI---RAMEVDSS-QYS------------------------LELIQ-MVHSCLDQDPEQRPT-----ADELLDRPL-L-------------
--IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAV-KAL---K-E--A-SE-SA--RQ-D-FQ-R----EAELLTML--Q---HQHIVRFFGVCT--E-------GRP------LLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG-L--------HFVHRDLATRNCLVGQ---GLVV----KIGDFGMSRDI-------------Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRK---FTTESDVWSFGVVLWEIFTYGK--------------QP---------------WYQL-----SNTEAIDCI----TQ----GRE----LE---RPRACP------------------------------PEVYA-IMRGCWQREPQQRHS-----IKDVHARL----------------
---I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAV-KTL---K-D--A-SD-NA--RK-D-FH-R----EAELLTNL--Q---HEHIVKFYGVCV--E-------GDP------LIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLAS-Q--------HFVHRDLATRNCLVGE---NLLV----KIGDFGMSRDV-------------Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSLGVVLWEIFTYGK--------------QP---------------WYQL-----SNNEVIECI----TQ----GRV----LQ---RPRTCP------------------------------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L--------------
---I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAV-KAL---K-D--P-TL-AA--RK-D-FQ-R----EAELLTNL--Q---HEHIVKFYGVCG--D-------GDP------LIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLAS-Q--------HFVHRDLATRNCLVGA---NLLV----KIGDFGMSRDV-------------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSFGVILWEIFTYGK--------------QP---------------WFQL-----SNTEVIECI----TQ----GRV----LE---RPRVCP------------------------------KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL----------------
----YELQEVIGSGATAVV---QAAYCA----------------PKKE---KVAI-KRI---NLE--K-CQTSM---D-E--LLK----EIQAMSQC--H---HPNIVSYYTSFV--V-------KDE------LWLVMKLLSGGSVLDIIKHIVAKGEHKSG----------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHK-N--------GQIHRDVKAGNILLGE---DGSV----QIADFGVSAFLAT------------GGDITRNKVR--------------KT---FVGTPCWMAPEVME-----QVRG---YDFKADIWSFGITAIELAT-GA--------------AP---------------YHKY-----PPMKVLMLT----LQ----NDP----PS---LETGVQDKE--MLK-------------------KYGKSFRK-MISLCLQKDPEKRPT-----AAELLRHKFF--------------
DNFI-----KIGEGSTGIV---CIATVR----------------SSGK---LVAV-KKM---DLR--K-QQRRE---L----LFN----EVVIMRDY--Q---HENVVEMYNSYL--V-------GDE------LWVVMEFLEGGALTDIVT---------HT----------------------------------------------------------------------------------------------------RMNEEQIAAVCLAVLQALSVLHA-Q--------GVIHRDIKSDSILLTH---DGRV----KLSDFGFCAQV-----------------SKEVPRR--------------KS---LVGTPYWMAPELIS------RLP---YGPEVDIWSLGIMVIEMVD-GE--------------PP---------------YFNE-----PPLKAMKMI----RD----NLP----PR---LKNLHKVS----------------------------PSLKG-FLDRLLVRDPAQRAT-----AAELLKHPFL--------------
---L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAV-KML---K-P--T-AR-SSE-KQ-A-LM-S----ELKIMTHLG-P---HLNIVNLLGACT--K-------SGP------IYIITEYCFYGDLVNYLH---------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLAS-K--------NCVHRDLAARNVLLAQ---GKIV----KICDFGLARDI-------------M---H--DSNY--------------VSKGSTFLPVKWMAPESIF------DNL---YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KS----GYR----MA---KPDHAT------------------------------SEVYE-IMVKCWNSEPEKRPS-----FYHLSE---IV-------------
---L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAV-KML---K-S--T-AR-SSE-KQ-A-LM-S----ELKIMSHLG-P---HLNVVNLLGACT--K-------GGP------IYIITEYCRYGDLVDYLH---------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLAS-K--------NCVHRDLAARNVLICE---GKLV----KICDFGLARDI-------------M---R--DSNY--------------ISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KR----GYR----MA---QPAHAS------------------------------DEIYE-IMQKCWEEKFEIRPP-----FSQLVL---LL-------------
---F-KFGKILGEGSFSTV---VLAREL----------------ATSR---EYAI-KIL---EKR--H-IIKEN---K-VPYVTR----ERDVMSRL--D---HPFFVKLYFTFQ--D-------DEK------LYFGLSYAKNGELLKYIR--------KIG----------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHG-K--------GIIHRDLKPENILLNE---DMHI----QITDFGTAKVLS---------------PESKQARA--------------NS---FVGTAQYVSPELLT------EKS---ACKSSDLWALGCIIYQLVA-GL--------------PP---------------FRAG--------NEYLIF----QK----IIK----LE---YDFPEKFF----------------------------PKARD-LVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF---
---F-NFLMVLGKGSFGKV---MLADRK----------------GTEE---LYAI-KIL---KKD--V-VIQDD---D-V-ECTM---VEKRVLALL-DK---PPFLTQLHSCFQ--T-------VDR------LYFVMEYVNGGDLMYHIQ--------QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHK-R--------GIIYRDLKLDNVMLDS---EGHI----KIADFGMCKEH-----------------MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQP---YGKSVDWWAYGVLLYEMLA-GQ--------------PP---------------FDGE--------DEDELF----QS----IME----HN---VSYPKSLS----------------------------KEAVS-VCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
--PD----EVLGSGQFGIV---YGGKHR----------------KTGR---DVAI-KII---DKL--R-FPTKQ---E-S-QLRN----EVAILQNL--H---HPGVVNLECMFE--T-------PER------VFVVMEKLHGDMLEMILS-------SEKG----------------------------------------------------------------------------------------------------RLPEHITKFLITQILVALRHLHF-K--------NIVHCDLKPENVLLAS---ADPFP-QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------NKG---YNRSLDMWSVGVIIYVSLS-GT--------------FP---------------FNED----------EDIH----DQ----IQN----AA---FMYPPNPWKEIS------------------------HEAID-LINNLLQVKMRKRYS-----VDKTLSHPWL--------------
--PD----EVLGSGQFGVV---YGGKHR----------------KTGR---DVAV-KVI---DKL--R-FPTKQ---E-S-QLRN----EVAILQSL--R---HPGIVNLECMFE--T-------PEK------VFVVMEKLHGDMLEMILS-------SEKG----------------------------------------------------------------------------------------------------RLPERLTKFLITQILVALRHLHF-K--------NIVHCDLKPENVLLAS---ADPFP-QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEVLL------NQG---YNRSLDMWSVGVIMYVSLS-GT--------------FP---------------FNED----------EDIN----DQ----IQN----AA---FMYPASPWSHIS------------------------AGAID-LINNLLQVKMRKRYS-----VDKSLSHPWL--------------
-FAD----EVLGSGQFGIV---YGGKHR----------------KTGR---DVAI-KVI---DKM--R-FPTKQ---E-S-QLRN----EVAILQNL--H---HPGIVNLECMFE--T-------PER------VFVVMEKLHGDMLEMILS-------SEKS----------------------------------------------------------------------------------------------------RLPERITKFMVTQILVALRNLHF-K--------NIVHCDLKPENVLLAS---AEPFP-QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------SKG---YNRSLDMWSVGVIIYVSLS-GT--------------FP---------------FNED----------EDIN----DQ----IQN----AA---FMYPPNPWREIS------------------------GEAID-LINNLLQVKMRKRYS-----VDKSLSHPWL--------------
---L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAV-KML---K-E--N-AS-PSE-LR-D-LL-S----EFNVLKQV--N---HPHVIKLYGACS--Q-------DGP------LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-M--------KLVHRDLAARNILVAE---GRKM----KISDFGLSRDV-------------Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KT----GHR----ME---RPDNCS------------------------------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL----------------
-LES----AELDSGGFGKV---SLCFHR-----------------TQG---LMIM-KTV--YK-G--P-NC-IEH-NE-A-LL-E----EAKMMNRL--R---HSRVVKLLGVII--E-------EGK------YSLVMEYMEKGNLMHVLK---------AE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHG-K--------GVIHKDLKPENILVDN---DFHI----KIADLGLASFKMWS------KLNNE-------EHNELR--------EVDGTAKKNGGTLYYMAPEHLN------DVNA-KPTEKSDVYSFAVVLWAIFA-NK--------------EP---------------YENA-I---CEQQLIMCI----KS----GNR----PDVDDITEYCP------------------------------REIIS-LMKLCWEANPEARPT-----FPGIEEK--F--------------
----FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAM-KVL---KKA--T-LKVRD---R-V-RTKM----ERDILADV--N---HPFVVKLHYAFQ--T-------EGK------LYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHS-L--------GIIYRDLKPENILLDE---EGHI----KLTDFGLSKEA-----------------IDHEKKA--------------YS---FCGTVEYMAPEVVN------RQG---HSHSADWWSYGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----TL----ILK----AK---LGMPQFLS----------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY------------
----FELLKVLGQGSYGKV---FLVRKV----------------KGSDAGQLYAM-KVL---KKA--T-LKVRD---R-V-RSKM----ERDILAEV--N---HPFIVKLHYAFQ--T-------EGK------LYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHS-L--------GIIYRDLKPENILLDE---EGHI----KITDFGLSKEA-----------------IDHDKRA--------------YS---FCGTIEYMAPEVVN------RRG---HTQSADWWSFGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----AL----ILK----AK---LGMPQFLS----------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF--------------
----FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAM-KVL---KKA--T-LKVRD---R-V-RTKM----ERDILVEV--N---HPFIVKLHYAFQ--T-------EGK------LYLILDFLRGGDLFTRLS--------KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHS-L--------GIIYRDLKPENILLDE---EGHI----KLTDFGLSKES-----------------IDHEKKA--------------YS---FCGTVEYMAPEVVN------RRG---HTQSADWWSFGVLMFEMLT-GT--------------LP---------------FQGK--------DRKETM----TM----ILK----AK---LGMPQFLS----------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF--------------
----FELLKVLGQGSFGKV---FLVRKK----------------TGPDAGQLYAM-KVL---KKA--S-LKVRD---R-V-RTKM----ERDILVEV--N---HPFIVKLHYAFQ--T-------EGK------LYLILDFLRGGDVFTRLS--------KEV----------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQ-L--------GIVYRDLKPENILLDE---IGHI----KLTDFGLSKES-----------------VDQEKKA--------------YS---FCGTVEYMAPEVVN------RRG---HSQSADWWSYGVLMFEMLT-GT--------------LP---------------FQGK--------DRNETM----NM----ILK----AK---LGMPQFLS----------------------------AEAQS-LLRMLFKRNPANRLGS--EGVEEIKRHLFF--------------
----WEIIGELGDGAFGKV---YKAQNK----------------ETSV---LAAA-KVI---DTK--S-EEELE---D-Y-M--V----EIDILASC--D---HPNIVKLLDAFY--Y-------ENN------LWILIEFCAGGAVDAVML-------ELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHD-N--------KIIHRDLKAGNILFTL---DGDI----KLADFGVSAKN-----------------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE-TSKDRP---YDYKADVWSLGITLIEMAE-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SEP----PT---LAQPSRWS----------------------------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV--------------
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAI-KTL---K-P--G-TM-SP---E-A-FL-Q----EAQVMKKL--R---HEKLVQLYAVVS----------EEP------IYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVER-M--------NYVHRDLRAANILVGE---NLVC----KVADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ER----GYR----MP---CPPECP------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L--------------
--FA--LGRKLGEGYFGEV---WEGLWL-----------------GSL---PVAI-KVI---K-S--A-NM-K---LT-D-LA-K----EIQTLKGL--R---HERLIRLHAVCS--G-------GEP------VYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEE-Q--------RVVHRDLAARNVLVDD---GLAC----KVADFGLARLL-----------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN------YRV---FSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHETLQQI----MR----GYR----LP---RPAACP------------------------------AEVYV-LMLECWRSSPEERPS-----FATLREKL----------------
----WEIVGELGDGAFGKV---YKAKNK----------------ETGA---LAAA-KVI---ETK--S-EEELE---D-Y-I--V----EIEILATC--D---HPYIVKLLGAYY--H-------DGK------LWIMIEFCPGGAVDAIML-------ELDR----------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHS-K--------RIIHRDLKAGNVLMTL---EGDI----RLADFGVSAKN-----------------LKTLQKR--------------DS---FIGTPYWMAPEVVMCE-TMKDTP---YDYKADIWSLGITLIEMAQ-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SDP----PT---LLTPSKWS----------------------------VEFRD-FLKIALDKNPETRPS-----AAQLLEHPFV--------------
-ILT---SKELGRGKFAVV---RQCISK----------------STGQ---EYAA-KFL---KKR--R-RGQDC---R-A-EILH----EIAVLELA-KS---CPRVINLHEVYE--N-------TSE------IILILEYAAGGEIFSLCLP------ELAE----------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQ-N--------NIVHLDLKPQNILLSS---IYPLG-DIKIVDFGMSRK------------------IGHACEL--------------RE---IMGTPEYLAPEILN------YDP---ITTATDMWNIGIIAYMLLT-HT--------------SP---------------FVGE--------DNQETY----LN----ISQ----VN---VDYSEETFSSVS------------------------QLATD-FIQSLLVKNPEKRPT-----AEICLSHSWL--------------
----FTKLEKIGKGSFGEV---FKGIDN----------------RTQK---VVAI-KII---DLE--E-AEDEI---E-D-IQ-Q----EITVLSQC--D---SPYVTKYYGSYL--K-------DTK------LWIIMEYLGGGSALDLLE---------PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHS-E--------KKIHRDIKAANVLLSE---HGEV----KLADFGVAGQL-----------------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSA---YDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----HPMKVLFLI----PK----NNP----PT---LEGNYS------------------------------KPLKE-FVEACLNKEPSFRPT-----AKELLKHKFI--------------
----YELQEVIGSGATAVV---QAALCK----------------PRQE---RVAI-KRI---NLE--K-CQTSM---D-E--LLK----EIQAMSQC--S---HPNVVTYYTSFV--V-------KDE------LWLVMKLLSGGSMLDIIKYIVNRGEHKNG----------------------------------------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHR-N--------GQIHRDLKAGNILLGE---DGSV----QIADFGVSAFLAT------------GGDVTRNKVR--------------KT---FVGTPCWMAPEVME-----QVRG---YDFKADMWSFGITAIELAT-GA--------------AP---------------YHKY-----PPMKVLMLT----LQ----NDP----PT---LETGVEDKE--MMK-------------------KYGKSFRK-LLSLCLQKDPSKRPT-----AAELLKCKFF--------------
-TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAV-KIL---K-N--E-AN-DPALKD-E-LL-A----EANVMQQL--D---NPYIVRMIGICE----------AES------WMLVMEMAELGPLNKYLQ---------QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEE-S--------NFVHRDLAARNVLLVT---QHYA----KISDFGLSKAL-------------R---A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYK---FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EK----GER----MG---CPAGCP------------------------------REMYD-LMNLCWTYDVENRPG-----FAAVE----LRL------------
-VCR---GELLGSGCFGVV---HRGLWT-------------LPSGKSV---PVAV-KSLRVGP-E--G-PM-GTE-LG-D-FL-R----EVSVMMNL--E---HPHVLRLHGLVL----------GQP------LQMVMELAPLGSLHARLT---------AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGA-R--------GLVHRDLATRNLLLAS---PRTI----KVADFGLVRPL------------GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR------HGA---FSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----PPYLILQRL----ED----RAR----LP---RPPLCS------------------------------RALYS-LALRCWAPHPADRPS-----FSHLE----GLL------------
---L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAV-KCL---K-PDVL-SQ-PEA-MD-D-FI-R----EVNAMHSL--D---HRNLIRLYGVVL----------TPP------MKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLES-K--------RFIHRDLAARNLLLAT---RDLV----KIGDFGLMRAL------------PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKE----GER----LP---RPEDCP------------------------------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L--------------
---L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAI-KAI---N-E--G-SM-SE---E-D-FI-E----EAKVMMKL--S---HSKLVQLYGVCI--Q-------RKP------LYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLER-N--------GYIHRDLAARNCLVSS---TCIV----KISDFGMTRYV-----------------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNK---YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SE----GFR----LY---RPHLAP------------------------------MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV-------------
---L-KKIRDLGEGHFGKV---SLYCYDP------------TNDGTGE---MVAV-KAL---K-A--D-CG-PQH-RS-G-WK-Q----EIDILRTL--Y---HEHIIKYKGCCEDQG-------EKS------LQLVMEYVPLGSLRDYLP---------RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHA-Q--------HYIHRDLAARNVLLDN---DRLV----KIGDFGLAKAV------------PE---G--HEYY--------------RVREDGDSPVFWYAPECLK------EYK---FYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER----LP---RPDKCP------------------------------CEVYH-LMKNCWETEASFRPT-----FENLIP---IL-------------
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAI-KTL---K-P--G-TM-MP---E-A-FL-Q----EAQIMKKL--R---HDKLVPLYAVVS----------EEP------IYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIER-M--------NYIHRDLRAANILVGE---NLVC----KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ER----GYR----MP---CPQGCP------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL----------------
LIAD----IELGCGNFGSV---RQGVYR--------------MRKKQI---DVAI-KVL---K-Q--G-TE-KAD-TE-E-MM-R----EAQIMHQL--D---NPYIVRLIGVCQ----------AEA------LMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEE-K--------NFVHRDLAARNVLLVN---RHYA----KISDFGLSKAL------------GA---D--DSYY--------------TARSAGKWPLKWYAPECIN------FRK---FSSRSDVWSYGVTMWEALSYGQ--------------KP---------------YKKM-----KGPEVMAFI----EQ----GKR----ME---CPPECP------------------------------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M--------------
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